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Edward Parry - One of the best experts on this subject based on the ideXlab platform.

  • Eccrine Porocarcinoma of the eyelid treated with Mohs micrographic surgery.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2020
    Co-Authors: Renee A D'ambrosia, Holly Ward, Edward Parry
    Abstract:

    Eccrine Porocarcinoma (EPC) is a rare malignant tumor of the Eccrine sweat glands. The lesions are reported to occur most commonly on the lower extremity with variable prognosis. To discuss the clinical and histologic features and the prognosis of EPC. We report a 71-year-old man who presented with an asymptomatic lesion on his lower eyelid that had been present for 6 weeks. The 4 x 4-mm lesion was removed in two stages using the Mohs micrographic surgery fresh-tissue technique. The histopathologic diagnosis was primary EPC. EPCs most commonly occur on the lower extremity. This case is interesting because the lesion was located on the lower eyelid.

  • Eccrine Porocarcinoma of the eyelid treated with mohs micrographic surgery
    Dermatologic Surgery, 2004
    Co-Authors: Renee A Dambrosia, Holly Ward, Edward Parry
    Abstract:

    Background. Eccrine Porocarcinoma (EPC) is a rare malignant tumor of the Eccrine sweat glands. The lesions are reported to occur most commonly on the lower extremity with variable prognosis. Objective. To discuss the clinical and histologic features and the prognosis of EPC. Methods. We report a 71-year-old man who presented with an asymptomatic lesion on his lower eyelid that had been present for 6 weeks. Results. The 4×4-mm lesion was removed in two stages using the Mohs micrographic surgery fresh-tissue technique. The histopathologic diagnosis was primary EPC. Conclusion. EPCs most commonly occur on the lower extremity. This case is interesting because the lesion was located on the lower eyelid.

T Jouary - One of the best experts on this subject based on the ideXlab platform.

  • factors in the surgical management of primary Eccrine Porocarcinoma prognostic histological factors can guide the surgical procedure
    British Journal of Dermatology, 2011
    Co-Authors: Emilie Belin, K Ezzedine, S Stanislas, N Lalanne, M Beylotbarry, A Taieb, B Vergier, T Jouary
    Abstract:

    BACKGROUND: Primary Eccrine Porocarcinoma is a rare cutaneous neoplasm and there is no consensus concerning its surgical management. OBJECTIVES: To conduct a retrospective analysis of all the cases of Eccrine Porocarcinoma seen in our hospital in order to identify prognostic factors. METHODS: Clinical data were retrieved from the patients' files. Each histological sample was reviewed by the pathologist and classified into three Eccrine Porocarcinoma subtypes: 'infiltrative', 'pushing' and 'pagetoid' Eccrine Porocarcinoma, according to Robson's criteria. Statistical methods were used to estimate the recurrence risk. RESULTS: Twenty-four patients were included. The surgical margins realized were ≥ 2 cm or < 2 cm in six and 13 patients, respectively, and slow Mohs procedure was performed in two patients. Ten, seven and two patients presented with 'infiltrative', 'pushing' or 'pagetoid' Eccrine Porocarcinoma, respectively. Eight patients (of 23) experienced recurrences (35%). The recurrence risk was linked to the histological subtype: two out of two pagetoid Eccrine Porocarcinoma, four out of 10 'infiltrative' and none of seven 'pushing' Eccrine Porocarcinoma recurred (P=0·026). The recurrence risk was not associated with epidermal growth factor receptor status, nor the margin realized. CONCLUSIONS: The recurrence risk of 'pushing' Eccrine Porocarcinoma is significantly lower than for 'infiltrative' Eccrine Porocarcinoma. Based on these considerations, a decisional algorithm might be proposed: first step, excisional biopsy of the primary Eccrine Porocarcinoma and identification of the histological subtype; second step, infiltrative or pagetoid Porocarcinoma should be excised with an additional modified micrographic Mohs procedure, while no additional surgery is needed for 'pushing' Eccrine Porocarcinoma if the first excisional biopsy is complete. Although demonstrated in a limited case series, the histological subtype might guide the surgical management of primary Eccrine Porocarcinoma.

  • Factors in the surgical management of primary Eccrine Porocarcinoma: prognostic histological factors can guide the surgical procedure
    British Journal of Dermatology, 2011
    Co-Authors: Emilie Belin, K Ezzedine, S Stanislas, N Lalanne, A Taieb, B Vergier, M. Beylot-barry, T Jouary
    Abstract:

    Summary Background  Primary Eccrine Porocarcinoma is a rare cutaneous neoplasm and there is no consensus concerning its surgical management. Objectives  To conduct a retrospective analysis of all the cases of Eccrine Porocarcinoma seen in our hospital in order to identify prognostic factors. Methods  Clinical data were retrieved from the patients’ files. Each histological sample was reviewed by the pathologist and classified into three Eccrine Porocarcinoma subtypes: ‘infiltrative’, ‘pushing’ and ‘pagetoid’ Eccrine Porocarcinoma, according to Robson’s criteria. Statistical methods were used to estimate the recurrence risk. Results  Twenty-four patients were included. The surgical margins realized were ≥ 2 cm or

Emilie Belin - One of the best experts on this subject based on the ideXlab platform.

  • factors in the surgical management of primary Eccrine Porocarcinoma prognostic histological factors can guide the surgical procedure
    British Journal of Dermatology, 2011
    Co-Authors: Emilie Belin, K Ezzedine, S Stanislas, N Lalanne, M Beylotbarry, A Taieb, B Vergier, T Jouary
    Abstract:

    BACKGROUND: Primary Eccrine Porocarcinoma is a rare cutaneous neoplasm and there is no consensus concerning its surgical management. OBJECTIVES: To conduct a retrospective analysis of all the cases of Eccrine Porocarcinoma seen in our hospital in order to identify prognostic factors. METHODS: Clinical data were retrieved from the patients' files. Each histological sample was reviewed by the pathologist and classified into three Eccrine Porocarcinoma subtypes: 'infiltrative', 'pushing' and 'pagetoid' Eccrine Porocarcinoma, according to Robson's criteria. Statistical methods were used to estimate the recurrence risk. RESULTS: Twenty-four patients were included. The surgical margins realized were ≥ 2 cm or < 2 cm in six and 13 patients, respectively, and slow Mohs procedure was performed in two patients. Ten, seven and two patients presented with 'infiltrative', 'pushing' or 'pagetoid' Eccrine Porocarcinoma, respectively. Eight patients (of 23) experienced recurrences (35%). The recurrence risk was linked to the histological subtype: two out of two pagetoid Eccrine Porocarcinoma, four out of 10 'infiltrative' and none of seven 'pushing' Eccrine Porocarcinoma recurred (P=0·026). The recurrence risk was not associated with epidermal growth factor receptor status, nor the margin realized. CONCLUSIONS: The recurrence risk of 'pushing' Eccrine Porocarcinoma is significantly lower than for 'infiltrative' Eccrine Porocarcinoma. Based on these considerations, a decisional algorithm might be proposed: first step, excisional biopsy of the primary Eccrine Porocarcinoma and identification of the histological subtype; second step, infiltrative or pagetoid Porocarcinoma should be excised with an additional modified micrographic Mohs procedure, while no additional surgery is needed for 'pushing' Eccrine Porocarcinoma if the first excisional biopsy is complete. Although demonstrated in a limited case series, the histological subtype might guide the surgical management of primary Eccrine Porocarcinoma.

  • Factors in the surgical management of primary Eccrine Porocarcinoma: prognostic histological factors can guide the surgical procedure
    British Journal of Dermatology, 2011
    Co-Authors: Emilie Belin, K Ezzedine, S Stanislas, N Lalanne, A Taieb, B Vergier, M. Beylot-barry, T Jouary
    Abstract:

    Summary Background  Primary Eccrine Porocarcinoma is a rare cutaneous neoplasm and there is no consensus concerning its surgical management. Objectives  To conduct a retrospective analysis of all the cases of Eccrine Porocarcinoma seen in our hospital in order to identify prognostic factors. Methods  Clinical data were retrieved from the patients’ files. Each histological sample was reviewed by the pathologist and classified into three Eccrine Porocarcinoma subtypes: ‘infiltrative’, ‘pushing’ and ‘pagetoid’ Eccrine Porocarcinoma, according to Robson’s criteria. Statistical methods were used to estimate the recurrence risk. Results  Twenty-four patients were included. The surgical margins realized were ≥ 2 cm or

Michael Wallace - One of the best experts on this subject based on the ideXlab platform.

  • widespread metastatic Eccrine Porocarcinoma
    Journal of The American Academy of Dermatology, 2003
    Co-Authors: Rajat Goel, Melissa J Contos, Michael Wallace
    Abstract:

    Abstract Eccrine Porocarcinoma is a rare malignant sweat gland tumor arising from the acrosyringium. These lesions can show multiple epidermotropic metastases, however, systemic spread is rare. We describe the case of a 42-year-old African American man who presented in February 1998 with a lesion on the plantar surface of his right foot that was diagnosed as an Eccrine Porocarcinoma. Subsequently, during the next year, cutaneous metastases developed to his left shoulder and flank. Two years after his initial presentation, he was admitted with an esophageal mass and multiple gastric ulcers. Biopsy specimens of these lesions demonstrated metastatic Eccrine Porocarcinoma. Further evaluation revealed multiple metastases to lymph nodes, lungs, and brain. Histologic examination revealed nests of basaloid cells with eosinophilic cytoplasm and intracellular ductlike lumina lined by eosinophilic basement membranelike material. These ductular structures where highlighted by immunohistochemical stains for carcinoembryonic antigen, confirming their Eccrine differentiation. There were mitotic figures and individual cell necrosis. Although rare, systemic metastases from an Eccrine Porocarcinoma must enter the differential diagnoses of a tumor mass in such patients.

Renee A Dambrosia - One of the best experts on this subject based on the ideXlab platform.

  • Eccrine Porocarcinoma of the eyelid treated with mohs micrographic surgery
    Dermatologic Surgery, 2004
    Co-Authors: Renee A Dambrosia, Holly Ward, Edward Parry
    Abstract:

    Background. Eccrine Porocarcinoma (EPC) is a rare malignant tumor of the Eccrine sweat glands. The lesions are reported to occur most commonly on the lower extremity with variable prognosis. Objective. To discuss the clinical and histologic features and the prognosis of EPC. Methods. We report a 71-year-old man who presented with an asymptomatic lesion on his lower eyelid that had been present for 6 weeks. Results. The 4×4-mm lesion was removed in two stages using the Mohs micrographic surgery fresh-tissue technique. The histopathologic diagnosis was primary EPC. Conclusion. EPCs most commonly occur on the lower extremity. This case is interesting because the lesion was located on the lower eyelid.