The Experts below are selected from a list of 348912 Experts worldwide ranked by ideXlab platform

Hirohisa Takano - One of the best experts on this subject based on the ideXlab platform.

  • extract of perilla frutescens enriched for rosmarinic acid a polyphenolic phytochemical inhibits seasonal allergic rhinoconjunctivitis in humans
    Experimental Biology and Medicine, 2004
    Co-Authors: Hirohisa Takano, Naomi Osakabe, Chiaki Sanbongi, Rie Yanagisawa, Ken-ichiro Inoue, Akiko Yasuda, Midori Natsume, Seigo Baba, Ei Ichiro Ichiishi
    Abstract:

    Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, suppresses allergic immunoglobulin responses and inflammation caused by polymorphonuclear leukocytes (PMNL) in mice. However, few placebo-controlled clinical trials have examined the efficacy and safety of polyphenolic phytochemicals for treatment of allergic inflammatory diseases in humans. The present study determined whether oral supplementation with rosmarinic acid is an Effective Intervention for patients with seasonal allergic rhinoconjunctivitis (SAR). In this 21-day, randomized, double-blind, age-matched, placebo-controlled parallel group study, patients with mild SAR were treated daily with extract of Perilla frutescens enriched for rosmarinic acid (200 mg [n=10] or 50 mg [n=9]) or placebo (n=10). Patients recorded symptoms daily in a diary. Profiles of infiltrating cells and concentrations of eotaxin, IL-1beta, IL-8, and histamine were measured in nasal lavage fluid. Serum IgE concentrations and routine blood tests were also examined. As compared with placebo supplementation, supplementation with extract of Perilla frutescens enriched for rosmarinic acid resulted in a significant increase in responder rates for itchy nose, watery eyes, itchy eyes, and total symptoms (P<0.05). Active treatment significantly decreased the numbers of neutrophils and eosinophils in nasal lavage fluid (P<0.05 vs. placebo). Patients reported no adverse events, and no significant abnormalities were detected in routine blood tests. In conclusion, extract of Perilla frutescens enriched for rosmarinic acid can be an Effective Intervention for mild SAR at least partly through inhibition of PMNL infiltration into the nostrils. Use of this alternative treatment for SAR might reduce treatment costs for allergic diseases.

  • anti inflammatory and anti allergic effect of rosmarinic acid ra inhibition of seasonal allergic rhinoconjunctivitis sar and its mechanism
    Biofactors, 2004
    Co-Authors: Naomi Osakabe, Hirohisa Takano, Chiaki Sanbongi, Rie Yanagisawa, Ken-ichiro Inoue, Akiko Yasuda, Toshikazu Yoshikawa
    Abstract:

    The present study was undertaken to determine whether oral supplementation with rosmarinic acid (RA) is an Effective Intervention for patients with SAR. In addition, the anti-inflammatory mechanism of RA also estimated in the ear edema models. Clinical trial: Patients were treated daily with RA (200 mg or 50 mg) or placebo for 21 days. Patients recorded symptoms daily and profiles of infiltrating cells and concentration of cytokines were measured in nasal lavage fluid. Compared to placebo, supplementation with RA resulted in a significant decrease in responder rates for each symptom. RA also significantly decreased the numbers of neutrophils and eosinophils in nasal lavage fluid. Animal Study: Topical application RA showed anti-inflammatory activity 5-hours after 12-tetradecanoylphorbol 13-acetate (TPA) treatment with marked inhibition of neutrophil infiltration. Up regulation of ICAM-1, VCAM-1 cyclooxygenase-2 (COX-2), KC and MIP-2 by TPA were markedly reduced by pre-treatment with extract of perilla (PE) or RA. Reactive oxygen radical production detected as thiobarbituric acid reactive substance (TBARS), lipid peroxide (LPO) and 8-hydroxy-2'deoxyguanosine (8OH-dG), by double treatment of TPA was reduced by pretreatment with PE or RA. RA is an Effective Intervention for SAR that is mediated by inhibition of PMNL infiltration. This effect of RA is due to two independent mechanisms: inhibition of the inflammatory response and scavenging of ROS.

Naomi Osakabe - One of the best experts on this subject based on the ideXlab platform.

  • extract of perilla frutescens enriched for rosmarinic acid a polyphenolic phytochemical inhibits seasonal allergic rhinoconjunctivitis in humans
    Experimental Biology and Medicine, 2004
    Co-Authors: Hirohisa Takano, Naomi Osakabe, Chiaki Sanbongi, Rie Yanagisawa, Ken-ichiro Inoue, Akiko Yasuda, Midori Natsume, Seigo Baba, Ei Ichiro Ichiishi
    Abstract:

    Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, suppresses allergic immunoglobulin responses and inflammation caused by polymorphonuclear leukocytes (PMNL) in mice. However, few placebo-controlled clinical trials have examined the efficacy and safety of polyphenolic phytochemicals for treatment of allergic inflammatory diseases in humans. The present study determined whether oral supplementation with rosmarinic acid is an Effective Intervention for patients with seasonal allergic rhinoconjunctivitis (SAR). In this 21-day, randomized, double-blind, age-matched, placebo-controlled parallel group study, patients with mild SAR were treated daily with extract of Perilla frutescens enriched for rosmarinic acid (200 mg [n=10] or 50 mg [n=9]) or placebo (n=10). Patients recorded symptoms daily in a diary. Profiles of infiltrating cells and concentrations of eotaxin, IL-1beta, IL-8, and histamine were measured in nasal lavage fluid. Serum IgE concentrations and routine blood tests were also examined. As compared with placebo supplementation, supplementation with extract of Perilla frutescens enriched for rosmarinic acid resulted in a significant increase in responder rates for itchy nose, watery eyes, itchy eyes, and total symptoms (P<0.05). Active treatment significantly decreased the numbers of neutrophils and eosinophils in nasal lavage fluid (P<0.05 vs. placebo). Patients reported no adverse events, and no significant abnormalities were detected in routine blood tests. In conclusion, extract of Perilla frutescens enriched for rosmarinic acid can be an Effective Intervention for mild SAR at least partly through inhibition of PMNL infiltration into the nostrils. Use of this alternative treatment for SAR might reduce treatment costs for allergic diseases.

  • anti inflammatory and anti allergic effect of rosmarinic acid ra inhibition of seasonal allergic rhinoconjunctivitis sar and its mechanism
    Biofactors, 2004
    Co-Authors: Naomi Osakabe, Hirohisa Takano, Chiaki Sanbongi, Rie Yanagisawa, Ken-ichiro Inoue, Akiko Yasuda, Toshikazu Yoshikawa
    Abstract:

    The present study was undertaken to determine whether oral supplementation with rosmarinic acid (RA) is an Effective Intervention for patients with SAR. In addition, the anti-inflammatory mechanism of RA also estimated in the ear edema models. Clinical trial: Patients were treated daily with RA (200 mg or 50 mg) or placebo for 21 days. Patients recorded symptoms daily and profiles of infiltrating cells and concentration of cytokines were measured in nasal lavage fluid. Compared to placebo, supplementation with RA resulted in a significant decrease in responder rates for each symptom. RA also significantly decreased the numbers of neutrophils and eosinophils in nasal lavage fluid. Animal Study: Topical application RA showed anti-inflammatory activity 5-hours after 12-tetradecanoylphorbol 13-acetate (TPA) treatment with marked inhibition of neutrophil infiltration. Up regulation of ICAM-1, VCAM-1 cyclooxygenase-2 (COX-2), KC and MIP-2 by TPA were markedly reduced by pre-treatment with extract of perilla (PE) or RA. Reactive oxygen radical production detected as thiobarbituric acid reactive substance (TBARS), lipid peroxide (LPO) and 8-hydroxy-2'deoxyguanosine (8OH-dG), by double treatment of TPA was reduced by pretreatment with PE or RA. RA is an Effective Intervention for SAR that is mediated by inhibition of PMNL infiltration. This effect of RA is due to two independent mechanisms: inhibition of the inflammatory response and scavenging of ROS.

Ei Ichiro Ichiishi - One of the best experts on this subject based on the ideXlab platform.

  • extract of perilla frutescens enriched for rosmarinic acid a polyphenolic phytochemical inhibits seasonal allergic rhinoconjunctivitis in humans
    Experimental Biology and Medicine, 2004
    Co-Authors: Hirohisa Takano, Naomi Osakabe, Chiaki Sanbongi, Rie Yanagisawa, Ken-ichiro Inoue, Akiko Yasuda, Midori Natsume, Seigo Baba, Ei Ichiro Ichiishi
    Abstract:

    Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, suppresses allergic immunoglobulin responses and inflammation caused by polymorphonuclear leukocytes (PMNL) in mice. However, few placebo-controlled clinical trials have examined the efficacy and safety of polyphenolic phytochemicals for treatment of allergic inflammatory diseases in humans. The present study determined whether oral supplementation with rosmarinic acid is an Effective Intervention for patients with seasonal allergic rhinoconjunctivitis (SAR). In this 21-day, randomized, double-blind, age-matched, placebo-controlled parallel group study, patients with mild SAR were treated daily with extract of Perilla frutescens enriched for rosmarinic acid (200 mg [n=10] or 50 mg [n=9]) or placebo (n=10). Patients recorded symptoms daily in a diary. Profiles of infiltrating cells and concentrations of eotaxin, IL-1beta, IL-8, and histamine were measured in nasal lavage fluid. Serum IgE concentrations and routine blood tests were also examined. As compared with placebo supplementation, supplementation with extract of Perilla frutescens enriched for rosmarinic acid resulted in a significant increase in responder rates for itchy nose, watery eyes, itchy eyes, and total symptoms (P<0.05). Active treatment significantly decreased the numbers of neutrophils and eosinophils in nasal lavage fluid (P<0.05 vs. placebo). Patients reported no adverse events, and no significant abnormalities were detected in routine blood tests. In conclusion, extract of Perilla frutescens enriched for rosmarinic acid can be an Effective Intervention for mild SAR at least partly through inhibition of PMNL infiltration into the nostrils. Use of this alternative treatment for SAR might reduce treatment costs for allergic diseases.

Chiaki Sanbongi - One of the best experts on this subject based on the ideXlab platform.

  • extract of perilla frutescens enriched for rosmarinic acid a polyphenolic phytochemical inhibits seasonal allergic rhinoconjunctivitis in humans
    Experimental Biology and Medicine, 2004
    Co-Authors: Hirohisa Takano, Naomi Osakabe, Chiaki Sanbongi, Rie Yanagisawa, Ken-ichiro Inoue, Akiko Yasuda, Midori Natsume, Seigo Baba, Ei Ichiro Ichiishi
    Abstract:

    Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, suppresses allergic immunoglobulin responses and inflammation caused by polymorphonuclear leukocytes (PMNL) in mice. However, few placebo-controlled clinical trials have examined the efficacy and safety of polyphenolic phytochemicals for treatment of allergic inflammatory diseases in humans. The present study determined whether oral supplementation with rosmarinic acid is an Effective Intervention for patients with seasonal allergic rhinoconjunctivitis (SAR). In this 21-day, randomized, double-blind, age-matched, placebo-controlled parallel group study, patients with mild SAR were treated daily with extract of Perilla frutescens enriched for rosmarinic acid (200 mg [n=10] or 50 mg [n=9]) or placebo (n=10). Patients recorded symptoms daily in a diary. Profiles of infiltrating cells and concentrations of eotaxin, IL-1beta, IL-8, and histamine were measured in nasal lavage fluid. Serum IgE concentrations and routine blood tests were also examined. As compared with placebo supplementation, supplementation with extract of Perilla frutescens enriched for rosmarinic acid resulted in a significant increase in responder rates for itchy nose, watery eyes, itchy eyes, and total symptoms (P<0.05). Active treatment significantly decreased the numbers of neutrophils and eosinophils in nasal lavage fluid (P<0.05 vs. placebo). Patients reported no adverse events, and no significant abnormalities were detected in routine blood tests. In conclusion, extract of Perilla frutescens enriched for rosmarinic acid can be an Effective Intervention for mild SAR at least partly through inhibition of PMNL infiltration into the nostrils. Use of this alternative treatment for SAR might reduce treatment costs for allergic diseases.

  • anti inflammatory and anti allergic effect of rosmarinic acid ra inhibition of seasonal allergic rhinoconjunctivitis sar and its mechanism
    Biofactors, 2004
    Co-Authors: Naomi Osakabe, Hirohisa Takano, Chiaki Sanbongi, Rie Yanagisawa, Ken-ichiro Inoue, Akiko Yasuda, Toshikazu Yoshikawa
    Abstract:

    The present study was undertaken to determine whether oral supplementation with rosmarinic acid (RA) is an Effective Intervention for patients with SAR. In addition, the anti-inflammatory mechanism of RA also estimated in the ear edema models. Clinical trial: Patients were treated daily with RA (200 mg or 50 mg) or placebo for 21 days. Patients recorded symptoms daily and profiles of infiltrating cells and concentration of cytokines were measured in nasal lavage fluid. Compared to placebo, supplementation with RA resulted in a significant decrease in responder rates for each symptom. RA also significantly decreased the numbers of neutrophils and eosinophils in nasal lavage fluid. Animal Study: Topical application RA showed anti-inflammatory activity 5-hours after 12-tetradecanoylphorbol 13-acetate (TPA) treatment with marked inhibition of neutrophil infiltration. Up regulation of ICAM-1, VCAM-1 cyclooxygenase-2 (COX-2), KC and MIP-2 by TPA were markedly reduced by pre-treatment with extract of perilla (PE) or RA. Reactive oxygen radical production detected as thiobarbituric acid reactive substance (TBARS), lipid peroxide (LPO) and 8-hydroxy-2'deoxyguanosine (8OH-dG), by double treatment of TPA was reduced by pretreatment with PE or RA. RA is an Effective Intervention for SAR that is mediated by inhibition of PMNL infiltration. This effect of RA is due to two independent mechanisms: inhibition of the inflammatory response and scavenging of ROS.

Rie Yanagisawa - One of the best experts on this subject based on the ideXlab platform.

  • extract of perilla frutescens enriched for rosmarinic acid a polyphenolic phytochemical inhibits seasonal allergic rhinoconjunctivitis in humans
    Experimental Biology and Medicine, 2004
    Co-Authors: Hirohisa Takano, Naomi Osakabe, Chiaki Sanbongi, Rie Yanagisawa, Ken-ichiro Inoue, Akiko Yasuda, Midori Natsume, Seigo Baba, Ei Ichiro Ichiishi
    Abstract:

    Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, suppresses allergic immunoglobulin responses and inflammation caused by polymorphonuclear leukocytes (PMNL) in mice. However, few placebo-controlled clinical trials have examined the efficacy and safety of polyphenolic phytochemicals for treatment of allergic inflammatory diseases in humans. The present study determined whether oral supplementation with rosmarinic acid is an Effective Intervention for patients with seasonal allergic rhinoconjunctivitis (SAR). In this 21-day, randomized, double-blind, age-matched, placebo-controlled parallel group study, patients with mild SAR were treated daily with extract of Perilla frutescens enriched for rosmarinic acid (200 mg [n=10] or 50 mg [n=9]) or placebo (n=10). Patients recorded symptoms daily in a diary. Profiles of infiltrating cells and concentrations of eotaxin, IL-1beta, IL-8, and histamine were measured in nasal lavage fluid. Serum IgE concentrations and routine blood tests were also examined. As compared with placebo supplementation, supplementation with extract of Perilla frutescens enriched for rosmarinic acid resulted in a significant increase in responder rates for itchy nose, watery eyes, itchy eyes, and total symptoms (P<0.05). Active treatment significantly decreased the numbers of neutrophils and eosinophils in nasal lavage fluid (P<0.05 vs. placebo). Patients reported no adverse events, and no significant abnormalities were detected in routine blood tests. In conclusion, extract of Perilla frutescens enriched for rosmarinic acid can be an Effective Intervention for mild SAR at least partly through inhibition of PMNL infiltration into the nostrils. Use of this alternative treatment for SAR might reduce treatment costs for allergic diseases.

  • anti inflammatory and anti allergic effect of rosmarinic acid ra inhibition of seasonal allergic rhinoconjunctivitis sar and its mechanism
    Biofactors, 2004
    Co-Authors: Naomi Osakabe, Hirohisa Takano, Chiaki Sanbongi, Rie Yanagisawa, Ken-ichiro Inoue, Akiko Yasuda, Toshikazu Yoshikawa
    Abstract:

    The present study was undertaken to determine whether oral supplementation with rosmarinic acid (RA) is an Effective Intervention for patients with SAR. In addition, the anti-inflammatory mechanism of RA also estimated in the ear edema models. Clinical trial: Patients were treated daily with RA (200 mg or 50 mg) or placebo for 21 days. Patients recorded symptoms daily and profiles of infiltrating cells and concentration of cytokines were measured in nasal lavage fluid. Compared to placebo, supplementation with RA resulted in a significant decrease in responder rates for each symptom. RA also significantly decreased the numbers of neutrophils and eosinophils in nasal lavage fluid. Animal Study: Topical application RA showed anti-inflammatory activity 5-hours after 12-tetradecanoylphorbol 13-acetate (TPA) treatment with marked inhibition of neutrophil infiltration. Up regulation of ICAM-1, VCAM-1 cyclooxygenase-2 (COX-2), KC and MIP-2 by TPA were markedly reduced by pre-treatment with extract of perilla (PE) or RA. Reactive oxygen radical production detected as thiobarbituric acid reactive substance (TBARS), lipid peroxide (LPO) and 8-hydroxy-2'deoxyguanosine (8OH-dG), by double treatment of TPA was reduced by pretreatment with PE or RA. RA is an Effective Intervention for SAR that is mediated by inhibition of PMNL infiltration. This effect of RA is due to two independent mechanisms: inhibition of the inflammatory response and scavenging of ROS.