The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Ryuichi Arakawa - One of the best experts on this subject based on the ideXlab platform.
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investigation of the Electrochemical Oxidation products of zotepine and their fragmentation using on line electrochemistry electrospray ionization mass spectrometry
Journal of Mass Spectrometry, 2006Co-Authors: Kazuyoshi Nozaki, Sumihisa Kimura, Hiroshi Kitagawa, Akira Kagayama, Ryuichi ArakawaAbstract:When zotepine, an antipsychotic drug, was Electrochemically oxidized using electrospray ionization mass spectrometry (ESI-MS) coupled with a microflow electrolytic cell, [M + 16 + H]+ (m/z 348), [M—H]+ (m/z 330) and [M—14 + H]+ (m/z 318) were observed as Electrochemical Oxidation product ions (M represents the zotepine molecule). Although a major fragment ion that was derived from the dimethyl aminoethyl moiety was observed only at m/z 72 in the collision-induced dissociation (CID) spectrum of zotepine, new fragments such as m/z 315 and 286 ions could be generated in the CID spectrum by combining Electrochemical Oxidation and CID. Since these fragments were relatively specific with high ion strength, it was thought that they would be useful for developing a sensitive LC-MS/MS assay. The S-oxide and N-demethylated products were detected by electrolysis assuring that a portion of P450 metabolites of zotepine could be mimicked by the electrochemistry/electrospray ionization mass spectrometry (EC/ESI-MS) system. Copyright © 2006 John Wiley & Sons, Ltd.
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investigation of the Electrochemical Oxidation products of zotepine and their fragmentation using on line electrochemistry electrospray ionization mass spectrometry
Journal of Mass Spectrometry, 2006Co-Authors: Kazuyoshi Nozaki, Sumihisa Kimura, Hiroshi Kitagawa, Akira Kagayama, Ryuichi ArakawaAbstract:When zotepine, an antipsychotic drug, was Electrochemically oxidized using electrospray ionization mass spectrometry (ESI-MS) coupled with a microflow electrolytic cell, [M + 16 + H]+ (m/z 348), [M—H]+ (m/z 330) and [M—14 + H]+ (m/z 318) were observed as Electrochemical Oxidation product ions (M represents the zotepine molecule). Although a major fragment ion that was derived from the dimethyl aminoethyl moiety was observed only at m/z 72 in the collision-induced dissociation (CID) spectrum of zotepine, new fragments such as m/z 315 and 286 ions could be generated in the CID spectrum by combining Electrochemical Oxidation and CID. Since these fragments were relatively specific with high ion strength, it was thought that they would be useful for developing a sensitive LC-MS/MS assay. The S-oxide and N-demethylated products were detected by electrolysis assuring that a portion of P450 metabolites of zotepine could be mimicked by the electrochemistry/electrospray ionization mass spectrometry (EC/ESI-MS) system. Copyright © 2006 John Wiley & Sons, Ltd.
Kazuyoshi Nozaki - One of the best experts on this subject based on the ideXlab platform.
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investigation of the Electrochemical Oxidation products of zotepine and their fragmentation using on line electrochemistry electrospray ionization mass spectrometry
Journal of Mass Spectrometry, 2006Co-Authors: Kazuyoshi Nozaki, Sumihisa Kimura, Hiroshi Kitagawa, Akira Kagayama, Ryuichi ArakawaAbstract:When zotepine, an antipsychotic drug, was Electrochemically oxidized using electrospray ionization mass spectrometry (ESI-MS) coupled with a microflow electrolytic cell, [M + 16 + H]+ (m/z 348), [M—H]+ (m/z 330) and [M—14 + H]+ (m/z 318) were observed as Electrochemical Oxidation product ions (M represents the zotepine molecule). Although a major fragment ion that was derived from the dimethyl aminoethyl moiety was observed only at m/z 72 in the collision-induced dissociation (CID) spectrum of zotepine, new fragments such as m/z 315 and 286 ions could be generated in the CID spectrum by combining Electrochemical Oxidation and CID. Since these fragments were relatively specific with high ion strength, it was thought that they would be useful for developing a sensitive LC-MS/MS assay. The S-oxide and N-demethylated products were detected by electrolysis assuring that a portion of P450 metabolites of zotepine could be mimicked by the electrochemistry/electrospray ionization mass spectrometry (EC/ESI-MS) system. Copyright © 2006 John Wiley & Sons, Ltd.
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investigation of the Electrochemical Oxidation products of zotepine and their fragmentation using on line electrochemistry electrospray ionization mass spectrometry
Journal of Mass Spectrometry, 2006Co-Authors: Kazuyoshi Nozaki, Sumihisa Kimura, Hiroshi Kitagawa, Akira Kagayama, Ryuichi ArakawaAbstract:When zotepine, an antipsychotic drug, was Electrochemically oxidized using electrospray ionization mass spectrometry (ESI-MS) coupled with a microflow electrolytic cell, [M + 16 + H]+ (m/z 348), [M—H]+ (m/z 330) and [M—14 + H]+ (m/z 318) were observed as Electrochemical Oxidation product ions (M represents the zotepine molecule). Although a major fragment ion that was derived from the dimethyl aminoethyl moiety was observed only at m/z 72 in the collision-induced dissociation (CID) spectrum of zotepine, new fragments such as m/z 315 and 286 ions could be generated in the CID spectrum by combining Electrochemical Oxidation and CID. Since these fragments were relatively specific with high ion strength, it was thought that they would be useful for developing a sensitive LC-MS/MS assay. The S-oxide and N-demethylated products were detected by electrolysis assuring that a portion of P450 metabolites of zotepine could be mimicked by the electrochemistry/electrospray ionization mass spectrometry (EC/ESI-MS) system. Copyright © 2006 John Wiley & Sons, Ltd.
Pradeep Haldar - One of the best experts on this subject based on the ideXlab platform.
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Electrochemical Oxidation behavior of titanium nitride based electrocatalysts under pem fuel cell conditions
Electrochimica Acta, 2010Co-Authors: Bharat Avasarala, Pradeep HaldarAbstract:Abstract Titanium nitride (TiN) is attracting attention as a promising material for low temperature proton exchange membrane fuel cells. With its high electrical conductivity and resistance to Oxidation, TiN has a potential to act as a durable electrocatalyst material. Using Electrochemical and spectroscopic techniques, the Electrochemical Oxidation properties of TiN nanoparticles (NP) are studied under PEM fuel cell conditions and compared with conventional carbon black supports. It is observed that TiN NP has a significantly lower rate of Electrochemical Oxidation than carbon black due to its inert nature and the presence of a native oxide/oxynitride layer on its surface. Depending on the temperature and the acidic media used in the Electrochemical conditions, the open circuit potential (OCP) curves shows the overlayer dissolved in the acidic solution leading to the passivation of the exposed nitride surface. It is shown that TiN NP displays passive behavior under the tested conditions. The XPS characterization further supports the dissolution argument and shows that the surface becomes passivated with the O–H groups reducing the electrical conductivity of TiN NP. The long-term stability of the Pt/TiN electrocatalysts is tested under PEM fuel cell conditions and the trends of the measured Electrochemical surface area at different temperatures is shown to agree with the proposed passivation model.
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Electrochemical Oxidation behavior of titanium nitride based electrocatalysts under pem fuel cell conditions
Electrochimica Acta, 2010Co-Authors: Bharat Avasarala, Pradeep HaldarAbstract:Abstract Titanium nitride (TiN) is attracting attention as a promising material for low temperature proton exchange membrane fuel cells. With its high electrical conductivity and resistance to Oxidation, TiN has a potential to act as a durable electrocatalyst material. Using Electrochemical and spectroscopic techniques, the Electrochemical Oxidation properties of TiN nanoparticles (NP) are studied under PEM fuel cell conditions and compared with conventional carbon black supports. It is observed that TiN NP has a significantly lower rate of Electrochemical Oxidation than carbon black due to its inert nature and the presence of a native oxide/oxynitride layer on its surface. Depending on the temperature and the acidic media used in the Electrochemical conditions, the open circuit potential (OCP) curves shows the overlayer dissolved in the acidic solution leading to the passivation of the exposed nitride surface. It is shown that TiN NP displays passive behavior under the tested conditions. The XPS characterization further supports the dissolution argument and shows that the surface becomes passivated with the O–H groups reducing the electrical conductivity of TiN NP. The long-term stability of the Pt/TiN electrocatalysts is tested under PEM fuel cell conditions and the trends of the measured Electrochemical surface area at different temperatures is shown to agree with the proposed passivation model.
Akira Kagayama - One of the best experts on this subject based on the ideXlab platform.
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investigation of the Electrochemical Oxidation products of zotepine and their fragmentation using on line electrochemistry electrospray ionization mass spectrometry
Journal of Mass Spectrometry, 2006Co-Authors: Kazuyoshi Nozaki, Sumihisa Kimura, Hiroshi Kitagawa, Akira Kagayama, Ryuichi ArakawaAbstract:When zotepine, an antipsychotic drug, was Electrochemically oxidized using electrospray ionization mass spectrometry (ESI-MS) coupled with a microflow electrolytic cell, [M + 16 + H]+ (m/z 348), [M—H]+ (m/z 330) and [M—14 + H]+ (m/z 318) were observed as Electrochemical Oxidation product ions (M represents the zotepine molecule). Although a major fragment ion that was derived from the dimethyl aminoethyl moiety was observed only at m/z 72 in the collision-induced dissociation (CID) spectrum of zotepine, new fragments such as m/z 315 and 286 ions could be generated in the CID spectrum by combining Electrochemical Oxidation and CID. Since these fragments were relatively specific with high ion strength, it was thought that they would be useful for developing a sensitive LC-MS/MS assay. The S-oxide and N-demethylated products were detected by electrolysis assuring that a portion of P450 metabolites of zotepine could be mimicked by the electrochemistry/electrospray ionization mass spectrometry (EC/ESI-MS) system. Copyright © 2006 John Wiley & Sons, Ltd.
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investigation of the Electrochemical Oxidation products of zotepine and their fragmentation using on line electrochemistry electrospray ionization mass spectrometry
Journal of Mass Spectrometry, 2006Co-Authors: Kazuyoshi Nozaki, Sumihisa Kimura, Hiroshi Kitagawa, Akira Kagayama, Ryuichi ArakawaAbstract:When zotepine, an antipsychotic drug, was Electrochemically oxidized using electrospray ionization mass spectrometry (ESI-MS) coupled with a microflow electrolytic cell, [M + 16 + H]+ (m/z 348), [M—H]+ (m/z 330) and [M—14 + H]+ (m/z 318) were observed as Electrochemical Oxidation product ions (M represents the zotepine molecule). Although a major fragment ion that was derived from the dimethyl aminoethyl moiety was observed only at m/z 72 in the collision-induced dissociation (CID) spectrum of zotepine, new fragments such as m/z 315 and 286 ions could be generated in the CID spectrum by combining Electrochemical Oxidation and CID. Since these fragments were relatively specific with high ion strength, it was thought that they would be useful for developing a sensitive LC-MS/MS assay. The S-oxide and N-demethylated products were detected by electrolysis assuring that a portion of P450 metabolites of zotepine could be mimicked by the electrochemistry/electrospray ionization mass spectrometry (EC/ESI-MS) system. Copyright © 2006 John Wiley & Sons, Ltd.
Hiroshi Kitagawa - One of the best experts on this subject based on the ideXlab platform.
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investigation of the Electrochemical Oxidation products of zotepine and their fragmentation using on line electrochemistry electrospray ionization mass spectrometry
Journal of Mass Spectrometry, 2006Co-Authors: Kazuyoshi Nozaki, Sumihisa Kimura, Hiroshi Kitagawa, Akira Kagayama, Ryuichi ArakawaAbstract:When zotepine, an antipsychotic drug, was Electrochemically oxidized using electrospray ionization mass spectrometry (ESI-MS) coupled with a microflow electrolytic cell, [M + 16 + H]+ (m/z 348), [M—H]+ (m/z 330) and [M—14 + H]+ (m/z 318) were observed as Electrochemical Oxidation product ions (M represents the zotepine molecule). Although a major fragment ion that was derived from the dimethyl aminoethyl moiety was observed only at m/z 72 in the collision-induced dissociation (CID) spectrum of zotepine, new fragments such as m/z 315 and 286 ions could be generated in the CID spectrum by combining Electrochemical Oxidation and CID. Since these fragments were relatively specific with high ion strength, it was thought that they would be useful for developing a sensitive LC-MS/MS assay. The S-oxide and N-demethylated products were detected by electrolysis assuring that a portion of P450 metabolites of zotepine could be mimicked by the electrochemistry/electrospray ionization mass spectrometry (EC/ESI-MS) system. Copyright © 2006 John Wiley & Sons, Ltd.
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investigation of the Electrochemical Oxidation products of zotepine and their fragmentation using on line electrochemistry electrospray ionization mass spectrometry
Journal of Mass Spectrometry, 2006Co-Authors: Kazuyoshi Nozaki, Sumihisa Kimura, Hiroshi Kitagawa, Akira Kagayama, Ryuichi ArakawaAbstract:When zotepine, an antipsychotic drug, was Electrochemically oxidized using electrospray ionization mass spectrometry (ESI-MS) coupled with a microflow electrolytic cell, [M + 16 + H]+ (m/z 348), [M—H]+ (m/z 330) and [M—14 + H]+ (m/z 318) were observed as Electrochemical Oxidation product ions (M represents the zotepine molecule). Although a major fragment ion that was derived from the dimethyl aminoethyl moiety was observed only at m/z 72 in the collision-induced dissociation (CID) spectrum of zotepine, new fragments such as m/z 315 and 286 ions could be generated in the CID spectrum by combining Electrochemical Oxidation and CID. Since these fragments were relatively specific with high ion strength, it was thought that they would be useful for developing a sensitive LC-MS/MS assay. The S-oxide and N-demethylated products were detected by electrolysis assuring that a portion of P450 metabolites of zotepine could be mimicked by the electrochemistry/electrospray ionization mass spectrometry (EC/ESI-MS) system. Copyright © 2006 John Wiley & Sons, Ltd.