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Catherine Creuzot-garcher - One of the best experts on this subject based on the ideXlab platform.

  • Epidemiology of vitreomacular interface abnormalities using macular spectral-domain optical coherence tomography in an Elderly Population (the Montrachet study)
    RETINA, 2021
    Co-Authors: Inès Ben Ghezala, Christine Binquet, Cécile Delcourt, Alassane Seydou, Alain Bron, Pierre-henry Gabrielle, Jacques Bouche-pillon, Vincent Daien, Catherine Creuzot-garcher
    Abstract:

    PURPOSE: The aim of this study was to investigate the prevalence of vitreomacular interface abnormalities (VMIAs) and to identify associated factors in an Elderly Population in Europe. METHODS: The MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) Study is a Population-based study, conducted in subjects older than 75 years. Vitreomacular adhesions, vitreomacular tractions, macular holes, epiretinal membranes, and macular cysts were assessed on spectral-domain optical coherence tomography examinations. The prevalence of VMIAs was estimated. We studied the association of demographic and clinical factors with VMIAs. RESULTS: The mean age of the participants was 82.3 (SD, 3.8) years, and 37.3% were men. The prevalence rates of VMIAs were vitreomacular adhesions (17.7%), vitreomacular tractions (1.4%), lamellar macular holes (1.0%), full-thickness macular holes (0.2%), macular pseudoholes (0.4%), epiretinal membranes (38.9%), and macular cysts (5.8%). In multivariate analysis, vitreomacular adhesions were positively associated with male sex (P < 0.001) and negatively associated with older age (P < 0.001) and cataract extraction (P < 0.001). Epiretinal membranes were positively associated with older age (P < 0.001) and cataract extraction (P < 0.001). CONCLUSION: The prevalence of VMIAs based on spectral-domain optical coherence tomography analysis was high in subjects older than 75 years.

  • Vitreomacular interface abnormalities and glaucoma in an Elderly Population (the MONTRACHET study)
    Investigative Ophthalmology & Visual Science, 2019
    Co-Authors: Julie Blanc, Christine Binquet, Alain M. Bron, Alassane Seydou, Inès Ben Ghezala, Clémence Deschasse, Cyril Meillon, Catherine Creuzot-garcher
    Abstract:

    Purpose: To investigate the prevalence of vitreomacular interface abnormalities (VMIAs) in a French Elderly glaucomatous Population. Methods: Using a Population-based study, the MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) study conducted in Dijon from 2009 to 2013 in individuals older than 75 years, the prevalence of VMIAs was estimated on glaucoma patients. Results: A total of 1130 participants (2225 eyes) were included in the study. The mean age of participants was 82.3 +/- 3.8 years, and 62.74% were women. Regarding the frequency of all VMIAs, there was no statistical difference between glaucoma patients and nonglaucoma participants (51.85% vs. 53.92%, respectively, P = 0.372). In univariate analysis, vitreomacular adherences were more frequent in nonglaucoma participants (18.39% vs. 10.78%, P = 0.036). Epiretinal membranes were more frequent in the glaucomatous Population (47.06% vs. 38.13%, P = 0.018). The prevalence of macular cysts was comparable in the two groups (7.84% vs. 5.64%, P = 0.262). Macular cysts were more frequent in eyes treated with preservative-free, IOP-lowering eye drops when compared with the eyes of nonglaucomatous participants treated with IOP-lowering eye drops containing a preservative (26.67% vs. 3.37% and 5.76%, respectively, P < 0.001). In multivariate analysis, these results were no longer significant. Conclusions: The prevalence of VMIAs was high in this Elderly Population and similar in both glaucomatous and nonglaucomatous participants. The information provided by macular optical coherence tomography scans should be considered with caution when used for glaucoma management in Elderly patients.

  • Relationships of Macular Pigment Optical Density With Plasma Lutein, Zeaxanthin, and Diet in an Elderly Population
    Investigative Ophthalmology & Visual Science, 2016
    Co-Authors: Seydou Alassane, Christine Binquet, Vanessa Cottet, Olivier Fleck, Niyazi Acar, Sandrine Daniel, Cécile Delcourt, Lionel Bretillon, Alain M. Bron, Catherine Creuzot-garcher
    Abstract:

    PURPOSE. To investigate the association of macular pigment optical density (MPOD) with plasma lutein, zeaxanthin, and diet in an Elderly Population. METHODS. We conducted a Population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. The MPOD was measured by means of the two-wavelength autofluorescence technique. Plasma lutein and zeaxanthin were measured in fasting blood samples using HPLC. Food frequency consumption was assessed with self-reported food frequency questionnaires. RESULTS. Overall, 433 healthy participants (62.1% females) were included. Mean age was 82.0 +/- 3.6 years. Mean MPOD at 0.5 degrees eccentricity was 0.57 +/- 0.25 density units (DU) and was higher in women than in men (0.59 +/- 0.25 vs. 0.53 +/- 0.25, P = 0.017). The MPOD was lower in alcohol consumers than in non-alcohol consumers (0.55 +/- 0.25 vs. 0.61 +/- 0.25, P = 0.016). Median plasma lutein and zeaxanthin levels were 281.4 mu g/L and 20.0 mu g/L, respectively, and were higher in women (P = 0.010 and P = 0.003, respectively). The MPOD was positively correlated with plasma lutein and zeaxanthin (r = 0.10, P = 0.030 and r = 0.11, P = 0.027, respectively). A higher consumption of squash was associated with higher plasma lutein and zeaxanthin. Adjusting for confounders and diet revealed that MPOD was weakly associated with plasma lutein in nonsmokers (beta = 0.11, P = 0.021). CONCLUSIONS. This study suggests that plasma lutein is associated with MPOD after taking into account potential confounding factors in an Elderly Population.

  • The Montrachet Study: study design, methodology and analysis of visual acuity and refractive errors in an Elderly Population
    Acta Ophthalmologica Scandinavica -Supplement-, 2016
    Co-Authors: Catherine Creuzot-garcher, Christine Binquet, Sandrine Daniel, Lionel Bretillon, Alain M. Bron, Nyiazi Acar, Aurélie De Lazzer, Laurent Arnould, Christophe Tzourio, Cécile Delcourt
    Abstract:

    Purpose: To describe the design of the Montrachet Study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) and to report visual acuity and refractive errors in this Elderly Population. Methods: Participants were recruited in Dijon (France), from the ongoing Population-based 3C Study. In 2009-2011, 1153 participants from the 3 Cities Study, aged 75 years or more, had an initial eye examination and were scheduled for eye examinations. The eye examination comprised visual acuity, refraction, visual field, ocular surface assessment, photographs and OCT of the macula and the optic disc, measurement of intra-ocular pressure, central corneal thickness and macular pigment assessment. Information on cardiovascular and neurologic diseases and a large comprehensive database (blood samples, genetic testing, cognitive tests, MRI) were available from the 3C Study. Results: Presenting visual acuity

Christine Binquet - One of the best experts on this subject based on the ideXlab platform.

  • Epidemiology of vitreomacular interface abnormalities using macular spectral-domain optical coherence tomography in an Elderly Population (the Montrachet study)
    RETINA, 2021
    Co-Authors: Inès Ben Ghezala, Christine Binquet, Cécile Delcourt, Alassane Seydou, Alain Bron, Pierre-henry Gabrielle, Jacques Bouche-pillon, Vincent Daien, Catherine Creuzot-garcher
    Abstract:

    PURPOSE: The aim of this study was to investigate the prevalence of vitreomacular interface abnormalities (VMIAs) and to identify associated factors in an Elderly Population in Europe. METHODS: The MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) Study is a Population-based study, conducted in subjects older than 75 years. Vitreomacular adhesions, vitreomacular tractions, macular holes, epiretinal membranes, and macular cysts were assessed on spectral-domain optical coherence tomography examinations. The prevalence of VMIAs was estimated. We studied the association of demographic and clinical factors with VMIAs. RESULTS: The mean age of the participants was 82.3 (SD, 3.8) years, and 37.3% were men. The prevalence rates of VMIAs were vitreomacular adhesions (17.7%), vitreomacular tractions (1.4%), lamellar macular holes (1.0%), full-thickness macular holes (0.2%), macular pseudoholes (0.4%), epiretinal membranes (38.9%), and macular cysts (5.8%). In multivariate analysis, vitreomacular adhesions were positively associated with male sex (P < 0.001) and negatively associated with older age (P < 0.001) and cataract extraction (P < 0.001). Epiretinal membranes were positively associated with older age (P < 0.001) and cataract extraction (P < 0.001). CONCLUSION: The prevalence of VMIAs based on spectral-domain optical coherence tomography analysis was high in subjects older than 75 years.

  • Diagnostic ability of spectral‐domain optical coherence tomography peripapillary retinal nerve fiber layer thickness to discriminate glaucoma patients from controls in an Elderly Population (The MONTRACHET study)
    Acta Ophthalmologica Scandinavica -Supplement-, 2020
    Co-Authors: Louis Arnould, Christine Binquet, Aurélie De Lazzer, Alassane Seydou, Alain Bron, Catherine Creuzot‐garcher
    Abstract:

    Purpose To evaluate the capacity of retinal nerve fibre layer (RNFL) thickness measured by SD-OCT to discriminate glaucoma patients from controls in an Elderly Population. Methods The MONTRACHET (Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases) Study is a Population-based study including participants aged 75 years and over. All participants underwent a complete eye examination with optic nerve photographs, visual field testing and OCT peripapillary RNFL thickness measurement. Glaucoma was defined according to the ISGEO (International Society for Epidemiologic and Geographical Ophthalmology) classification. Performance indicators were calculated including area under the receiver operating characteristics curves (AUC), likelihood ratios (LR) and diagnostic odds ratios (DOR). Results In total, 1061 participants were included in the study, of whom 89 were classified as having glaucoma and 972 were classified as normal. The mean (SD) age of the Population was 82.3 (3.7) years. The average RNFL thickness was significantly lower in the glaucoma group than in controls 64.0 (14.9) mu m versus 88.9 (12.4) mu m, respectively, p < 0.001) and in all sectors compared with controls. The average RNFL thickness had the highest AUC (0.901) followed by the temporal-inferior (0.879) and temporal-superior sectors (0.862). When RNFL thickness was classified as abnormal by SD-OCT, the average RNFL thickness had the best sensitivity (83.75%) followed by the temporal-inferior sector (75.64%). The specificity for these two parameters was 87.34% and 91.08%, respectively. The highest DOR was 28.70 for average RNFL thickness and reached 34.84 when using the reference database of the OCT manufacturer. Conclusion This study confirms that SD-OCT could be useful as an additional test to discriminate glaucoma patients from controls in an Elderly Population.

  • Vitreomacular interface abnormalities and glaucoma in an Elderly Population (the MONTRACHET study)
    Investigative Ophthalmology & Visual Science, 2019
    Co-Authors: Julie Blanc, Christine Binquet, Alain M. Bron, Alassane Seydou, Inès Ben Ghezala, Clémence Deschasse, Cyril Meillon, Catherine Creuzot-garcher
    Abstract:

    Purpose: To investigate the prevalence of vitreomacular interface abnormalities (VMIAs) in a French Elderly glaucomatous Population. Methods: Using a Population-based study, the MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) study conducted in Dijon from 2009 to 2013 in individuals older than 75 years, the prevalence of VMIAs was estimated on glaucoma patients. Results: A total of 1130 participants (2225 eyes) were included in the study. The mean age of participants was 82.3 +/- 3.8 years, and 62.74% were women. Regarding the frequency of all VMIAs, there was no statistical difference between glaucoma patients and nonglaucoma participants (51.85% vs. 53.92%, respectively, P = 0.372). In univariate analysis, vitreomacular adherences were more frequent in nonglaucoma participants (18.39% vs. 10.78%, P = 0.036). Epiretinal membranes were more frequent in the glaucomatous Population (47.06% vs. 38.13%, P = 0.018). The prevalence of macular cysts was comparable in the two groups (7.84% vs. 5.64%, P = 0.262). Macular cysts were more frequent in eyes treated with preservative-free, IOP-lowering eye drops when compared with the eyes of nonglaucomatous participants treated with IOP-lowering eye drops containing a preservative (26.67% vs. 3.37% and 5.76%, respectively, P < 0.001). In multivariate analysis, these results were no longer significant. Conclusions: The prevalence of VMIAs was high in this Elderly Population and similar in both glaucomatous and nonglaucomatous participants. The information provided by macular optical coherence tomography scans should be considered with caution when used for glaucoma management in Elderly patients.

  • Relationships of Macular Pigment Optical Density With Plasma Lutein, Zeaxanthin, and Diet in an Elderly Population
    Investigative Ophthalmology & Visual Science, 2016
    Co-Authors: Seydou Alassane, Christine Binquet, Vanessa Cottet, Olivier Fleck, Niyazi Acar, Sandrine Daniel, Cécile Delcourt, Lionel Bretillon, Alain M. Bron, Catherine Creuzot-garcher
    Abstract:

    PURPOSE. To investigate the association of macular pigment optical density (MPOD) with plasma lutein, zeaxanthin, and diet in an Elderly Population. METHODS. We conducted a Population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. The MPOD was measured by means of the two-wavelength autofluorescence technique. Plasma lutein and zeaxanthin were measured in fasting blood samples using HPLC. Food frequency consumption was assessed with self-reported food frequency questionnaires. RESULTS. Overall, 433 healthy participants (62.1% females) were included. Mean age was 82.0 +/- 3.6 years. Mean MPOD at 0.5 degrees eccentricity was 0.57 +/- 0.25 density units (DU) and was higher in women than in men (0.59 +/- 0.25 vs. 0.53 +/- 0.25, P = 0.017). The MPOD was lower in alcohol consumers than in non-alcohol consumers (0.55 +/- 0.25 vs. 0.61 +/- 0.25, P = 0.016). Median plasma lutein and zeaxanthin levels were 281.4 mu g/L and 20.0 mu g/L, respectively, and were higher in women (P = 0.010 and P = 0.003, respectively). The MPOD was positively correlated with plasma lutein and zeaxanthin (r = 0.10, P = 0.030 and r = 0.11, P = 0.027, respectively). A higher consumption of squash was associated with higher plasma lutein and zeaxanthin. Adjusting for confounders and diet revealed that MPOD was weakly associated with plasma lutein in nonsmokers (beta = 0.11, P = 0.021). CONCLUSIONS. This study suggests that plasma lutein is associated with MPOD after taking into account potential confounding factors in an Elderly Population.

  • The Montrachet Study: study design, methodology and analysis of visual acuity and refractive errors in an Elderly Population
    Acta Ophthalmologica Scandinavica -Supplement-, 2016
    Co-Authors: Catherine Creuzot-garcher, Christine Binquet, Sandrine Daniel, Lionel Bretillon, Alain M. Bron, Nyiazi Acar, Aurélie De Lazzer, Laurent Arnould, Christophe Tzourio, Cécile Delcourt
    Abstract:

    Purpose: To describe the design of the Montrachet Study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) and to report visual acuity and refractive errors in this Elderly Population. Methods: Participants were recruited in Dijon (France), from the ongoing Population-based 3C Study. In 2009-2011, 1153 participants from the 3 Cities Study, aged 75 years or more, had an initial eye examination and were scheduled for eye examinations. The eye examination comprised visual acuity, refraction, visual field, ocular surface assessment, photographs and OCT of the macula and the optic disc, measurement of intra-ocular pressure, central corneal thickness and macular pigment assessment. Information on cardiovascular and neurologic diseases and a large comprehensive database (blood samples, genetic testing, cognitive tests, MRI) were available from the 3C Study. Results: Presenting visual acuity

Cécile Delcourt - One of the best experts on this subject based on the ideXlab platform.

  • Epidemiology of vitreomacular interface abnormalities using macular spectral-domain optical coherence tomography in an Elderly Population (the Montrachet study)
    RETINA, 2021
    Co-Authors: Inès Ben Ghezala, Christine Binquet, Cécile Delcourt, Alassane Seydou, Alain Bron, Pierre-henry Gabrielle, Jacques Bouche-pillon, Vincent Daien, Catherine Creuzot-garcher
    Abstract:

    PURPOSE: The aim of this study was to investigate the prevalence of vitreomacular interface abnormalities (VMIAs) and to identify associated factors in an Elderly Population in Europe. METHODS: The MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) Study is a Population-based study, conducted in subjects older than 75 years. Vitreomacular adhesions, vitreomacular tractions, macular holes, epiretinal membranes, and macular cysts were assessed on spectral-domain optical coherence tomography examinations. The prevalence of VMIAs was estimated. We studied the association of demographic and clinical factors with VMIAs. RESULTS: The mean age of the participants was 82.3 (SD, 3.8) years, and 37.3% were men. The prevalence rates of VMIAs were vitreomacular adhesions (17.7%), vitreomacular tractions (1.4%), lamellar macular holes (1.0%), full-thickness macular holes (0.2%), macular pseudoholes (0.4%), epiretinal membranes (38.9%), and macular cysts (5.8%). In multivariate analysis, vitreomacular adhesions were positively associated with male sex (P < 0.001) and negatively associated with older age (P < 0.001) and cataract extraction (P < 0.001). Epiretinal membranes were positively associated with older age (P < 0.001) and cataract extraction (P < 0.001). CONCLUSION: The prevalence of VMIAs based on spectral-domain optical coherence tomography analysis was high in subjects older than 75 years.

  • Relationships of Macular Pigment Optical Density With Plasma Lutein, Zeaxanthin, and Diet in an Elderly Population
    Investigative Ophthalmology & Visual Science, 2016
    Co-Authors: Seydou Alassane, Christine Binquet, Vanessa Cottet, Olivier Fleck, Niyazi Acar, Sandrine Daniel, Cécile Delcourt, Lionel Bretillon, Alain M. Bron, Catherine Creuzot-garcher
    Abstract:

    PURPOSE. To investigate the association of macular pigment optical density (MPOD) with plasma lutein, zeaxanthin, and diet in an Elderly Population. METHODS. We conducted a Population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. The MPOD was measured by means of the two-wavelength autofluorescence technique. Plasma lutein and zeaxanthin were measured in fasting blood samples using HPLC. Food frequency consumption was assessed with self-reported food frequency questionnaires. RESULTS. Overall, 433 healthy participants (62.1% females) were included. Mean age was 82.0 +/- 3.6 years. Mean MPOD at 0.5 degrees eccentricity was 0.57 +/- 0.25 density units (DU) and was higher in women than in men (0.59 +/- 0.25 vs. 0.53 +/- 0.25, P = 0.017). The MPOD was lower in alcohol consumers than in non-alcohol consumers (0.55 +/- 0.25 vs. 0.61 +/- 0.25, P = 0.016). Median plasma lutein and zeaxanthin levels were 281.4 mu g/L and 20.0 mu g/L, respectively, and were higher in women (P = 0.010 and P = 0.003, respectively). The MPOD was positively correlated with plasma lutein and zeaxanthin (r = 0.10, P = 0.030 and r = 0.11, P = 0.027, respectively). A higher consumption of squash was associated with higher plasma lutein and zeaxanthin. Adjusting for confounders and diet revealed that MPOD was weakly associated with plasma lutein in nonsmokers (beta = 0.11, P = 0.021). CONCLUSIONS. This study suggests that plasma lutein is associated with MPOD after taking into account potential confounding factors in an Elderly Population.

  • The Montrachet Study: study design, methodology and analysis of visual acuity and refractive errors in an Elderly Population
    Acta Ophthalmologica Scandinavica -Supplement-, 2016
    Co-Authors: Catherine Creuzot-garcher, Christine Binquet, Sandrine Daniel, Lionel Bretillon, Alain M. Bron, Nyiazi Acar, Aurélie De Lazzer, Laurent Arnould, Christophe Tzourio, Cécile Delcourt
    Abstract:

    Purpose: To describe the design of the Montrachet Study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) and to report visual acuity and refractive errors in this Elderly Population. Methods: Participants were recruited in Dijon (France), from the ongoing Population-based 3C Study. In 2009-2011, 1153 participants from the 3 Cities Study, aged 75 years or more, had an initial eye examination and were scheduled for eye examinations. The eye examination comprised visual acuity, refraction, visual field, ocular surface assessment, photographs and OCT of the macula and the optic disc, measurement of intra-ocular pressure, central corneal thickness and macular pigment assessment. Information on cardiovascular and neurologic diseases and a large comprehensive database (blood samples, genetic testing, cognitive tests, MRI) were available from the 3C Study. Results: Presenting visual acuity

Alassane Seydou - One of the best experts on this subject based on the ideXlab platform.

  • Epidemiology of vitreomacular interface abnormalities using macular spectral-domain optical coherence tomography in an Elderly Population (the Montrachet study)
    RETINA, 2021
    Co-Authors: Inès Ben Ghezala, Christine Binquet, Cécile Delcourt, Alassane Seydou, Alain Bron, Pierre-henry Gabrielle, Jacques Bouche-pillon, Vincent Daien, Catherine Creuzot-garcher
    Abstract:

    PURPOSE: The aim of this study was to investigate the prevalence of vitreomacular interface abnormalities (VMIAs) and to identify associated factors in an Elderly Population in Europe. METHODS: The MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) Study is a Population-based study, conducted in subjects older than 75 years. Vitreomacular adhesions, vitreomacular tractions, macular holes, epiretinal membranes, and macular cysts were assessed on spectral-domain optical coherence tomography examinations. The prevalence of VMIAs was estimated. We studied the association of demographic and clinical factors with VMIAs. RESULTS: The mean age of the participants was 82.3 (SD, 3.8) years, and 37.3% were men. The prevalence rates of VMIAs were vitreomacular adhesions (17.7%), vitreomacular tractions (1.4%), lamellar macular holes (1.0%), full-thickness macular holes (0.2%), macular pseudoholes (0.4%), epiretinal membranes (38.9%), and macular cysts (5.8%). In multivariate analysis, vitreomacular adhesions were positively associated with male sex (P < 0.001) and negatively associated with older age (P < 0.001) and cataract extraction (P < 0.001). Epiretinal membranes were positively associated with older age (P < 0.001) and cataract extraction (P < 0.001). CONCLUSION: The prevalence of VMIAs based on spectral-domain optical coherence tomography analysis was high in subjects older than 75 years.

  • Diagnostic ability of spectral‐domain optical coherence tomography peripapillary retinal nerve fiber layer thickness to discriminate glaucoma patients from controls in an Elderly Population (The MONTRACHET study)
    Acta Ophthalmologica Scandinavica -Supplement-, 2020
    Co-Authors: Louis Arnould, Christine Binquet, Aurélie De Lazzer, Alassane Seydou, Alain Bron, Catherine Creuzot‐garcher
    Abstract:

    Purpose To evaluate the capacity of retinal nerve fibre layer (RNFL) thickness measured by SD-OCT to discriminate glaucoma patients from controls in an Elderly Population. Methods The MONTRACHET (Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases) Study is a Population-based study including participants aged 75 years and over. All participants underwent a complete eye examination with optic nerve photographs, visual field testing and OCT peripapillary RNFL thickness measurement. Glaucoma was defined according to the ISGEO (International Society for Epidemiologic and Geographical Ophthalmology) classification. Performance indicators were calculated including area under the receiver operating characteristics curves (AUC), likelihood ratios (LR) and diagnostic odds ratios (DOR). Results In total, 1061 participants were included in the study, of whom 89 were classified as having glaucoma and 972 were classified as normal. The mean (SD) age of the Population was 82.3 (3.7) years. The average RNFL thickness was significantly lower in the glaucoma group than in controls 64.0 (14.9) mu m versus 88.9 (12.4) mu m, respectively, p < 0.001) and in all sectors compared with controls. The average RNFL thickness had the highest AUC (0.901) followed by the temporal-inferior (0.879) and temporal-superior sectors (0.862). When RNFL thickness was classified as abnormal by SD-OCT, the average RNFL thickness had the best sensitivity (83.75%) followed by the temporal-inferior sector (75.64%). The specificity for these two parameters was 87.34% and 91.08%, respectively. The highest DOR was 28.70 for average RNFL thickness and reached 34.84 when using the reference database of the OCT manufacturer. Conclusion This study confirms that SD-OCT could be useful as an additional test to discriminate glaucoma patients from controls in an Elderly Population.

  • Vitreomacular interface abnormalities and glaucoma in an Elderly Population (the MONTRACHET study)
    Investigative Ophthalmology & Visual Science, 2019
    Co-Authors: Julie Blanc, Christine Binquet, Alain M. Bron, Alassane Seydou, Inès Ben Ghezala, Clémence Deschasse, Cyril Meillon, Catherine Creuzot-garcher
    Abstract:

    Purpose: To investigate the prevalence of vitreomacular interface abnormalities (VMIAs) in a French Elderly glaucomatous Population. Methods: Using a Population-based study, the MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) study conducted in Dijon from 2009 to 2013 in individuals older than 75 years, the prevalence of VMIAs was estimated on glaucoma patients. Results: A total of 1130 participants (2225 eyes) were included in the study. The mean age of participants was 82.3 +/- 3.8 years, and 62.74% were women. Regarding the frequency of all VMIAs, there was no statistical difference between glaucoma patients and nonglaucoma participants (51.85% vs. 53.92%, respectively, P = 0.372). In univariate analysis, vitreomacular adherences were more frequent in nonglaucoma participants (18.39% vs. 10.78%, P = 0.036). Epiretinal membranes were more frequent in the glaucomatous Population (47.06% vs. 38.13%, P = 0.018). The prevalence of macular cysts was comparable in the two groups (7.84% vs. 5.64%, P = 0.262). Macular cysts were more frequent in eyes treated with preservative-free, IOP-lowering eye drops when compared with the eyes of nonglaucomatous participants treated with IOP-lowering eye drops containing a preservative (26.67% vs. 3.37% and 5.76%, respectively, P < 0.001). In multivariate analysis, these results were no longer significant. Conclusions: The prevalence of VMIAs was high in this Elderly Population and similar in both glaucomatous and nonglaucomatous participants. The information provided by macular optical coherence tomography scans should be considered with caution when used for glaucoma management in Elderly patients.

Inès Ben Ghezala - One of the best experts on this subject based on the ideXlab platform.

  • Epidemiology of vitreomacular interface abnormalities using macular spectral-domain optical coherence tomography in an Elderly Population (the Montrachet study)
    RETINA, 2021
    Co-Authors: Inès Ben Ghezala, Christine Binquet, Cécile Delcourt, Alassane Seydou, Alain Bron, Pierre-henry Gabrielle, Jacques Bouche-pillon, Vincent Daien, Catherine Creuzot-garcher
    Abstract:

    PURPOSE: The aim of this study was to investigate the prevalence of vitreomacular interface abnormalities (VMIAs) and to identify associated factors in an Elderly Population in Europe. METHODS: The MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) Study is a Population-based study, conducted in subjects older than 75 years. Vitreomacular adhesions, vitreomacular tractions, macular holes, epiretinal membranes, and macular cysts were assessed on spectral-domain optical coherence tomography examinations. The prevalence of VMIAs was estimated. We studied the association of demographic and clinical factors with VMIAs. RESULTS: The mean age of the participants was 82.3 (SD, 3.8) years, and 37.3% were men. The prevalence rates of VMIAs were vitreomacular adhesions (17.7%), vitreomacular tractions (1.4%), lamellar macular holes (1.0%), full-thickness macular holes (0.2%), macular pseudoholes (0.4%), epiretinal membranes (38.9%), and macular cysts (5.8%). In multivariate analysis, vitreomacular adhesions were positively associated with male sex (P < 0.001) and negatively associated with older age (P < 0.001) and cataract extraction (P < 0.001). Epiretinal membranes were positively associated with older age (P < 0.001) and cataract extraction (P < 0.001). CONCLUSION: The prevalence of VMIAs based on spectral-domain optical coherence tomography analysis was high in subjects older than 75 years.

  • Vitreomacular interface abnormalities and glaucoma in an Elderly Population (the MONTRACHET study)
    Investigative Ophthalmology & Visual Science, 2019
    Co-Authors: Julie Blanc, Christine Binquet, Alain M. Bron, Alassane Seydou, Inès Ben Ghezala, Clémence Deschasse, Cyril Meillon, Catherine Creuzot-garcher
    Abstract:

    Purpose: To investigate the prevalence of vitreomacular interface abnormalities (VMIAs) in a French Elderly glaucomatous Population. Methods: Using a Population-based study, the MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) study conducted in Dijon from 2009 to 2013 in individuals older than 75 years, the prevalence of VMIAs was estimated on glaucoma patients. Results: A total of 1130 participants (2225 eyes) were included in the study. The mean age of participants was 82.3 +/- 3.8 years, and 62.74% were women. Regarding the frequency of all VMIAs, there was no statistical difference between glaucoma patients and nonglaucoma participants (51.85% vs. 53.92%, respectively, P = 0.372). In univariate analysis, vitreomacular adherences were more frequent in nonglaucoma participants (18.39% vs. 10.78%, P = 0.036). Epiretinal membranes were more frequent in the glaucomatous Population (47.06% vs. 38.13%, P = 0.018). The prevalence of macular cysts was comparable in the two groups (7.84% vs. 5.64%, P = 0.262). Macular cysts were more frequent in eyes treated with preservative-free, IOP-lowering eye drops when compared with the eyes of nonglaucomatous participants treated with IOP-lowering eye drops containing a preservative (26.67% vs. 3.37% and 5.76%, respectively, P < 0.001). In multivariate analysis, these results were no longer significant. Conclusions: The prevalence of VMIAs was high in this Elderly Population and similar in both glaucomatous and nonglaucomatous participants. The information provided by macular optical coherence tomography scans should be considered with caution when used for glaucoma management in Elderly patients.