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Timothy J Wilt - One of the best experts on this subject based on the ideXlab platform.
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systematic review Effective Management strategies for lactose intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Tatyana Shamliyan, Brent C Taylor, Roderick Macdonald, Robert L. Kane, Michael Levitt, Timothy J WiltAbstract:Background: Lactose intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and Management of this condition remain unclear. Purpose: To assess the maximum tolerable dose of lactose and interventions for reducing symptoms of lactose intolerance among persons with lactose intolerance and malabsorption. Data Sources: Multiple electronic databases, including MEDLINE and the Cochrane Library, for trials published in English from 1967 through November 2009. Study Selection: Randomized, controlled trials of individuals with lactose intolerance or malabsorption. Data Extraction: Three investigators independently reviewed articles, extracted data, and assessed study quality. Data Synthesis: 36 unique randomized studies (26 on lactase- or lactose-hydrolyzed milk supplements, lactose-reduced milk, or tolerable doses of lactose; 7 on probiotics; 2 on incremental lactose administration for colonic adaptation; and 1 on another agent) met inclusion criteria. Moderate-quality evidence indicated that 12 to 15 g of lactose (approximately 1 cup of milk) is well tolerated by most adults. Evidence was insufficient that lactose-reduced solution or milk with a lactose content of 0 to 2 g, compared with greater than 12 g, is Effective in reducing symptoms of lactose intolerance. Evidence for probiotics, colonic adaptation, and other agents was also insufficient. Limitations: Most studies evaluated persons with lactose malabsorption rather than lactose intolerance. Variation in enrollment criteria, outcome reporting, and the composition and dosing of studied agents precluded pooling of results and limited interpretation. Conclusion: Most individuals with presumed lactose intolerance or malabsorption can tolerate 12 to 15 g of lactose. Additional studies are needed to determine the Effectiveness of lactose intolerance treatment. Primary Funding Source: Agency for Healthcare Research and Quality.
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systematic review Effective Management strategies for lactose intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Tatyana Shamliyan, Brent C Taylor, Roderick Macdonald, Robert L. Kane, Michael Levitt, Timothy J WiltAbstract:This systematic review provides background for the NIH consensus statement on lactose intolerance. The review includes evidence from 36 trials that evaluated a variety of dietary, behavioral, and p...
Aasma Shaukat - One of the best experts on this subject based on the ideXlab platform.
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systematic review Effective Management strategies for lactose intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Tatyana Shamliyan, Brent C Taylor, Roderick Macdonald, Robert L. Kane, Michael Levitt, Timothy J WiltAbstract:Background: Lactose intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and Management of this condition remain unclear. Purpose: To assess the maximum tolerable dose of lactose and interventions for reducing symptoms of lactose intolerance among persons with lactose intolerance and malabsorption. Data Sources: Multiple electronic databases, including MEDLINE and the Cochrane Library, for trials published in English from 1967 through November 2009. Study Selection: Randomized, controlled trials of individuals with lactose intolerance or malabsorption. Data Extraction: Three investigators independently reviewed articles, extracted data, and assessed study quality. Data Synthesis: 36 unique randomized studies (26 on lactase- or lactose-hydrolyzed milk supplements, lactose-reduced milk, or tolerable doses of lactose; 7 on probiotics; 2 on incremental lactose administration for colonic adaptation; and 1 on another agent) met inclusion criteria. Moderate-quality evidence indicated that 12 to 15 g of lactose (approximately 1 cup of milk) is well tolerated by most adults. Evidence was insufficient that lactose-reduced solution or milk with a lactose content of 0 to 2 g, compared with greater than 12 g, is Effective in reducing symptoms of lactose intolerance. Evidence for probiotics, colonic adaptation, and other agents was also insufficient. Limitations: Most studies evaluated persons with lactose malabsorption rather than lactose intolerance. Variation in enrollment criteria, outcome reporting, and the composition and dosing of studied agents precluded pooling of results and limited interpretation. Conclusion: Most individuals with presumed lactose intolerance or malabsorption can tolerate 12 to 15 g of lactose. Additional studies are needed to determine the Effectiveness of lactose intolerance treatment. Primary Funding Source: Agency for Healthcare Research and Quality.
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systematic review Effective Management strategies for lactose intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Tatyana Shamliyan, Brent C Taylor, Roderick Macdonald, Robert L. Kane, Michael Levitt, Timothy J WiltAbstract:This systematic review provides background for the NIH consensus statement on lactose intolerance. The review includes evidence from 36 trials that evaluated a variety of dietary, behavioral, and p...
Xu Zhao - One of the best experts on this subject based on the ideXlab platform.
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reverse logistics network design for Effective Management of medical waste in epidemic outbreaks insights from the coronavirus disease 2019 covid 19 outbreak in wuhan china
International Journal of Environmental Research and Public Health, 2020Co-Authors: Hao Yu, Wei Deng Solvang, Xu ZhaoAbstract:The outbreak of an epidemic disease may pose significant treats to human beings and may further lead to a global crisis. In order to control the spread of an epidemic, the Effective Management of rapidly increased medical waste through establishing a temporary reverse logistics system is of vital importance. However, no research has been conducted with the focus on the design of an epidemic reverse logistics network for dealing with medical waste during epidemic outbreaks, which, if improperly treated, may accelerate disease spread and pose a significant risk for both medical staffs and patients. Therefore, this paper proposes a novel multi-objective multi-period mixed integer program for reverse logistics network design in epidemic outbreaks, which aims at determining the best locations of temporary facilities and the transportation strategies for Effective Management of the exponentially increased medical waste within a very short period. The application of the model is illustrated with a case study based on the outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan, China. Even though the uncertainty of the future COVID-19 spread tendency is very high at the time of this research, several general policy recommendations can still be obtained based on computational experiments and quantitative analyses. Among other insights, the results suggest installing temporary incinerators may be an Effective solution for managing the tremendous increase of medical waste during the COVID-19 outbreak in Wuhan, but the location selection of these temporary incinerators is of significant importance. Due to the limitation on available data and knowledge at present stage, more real-world information are needed to assess the Effectiveness of the current solution.
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reverse logistics network design for Effective Management of medical waste in epidemic outbreaks insights from the coronavirus disease 2019 covid 19 outbreak in wuhan china
2020Co-Authors: Xu Sun, Wei Deng Solvang, Xu ZhaoAbstract:The outbreak of an epidemic disease may pose significant treats to human beings and may further lead to a global crisis. In order to control the spread of an epidemic, the Effective Management of rapidly increased medical waste through establishing a temporary reverse logistics system is of vital importance. However, no research has been conducted with the focus on the design of an epidemic reverse logistics network for dealing with medical waste during epidemic outbreaks, which, if improperly treated, may accelerate disease spread and pose a significant risk for both medical staffs and patients. Therefore, this paper proposes a novel multi-objective multi-period mixed integer program for reverse logistics network design in epidemic outbreaks, which aims at determining the best locations of temporary facilities and the transportation strategies for Effective Management of the exponentially increased medical waste within a very short period. The application of the model is illustrated with a case study based on the outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan, China. Even though the uncertainty of the future COVID-19 spread tendency is very high at the time of this research, several general policy recommendations can still be obtained based on computational experiments and quantitative analyses. Among other insights, the results suggest installing temporary incinerators may be an Effective solution for managing the tremendous increase of medical waste during the COVID-19 outbreak in Wuhan, but the location selection of these temporary incinerators is of significant importance. Due to the limitation on available data and knowledge at present stage, more real-world information are needed to assess the Effectiveness of the current solution. Funding: The publication charges for this article have been funded by a grant from the publication fund of UiT The Arctic University of Norway. Declaration of Interest: The authors declare no conflict of interest.
Robert L. Kane - One of the best experts on this subject based on the ideXlab platform.
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systematic review Effective Management strategies for lactose intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Tatyana Shamliyan, Brent C Taylor, Roderick Macdonald, Robert L. Kane, Michael Levitt, Timothy J WiltAbstract:Background: Lactose intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and Management of this condition remain unclear. Purpose: To assess the maximum tolerable dose of lactose and interventions for reducing symptoms of lactose intolerance among persons with lactose intolerance and malabsorption. Data Sources: Multiple electronic databases, including MEDLINE and the Cochrane Library, for trials published in English from 1967 through November 2009. Study Selection: Randomized, controlled trials of individuals with lactose intolerance or malabsorption. Data Extraction: Three investigators independently reviewed articles, extracted data, and assessed study quality. Data Synthesis: 36 unique randomized studies (26 on lactase- or lactose-hydrolyzed milk supplements, lactose-reduced milk, or tolerable doses of lactose; 7 on probiotics; 2 on incremental lactose administration for colonic adaptation; and 1 on another agent) met inclusion criteria. Moderate-quality evidence indicated that 12 to 15 g of lactose (approximately 1 cup of milk) is well tolerated by most adults. Evidence was insufficient that lactose-reduced solution or milk with a lactose content of 0 to 2 g, compared with greater than 12 g, is Effective in reducing symptoms of lactose intolerance. Evidence for probiotics, colonic adaptation, and other agents was also insufficient. Limitations: Most studies evaluated persons with lactose malabsorption rather than lactose intolerance. Variation in enrollment criteria, outcome reporting, and the composition and dosing of studied agents precluded pooling of results and limited interpretation. Conclusion: Most individuals with presumed lactose intolerance or malabsorption can tolerate 12 to 15 g of lactose. Additional studies are needed to determine the Effectiveness of lactose intolerance treatment. Primary Funding Source: Agency for Healthcare Research and Quality.
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systematic review Effective Management strategies for lactose intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Tatyana Shamliyan, Brent C Taylor, Roderick Macdonald, Robert L. Kane, Michael Levitt, Timothy J WiltAbstract:This systematic review provides background for the NIH consensus statement on lactose intolerance. The review includes evidence from 36 trials that evaluated a variety of dietary, behavioral, and p...
Brent C Taylor - One of the best experts on this subject based on the ideXlab platform.
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systematic review Effective Management strategies for lactose intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Tatyana Shamliyan, Brent C Taylor, Roderick Macdonald, Robert L. Kane, Michael Levitt, Timothy J WiltAbstract:Background: Lactose intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and Management of this condition remain unclear. Purpose: To assess the maximum tolerable dose of lactose and interventions for reducing symptoms of lactose intolerance among persons with lactose intolerance and malabsorption. Data Sources: Multiple electronic databases, including MEDLINE and the Cochrane Library, for trials published in English from 1967 through November 2009. Study Selection: Randomized, controlled trials of individuals with lactose intolerance or malabsorption. Data Extraction: Three investigators independently reviewed articles, extracted data, and assessed study quality. Data Synthesis: 36 unique randomized studies (26 on lactase- or lactose-hydrolyzed milk supplements, lactose-reduced milk, or tolerable doses of lactose; 7 on probiotics; 2 on incremental lactose administration for colonic adaptation; and 1 on another agent) met inclusion criteria. Moderate-quality evidence indicated that 12 to 15 g of lactose (approximately 1 cup of milk) is well tolerated by most adults. Evidence was insufficient that lactose-reduced solution or milk with a lactose content of 0 to 2 g, compared with greater than 12 g, is Effective in reducing symptoms of lactose intolerance. Evidence for probiotics, colonic adaptation, and other agents was also insufficient. Limitations: Most studies evaluated persons with lactose malabsorption rather than lactose intolerance. Variation in enrollment criteria, outcome reporting, and the composition and dosing of studied agents precluded pooling of results and limited interpretation. Conclusion: Most individuals with presumed lactose intolerance or malabsorption can tolerate 12 to 15 g of lactose. Additional studies are needed to determine the Effectiveness of lactose intolerance treatment. Primary Funding Source: Agency for Healthcare Research and Quality.
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systematic review Effective Management strategies for lactose intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Tatyana Shamliyan, Brent C Taylor, Roderick Macdonald, Robert L. Kane, Michael Levitt, Timothy J WiltAbstract:This systematic review provides background for the NIH consensus statement on lactose intolerance. The review includes evidence from 36 trials that evaluated a variety of dietary, behavioral, and p...