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Jean Wandji - One of the best experts on this subject based on the ideXlab platform.
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phytochemistry and pharmacology of the genus Drypetes a review
Journal of Ethnopharmacology, 2016Co-Authors: Jeanduplex Wansi, Jean Wandji, Norbert Sewald, Lutfun Nahar, Claire Martin, Satyajit D SarkerAbstract:Aims: Traditional medicinal use of species of the genus Drypetes is widespread in the tropical regions. The aim of this review is to systematically appraise the literature available to date on phytochemistry, ethnopharmacology, toxicology and bioactivity (in vitro and in vivo) of crude extracts and purified compounds. Ethnopharmacological relevance: Plants of the genus Drypetes (Putranjivaceae) are used in the Subsaharan African and Asian traditional medicines to treat a multitude of disorders, like dysentery, gonorrhoea, malaria, rheumatism, sinusitis, tumours, as well as for the treatment of wounds, headache, urethral problems, fever in young children, typhoid and several other ailments. Some Drypetes species are used to protect food against pests, as an aphrodisiac, a stimulant/depressant, a rodenticide and a fish poison, against insect bites, to induce conception and for general healing. This review deals with updated information on the ethnobotany, phytochemistry, and biological activities of ethnomedicinally important Drypetes species, in order to provide an input for the future research opportunities. Methods: An extensive review of the literature available in various recognized databases e.g., Google Scholar, PubMed, Science Direct, SciFinder, Web of Science, www.theplantlist.org and www.gbif.org, as well as the Herbier National du Cameroun (Yaounde) and Botanic Gardens of Limbe databases on the uses and bioactivity of various species of the Drypetes was undertaken. Results: The literature provided information on ethnopharmacological uses of the Subsaharan African and Asian species of the genus Drypetes, e.g., Drypetes aubrevillii, D. capillipes, D. chevalieri, D. gerrardii, D. gossweileri, D. ivorensis, D. klainei, D. natalensis, D. pellegrini (all endemic to Africa) and D. roxburghii (Asian species), for the treatment of multiple disorders. From a total of 19 species, more than 140 compounds including diterpenes, sesquiterpenes, triterpenes (friedelane, oleanane, lupane and hopane-type), flavonoids, lignans, phenylpropanoids and steroids, as well as some thiocyanates, were isolated. Several crude extracts of these plants, and isolated compounds displayed significant analgesic, anthelmintic, antidiabetic, anti-emetic anti-inflammatory, antioxidant, antiparasitic, central nervous system depressant, cytotoxic, and insecticidal activities both in vitro and in vivo. Some toxicities associated with the stem, bark, seed and leaf extracts of D. roxburghii, and the flavonoid, amentoflavone, isolated from the stem extract of D. littoralis as well as D. gerrardii, were confirmed in the animal models and in the rat skeletal myoblast cells assays. As a consequence, traditional medicine from this genus should in future be applied with care. Conclusions: Plants of this genus have offered bioactive samples, both from crude extracts and pure compounds, partly validating their effectivity in traditional medicine. However, most of the available scientific litteratures lacks information on relevant doses, duration of the treatment, storage conditions and positive controls for examining bioefficacy of extract and its active compounds. Additional toxicological studies on the species used in local pharmacopeia are urgently needed to guarantee safe application due to higth toxicity of some crude extracts. Interestingly, this review also reports 10 pimarane dinorditerpenoids structures with the aromatic ring C, isolated from the species collected in Asia Drypetes littoralis (Taiwan), D. perreticulata (China), and in Africa D. gerrardii (Kenya), D. gossweileri (Cameroon). These compounds might turn out to be good candidates for chemotaxonomic markers of the genus.
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a new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata
Chinese Chemical Letters, 2011Co-Authors: Simone Veronique Fannang, Jeanduplex Wansi, Francois Tillequin, Elisabeth Seguin, Victor Kuete, Celine Mbazoa Djama, Marlise Diane J Dongfack, Elizabeth Chosson, Jean WandjiAbstract:Abstract A new friedelane-type triterpene named 3 β -hydroxyfriedelane-7,12,22-trione, as well as nine known compounds were isolated from the whole stems of Drypetes laciniata Hutch. (Euphorbiaceae). Their structures were established on the basis of spectroscopic methods. The new triterpene derivative and a known saponin were tested for antimicrobial and antifungal activities and they appeared to be moderate active.
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antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana
Chinese Journal of Integrative Medicine, 2010Co-Authors: Victor Kuete, Jeanduplex Wansi, Francois Tillequin, Marlise Diane Jiofack Dongfack, Hanh Trinh Vandufat, Mariechristine Lallemand, Elisabeth Seguin, A T Mbaveng, Jean WandjiAbstract:Objective To evaluate the antimicrobial activity of the methanol extract from the stem bark of Drypetes tessmanniana, fractions (DTB1-5) as well as compounds [friedelin (2), 3,7-dioxofriedelane (3), 3,15-dioxofriedelane (4), 3β- O-(E)-3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene (6), and 3β,6α-dihydroxylup-20(29)-ene (7).
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Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana
Chinese Journal of Integrative Medicine, 2010Co-Authors: Victor Kuete, Jeanduplex Wansi, Francois Tillequin, Mariechristine Lallemand, Elisabeth Seguin, A T Mbaveng, Marlise D. J. Dongfack, Hanh T. Van-dufat, Jean WandjiAbstract:Objective To evaluate the antimicrobial activity of the methanol extract from the stem bark of Drypetes tessmanniana , fractions (DTB1-5) as well as compounds [friedelin (2), 3,7-dioxofriedelane (3), 3,15-dioxofriedelane (4), 3β- O -( E )-3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene (6), and 3β,6α-dihydroxylup-20(29)-ene (7). Methods Agar disc diffusion was used to determine the sensitivity of the above samples, whilst the microdilution method was used for the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentrations (MMC). Results The diffusion test showed that the crude extract was able to prevent the growth of all tested organisms. All other samples showed selective activity. The inhibitory effect of the fraction DTB2 was noted on 63.7%, that of DTB1 and DBT3 on 54.6%, whilst DTB4 and DTB5 were active on 9.1% of the 11 tested organisms. The tested compounds prevented the growth of 81.8% of the tested microbial species for compounds 3 and 4, 36.7% for compound 6, and 18.2% for compound 7. The results of the MIC determinations indicated perceptible values for DTB and compound 4 on 81.8% of the tested organisms. For other samples, MICs were detected on 0–63.7%. The lowest MIC value (78.12 μg/mL) for the crude extract and fractions (DTB2) was observed on M. audouinii . The corresponding value for isolated compounds (156.25 μg/mL) was noted with compounds 3 on S. faecalis and 4 on M. audouinii audouinii. The results of the MMC determination suggested that the microbicidal effect of most of the tested samples on the studied microorganisms could be expected. Conclusion The methanol extract from the stem bark of Drypetes. tessmanniana (Euphorbiaceae) as well as some of the isolated compounds might be potential sources of new antimicrobial drugs.
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new friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii
Chemical & Pharmaceutical Bulletin, 2009Co-Authors: David Dako Chiozem, Jeanduplex Wansi, Francois Tillequin, Elisabeth Seguin, Celine Mbazoa Djama, Hanh Trinhvandufat, Veronique Simone Fannang, Jean WandjiAbstract:Two new friedelane-type triterpenes named 12α-hydroxyfriedelane-3,15-dione and 3β-hydroxyfriedelan-25-al, together with six known compounds were isolated from the stems of Drypetes paxii HUTCH. (Euphorbiaceae). Their structures were established on the basis of conventional 1 dimensional (1D) NMR methods, 2D shift-correlated NMR experiments and mass spectra. The five friedelane-type triterpene derivatives and one olean-12-ene triterpene saponin were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria, and they appeared to be modestly active.
Francois Tillequin - One of the best experts on this subject based on the ideXlab platform.
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a new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata
Chinese Chemical Letters, 2011Co-Authors: Simone Veronique Fannang, Jeanduplex Wansi, Francois Tillequin, Elisabeth Seguin, Victor Kuete, Celine Mbazoa Djama, Marlise Diane J Dongfack, Elizabeth Chosson, Jean WandjiAbstract:Abstract A new friedelane-type triterpene named 3 β -hydroxyfriedelane-7,12,22-trione, as well as nine known compounds were isolated from the whole stems of Drypetes laciniata Hutch. (Euphorbiaceae). Their structures were established on the basis of spectroscopic methods. The new triterpene derivative and a known saponin were tested for antimicrobial and antifungal activities and they appeared to be moderate active.
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antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana
Chinese Journal of Integrative Medicine, 2010Co-Authors: Victor Kuete, Jeanduplex Wansi, Francois Tillequin, Marlise Diane Jiofack Dongfack, Hanh Trinh Vandufat, Mariechristine Lallemand, Elisabeth Seguin, A T Mbaveng, Jean WandjiAbstract:Objective To evaluate the antimicrobial activity of the methanol extract from the stem bark of Drypetes tessmanniana, fractions (DTB1-5) as well as compounds [friedelin (2), 3,7-dioxofriedelane (3), 3,15-dioxofriedelane (4), 3β- O-(E)-3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene (6), and 3β,6α-dihydroxylup-20(29)-ene (7).
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Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana
Chinese Journal of Integrative Medicine, 2010Co-Authors: Victor Kuete, Jeanduplex Wansi, Francois Tillequin, Mariechristine Lallemand, Elisabeth Seguin, A T Mbaveng, Marlise D. J. Dongfack, Hanh T. Van-dufat, Jean WandjiAbstract:Objective To evaluate the antimicrobial activity of the methanol extract from the stem bark of Drypetes tessmanniana , fractions (DTB1-5) as well as compounds [friedelin (2), 3,7-dioxofriedelane (3), 3,15-dioxofriedelane (4), 3β- O -( E )-3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene (6), and 3β,6α-dihydroxylup-20(29)-ene (7). Methods Agar disc diffusion was used to determine the sensitivity of the above samples, whilst the microdilution method was used for the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentrations (MMC). Results The diffusion test showed that the crude extract was able to prevent the growth of all tested organisms. All other samples showed selective activity. The inhibitory effect of the fraction DTB2 was noted on 63.7%, that of DTB1 and DBT3 on 54.6%, whilst DTB4 and DTB5 were active on 9.1% of the 11 tested organisms. The tested compounds prevented the growth of 81.8% of the tested microbial species for compounds 3 and 4, 36.7% for compound 6, and 18.2% for compound 7. The results of the MIC determinations indicated perceptible values for DTB and compound 4 on 81.8% of the tested organisms. For other samples, MICs were detected on 0–63.7%. The lowest MIC value (78.12 μg/mL) for the crude extract and fractions (DTB2) was observed on M. audouinii . The corresponding value for isolated compounds (156.25 μg/mL) was noted with compounds 3 on S. faecalis and 4 on M. audouinii audouinii. The results of the MMC determination suggested that the microbicidal effect of most of the tested samples on the studied microorganisms could be expected. Conclusion The methanol extract from the stem bark of Drypetes. tessmanniana (Euphorbiaceae) as well as some of the isolated compounds might be potential sources of new antimicrobial drugs.
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new friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii
Chemical & Pharmaceutical Bulletin, 2009Co-Authors: David Dako Chiozem, Jeanduplex Wansi, Francois Tillequin, Elisabeth Seguin, Celine Mbazoa Djama, Hanh Trinhvandufat, Veronique Simone Fannang, Jean WandjiAbstract:Two new friedelane-type triterpenes named 12α-hydroxyfriedelane-3,15-dione and 3β-hydroxyfriedelan-25-al, together with six known compounds were isolated from the stems of Drypetes paxii HUTCH. (Euphorbiaceae). Their structures were established on the basis of conventional 1 dimensional (1D) NMR methods, 2D shift-correlated NMR experiments and mass spectra. The five friedelane-type triterpene derivatives and one olean-12-ene triterpene saponin were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria, and they appeared to be modestly active.
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triterpenoids with antimicrobial activity from Drypetes inaequalis
Phytochemistry, 2009Co-Authors: Simon Suh Awanchiri, Elisabeth Seguin, Jovita Chi Shirri, Philippe Verite, Marlise Diane J Dongfack, Hanh Trinhvandufat, Guy Merlin Nguenang, Sabrina Boutefnouchet, Z T Fomum, Francois TillequinAbstract:The air-dried stems and ripe fruit of Drypetes inaequalis Hutch. (Euphorbiaceae) were studied. Four triterpene derivatives, characterized as lup-20(29)-en-3β,6α-diol, 3β-acetoxylup-20(29)-en-6α-ol, 3β-caffeoyloxylup-20(29)-en-6α-ol and 28-β d-glucopyranosyl-30-methyl 3β-hydroxyolean-12-en-28,30-dioate along with 10 known compounds were isolated from the whole stems. One triterpene, characterized as 3α-hydroxyfriedelan-25-al along with six known compounds were isolated from the ripe fruit. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The triterpenes were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria, and two of them appeared to be modestly active.
Jeanduplex Wansi - One of the best experts on this subject based on the ideXlab platform.
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phytochemistry and pharmacology of the genus Drypetes a review
Journal of Ethnopharmacology, 2016Co-Authors: Jeanduplex Wansi, Jean Wandji, Norbert Sewald, Lutfun Nahar, Claire Martin, Satyajit D SarkerAbstract:Aims: Traditional medicinal use of species of the genus Drypetes is widespread in the tropical regions. The aim of this review is to systematically appraise the literature available to date on phytochemistry, ethnopharmacology, toxicology and bioactivity (in vitro and in vivo) of crude extracts and purified compounds. Ethnopharmacological relevance: Plants of the genus Drypetes (Putranjivaceae) are used in the Subsaharan African and Asian traditional medicines to treat a multitude of disorders, like dysentery, gonorrhoea, malaria, rheumatism, sinusitis, tumours, as well as for the treatment of wounds, headache, urethral problems, fever in young children, typhoid and several other ailments. Some Drypetes species are used to protect food against pests, as an aphrodisiac, a stimulant/depressant, a rodenticide and a fish poison, against insect bites, to induce conception and for general healing. This review deals with updated information on the ethnobotany, phytochemistry, and biological activities of ethnomedicinally important Drypetes species, in order to provide an input for the future research opportunities. Methods: An extensive review of the literature available in various recognized databases e.g., Google Scholar, PubMed, Science Direct, SciFinder, Web of Science, www.theplantlist.org and www.gbif.org, as well as the Herbier National du Cameroun (Yaounde) and Botanic Gardens of Limbe databases on the uses and bioactivity of various species of the Drypetes was undertaken. Results: The literature provided information on ethnopharmacological uses of the Subsaharan African and Asian species of the genus Drypetes, e.g., Drypetes aubrevillii, D. capillipes, D. chevalieri, D. gerrardii, D. gossweileri, D. ivorensis, D. klainei, D. natalensis, D. pellegrini (all endemic to Africa) and D. roxburghii (Asian species), for the treatment of multiple disorders. From a total of 19 species, more than 140 compounds including diterpenes, sesquiterpenes, triterpenes (friedelane, oleanane, lupane and hopane-type), flavonoids, lignans, phenylpropanoids and steroids, as well as some thiocyanates, were isolated. Several crude extracts of these plants, and isolated compounds displayed significant analgesic, anthelmintic, antidiabetic, anti-emetic anti-inflammatory, antioxidant, antiparasitic, central nervous system depressant, cytotoxic, and insecticidal activities both in vitro and in vivo. Some toxicities associated with the stem, bark, seed and leaf extracts of D. roxburghii, and the flavonoid, amentoflavone, isolated from the stem extract of D. littoralis as well as D. gerrardii, were confirmed in the animal models and in the rat skeletal myoblast cells assays. As a consequence, traditional medicine from this genus should in future be applied with care. Conclusions: Plants of this genus have offered bioactive samples, both from crude extracts and pure compounds, partly validating their effectivity in traditional medicine. However, most of the available scientific litteratures lacks information on relevant doses, duration of the treatment, storage conditions and positive controls for examining bioefficacy of extract and its active compounds. Additional toxicological studies on the species used in local pharmacopeia are urgently needed to guarantee safe application due to higth toxicity of some crude extracts. Interestingly, this review also reports 10 pimarane dinorditerpenoids structures with the aromatic ring C, isolated from the species collected in Asia Drypetes littoralis (Taiwan), D. perreticulata (China), and in Africa D. gerrardii (Kenya), D. gossweileri (Cameroon). These compounds might turn out to be good candidates for chemotaxonomic markers of the genus.
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a new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata
Chinese Chemical Letters, 2011Co-Authors: Simone Veronique Fannang, Jeanduplex Wansi, Francois Tillequin, Elisabeth Seguin, Victor Kuete, Celine Mbazoa Djama, Marlise Diane J Dongfack, Elizabeth Chosson, Jean WandjiAbstract:Abstract A new friedelane-type triterpene named 3 β -hydroxyfriedelane-7,12,22-trione, as well as nine known compounds were isolated from the whole stems of Drypetes laciniata Hutch. (Euphorbiaceae). Their structures were established on the basis of spectroscopic methods. The new triterpene derivative and a known saponin were tested for antimicrobial and antifungal activities and they appeared to be moderate active.
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antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana
Chinese Journal of Integrative Medicine, 2010Co-Authors: Victor Kuete, Jeanduplex Wansi, Francois Tillequin, Marlise Diane Jiofack Dongfack, Hanh Trinh Vandufat, Mariechristine Lallemand, Elisabeth Seguin, A T Mbaveng, Jean WandjiAbstract:Objective To evaluate the antimicrobial activity of the methanol extract from the stem bark of Drypetes tessmanniana, fractions (DTB1-5) as well as compounds [friedelin (2), 3,7-dioxofriedelane (3), 3,15-dioxofriedelane (4), 3β- O-(E)-3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene (6), and 3β,6α-dihydroxylup-20(29)-ene (7).
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Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana
Chinese Journal of Integrative Medicine, 2010Co-Authors: Victor Kuete, Jeanduplex Wansi, Francois Tillequin, Mariechristine Lallemand, Elisabeth Seguin, A T Mbaveng, Marlise D. J. Dongfack, Hanh T. Van-dufat, Jean WandjiAbstract:Objective To evaluate the antimicrobial activity of the methanol extract from the stem bark of Drypetes tessmanniana , fractions (DTB1-5) as well as compounds [friedelin (2), 3,7-dioxofriedelane (3), 3,15-dioxofriedelane (4), 3β- O -( E )-3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene (6), and 3β,6α-dihydroxylup-20(29)-ene (7). Methods Agar disc diffusion was used to determine the sensitivity of the above samples, whilst the microdilution method was used for the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentrations (MMC). Results The diffusion test showed that the crude extract was able to prevent the growth of all tested organisms. All other samples showed selective activity. The inhibitory effect of the fraction DTB2 was noted on 63.7%, that of DTB1 and DBT3 on 54.6%, whilst DTB4 and DTB5 were active on 9.1% of the 11 tested organisms. The tested compounds prevented the growth of 81.8% of the tested microbial species for compounds 3 and 4, 36.7% for compound 6, and 18.2% for compound 7. The results of the MIC determinations indicated perceptible values for DTB and compound 4 on 81.8% of the tested organisms. For other samples, MICs were detected on 0–63.7%. The lowest MIC value (78.12 μg/mL) for the crude extract and fractions (DTB2) was observed on M. audouinii . The corresponding value for isolated compounds (156.25 μg/mL) was noted with compounds 3 on S. faecalis and 4 on M. audouinii audouinii. The results of the MMC determination suggested that the microbicidal effect of most of the tested samples on the studied microorganisms could be expected. Conclusion The methanol extract from the stem bark of Drypetes. tessmanniana (Euphorbiaceae) as well as some of the isolated compounds might be potential sources of new antimicrobial drugs.
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new friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii
Chemical & Pharmaceutical Bulletin, 2009Co-Authors: David Dako Chiozem, Jeanduplex Wansi, Francois Tillequin, Elisabeth Seguin, Celine Mbazoa Djama, Hanh Trinhvandufat, Veronique Simone Fannang, Jean WandjiAbstract:Two new friedelane-type triterpenes named 12α-hydroxyfriedelane-3,15-dione and 3β-hydroxyfriedelan-25-al, together with six known compounds were isolated from the stems of Drypetes paxii HUTCH. (Euphorbiaceae). Their structures were established on the basis of conventional 1 dimensional (1D) NMR methods, 2D shift-correlated NMR experiments and mass spectra. The five friedelane-type triterpene derivatives and one olean-12-ene triterpene saponin were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria, and they appeared to be modestly active.
Kongkanda Chayamarit - One of the best experts on this subject based on the ideXlab platform.
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Drypetes dasycarpa (Airy Shaw) Phuph. & Chayamarit stat. nov. (Euphorbiaceae)
2020Co-Authors: Leena Phuphathanaphong, Kongkanda ChayamaritAbstract:Based on recently collected material. Drypetes indica var. dasycarpa is given specific status as D. dasycarpa.
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Drypetes dasycarpa airy shaw phuph chayamarit stat nov euphorbiaceae
Thai Forest Bulletin (Botany), 2000Co-Authors: Leena Phuphathanaphong, Kongkanda ChayamaritAbstract:Based on recently collected material. Drypetes indica var. dasycarpa is given specific status as D. dasycarpa.
Tanee Z Fomum - One of the best experts on this subject based on the ideXlab platform.
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antileishmanial furanosesquiterpene and triterpenoids from Drypetes chevalieri beille euphorbiaceae furanosesquiterpenos y triterpenoides de Drypetes chevalieri beille euphorbiaceae con actividad antileismania
2007Co-Authors: Jeanduplex Wansi, Jean Wandji, D D Chiozem, M I Choudhary, Francois Tillequin, Mariechristine Lallemand, Tanee Z FomumAbstract:The CH2Cl2/CH3OH (1/1) extract of the dried stems of Drypetes chevalieri Beille afforded two new compounds, furanoeudesm-1-on-13-oic acid and 3,6-dioxo-D:A-friedooleanan-24-al along with six known compounds. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The furanoeudesm-1-on13-oic acid showed a significant antileishmanial activity.
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phenolic constituents from Drypetes armoracia
Phytochemistry, 2003Co-Authors: Jean Wandji, Jeanduplex Wansi, Francois Tillequin, Elisabeth Seguin, Dulcie A Mulholland, Agathe D Temgoua, Tanee Z FomumAbstract:Abstract The methanol extract of the dried stem bark of Drypetes armoracia Pax & Hoffm. afforded two compounds named drypearmoracein A, (E)-4,5,6,7-tetrahydroxy-2-benzylhept-2-enoic acid and drypearmoracein B, 2,3-dihydroxy-9,10-tetrahydroanthra-1,4-quinone along with five known compounds: friedelan-3 β-ol, friedelin, friedelane-3,7-dione, drypemolundein B and β-stigmasterol. Their structures were established on the basis of spectroscopic analysis and chemical evidence.
