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Wolfgang Petrich - One of the best experts on this subject based on the ideXlab platform.

  • biocompatibility of an Electrochemical Sensor for continuous glucose monitoring in subcutaneous tissue
    Diabetes Technology & Therapeutics, 2005
    Co-Authors: Andreas Mang, H Buck, Michael Schoemaker, Johannes Pill, Bettina Kranzlin, Norbert Gretz, Wolfgang Petrich
    Abstract:

    Background: The continuous monitoring of glucose allows for tighter control of the glucose concentration and thus may prevent hyper- and hypoglycemia as well as long-term complications of diabetes. While most current systems depend on the transport of fluid to a glucose Sensor outside the body, we investigate the possibility of implanting a reagent-based Sensor directly into the skin. In this manuscript, the biocompatibility of an Electrochemical Sensor for continuous glucose monitoring was assessed in vitro and in vivo. Methods: Cytotoxicity was investigated in vitro using agar diffusion testing. In vivo biocompatibility was assessed by means of histomorphological examination of the surrounding tissue 10 days after Sensor implantation in rats. Results: The grade of cytotoxicity of the individual Sensor components in vitro was between none and mild based on agar diffusion testing. The complete Sensor also showed no cytotoxic effects when coated with the co-polymer MPC (2-methacryloyloxyethyl phosphorylcho...

  • Biocompatibility of an Electrochemical Sensor for continuous glucose monitoring in subcutaneous tissue.
    Diabetes technology & therapeutics, 2005
    Co-Authors: Andreas Mang, H Buck, Michael Schoemaker, Johannes Pill, Bettina Kranzlin, Norbert Gretz, Wolfgang Petrich
    Abstract:

    The continuous monitoring of glucose allows for tighter control of the glucose concentration and thus may prevent hyper- and hypoglycemia as well as long-term complications of diabetes. While most current systems depend on the transport of fluid to a glucose Sensor outside the body, we investigate the possibility of implanting a reagent-based Sensor directly into the skin. In this manuscript, the biocompatibility of an Electrochemical Sensor for continuous glucose monitoring was assessed in vitro and in vivo.

Massood Zandi Atashbar - One of the best experts on this subject based on the ideXlab platform.

  • A Flexible Copper Based Electrochemical Sensor Using Laser-Assisted Patterning Process
    2018 IEEE SENSORS, 2018
    Co-Authors: Dinesh Maddipatla, Binu Baby Narakathu, Bradley J. Bazuin, Vikram S. Turkani, Sajjad Hajian, Massood Zandi Atashbar
    Abstract:

    A novel impedance based Electrochemical Sensor was fabricated on a flexible polyethylene terephthalate (PET) film to detect various bio/chemicals. The flexible Electrochemical Sensor was developed using a thin metallic copper foil tape (electrodes) and PET (substrate). The copper tape was attached to the PET substrate and a two-electrode device configuration, including the working and circular electrodes, was created by patterning and cutting the copper on the PET substrate using a laser-assisted patterning process. The capability of the fabricated Sensor was investigated by performing electrical impedance spectroscopy (EIS) for the detection of a heavy metal: cadmium sulfide (CdS). An impedance change of 69.9±3.4%, 77.8±2.1 %, 92.1±1.0% and 99.5±0.2% was obtained as the concentration of the CdS increased from 100 pM to 100 nM to 100 f.1M to 100 mM, respectively. The EIS based response demonstrated the detection capability of the Sensor for concentrations as low as picomolar (pM) levels and was also able to successfully distinguish among varying concentrations (pico, nano, micro and milli) of CdS. The fabrication of the Sensor and its EIS based response towards CdS has been analyzed and is presented in this paper.

  • Development of a printed impedance based Electrochemical Sensor on paper substrate
    Proceedings of IEEE Sensors, 2017
    Co-Authors: Dinesh Maddipatla, Binu Baby Narakathu, Bradley J. Bazuin, Massood Zandi Atashbar
    Abstract:

    A novel printed impedance based Electrochemical Sensor has been successfully developed on a paper substrate for the detection of various bio/chemicals. This flexible analytical device was fabricated by screen printing a two electrode Sensor configuration on a wax-printed chromatography paper substrate. Silver (Ag) ink was used for screen printing the working and circular electrodes. The capability of the fabricated Electrochemical Sensor for detecting trace concentrations of bio/chemicals such potassium chloride (KCl) and glucose (C6H12O6) was investigated. The electrical impedance spectroscopy (EIS) based response of the printed Sensor revealed detection levels as low as picomolar (pM) concentrations as well as the capability of the Sensor to distinguish among varying levels (pico, nano, micro and milli) of sample concentrations. The response of the developed Electrochemical Sensor has been analyzed and is presented in this paper.

  • A Screen Printed Phenanthroline-Based Flexible Electrochemical Sensor for Selective Detection of Toxic Heavy Metal Ions
    IEEE Sensors Journal, 2016
    Co-Authors: Sai Guruva Reddy Avuthu, J.t. Wabeke, J.s. Arachchilage, Binu Baby Narakathu, Dinesh Maddipatla, Sherine O. Obare, Massood Zandi Atashbar
    Abstract:

    © 2016 IEEE. A flexible Electrochemical Sensor was screen printed on polyethylene terephthalate. Carbon-and silver-based inks were used for metallization of the working, counter, and reference electrodes. 1,10-phenanthroline and its derivative naphtho[2,3-a]dipyrido[3,2-h: 2' , 3'-f] phenazine-5,18-dione were synthesized as sensitive layers for Hg 2+ and Pb 2+ , respectively. Cyclic voltammetry response of the Sensor resulted in reduction peaks at 0.2 and-0.6 eV for the selective detection of Hg 2+ and Pb 2+ , respectively. An 87% and 9% change in the average peak currents were observed for the 50-μM concentration of Pb 2+ and Hg 2+ , respectively, against a reference signal established for deionized water. The response of the Electrochemical Sensor demonstrated the use of traditional printing processes and synthesized chemicals for the selective detection of heavy metal ions.

  • Detection of heavy metals using fully printed three electrode Electrochemical Sensor
    Proceedings of IEEE Sensors, 2014
    Co-Authors: Sai Guruva Reddy Avuthu, Ali Eshkeiti, Binu Baby Narakathu, Michael Joyce, Sepehr Emamian, Bradley J. Bazuin, Massood Zandi Atashbar
    Abstract:

    © 2014 IEEE. A flexible three electrode Electrochemical Sensor was successfully screen printed on a polyethylene terephthalate (PET) film. Silver (Ag) ink, silver/silver chloride (Ag/AgCl) ink and carbon ink was used for the counter, reference and working electrodes, respectively. The feasibility of the fully printed Sensor for detecting very low concentrations of toxic heavy metal ions was demonstrated. The Electrochemical impedance spectroscopy (EIS) response of the printed Sensor revealed a very high sensitivity at nano molar (nM) concentration levels of lead nitrate (Pb(NO < inf > 3 < /inf > ) < inf > 2 < /inf > ) and cadmium nitrate (Cd(NO < inf > 3 < /inf > ) < inf > 2 < /inf > ). A percentage change of 18 %, in impedance, was observed for the 1 nM concentration of Pb(NO < inf > 3 < /inf > ) < inf > 2 < /inf > when compared with DI water. The response of the Electrochemical Sensor is analyzed and presented in this paper.

  • A novel gravure printed impedance based flexible Electrochemical Sensor
    SENSORS 2011 IEEE, 2011
    Co-Authors: Binu Baby Narakathu, Massood Zandi Atashbar, S. G. A. Reddy, E. Rebrosova, M. Rebros, M.k. Joyce
    Abstract:

    A novel flexible Electrochemical Sensor was successfully gravure printed on a polyethylene terephthalate (PET) film with silver (Ag) electrodes using Ag nanoparticle based ink. The Sensor consisted of a circular working electrode with diameter of 1700 μm and a counter electrode with outer and inner diameter of 3900 μm and 2900 μm, respectively. The capability of the fabricated Sensor for detecting very low concentrations of toxic chemicals was demonstrated. The Electrochemical impedance spectroscopy (EIS) response of the printed Sensor revealed a very high sensitivity at pico molar (pM) concentration levels of mercury sulfide (HgS), lead sulfide (PbS), D-proline and sarcosine.

Huabin Zhang - One of the best experts on this subject based on the ideXlab platform.

  • layer by layer assembly sensitive Electrochemical Sensor for selectively probing l histidine based on molecular imprinting sol gel at functionalized indium tin oxide electrode
    Biosensors and Bioelectronics, 2010
    Co-Authors: Zhaohui Zhang, Yufang Hu, Huabin Zhang
    Abstract:

    Abstract A novel sensitive and selective imprinted Electrochemical Sensor was successfully constructed for the direct detection of l -histidine by combination of a molecular imprinting film and multi-walled carbon nanotubes (MWNTs). The Sensor was fabricated onto an indium tin oxide (ITO) electrode via stepwise modification of MWNTs and a thin film of molecularly imprinted polymers (MIPs) via sol–gel technology. The introduced MWNTs exhibited noticeable enhancement on the sensitivity of the MIPs Sensor. Meanwhile, the molecularly imprinted film displayed high sensitivity and excellent selectivity for the target molecule l -histidine. The proposed imprinted Sensor was characterized by using scanning electron microscope (SEM) and Electrochemical methods involving cyclic voltammetry (CV), differential pulse voltammetry (DPV) and amperometric i–t curve. A linear ranging from 2.0 μmol L−1 to 1.0 mmol L−1 for the detection of l -histidine was observed with the detection limit of 5.8 × 10−9 mol L−1 for S/N = 3. This imprinted Electrochemical Sensor was successfully employed to detect l -histidine in human blood serum.

Mehul Vora - One of the best experts on this subject based on the ideXlab platform.

Andreas Mang - One of the best experts on this subject based on the ideXlab platform.

  • biocompatibility of an Electrochemical Sensor for continuous glucose monitoring in subcutaneous tissue
    Diabetes Technology & Therapeutics, 2005
    Co-Authors: Andreas Mang, H Buck, Michael Schoemaker, Johannes Pill, Bettina Kranzlin, Norbert Gretz, Wolfgang Petrich
    Abstract:

    Background: The continuous monitoring of glucose allows for tighter control of the glucose concentration and thus may prevent hyper- and hypoglycemia as well as long-term complications of diabetes. While most current systems depend on the transport of fluid to a glucose Sensor outside the body, we investigate the possibility of implanting a reagent-based Sensor directly into the skin. In this manuscript, the biocompatibility of an Electrochemical Sensor for continuous glucose monitoring was assessed in vitro and in vivo. Methods: Cytotoxicity was investigated in vitro using agar diffusion testing. In vivo biocompatibility was assessed by means of histomorphological examination of the surrounding tissue 10 days after Sensor implantation in rats. Results: The grade of cytotoxicity of the individual Sensor components in vitro was between none and mild based on agar diffusion testing. The complete Sensor also showed no cytotoxic effects when coated with the co-polymer MPC (2-methacryloyloxyethyl phosphorylcho...

  • Biocompatibility of an Electrochemical Sensor for continuous glucose monitoring in subcutaneous tissue.
    Diabetes technology & therapeutics, 2005
    Co-Authors: Andreas Mang, H Buck, Michael Schoemaker, Johannes Pill, Bettina Kranzlin, Norbert Gretz, Wolfgang Petrich
    Abstract:

    The continuous monitoring of glucose allows for tighter control of the glucose concentration and thus may prevent hyper- and hypoglycemia as well as long-term complications of diabetes. While most current systems depend on the transport of fluid to a glucose Sensor outside the body, we investigate the possibility of implanting a reagent-based Sensor directly into the skin. In this manuscript, the biocompatibility of an Electrochemical Sensor for continuous glucose monitoring was assessed in vitro and in vivo.