The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform
Jiro Takahara - One of the best experts on this subject based on the ideXlab platform.
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A Case of Small Cell Lung Cancer that Developed during Therapy for Myasthenia Gravis
The Japanese journal of thoracic diseases, 1995Co-Authors: Reiko Miyoshi, Jiro Fujita, Yasufumi Yamaji, Satsuki Shima, Hiroki Okada, Jiro TakaharaAbstract:A 56-year-old man had been complaining of progressive proximal muscle weakness and bilateral ptosis before his first admission to our hospital. He received an injection of edrophonium chloride, which resulted in remarkable improvement of muscle strength. Electromyographic studies revealed a compound muscle action potential that decreased after repetitive stimulation at a high rate (15 Hz). He was regarded as having myasthenia gravis (MG) rather than Eaton-Lambert Syndrome because of these findings. Eighteen months after successful treatment of MG with oral anticholinesterase medication, he complained of an abdominal mass. The mass was found to be a tumor that had metastasized from a primary small cell carcinoma of the lung. Cases of MG with small cell carcinoma of the lung seem to be very rare, and the details of the relationship between them remain unknown. In this patient, MG may have developed by paraneoplastic mechanisms. This hypothesis is interesting, since it has been demonstrated recently by molecular biological techniques that small cell carcinomas of the lung express nicotinic acetylcholine receptors.
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Myasthenia Gravis Associated With Small-Cell Carcinoma of the Lung
Chest, 1994Co-Authors: Jiro Fujita, Ichiro Yamadori, Yasufumi Yamaji, Yoshifumi Yamagishi, Keiichi Takigawa, Jiro TakaharaAbstract:A 49-year-old man complained of a 3-month history of progressive generalized muscle weakness. He was diagnosed as having small-cell lung carcinoma at the same time. He received an intravenous injection of edrophonium chloride with remarkable improvement of muscle strength. Electromyographic studies revealed a compound muscle action potential that decreased after repetitive stimulation. These findings were considered representative of myasthenia gravis (MG), and inconsistent with Eaton-Lambert Syndrome. The appearance of MG with small-cell lung carcinoma seems to be very rare, but possible.
Jiro Fujita - One of the best experts on this subject based on the ideXlab platform.
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A Case of Small Cell Lung Cancer that Developed during Therapy for Myasthenia Gravis
The Japanese journal of thoracic diseases, 1995Co-Authors: Reiko Miyoshi, Jiro Fujita, Yasufumi Yamaji, Satsuki Shima, Hiroki Okada, Jiro TakaharaAbstract:A 56-year-old man had been complaining of progressive proximal muscle weakness and bilateral ptosis before his first admission to our hospital. He received an injection of edrophonium chloride, which resulted in remarkable improvement of muscle strength. Electromyographic studies revealed a compound muscle action potential that decreased after repetitive stimulation at a high rate (15 Hz). He was regarded as having myasthenia gravis (MG) rather than Eaton-Lambert Syndrome because of these findings. Eighteen months after successful treatment of MG with oral anticholinesterase medication, he complained of an abdominal mass. The mass was found to be a tumor that had metastasized from a primary small cell carcinoma of the lung. Cases of MG with small cell carcinoma of the lung seem to be very rare, and the details of the relationship between them remain unknown. In this patient, MG may have developed by paraneoplastic mechanisms. This hypothesis is interesting, since it has been demonstrated recently by molecular biological techniques that small cell carcinomas of the lung express nicotinic acetylcholine receptors.
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Myasthenia Gravis Associated With Small-Cell Carcinoma of the Lung
Chest, 1994Co-Authors: Jiro Fujita, Ichiro Yamadori, Yasufumi Yamaji, Yoshifumi Yamagishi, Keiichi Takigawa, Jiro TakaharaAbstract:A 49-year-old man complained of a 3-month history of progressive generalized muscle weakness. He was diagnosed as having small-cell lung carcinoma at the same time. He received an intravenous injection of edrophonium chloride with remarkable improvement of muscle strength. Electromyographic studies revealed a compound muscle action potential that decreased after repetitive stimulation. These findings were considered representative of myasthenia gravis (MG), and inconsistent with Eaton-Lambert Syndrome. The appearance of MG with small-cell lung carcinoma seems to be very rare, but possible.
Fernández Ruiz Lc - One of the best experts on this subject based on the ideXlab platform.
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The association of the Eaton-Lambert myasthenic Syndrome and subacute cerebellar degeneration of nonparaneoplastic origin
Medicina Clinica, 1995Co-Authors: García Castañón, Iñigo Corral, De Blas G, Fernández Ruiz LcAbstract:A 52-year-old male with Eaton-Lambert Syndrome associated to seven years subacute cerebellar degeneration of non paraneoplastic origin is presented. Immunosuppressive treatment with azathioprine allowed the neuromuscular symptoms to be controlled although no appreciable effects were observed in the cerebellar symptoms which remained stable.
Yasufumi Yamaji - One of the best experts on this subject based on the ideXlab platform.
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A Case of Small Cell Lung Cancer that Developed during Therapy for Myasthenia Gravis
The Japanese journal of thoracic diseases, 1995Co-Authors: Reiko Miyoshi, Jiro Fujita, Yasufumi Yamaji, Satsuki Shima, Hiroki Okada, Jiro TakaharaAbstract:A 56-year-old man had been complaining of progressive proximal muscle weakness and bilateral ptosis before his first admission to our hospital. He received an injection of edrophonium chloride, which resulted in remarkable improvement of muscle strength. Electromyographic studies revealed a compound muscle action potential that decreased after repetitive stimulation at a high rate (15 Hz). He was regarded as having myasthenia gravis (MG) rather than Eaton-Lambert Syndrome because of these findings. Eighteen months after successful treatment of MG with oral anticholinesterase medication, he complained of an abdominal mass. The mass was found to be a tumor that had metastasized from a primary small cell carcinoma of the lung. Cases of MG with small cell carcinoma of the lung seem to be very rare, and the details of the relationship between them remain unknown. In this patient, MG may have developed by paraneoplastic mechanisms. This hypothesis is interesting, since it has been demonstrated recently by molecular biological techniques that small cell carcinomas of the lung express nicotinic acetylcholine receptors.
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Myasthenia Gravis Associated With Small-Cell Carcinoma of the Lung
Chest, 1994Co-Authors: Jiro Fujita, Ichiro Yamadori, Yasufumi Yamaji, Yoshifumi Yamagishi, Keiichi Takigawa, Jiro TakaharaAbstract:A 49-year-old man complained of a 3-month history of progressive generalized muscle weakness. He was diagnosed as having small-cell lung carcinoma at the same time. He received an intravenous injection of edrophonium chloride with remarkable improvement of muscle strength. Electromyographic studies revealed a compound muscle action potential that decreased after repetitive stimulation. These findings were considered representative of myasthenia gravis (MG), and inconsistent with Eaton-Lambert Syndrome. The appearance of MG with small-cell lung carcinoma seems to be very rare, but possible.
Kuwabara H - One of the best experts on this subject based on the ideXlab platform.
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Eaton-Lambert Syndrome manifested by respiratory failure associated with small cell carcinoma of the lung
Rinshō shinkeigaku Clinical neurology, 1990Co-Authors: Yamada A, Hiroaki Takeuchi, Touge T, Miki H, Kuwabara HAbstract:A 63-year-old man with Eaton-Lambert Syndrome manifested by marked respiratory failure was reported. He began to notice blepharoptosis and diplopia in September, 1987, followed by weakness and easy fatigability in bulbar, neck and limb muscles in association with impotence by February, 1988. On admission in August, 1988, Gowers' sign, decreased tendon reflexes and muscle weakness improved by the injection of edrophonium were found. Anti-acetylcholine receptor antibody was negative. Single muscle action potential evoked in the thenar muscle was abnormally low in amplitude with the stimulation of the median nerve: repetitive nerve stimulation study revealed the waning at the low rates, but the waxing at the high rate (30 Hz), suggesting the diagnosis of Eaton-Lambert Syndrome. Early gastric cancer (adenocarcinoma) was diagnosed from needle biopsy specimens in August, 1988, but no other neoplasm including thymoma or lung cancer was found. After subtotal gastric resection in September, 1988, he failed into respiratory failure, requiring artificial ventilation for seven months. Plasmapheresis and drugs such as anticholinesterase, guanidine hydrochloride, and corticosteroid were ineffective for the recovery from weakness in respiratory muscle. Lung cancer was suspected, based on a chest X-ray in March, 1989, and one month later he died of pneumonia. At autopsy, small cell carcinoma of the lung was observed, but there was neither recurrence nor metastasis of the gastric cancer. Emphasis was placed on the respiratory failure in Eaton-Lambert Syndrome which has rarely been reported.