The Experts below are selected from a list of 12981 Experts worldwide ranked by ideXlab platform
Pak Kin Wong - One of the best experts on this subject based on the ideXlab platform.
-
case based reasoning for automotive engine performance tune up
PROCEEDINGS OF THE 2ND INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL MECHANICS AND THE 12TH INTERNATIONAL CONFERENCE ON THE ENHANCEMENT AND PROMOTION OF CO, 2010Co-Authors: Chiman Vong, H Huang, Pak Kin WongAbstract:The automotive engine performance tune‐up is greatly affected by the calibration of its electronic control unit (ECU). The ECU calibration is traditionally done by trial‐and‐error method. This traditional method consumes a large amount of time and money because of a large number of dynamometer tests. To resolve this problem, case based reasoning (CBR) is employed, so that an existing and effective ECU setup can be adapted to fit another similar class of engines. The adaptation procedure is done through a more sophisticated step called case‐based adaptation (CBA) [1, 2]. CBA is an effective knowledge management tool, which can interactively learn the expert adaptation knowledge. The paper briefly reviews the methodologies of CBR and CBA. Then the application to ECU calibration is described via a case study. With CBR and CBA, the efficiency of calibrating an ECU can be enhanced. A prototype system has also been developed to verify the usefulness of CBR in ECU calibration.
-
case based adaptation for automotive engine electronic control unit calibration
Expert Systems With Applications, 2010Co-Authors: Chiman Vong, Pak Kin WongAbstract:The automotive engine performance is greatly affected by the calibration of its electronic control unit (ECU). The method for ECU calibration is traditionally done by trial-and-error. This traditional method consumes a large amount of time and money. To resolve this problem, case-based reasoning (CBR) is employed, so that an existing and effective ECU setup can be adapted to fit another similar class of engines. The adaptation procedure is done through a more sophisticated step called case-based adaptation (CBA) (Craw, Jarmulak, & Rowe, 2001; Craw, Wiratunga, & Rowe, 2006; Leake, Kinley, & Wilson, 1996, 1997). CBA is an effective knowledge management tool, which can interactively learn the expert adaptation knowledge. The paper briefly reviews the methodologies of CBR and CBA. Then the application to ECU calibration is described via a case study. With CBR and CBA, the efficiency of calibrating an ECU can be enhanced. A prototype system has also been developed to verify the usefulness of CBR in ECU calibration.
-
case based reasoning for automotive engine electronic control unit calibration
International Conference on Information and Automation, 2009Co-Authors: Chiman Vong, Pak Kin Wong, H HuangAbstract:The automotive engine performance is greatly affected by the calibration of ECU, which controls fuel injection and ignition advance over different timing. Fine tuning an engine giving maximum performance is equivalent to calibrating the ECU of that engine. However, the method for ECU calibration is traditionally done in a trial-and-error way. Every trial means an adjustment to the fuel and ignition maps and then run on a dynamometer to verify the engine performance. This traditional method expenses a large amount of time and money. In order to resolve this problem, Case-based Reasoning (CBR) from artificial intelligence field is employed so that the maps of a fully calibrated ECU can be adapted to fit another similar class of engines. This paper briefly reviews the methodology of CBR. Then the application of CBR to ECU calibration is described. By applying CBR, the efficiency of calibrating an automotive ECU becomes higher. Furthermore, expert and novice automotive engineers may use this system as an assistant when calibrating an ECU. A prototype system has been developed to verify the usefulness of CBR in ECU calibration.
Luis A Diaz - One of the best experts on this subject based on the ideXlab platform.
-
The Role of IntramolECUlar Epitope Spreading in the Pathogenesis of Endemic Pemphigus Foliaceus (Fogo Selvagem)
2013Co-Authors: Gunter Hans-filho, Ro A. Rivitti, Luis A DiazAbstract:We report here a relationship between intramolECUlar epitope spreading and the clinical onset of the endemic form of pemphigus foliaceus in a Brazilian community with a high prevalence and incidence of the disease. Also known as Fogo Selvagem (FS), this disease is characterized by severe skin blistering and pathogenic anti–desmoglein-1 (Dsg1) autoantibodies. These autoantibodies bind the Dsg1 ectodomain and trigger keratinocyte cell detachment, the hallmark of FS. We show that (a) sera from FS patients in the preclinical stage recognized epitopes on the COOH-terminal EC5 domain of Dsg1, (b) disease onset was associated with the emergence of antibodies specific for epitopes on the NH2-terminal EC1 and EC2 domains, (c) all sera from FS patients with active disease recognized the EC1 and/or EC2 domains, and (d) sera from FS patients in remission showed reactivity restricted to EC5. These results suggest that anti-Dsg1 autoantibodies in FS are initially raised against the COOH-terminal EC5 domain of Dsg1 in individuals without skin disease; in genetically predisposed subjects the autoimmune response may then undergo intramolECUlar epitope spreading toward epitopes on the NH2-terminal EC1 and EC2 domains of Dsg1 leading to disease onset. Moreover, intramolECUlar epitope spreading may also modulate remissions and relapses of FS. Key words: autoimmunity • autoantibodies • desmogleins • epitope spreading • pemphigu
-
The Role of IntramolECUlar Epitope Spreading in the Pathogenesis of Endemic Pemphigus Foliaceus (Fogo Selvagem)
The Journal of experimental medicine, 2003Co-Authors: Gunter Hans-filho, Evandro A. Rivitti, Luis A DiazAbstract:We report here a relationship between intramolECUlar epitope spreading and the clinical onset of the endemic form of pemphigus foliaceus in a Brazilian community with a high prevalence and incidence of the disease. Also known as Fogo Selvagem (FS), this disease is characterized by severe skin blistering and pathogenic anti–desmoglein-1 (Dsg1) autoantibodies. These autoantibodies bind the Dsg1 ectodomain and trigger keratinocyte cell detachment, the hallmark of FS. We show that (a) sera from FS patients in the preclinical stage recognized epitopes on the COOH-terminal EC5 domain of Dsg1, (b) disease onset was associated with the emergence of antibodies specific for epitopes on the NH2-terminal EC1 and EC2 domains, (c) all sera from FS patients with active disease recognized the EC1 and/or EC2 domains, and (d) sera from FS patients in remission showed reactivity restricted to EC5. These results suggest that anti-Dsg1 autoantibodies in FS are initially raised against the COOH-terminal EC5 domain of Dsg1 in individuals without skin disease; in genetically predisposed subjects the autoimmune response may then undergo intramolECUlar epitope spreading toward epitopes on the NH2-terminal EC1 and EC2 domains of Dsg1 leading to disease onset. Moreover, intramolECUlar epitope spreading may also modulate remissions and relapses of FS.
Chiman Vong - One of the best experts on this subject based on the ideXlab platform.
-
case based reasoning for automotive engine performance tune up
PROCEEDINGS OF THE 2ND INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL MECHANICS AND THE 12TH INTERNATIONAL CONFERENCE ON THE ENHANCEMENT AND PROMOTION OF CO, 2010Co-Authors: Chiman Vong, H Huang, Pak Kin WongAbstract:The automotive engine performance tune‐up is greatly affected by the calibration of its electronic control unit (ECU). The ECU calibration is traditionally done by trial‐and‐error method. This traditional method consumes a large amount of time and money because of a large number of dynamometer tests. To resolve this problem, case based reasoning (CBR) is employed, so that an existing and effective ECU setup can be adapted to fit another similar class of engines. The adaptation procedure is done through a more sophisticated step called case‐based adaptation (CBA) [1, 2]. CBA is an effective knowledge management tool, which can interactively learn the expert adaptation knowledge. The paper briefly reviews the methodologies of CBR and CBA. Then the application to ECU calibration is described via a case study. With CBR and CBA, the efficiency of calibrating an ECU can be enhanced. A prototype system has also been developed to verify the usefulness of CBR in ECU calibration.
-
case based adaptation for automotive engine electronic control unit calibration
Expert Systems With Applications, 2010Co-Authors: Chiman Vong, Pak Kin WongAbstract:The automotive engine performance is greatly affected by the calibration of its electronic control unit (ECU). The method for ECU calibration is traditionally done by trial-and-error. This traditional method consumes a large amount of time and money. To resolve this problem, case-based reasoning (CBR) is employed, so that an existing and effective ECU setup can be adapted to fit another similar class of engines. The adaptation procedure is done through a more sophisticated step called case-based adaptation (CBA) (Craw, Jarmulak, & Rowe, 2001; Craw, Wiratunga, & Rowe, 2006; Leake, Kinley, & Wilson, 1996, 1997). CBA is an effective knowledge management tool, which can interactively learn the expert adaptation knowledge. The paper briefly reviews the methodologies of CBR and CBA. Then the application to ECU calibration is described via a case study. With CBR and CBA, the efficiency of calibrating an ECU can be enhanced. A prototype system has also been developed to verify the usefulness of CBR in ECU calibration.
-
case based reasoning for automotive engine electronic control unit calibration
International Conference on Information and Automation, 2009Co-Authors: Chiman Vong, Pak Kin Wong, H HuangAbstract:The automotive engine performance is greatly affected by the calibration of ECU, which controls fuel injection and ignition advance over different timing. Fine tuning an engine giving maximum performance is equivalent to calibrating the ECU of that engine. However, the method for ECU calibration is traditionally done in a trial-and-error way. Every trial means an adjustment to the fuel and ignition maps and then run on a dynamometer to verify the engine performance. This traditional method expenses a large amount of time and money. In order to resolve this problem, Case-based Reasoning (CBR) from artificial intelligence field is employed so that the maps of a fully calibrated ECU can be adapted to fit another similar class of engines. This paper briefly reviews the methodology of CBR. Then the application of CBR to ECU calibration is described. By applying CBR, the efficiency of calibrating an automotive ECU becomes higher. Furthermore, expert and novice automotive engineers may use this system as an assistant when calibrating an ECU. A prototype system has been developed to verify the usefulness of CBR in ECU calibration.
Elisabetta Dejana - One of the best experts on this subject based on the ideXlab platform.
-
a monoclonal antibody to vascular endothelial cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
Blood, 2002Co-Authors: Monica Corada, Francescafang Liao, Lucia Zanetta, Maria Grazia Lampugnani, Sergio Bernasconi, Fabrizio Orsenigo, Ferruccio Breviario, Daniel J Hicklin, Peter Bohlen, Elisabetta DejanaAbstract:Vascular endothelial cadherin (VE-cadherin) is an endothelial-specific, trans-membrane protein that promotes homophilic cell adhesion. Inhibition of VE-cadherin by the blocking monoclonal antibody (mAb) BV13 inhibited angiogenesis and tumor growth in vivo. However, this effect was accompanied by a marked increase in lung and heart permeability. In the present paper, we characterize a different VE-cadherin mAb (BV14) that is able to inhibit angiogenesis without affecting vascular permeability. In vitro studies show that BV14, in contrast to BV13, did not increase paracellular permeability of endothelial monolayers and did not disrupt VE-cadherin clusters at junctions. However, both antibodies could inhibit formation of vascularlike structures in collagen gels and increase migration of endothelial cells into wounded areas. In vivo, BV14 and BV13 were equally active in inhibiting angiogenesis in the mouse cornea and in reducing the growth of hemangioma and C6 glioma. In contrast to BV13, BV14 did not change vascular permeability in all the organs tested and at any dose used. BV14 and BV13 bind to VE-cadherin extracellular repeats EC4 and EC1, respectively. We propose that, in resting vessels, where junctions are stable and well-structured, antibody binding to EC1 but not EC4 disrupts their organization and increases permeability. In contrast, in growing vessels, where endothelial cells are migrating and junctions are weaker, antibody binding to EC4 may be sufficient to disrupt cell-to-cell adhesion and inhibit assembly of new vascular structures.
-
monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability
Blood, 2001Co-Authors: Monica Corada, Maria Grazia Lampugnani, Fang Liao, Maria Lindgren, Ronald Frank, William A Muller, Ferruccio Breviario, Daniel J Hicklin, Peter Bohlen, Elisabetta DejanaAbstract:Vascular endothelial cadherin (VE-cadherin) is an endothelial cell–specific cadherin that plays an important role in the control of vascular organization. Blocking VE-cadherin antibodies strongly inhibit angiogenesis, and inactivation of VE-cadherin gene causes embryonic lethality due to a lack of correct organization and remodeling of the vasculature. Hence, inhibitors of VE-cadherin adhesive properties may constitute a tool to prevent tumor neovascularization. In this paper, we tested different monoclonal antibodies (mAbs) directed to human VE-cadherin ectodomain for their functional activity. Three mAbs (Cad 5, BV6, BV9) were able to increase paracellular permeability, inhibit VE-cadherin reorganization, and block angiogenesis in vitro. These mAbs could also induce endothelial cell apoptosis in vitro. Two additional mAbs, TEA 1.31 and Hec 1.2, had an intermediate or undetectable activity, respectively, in these assays. Epitope mapping studies show that BV6, BV9, TEA 1.31, and Hec 1.2 bound to a recombinant fragment spanning the extracellular juxtamembrane domains EC3 through EC4. In contrast, Cad 5 bound to the aminoterminal domain EC1. By peptide scanning analysis and competition experiments, we defined the sequences TIDLRY located on EC3 and KVFRVDAETGDVFAI on EC1 as the binding domain of BV6 and Cad 5, respectively. Overall, these results support the concept that VE-cadherin plays a relevant role on human endothelial cell properties. Antibodies directed to the extracellular domains EC1 but also EC3-EC4 affect VE-cadherin adhesion and clustering and alter endothelial cell permeability, apoptosis, and vascular structure formation.
Fabio Imoto - One of the best experts on this subject based on the ideXlab platform.
-
extensor carpi ulnaris tendon dislocation a wrist
Hand, 2016Co-Authors: Eduardo S Pereira, Luciano Pereira, Fabio ImotoAbstract:Objective: Extensor carpi ulnares (ECU) has a stabilizing role at distal radioulnar joint, and besides the extensor retinaculum coverage, it is held tight to the ulnar groove by the ECU subsheath. Graham (2012) described a reinforced insertion of the ECU subsheath at medial edge of ulnar sulcus that creates a labrum, a critical barrier for ECU subluxation. Forced supination, palmar flexion, and ulnar deviation can rupture or attenuate the ECU subsheath and the ECU tendon can dislocate, causing ulnar side wrist pain. We present our experience dealing with diagnostic (special test for ECU instability, dynamic ultrasound, and wrist MRI) and treatment details of ulnar side wrist pain related to ECU tendon dislocation. Material and Methods: From 2010 to 2015, we treated 9 patients with ulnar side wrist pain related to ECU dislocation. All patients had a failed conservative treatment (Immobilization + Physical Therapy) for at least 3 months. Diagnostic was confirmed by clinical examination, dynamic ultrasound, ...
