Earache

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Jagadeesan Arunakaran - One of the best experts on this subject based on the ideXlab platform.

  • antiproliferative effect of diallyl disulfide dads on prostate cancer cell line lncap
    Cell Biochemistry and Function, 2006
    Co-Authors: D. N. Gunadharini, M R Vijayababu, P. Kanagaraj, M.m. Aruldhas, A. Arunkumar, G. Krishnamoorthy, R. Muthuvel, N. Srinivasan, Jagadeesan Arunakaran
    Abstract:

    Garlic has been used throughout the world to treat coughs, toothache, Earache, dandruff, hypertension, hysteria, diarrhoea, dysentery, diptheria, vaginitis and many other conditions. Garlic contains a complex mixture of oil and water-soluble organosulfur compounds. Diallyl disulfide (DADS), an oil-soluble constituent of garlic seems to be effective in reducing tumour cells originating from colon, lung and skin. Hence our present study focuses on the dose-dependent effect of DADS on an androgen-dependent prostate cancer cell line. Various concentrations of DADS ranging from 25 to 100 µM were given to LNCaP cells and the activity of lactate dehydrogenase (LDH) prostatic acid phosphatase (PAcP) and the level of prostate specific antigen were studied. DADS reduced the secretory activity of LNCaP cells with the gradual increase in dosage. DADS was found to act as a good antiproliferative agent, which was confirmed by proliferation assay. DADS also induced apoptosis and nuclear segmentation in the higher doses. Copyright © 2005 John Wiley & Sons, Ltd.

  • Antiproliferative effect of diallyl disulfide (DADS) on prostate cancer cell line LNCaP.
    Cell biochemistry and function, 2006
    Co-Authors: D. N. Gunadharini, M R Vijayababu, P. Kanagaraj, M.m. Aruldhas, A. Arunkumar, G. Krishnamoorthy, R. Muthuvel, N. Srinivasan, Jagadeesan Arunakaran
    Abstract:

    Garlic has been used throughout the world to treat coughs, toothache, Earache, dandruff, hypertension, hysteria, diarrhoea, dysentery, diptheria, vaginitis and many other conditions. Garlic contains a complex mixture of oil and water-soluble organosulfur compounds. Diallyl disulfide (DADS), an oil-soluble constituent of garlic seems to be effective in reducing tumour cells originating from colon, lung and skin. Hence our present study focuses on the dose-dependent effect of DADS on an androgen-dependent prostate cancer cell line. Various concentrations of DADS ranging from 25 to 100 microM were given to LNCaP cells and the activity of lactate dehydrogenase (LDH) prostatic acid phosphatase (PAcP) and the level of prostate specific antigen were studied. DADS reduced the secretory activity of LNCaP cells with the gradual increase in dosage. DADS was found to act as a good antiproliferative agent, which was confirmed by proliferation assay. DADS also induced apoptosis and nuclear segmentation in the higher doses.

Arto A Palmu - One of the best experts on this subject based on the ideXlab platform.

  • otitis media and its consequences beyond the Earache
    Lancet Infectious Diseases, 2010
    Co-Authors: Anne Vergison, Ron Dagan, Adriano Arguedas, Jan Bonhoeffer, Robert Cohen, Ingeborg Dhooge, Alejandro Hoberman, Johannes G Liese, Paola Marchisio, Arto A Palmu
    Abstract:

    An international group of multidisciplinary experts on middle-ear and paediatric infections met to explore where consensus exists on the management of acute otitis media. After informal discussions among several specialists of paediatric infectious disease, the group was expanded to include a larger spectrum of professionals with complementary expertise in middle-ear disease. Acute otitis media is a very common bacterial infection in children worldwide, leading to excessive antibiotic consumption in children in most countries and to a substantial burden of deafness and suppurative complications in developing countries. The group attempted to move beyond the existing controversies surrounding guidelines on acute otitis media, and to propose to clinicians and public health officials their views on the actions needed to be taken to reduce the disease burden caused by acute otitis media and the microbial antibiotic resistance from the resulting use of antibiotics. Definition of acute otitis media and diagnostic accuracy are crucial steps to identify children who will potentially benefit from treatment with antibiotics and to eliminate unnecessary prescribing. Although the group agreed that antibiotics are distributed indiscriminately, even to children who do not seem to have the disease, no consensus could be reached on whether antibiotics should be given to all appropriately diagnosed children, reflecting the wide range of practices and lack of convincing evidence from observational studies. The major unanimous concern was an urgent need to reduce unnecessary prescribing of antibiotics to prevent further increases in antibiotic resistance. Prevention of acute otitis media with existing and future viral and bacterial vaccines seems the most promising approach to affect disease burden and consequences, both in developed and developing countries.

  • otitis media and its consequences beyond the Earache
    WOS, 2010
    Co-Authors: Anne Vergison, Ron Dagan, Adriano Arguedas, Jan Bonhoeffer, Ingeborg Dhooge, Johannes G Liese, Paola Marchisio, Robert M Cohen, Alejandro Haberman, Arto A Palmu
    Abstract:

    Paediatric Infectious Diseases, Infection Control and Epidemiology Unit, Universite Libre de Bruxelles, Brussels, Belgium (A Vergison MD); Pediatric Infectious Diseases Unit, Ben Gurion University of the Negev and Soroka University Medical Center, Beer-Sheva, Israel (R Dagan MD); Pediatric Infectious Diseases, Division of Pediatrics, Instituto de Atencion Pediatrica, University of Medical Sciences, San Jose, Costa Rica (A Arguedas MD); Paediatric Infectious Diseases and Vaccines, University Children’s Hospital, Basel, Switzerland (J Bonhoeff er MD); Paediatric Infectious Diseases Unit, Creteil Hospital, France (R Cohen MD); Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium (I DHooge MD); Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (A Hoberman MD); Department of Vaccines and Infectious Disease Epidemiology, Children’s Hospital Wurzburg, Germany (J Liese MD); Paediatric Department, University of Milan and Fondazione IRCCS Ospedale Maggiore, Policlinico Mangiagalli e Regina Elena, Milan, Italy (P Marchisio MD); Clinical Research Unit, National Institute for Health and Welfare, Helsinki, Finland (A A Palmu MD); Division of Research, Kaiser Permanente, Oakland, CA, USA (G T Ray MBA); Department of Paediatric Immunology, University Medical Centre, Utrecht, Netherlands (E A M Sanders MD); Department of Pediatrics, Pediatric Infectious Diseases, University of Colorado, Denver, CO, USA (E A F Simoes MD); Department of Pediatrics and Adolescence, University of Oulu, Oulu, Finland (M Uhari MD); Department of Laboratory Medicine, University Hospital Gasthuisberg, Leuven, Belgium Otitis media and its consequences: beyond the Earache

  • association of clinical signs and symptoms with bacterial findings in acute otitis media
    Clinical Infectious Diseases, 2004
    Co-Authors: Arto A Palmu, E Herva, Helja Savolainen, Pekka Karma, Helena P Makela, Terhi Kilpi
    Abstract:

    In acute otitis media (AOM), a means of prediction of the bacterial pathogen based on symptoms and signs would be valuable in selecting appropriate antimicrobial treatment. Children in the control arm (n=831) in the Finnish Otitis Media Vaccine Trial were prospectively observed in a study clinic setting from the age of 2 to 24 months. In patients with AOM, myringotomy with aspiration was performed, and middle ear fluid samples were cultured for bacterial pathogens. Symptoms and signs of respiratory infections were thoroughly recorded. Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae were the most common bacterial pathogens. Pneumococcal AOM was associated with more-severe AOM characterized by fever and Earache. AOM due to H. influenzae was associated with eye symptoms and findings. Accurate prediction of a bacterial cause of infection based on symptoms and signs of AOM was not possible, but a specific cause was predicted in some situations, with a high probability of applicability to clinical practice.

  • the symptoms and clinical course of acute bullous myringitis in children less than two years of age
    International Journal of Pediatric Otorhinolaryngology, 2003
    Co-Authors: Mikko J Kotikoski, Arto A Palmu, H Puhakka
    Abstract:

    Abstract Objective: the most characteristic symptom of acute bullous myringitis (inflammation of the tympanic membrane) is a sudden onset of severe ear pain. However, in infants and young children a precise symptom history is more difficult to obtain and the symptoms may be less specific. Our objective was to determine the occurrence of different symptoms, signs and the recovery of symptoms during the course of acute bullous myringitis in children less than 2 years. We also evaluated whether there were any specific features in bullous myringitis in comparison with acute otitis media (AOM). Methods: 2028 children (aged 7–24 months) at primary care level in a prospective longitudinal cohort study in the Finnish Otitis Media Vaccine Trial. Results: during the follow-up there were 86 office visits with bullous myringitis in 92 ears and 1876 office visits with acute otitis media in 2683 ears. Middle ear fluid developed in 97% of cases of bullous myringitis during the course of disease. Earache was present in 58% and fever (≥38 °C) in 62% of cases of bullous myringitis. The symptoms of upper respiratory tract infection (rhinitis in 93% and cough in 73% of events) were present in a majority of cases. Earache, fever, rubbing of the ear, restless sleeping, excessive crying and poor appetite were present more often in bullous myringitis than in acute otitis media. The symptoms were relieved in 1–2 days in a majority of cases. There were no recognized cases of bullous myringitis in ears with patent tympanostomy tubes. Conclusions: acute bullous myringitis in children represents a special form of AOM with more severe symptoms. Earache and fever were more common in bullous myringitis than in AOM. However, the condition resolved rapidly and the short-term outcome was good.

D. N. Gunadharini - One of the best experts on this subject based on the ideXlab platform.

  • antiproliferative effect of diallyl disulfide dads on prostate cancer cell line lncap
    Cell Biochemistry and Function, 2006
    Co-Authors: D. N. Gunadharini, M R Vijayababu, P. Kanagaraj, M.m. Aruldhas, A. Arunkumar, G. Krishnamoorthy, R. Muthuvel, N. Srinivasan, Jagadeesan Arunakaran
    Abstract:

    Garlic has been used throughout the world to treat coughs, toothache, Earache, dandruff, hypertension, hysteria, diarrhoea, dysentery, diptheria, vaginitis and many other conditions. Garlic contains a complex mixture of oil and water-soluble organosulfur compounds. Diallyl disulfide (DADS), an oil-soluble constituent of garlic seems to be effective in reducing tumour cells originating from colon, lung and skin. Hence our present study focuses on the dose-dependent effect of DADS on an androgen-dependent prostate cancer cell line. Various concentrations of DADS ranging from 25 to 100 µM were given to LNCaP cells and the activity of lactate dehydrogenase (LDH) prostatic acid phosphatase (PAcP) and the level of prostate specific antigen were studied. DADS reduced the secretory activity of LNCaP cells with the gradual increase in dosage. DADS was found to act as a good antiproliferative agent, which was confirmed by proliferation assay. DADS also induced apoptosis and nuclear segmentation in the higher doses. Copyright © 2005 John Wiley & Sons, Ltd.

  • Antiproliferative effect of diallyl disulfide (DADS) on prostate cancer cell line LNCaP.
    Cell biochemistry and function, 2006
    Co-Authors: D. N. Gunadharini, M R Vijayababu, P. Kanagaraj, M.m. Aruldhas, A. Arunkumar, G. Krishnamoorthy, R. Muthuvel, N. Srinivasan, Jagadeesan Arunakaran
    Abstract:

    Garlic has been used throughout the world to treat coughs, toothache, Earache, dandruff, hypertension, hysteria, diarrhoea, dysentery, diptheria, vaginitis and many other conditions. Garlic contains a complex mixture of oil and water-soluble organosulfur compounds. Diallyl disulfide (DADS), an oil-soluble constituent of garlic seems to be effective in reducing tumour cells originating from colon, lung and skin. Hence our present study focuses on the dose-dependent effect of DADS on an androgen-dependent prostate cancer cell line. Various concentrations of DADS ranging from 25 to 100 microM were given to LNCaP cells and the activity of lactate dehydrogenase (LDH) prostatic acid phosphatase (PAcP) and the level of prostate specific antigen were studied. DADS reduced the secretory activity of LNCaP cells with the gradual increase in dosage. DADS was found to act as a good antiproliferative agent, which was confirmed by proliferation assay. DADS also induced apoptosis and nuclear segmentation in the higher doses.

K Venkateshwarlu - One of the best experts on this subject based on the ideXlab platform.

  • a randomized double blind placebo controlled clinical evaluation of extract of andrographis paniculata kalmcold in patients with uncomplicated upper respiratory tract infection
    Phytomedicine, 2010
    Co-Authors: R C Saxena, Rana P Singh, Pratyush Kumar, S C Yadav, M P S Negi, V S Saxena, A J Joshua, V Vijayabalaji, K S Goudar, K Venkateshwarlu
    Abstract:

    A randomized, double blind placebo controlled clinical study was conducted to evaluate the efficacy of KalmCold, an extract of Andrographis paniculata, in patients with uncomplicated upper respiratory tract infection (URTI). The assessment involved quantification of symptom scores by Visual Analogue Scale. Nine self evaluated symptoms of cough, expectoration, nasal discharge, headache, fever, sore throat, Earache, malaise/fatigue and sleep disturbance were scored. A total of 223 patients of both sexes were randomized in two groups which received either KalmCold (200 mg/day) or placebo in a double blind manner. In both the treatments, mean scores of all symptoms showed a decreasing trend from day 1 to day 3 but from day 3 to day 5 most of the symptoms in placebo treated group either remained unchanged (cough, headache and Earache) or got aggravated (sore throat and sleep disturbance) whereas in KalmCold treated group all symptoms showed a decreasing trend. Within groups, mean scores of symptoms in both the groups decreased significantly (p 0.05). The comparison of overall efficacy of KalmCold over placebo was found to be significant (p < or = 0.05) and it was 2.1 times (52.7%) higher than placebo. The findings of this study revealed that KalmCold was effective in reducing symptoms of upper respiratory tract infection.

G K Wikman - One of the best experts on this subject based on the ideXlab platform.

  • use of visual analogue scale measurements vas to asses the effectiveness of standardized andrographis paniculata extract sha 10 in reducing the symptoms of common cold a randomized double blind placebo study
    Phytomedicine, 1999
    Co-Authors: Dante Caceres, J L Hancke, Rafael A Burgos, F Sandberg, G K Wikman
    Abstract:

    The objective of our study was to measure the effectiveness of Andrographis paniculata SHA-10 extract in reducing the prevalence and intensity of symptoms and signs of common cold as compared with a placebo. A group of 158 adult patients of both sexes completed the randomized double blind study in Valdivia, Chile. The patients were divided in two equal size groups, one of which received Andrographis paniculata dried extract (1200 mg/day) and the other a placebo during a period of 5 days. Evaluations for efficacy were performed by the patient at day 0, 2, and 4 of the treatment; each completed a self-evaluation (VAS) sheet with the following parameters: headache, tiredness, Earache, sleeplessness, sore throat, nasal secretion, phlegm, frequency and intensity of cough. In order to quantify the magnitude of the reduction in the prevalence and intensity of the signs and symptoms of common cold, the risk (Odds Ratio = OR) was calculated using a logistic regression model. At day 2 of treatment a significant decrease in the intensity of the symptoms of tiredness (OR = 1.28; 95% CI 1.07-1.53), sleeplessness (OR = 1.71; 95% CI 1.38-2.11), sore throat (OR = 2.3; 95% CI 1.69-3.14) and nasal secretion (OR = 2.51; 95% CI 1.82-3.46) was observed in the Andrographis SHA-10 group as compared with the placebo group. At day 4, a significant decrease in the intensity of all symptoms was observed for the Andrographis paniculata group. The higher OR values were for the following parameters: sore throat (OR = 3.59; 95% CI 2.04-5.35), nasal secretion (OR = 3.27; 95% CI 2.31-4.62) and Earache (OR = 3.11; 95% CI 2.01-4.80) for Andrographis paniculata treatment over placebo, respectively. It is concluded that Andrographis paniculata had a high degree of effectiveness in reducing the prevalence and intensity of the symptoms in uncomplicated common cold beginning at day two of treatment. No adverse effects were observed or reported.