The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform
R Garnier - One of the best experts on this subject based on the ideXlab platform.
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a comparative study of Edetate Calcium Disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults
Clinical Toxicology, 2018Co-Authors: Kirushanthi Sakthithasan, Pierre Levy, Joel Poupon, R GarnierAbstract:Background: We evaluated the efficacy of two antidotes, Edetate Calcium Disodium (CaNa2EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults.Methods: Thirty-seven ...
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A comparative study of Edetate Calcium Disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults
Clinical Toxicology, 2018Co-Authors: Kirushanthi Sakthithasan, Pierre Levy, Joel Poupon, R GarnierAbstract:BACKGROUND: We evaluated the efficacy of two antidotes, Edetate Calcium Disodium (CaNa2EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults. METHODS: Thirty-seven patients with blood lead concentrations >40 μg/dL and positive CaNa2EDTA lead mobilization were randomized to receive 1050 mg/m2/day of oral DMSA (n = 21) or 500 mg/m2/day of intravenous CaNa2EDTA (n = 16) over two five-day courses separated by a 10-day rest period. Efficacy of treatment was evaluated by blood lead assays on the first day of the two courses and 14 days after the end of treatment and baseline CaNa2EDTA lead mobilization test and 14 days after the end of treatment. RESULTS AND CONCLUSION: Both treatments significantly reduced the prevalence of clinical symptoms, blood lead levels and CaNa2EDTA lead mobilization and were well tolerated. DMSA had a greater impact on reducing blood lead concentrations (p = .005) and CaNa2EDTA on lead mobilization (p = .04). Comparison of equimolar doses showed that CaNa2EDTA was more effective than DMSA (p
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lead mobilization test in children with lead poisoning validation of a 5 hour Edetate Calcium Disodium provocation test
JAMA Pediatrics, 1995Co-Authors: J L Iniguez, R Garnier, G Leverger, C Dollfus, F Gouraud, P BeauvaisAbstract:Since 1985, more than 400 new cases of childhood lead poisoning were diagnosed in Paris, France. The resurgence of lead poisoning is a major public health concern.1,2The treatment of these children with increased blood lead levels was consistent with the guidelines of the Centers for Disease Control and Prevention (CDC), Atlanta, Ga,2-4which recommend a lead mobilization test for patients with intermediate lead intoxication to determine which children would benefit from chelation therapy. However, performing 24-hour provocative tests in young children has proved difficult: urine collection is often incomplete, and hospitalization is often necessary. The aim of our study was to decrease the urinary collection period of provocative tests to 5 hours and to assess the validity of this shortened procedure. Patients and Methods.During a 17-month period between May 1989 and October 1990, 34 Edetate Calcium Disodium (CaNa2EDTA) mobilization tests were attempted in 32
Kirushanthi Sakthithasan - One of the best experts on this subject based on the ideXlab platform.
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a comparative study of Edetate Calcium Disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults
Clinical Toxicology, 2018Co-Authors: Kirushanthi Sakthithasan, Pierre Levy, Joel Poupon, R GarnierAbstract:Background: We evaluated the efficacy of two antidotes, Edetate Calcium Disodium (CaNa2EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults.Methods: Thirty-seven ...
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A comparative study of Edetate Calcium Disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults
Clinical Toxicology, 2018Co-Authors: Kirushanthi Sakthithasan, Pierre Levy, Joel Poupon, R GarnierAbstract:BACKGROUND: We evaluated the efficacy of two antidotes, Edetate Calcium Disodium (CaNa2EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults. METHODS: Thirty-seven patients with blood lead concentrations >40 μg/dL and positive CaNa2EDTA lead mobilization were randomized to receive 1050 mg/m2/day of oral DMSA (n = 21) or 500 mg/m2/day of intravenous CaNa2EDTA (n = 16) over two five-day courses separated by a 10-day rest period. Efficacy of treatment was evaluated by blood lead assays on the first day of the two courses and 14 days after the end of treatment and baseline CaNa2EDTA lead mobilization test and 14 days after the end of treatment. RESULTS AND CONCLUSION: Both treatments significantly reduced the prevalence of clinical symptoms, blood lead levels and CaNa2EDTA lead mobilization and were well tolerated. DMSA had a greater impact on reducing blood lead concentrations (p = .005) and CaNa2EDTA on lead mobilization (p = .04). Comparison of equimolar doses showed that CaNa2EDTA was more effective than DMSA (p
Joel Poupon - One of the best experts on this subject based on the ideXlab platform.
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a comparative study of Edetate Calcium Disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults
Clinical Toxicology, 2018Co-Authors: Kirushanthi Sakthithasan, Pierre Levy, Joel Poupon, R GarnierAbstract:Background: We evaluated the efficacy of two antidotes, Edetate Calcium Disodium (CaNa2EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults.Methods: Thirty-seven ...
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A comparative study of Edetate Calcium Disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults
Clinical Toxicology, 2018Co-Authors: Kirushanthi Sakthithasan, Pierre Levy, Joel Poupon, R GarnierAbstract:BACKGROUND: We evaluated the efficacy of two antidotes, Edetate Calcium Disodium (CaNa2EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults. METHODS: Thirty-seven patients with blood lead concentrations >40 μg/dL and positive CaNa2EDTA lead mobilization were randomized to receive 1050 mg/m2/day of oral DMSA (n = 21) or 500 mg/m2/day of intravenous CaNa2EDTA (n = 16) over two five-day courses separated by a 10-day rest period. Efficacy of treatment was evaluated by blood lead assays on the first day of the two courses and 14 days after the end of treatment and baseline CaNa2EDTA lead mobilization test and 14 days after the end of treatment. RESULTS AND CONCLUSION: Both treatments significantly reduced the prevalence of clinical symptoms, blood lead levels and CaNa2EDTA lead mobilization and were well tolerated. DMSA had a greater impact on reducing blood lead concentrations (p = .005) and CaNa2EDTA on lead mobilization (p = .04). Comparison of equimolar doses showed that CaNa2EDTA was more effective than DMSA (p
Pierre Levy - One of the best experts on this subject based on the ideXlab platform.
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a comparative study of Edetate Calcium Disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults
Clinical Toxicology, 2018Co-Authors: Kirushanthi Sakthithasan, Pierre Levy, Joel Poupon, R GarnierAbstract:Background: We evaluated the efficacy of two antidotes, Edetate Calcium Disodium (CaNa2EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults.Methods: Thirty-seven ...
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A comparative study of Edetate Calcium Disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults
Clinical Toxicology, 2018Co-Authors: Kirushanthi Sakthithasan, Pierre Levy, Joel Poupon, R GarnierAbstract:BACKGROUND: We evaluated the efficacy of two antidotes, Edetate Calcium Disodium (CaNa2EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults. METHODS: Thirty-seven patients with blood lead concentrations >40 μg/dL and positive CaNa2EDTA lead mobilization were randomized to receive 1050 mg/m2/day of oral DMSA (n = 21) or 500 mg/m2/day of intravenous CaNa2EDTA (n = 16) over two five-day courses separated by a 10-day rest period. Efficacy of treatment was evaluated by blood lead assays on the first day of the two courses and 14 days after the end of treatment and baseline CaNa2EDTA lead mobilization test and 14 days after the end of treatment. RESULTS AND CONCLUSION: Both treatments significantly reduced the prevalence of clinical symptoms, blood lead levels and CaNa2EDTA lead mobilization and were well tolerated. DMSA had a greater impact on reducing blood lead concentrations (p = .005) and CaNa2EDTA on lead mobilization (p = .04). Comparison of equimolar doses showed that CaNa2EDTA was more effective than DMSA (p
Keigo Endo - One of the best experts on this subject based on the ideXlab platform.
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effect of Edetate Calcium Disodium on yttrium 90 activity in bone of mice
Annals of Nuclear Medicine, 1999Co-Authors: Naoyuki Watanabe, Noboru Oriuchi, Tomio Inoue, Shuji Tanada, Hajime Murata, Yasuhito Sasaki, Edmund E Kim, Keigo EndoAbstract:The kinetics of Yttrium-90 (Y-90) in bone of mice was investigated in combination with Edetate Calcium Disodium (CaNa2EDTA). One group of mice were intraperitoneally administered 37.5 mg/ kg CaNa2EDTA or 0.9% NaCl as a control at 1, 22, 34, 46, 58, 70, 82, 94, 154 and 166 h after injection of Y-90 acetate (post-administration), and the biodistribution was studied at 3, 24, 72, 120 and 168 h postinjection of Y-90 acetate. No difference between the post-CaNa2EDTA-treated mice and the control was demonstrated in the radioactivity in the bone. A decrease in radioactivity in the liver and kidneys was accelerated, and the radioactivity was lower than the control at 120 h postinjection. The other group of mice were also given the same dose of chelator at 12 h and 1 h preinjection of Y-90 acetate and at 1, 22, 34, 46, 58, 70, 82, 94, 154 and 166 h after injection of Y-90 acetate (pre- and post-administration), the radioactivity in bone at 3 h postinjection was significantly lower than in the control (24.4 ± 3.92% ID/g vs. 31.7 ± 2.26% ID/g, p < 0.05), but the decrease was not sequential. A significant reduction in radioactivity in the blood, kidneys and liver was demonstrated at 3 h, 72 h and 72 h postinjection. In conclusion, the CaNa2EDTA with the administration schedule employed here cannot chelate the Y-90 from bone but the free Y-90 before deposition into bone.
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Localization of indium-111 in human malignant tumor xenografts and control by chelators.
Nuclear medicine and biology, 1999Co-Authors: Naoyuki Watanabe, Noboru Oriuchi, Keigo Endo, Tomio Inoue, Shuji Tanada, Hajime Murata, E. Edmund Kim, Yasuhito SasakiAbstract:Abstract The kinetics of soluble indium-111 ( 111 In) in human malignant tumor xenografts and cells was investigated in combination with chelators. Firstly, without chelator, the kinetics of 111 In-chloride was investigated in vitro and in vivo using four human malignant neuroblastoma SK-N-MC, pulmonary papillary adenocarcinoma NCI-H441, pulmonary squamous cell carcinoma PC 9, and colon adenocarcinoma LS 180 cells and xenografts. 111 In was incorporated into tumor cells in vitro to a maximum level during a 60-min incubation. A maximum level of radioactivity was demonstrated in vivo in four human malignant tumors xenografted into nude mice at 24 h postinjection of 111 In-chloride. Secondly, the effect of Edetate Calcium Disodium (CaNa 2 EDTA) on radioactivity in 111 In-labeled tumors xenografts and cells was studied in vitro and in vivo. CaNa 2 EDTA significantly reduced 111 In-activity from the labeled tumor xenografts, whereas it had no affect on the radioactivity in the labeled cells. Thirdly, the effect of CaNa 2 EDTA on radioactivity in human malignant tumors xenografted into nude mice injected with 111 In-chloride was investigated. In one group of mice CaNa 2 EDTA administered intraperitoneally at 1, 22, 34, 46, 58, and 70 h after injection of 111 In-chloride (postadministration), the localization of 111 In at the tumors was significantly decreased at 72 h compared with the control in all four tumor types. In the other group of mice, CaNa 2 EDTA administered intraperitoneally at 12 and 1 h before injection of 111 In-chloride and 1, 22, 34, 46, 58, and 70 h postinjection (pre- and postadministration), the radioactivity of tumors was also significantly decreased at 72 h, and the reduction was greater than that with use of postadministration. In a comparative study, CaNa 3 DTPA had a more powerful effect than CaNa 2 EDTA. In conclusion, 111 In-activity in tumors consists of intracellular and extracellular components, and the extracellular 111 In may be cleared by chelators. Pre- and postadministration of CaNa 3 DTPA could remove 111 In-nonspecific localization in tumors when 111 In is released from the radiolabeled agents.
