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J M Kim - One of the best experts on this subject based on the ideXlab platform.
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Mid dermal Elastolysis with wrinkling. Report of two cases and review of the literature.
Journal of the American Academy of Dermatology, 1992Co-Authors: J M KimAbstract:We observed two patients who had mid dermal Elastolysis with wrinkling. We reviewed the pertinent features of the four cases reported in the literature and of our two cases. We also compared mid dermal Elastolysis with other disorders of acquired Elastolysis, such as postinflammatory Elastolysis and cutis laxa, anetoderma, and (regular) cutis laxa. Our two patients with mid dermal Elastolysis with wrinkling were middle-aged, white women. Physical examination showed widespread wrinkling, erythematous patches (macules), and papules. Histologic examination showed patchy loss of elastic tissue limited to the mid dermis. In one of our patients, elastolytic skin lesions appeared on areas not covered by a two-piece swimsuit. She used to sunbathe frequently. In our other patient, skin lesions were also more prominent on exposed areas. We speculate that sun exposure is one of the main causative factors of mid dermal Elastolysis with wrinkling.
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Mid dermal Elastolysis with wrinkling. Report of two cases and review of the literature.
Journal of the American Academy of Dermatology, 1992Co-Authors: J M KimAbstract:Background: We observed two patients who had mid dermal Elastolysis with wrinkling. Objective and Methods: We reviewed the pertinent features of the four cases reported in the literature and of our two cases. We also compared mid dermal Elastolysis with other disorders of acquired Elastolysis, such as postinflammatory Elastolysis and cutis laxa, anetoderma, and (regular) cutis laxa. Results: Our two patients with mid dermal Elastolysis with wrinkling were middle-aged, white women. Physical examination showed widespread wrinkling, erythematous patches (macules), and papules. Histologic examination showed patchy loss of elastic tissue limited to the mid dermis. In one of our patients, elastolytic skin lesions appeared on areas not covered by a two-piece swimsuit. She used to sunbathe frequently. In our other patient, skin lesions were also more prominent on exposed areas. Conclusion: We speculate that sun exposure is one of the main causative factors of mid dermal Elastolysis with wrinkling.
Akira Kawada - One of the best experts on this subject based on the ideXlab platform.
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Fibroelastolytic papulosis in an elderly woman with a 30-year history: overlapping between pseudoxanthoma elasticum-like papillary dermal Elastolysis and white fibrous papulosis of the neck
European journal of dermatology : EJD, 2014Co-Authors: Naoki Oiso, Maiko Kato, Akira KawadaAbstract:Pseudoxanthoma elasticum (PXE)-like papillary dermal Elastolysis (PXE-like PDE) is an uncommon, acquired, elastic tissue disorder [1], which was originally reported by Rongioletti and Rebora in 1992 [2]. It is characterized by soft, yellowish, non-follicular papules forming plaques with a cobblestone appearance, on the neck and supraclavicular areas in senior women [2]. White fibrous papulosis of the neck (WFPN), which was initially reported by Shimizu et al. in 1985, is whitish, non-follicular, [...]
Naoki Oiso - One of the best experts on this subject based on the ideXlab platform.
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Fibroelastolytic papulosis in an elderly woman with a 30-year history: overlapping between pseudoxanthoma elasticum-like papillary dermal Elastolysis and white fibrous papulosis of the neck
European journal of dermatology : EJD, 2014Co-Authors: Naoki Oiso, Maiko Kato, Akira KawadaAbstract:Pseudoxanthoma elasticum (PXE)-like papillary dermal Elastolysis (PXE-like PDE) is an uncommon, acquired, elastic tissue disorder [1], which was originally reported by Rongioletti and Rebora in 1992 [2]. It is characterized by soft, yellowish, non-follicular papules forming plaques with a cobblestone appearance, on the neck and supraclavicular areas in senior women [2]. White fibrous papulosis of the neck (WFPN), which was initially reported by Shimizu et al. in 1985, is whitish, non-follicular, [...]
Olívia Bordalo - One of the best experts on this subject based on the ideXlab platform.
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doi:10.1155/2010/352724
2013Co-Authors: Rubina Alves, Lurdes Ferreira, Esmeralda Vale, Olívia Bordalo, Pseudoxanthoma Elasticum, Papillary Dermal ElastolysisAbstract:Copyright © 2010 Rubina Alves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PXE-PDE is a rare clinicopathological entity with few cases reported. It affects more often elderly women and is characterized by asymptomatic bilateral and symmetrical yellowish papules localized predominantly on the neck and supraclavicular regions. It is clinically similar to Pseudoxanthoma Elasticum. The authors report a case of a 64-year-old woman presenting asymptomatic, yellowish, non-follicular papules, affecting the occipital and the posterior region of the neck for 1 year. The patient denied pruritic or inflammatory changes, marked solar exposition or trauma on the affected areas. Routine laboratory studies: thoracic x-ray and ophthalmologic examination were normal. The histopathologic examination of a biopsy of one of the cutaneous lesions showed an absence of elastic fibers in the papillary dermis.The diagnosis of Pseudoxanthoma Elasticum—like Papillary Dermal Elastolysis (PXE-PDE) was made. Of great importance is the differential diagnosis with Pseudoxanthoma elasticum (PXE), but we have also to consider other elastolytic disorders: mid-dermal Elastolysis (MDE), linear focal elastosis (LFE) and white fibrous papulosis of the neck (WFPN). Until know, there is no effective treatment for this pathology
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Pseudoxanthoma Elasticum Papillary Dermal Elastolysis: A Case Report
Dermatology research and practice, 2010Co-Authors: Rubina Alves, Lurdes Ferreira, Esmeralda Vale, Olívia BordaloAbstract:PXE-PDE is a rare clinicopathological entity with few cases reported. It affects more often elderly women and is characterized by asymptomatic bilateral and symmetrical yellowish papules localized predominantly on the neck and supraclavicular regions. It is clinically similar to Pseudoxanthoma Elasticum. The authors report a case of a 64-year-old woman presenting asymptomatic, yellowish, non-follicular papules, affecting the occipital and the posterior region of the neck for 1 year. The patient denied pruritic or inflammatory changes, marked solar exposition or trauma on the affected areas. Routine laboratory studies: thoracic x-ray and ophthalmologic examination were normal. The histopathologic examination of a biopsy of one of the cutaneous lesions showed an absence of elastic fibers in the papillary dermis.The diagnosis of Pseudoxanthoma Elasticum—like Papillary Dermal Elastolysis (PXE-PDE) was made. Of great importance is the differential diagnosis with Pseudoxanthoma elasticum (PXE), but we have also to consider other elastolytic disorders: mid-dermal Elastolysis (MDE), linear focal elastosis (LFE) and white fibrous papulosis of the neck (WFPN). Until know, there is no effective treatment for this pathology.
Thilo Gambichler - One of the best experts on this subject based on the ideXlab platform.
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Non-invasive imaging of mid-dermal Elastolysis.
Clinical and experimental dermatology, 2011Co-Authors: N. Scola, A. Goulioumis, Thilo GambichlerAbstract:Mid-dermal Elastolysis (MDE) is a rare disease that is characterized histopathologically by selective loss of elastic tissue in the mid dermis. We aimed to assess MDE using noninvasive skin imaging techniques in vivo. We examined both the lesional and adjacent healthy skin of a woman with the reticular variant of MDE, using confocal scanning laser microscopy, optical coherence tomography (OCT) and high-frequency ultrasound (HFUS). The median diameter of blood vessels at the top of dermal papillae was significantly increased in erythematous lesional skin compared with healthy skin. The mid-dermal signal intensity detected by OCT was higher in healthy skin than in lesional skin. With HFUS, mid-dermal density values were significantly higher in healthy skin than in lesional skin. Our preliminary findings indicate that noninvasive skin imaging methods such as OCT and HFUS might be suitable techniques for the evaluation and monitoring of elastolytic skin disorders such as MDE.
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Mid-dermal Elastolysis revisited
Archives of Dermatological Research, 2010Co-Authors: Thilo GambichlerAbstract:The clinical as well as histological data of 79 mid-dermal Elastolysis (MDE) patients reported in the literature were evaluated. MDE is an acquired skin condition of the elastic tissue predominantly manifesting on the trunk and proximal extremities of young women. Most commonly observed skin changes include patches of well-circumscribed fine wrinkles (type I) and perifollicular papular protrusions (type II). Rarely, MDE may also occur with persistent reticular erythema and wrinkling (type III). The critical diagnostic histopathological feature of MDE is the selective loss of elastic fibres in the mid-dermis. Mild lymphohistiocytic infiltrates, elastophagocytosis of elastic fibres by macrophages, and even multinucleate giant cells are occasionally observed in MDE lesions. Immunohistological studies and cell culture experiments indicate that dysbalances in elastin turnover are associated with pathological degradative processes including increased elastolytic activity that finally lead to loss of elastic fibres in the mid-dermis. First-line differential diagnoses may include closely related conditions such as anetoderma, annular elastolytic giant cell granuloma, cutis laxa acquisita and pseudoxanthoma elasticum-like papillary dermal Elastolysis. Future therapeutic approaches in MDE patients should focus on agents that are able to block increased elastase activity and induce elastin synthesis.
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Immunohistochemical investigation of mid-dermal Elastolysis.
Clinical and experimental dermatology, 2004Co-Authors: Thilo Gambichler, Frank Breuckmann, A. Kreuter, Stefanie Boms, Peter Altmeyer, Markus StückerAbstract:Summary We report a 31-year-old Caucasian woman presenting with remarkable wrinkling on her trunk and proximal extremities. Diagnosis of mid-dermal Elastolysis (MDE) was confirmed by Van Gieson's staining. Immunohistochemical investigations revealed enhanced expression of CD34+ and CD68+ cells accompanied by slightly increased expression of CD3+ and CD4+ lymphocytes in lesional skin. Furthermore an elevated cellular expression of matrix metalloproteinase (MMP)-1 and slightly increased presence of MMP-12 positive cells combined with a decrease of tissue inhibitor of metalloproteinases 1 (TIMP-1) positive cells was observed in lesional skin as compared with a control specimen obtained from nonlesional skin. Our data may indicate inflammatory processes and an altered balance between MMPs and TIMPs in MDE. Furthermore CD34+ dendritic fibroblasts and/or histiocytes are possibly involved in the pathogenesis of MDE.
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Mid-dermal Elastolysis associated with Hashimoto's thyroiditis.
Journal of the European Academy of Dermatology and Venereology : JEADV, 1999Co-Authors: Thilo Gambichler, Carola Linhart, Manfred WolterAbstract:We report the case of a 38-year-old Caucasian female presenting asymptomatic plaques of fine wrinkling and perifollicular papular protrusions especially on the trunk. Histological examination evidenced loss of elastic fibers in the mid-dermis due to elastophagocytosis, with giant cells and granuloma formation. Moreover, elevated titers of thyroid autoantibodies were detected and thyroid ultrasound revealed echo-poor tissue. These findings met the diagnoses of mid-dermal Elastolysis and Hashimoto's thyroiditis. This association has not been reported before. We present a comprehensive overview of the literature and discuss the pathogenetic aspects of mid-dermal Elastolysis and the significance of the association with Hashimoto's thyroiditis.