The Experts below are selected from a list of 48 Experts worldwide ranked by ideXlab platform

Pawel Sajkiewicz - One of the best experts on this subject based on the ideXlab platform.

  • poly glycerol sebacate poly l lactide nonwovens towards attractive Electrospun Material for tissue engineering
    Polymers, 2019
    Co-Authors: Piotr Denis, Michal Wrzecionek, Agnieszka Gadomskagajadhur, Pawel Sajkiewicz
    Abstract:

    Two types of poly(glycerol sebacate) (PGS) prepolymers were synthesized and Electrospun with poly(l-lactic acid) (PLA), resulting in bicomponent nonwovens. The obtained Materials were pre-heated in a vacuum, at different times, to crosslink PGS and investigate morphological and structural dependencies in that polymeric, Electrospun system. As both PGS and PLA are sensitive to pre-heating (crosslinking) conditions, research concerns both components. More interest is focused on the properties of PGS, considering further research for mechanical properties and subsequent experiments with PGS synthesis. Electrospinning of PGS blended with PLA does not bring difficulties, but obtaining elastomeric properties of nonwovens is problematic. Even though PGS has many potential advantages over other polyesters when soft tissue engineering is considered, its full utilization via the electrospinning process is much harder in practice. Further investigations are ongoing, especially with the promising PGS prepolymer with a higher esterification degree and its variations.

Dietmar Werner Hutmacher - One of the best experts on this subject based on the ideXlab platform.

  • design fabrication and characterization of pcl Electrospun scaffolds a review
    Journal of Materials Chemistry, 2011
    Co-Authors: Amaia Cipitria, Anthony Skelton, Paul D Dalton, Tim R Tr Dargaville, Dietmar Werner Hutmacher
    Abstract:

    The expanding interest in electrospinning fibers for bioengineering includes a significant use of polyesters, including poly(e-caprolactone) (PCL). This review summarizes literature on PCL and selected blends, and provides extensive descriptions of the broad range of parameters used in manufacturing such Electrospun fibers. Furthermore the chemical, physical and biological approaches for characterizing the Electrospun Material are described and opinions offered on important information to include in future publications with this Electrospun Material.

Piotr Denis - One of the best experts on this subject based on the ideXlab platform.

  • poly glycerol sebacate poly l lactide nonwovens towards attractive Electrospun Material for tissue engineering
    Polymers, 2019
    Co-Authors: Piotr Denis, Michal Wrzecionek, Agnieszka Gadomskagajadhur, Pawel Sajkiewicz
    Abstract:

    Two types of poly(glycerol sebacate) (PGS) prepolymers were synthesized and Electrospun with poly(l-lactic acid) (PLA), resulting in bicomponent nonwovens. The obtained Materials were pre-heated in a vacuum, at different times, to crosslink PGS and investigate morphological and structural dependencies in that polymeric, Electrospun system. As both PGS and PLA are sensitive to pre-heating (crosslinking) conditions, research concerns both components. More interest is focused on the properties of PGS, considering further research for mechanical properties and subsequent experiments with PGS synthesis. Electrospinning of PGS blended with PLA does not bring difficulties, but obtaining elastomeric properties of nonwovens is problematic. Even though PGS has many potential advantages over other polyesters when soft tissue engineering is considered, its full utilization via the electrospinning process is much harder in practice. Further investigations are ongoing, especially with the promising PGS prepolymer with a higher esterification degree and its variations.

Amaia Cipitria - One of the best experts on this subject based on the ideXlab platform.

  • design fabrication and characterization of pcl Electrospun scaffolds a review
    Journal of Materials Chemistry, 2011
    Co-Authors: Amaia Cipitria, Anthony Skelton, Paul D Dalton, Tim R Tr Dargaville, Dietmar Werner Hutmacher
    Abstract:

    The expanding interest in electrospinning fibers for bioengineering includes a significant use of polyesters, including poly(e-caprolactone) (PCL). This review summarizes literature on PCL and selected blends, and provides extensive descriptions of the broad range of parameters used in manufacturing such Electrospun fibers. Furthermore the chemical, physical and biological approaches for characterizing the Electrospun Material are described and opinions offered on important information to include in future publications with this Electrospun Material.

Frank Frank Baaijens - One of the best experts on this subject based on the ideXlab platform.

  • multi scale mechanical characterization of scaffolds for heart valve tissue engineering
    Journal of Biomechanics, 2012
    Co-Authors: Giulia G Argento, Marc M Simonet, Cwj Cees Oomens, Frank Frank Baaijens
    Abstract:

    Electrospinning is a promising technology to produce scaffolds for cardiovascular tissue engineering. Each Electrospun scaffold is characterized by a complex micro-scale structure that is responsible for its macroscopic mechanical behavior. In this study, we focus on the development and the validation of a computational micro-scale model that takes into account the structural features of the Electrospun Material, and is suitable for studying the multi-scale scaffold mechanics. We show that the computational tool developed is able to describe and predict the mechanical behavior of Electrospun scaffolds characterized by different microstructures. Moreover, we explore the global mechanical properties of valve-shaped scaffolds with different microstructural features, and compare the deformation of these scaffolds when submitted to diastolic pressures with a tissue engineered and a native valve. It is shown that a pronounced degree of anisotropy is necessary to reproduce the deformation patterns observed in the native heart valve.