The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform

L. Hilwerling - One of the best experts on this subject based on the ideXlab platform.

  • Sleep and Wake Cycle
    Dopamine in the CNS II, 2002
    Co-Authors: J. Bierbrauer, L. Hilwerling
    Abstract:

    At the end of the second decade of the twentieth century, Berger conducted the electroencephalograph (Jouvet 1972). Bremer (1935) carried out the first investigations by conduction transection experiments in cats. A preparation done in the intercollicular level (cerveau Isole) created a persistent slow-wave state in the midbrain, while an incision in the medulla oblongata (Encephale Isole) did not alter the sleep-wake cycle. Because of this, he assumed that sleep is a passive state, reversible to deafferentation (Bremer 1938). Moruzzzi and Magoun (1949) demonstrated the effect of the ascending activating reticular system by causing arousals in the cerveau Isole preparation. In further transection experiments, Nauta (1946) observed a long-lasting insomnia when setting a lesion in the rostral part of the hypothalamus. Lesions in the mammillary bodies induced sleep, while combined lesions had no effect.

J. Bierbrauer - One of the best experts on this subject based on the ideXlab platform.

  • Sleep and Wake Cycle
    Dopamine in the CNS II, 2002
    Co-Authors: J. Bierbrauer, L. Hilwerling
    Abstract:

    At the end of the second decade of the twentieth century, Berger conducted the electroencephalograph (Jouvet 1972). Bremer (1935) carried out the first investigations by conduction transection experiments in cats. A preparation done in the intercollicular level (cerveau Isole) created a persistent slow-wave state in the midbrain, while an incision in the medulla oblongata (Encephale Isole) did not alter the sleep-wake cycle. Because of this, he assumed that sleep is a passive state, reversible to deafferentation (Bremer 1938). Moruzzzi and Magoun (1949) demonstrated the effect of the ascending activating reticular system by causing arousals in the cerveau Isole preparation. In further transection experiments, Nauta (1946) observed a long-lasting insomnia when setting a lesion in the rostral part of the hypothalamus. Lesions in the mammillary bodies induced sleep, while combined lesions had no effect.

Pamela B. J. Thompson - One of the best experts on this subject based on the ideXlab platform.

  • Central and peripheral actions of anticholinergic drugs when administered with triflupromazine
    Neuropharmacology, 2002
    Co-Authors: R. W. Brimblecombe, D. M. Green, F.a.b. Aldous, Pamela B. J. Thompson
    Abstract:

    Abstract Triflupromazine was found to potentiate the actions of six anticholinergic drugs in producing elevation of EEG arousal thresholds, and dissociation between EEG and behavioural arousal thresholds, in cat Encephale Isole preparations. The effects of triflupromazine on the anticholinergic activity of the six drugs were studied using as tests antagonism of oxotremorine-induced salivation and tremors and production of mydriasis in mice. It is concluded that the potentiating effect of triflupromazine on the EEG cannot be explained on the basis of an addition of anticholinergic activities and that other, as yet not understood, synergistic mechanisms are involved.

R. W. Brimblecombe - One of the best experts on this subject based on the ideXlab platform.

  • Central and peripheral actions of anticholinergic drugs when administered with triflupromazine
    Neuropharmacology, 2002
    Co-Authors: R. W. Brimblecombe, D. M. Green, F.a.b. Aldous, Pamela B. J. Thompson
    Abstract:

    Abstract Triflupromazine was found to potentiate the actions of six anticholinergic drugs in producing elevation of EEG arousal thresholds, and dissociation between EEG and behavioural arousal thresholds, in cat Encephale Isole preparations. The effects of triflupromazine on the anticholinergic activity of the six drugs were studied using as tests antagonism of oxotremorine-induced salivation and tremors and production of mydriasis in mice. It is concluded that the potentiating effect of triflupromazine on the EEG cannot be explained on the basis of an addition of anticholinergic activities and that other, as yet not understood, synergistic mechanisms are involved.

D. M. Green - One of the best experts on this subject based on the ideXlab platform.

  • Central and peripheral actions of anticholinergic drugs when administered with triflupromazine
    Neuropharmacology, 2002
    Co-Authors: R. W. Brimblecombe, D. M. Green, F.a.b. Aldous, Pamela B. J. Thompson
    Abstract:

    Abstract Triflupromazine was found to potentiate the actions of six anticholinergic drugs in producing elevation of EEG arousal thresholds, and dissociation between EEG and behavioural arousal thresholds, in cat Encephale Isole preparations. The effects of triflupromazine on the anticholinergic activity of the six drugs were studied using as tests antagonism of oxotremorine-induced salivation and tremors and production of mydriasis in mice. It is concluded that the potentiating effect of triflupromazine on the EEG cannot be explained on the basis of an addition of anticholinergic activities and that other, as yet not understood, synergistic mechanisms are involved.