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Martin Kvac - One of the best experts on this subject based on the ideXlab platform.
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Encephalitozoon Cuniculi Genotype III Evinces a Resistance to Albendazole Treatment in both Immunodeficient and Immunocompetent Mice.
Antimicrobial agents and chemotherapy, 2020Co-Authors: Bohumil Sak, Klara Brdickova, Nikola Holubova, Lenka Hlaskova, Dana Květoňová, Martin KvacAbstract:Of four genotypes of Encephalitozoon Cuniculi, E. Cuniculi genotype II is considered to represent a parasite that occurs in many host species in a latent asymptomatic form, whereas E. Cuniculi genotype III seems to be more aggressive, and infections caused by this strain can lead to the death of even immunocompetent hosts. Although albendazole has been considered suitable for treatment of Encephalitozoon species, its failure in control of E. Cuniculi genotype III infection has been reported. This study determined the effect of a 100× recommended daily dose of albendazole on an Encephalitozoon Cuniculi genotype III course of infection in immunocompetent and immunodeficient mice and compared the results with those from experiments performed with a lower dose of albendazole and E. Cuniculi genotype II. The administration of the regular dose of abendazole during the acute phase of infection reduced the number of affected organs in all strains of mice and absolute counts of spores in screened organs. However, the effect on genotype III was minor. Surprisingly, no substantial effect was recorded after the use of a 100× dose of albendazole, with larger reductions seen only in the number of affected organs and absolute counts of spores in all strains of mice, implying variations in albendazole resistance between these Encephalitozoon Cuniculi genotypes. These results imply that differences in the course of infection and the response to treatment depend not only on the immunological status of the host but also on the genotype causing the infection. Understanding how microsporidia survive in hosts despite targeted antimicrosporidial treatment could significantly contribute to research related to human health.
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experimental Encephalitozoon Cuniculi infection acquired from fermented meat products
Foodborne Pathogens and Disease, 2019Co-Authors: Tereza Veckova, Klara Brdickova, Pavel Smetana, Nikola Holubova, Lenka Hlaskova, John Mcevoy, Marta Kicia, Martin KvacAbstract:Abstract This study describes the prevalence and concentration of Encephalitozoon Cuniculi spores in pork meat and evaluates the effect of sausage fermentation on E. Cuniculi infectivity for immuno...
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Symptomatic respiratory Encephalitozoon Cuniculi infection in renal transplant recipients
Elsevier, 2019Co-Authors: Marta Kicia, Katarzyna Jakuszko, Magdalena Krajewska, Bohumil Sak, Magdalena Szydłowicz, Kamil Cebulski, Paweł Piesiak, Aneta Kowal, Andrzej B. Hendrich, Martin KvacAbstract:Objectives: Encephalitozoon spp. and Enterocytozoon bieneusi are intracellular parasitic fungi from the phylum Microsporidia, which initially localize to the intestine. As opportunistic pathogens, Encephalitozoon spp. in particular can disseminate to the respiratory tract, among other locations. Patients on life-long immunosuppression are at higher risk of such infections, mostly symptomatic. Methods: Sputum samples and bronchial washings from 72 renal transplant recipients and 105 patients with various respiratory diseases were screened for Encephalitozoon spp. and E. bieneusi by microscopic examination and genus-specific nested PCR followed by genotyping. Results: A total of 8.3% (6/72) of immunosuppressed renal transplant recipients and 1.9% (2/105) of patients with various respiratory diseases, both immunocompetent and immunosuppressed, were positive for respiratory microsporidial infection. All six transplant recipients were Encephalitozoon Cuniculi-positive by PCR/sequencing and five of them suffered from respiratory symptoms. The presence of microsporidial spores was also confirmed microscopically in three of the transplant recipients. Of the two immunocompetent patients with various respiratory diseases, one had an E. Cuniculi infection, while the second had an E. bieneusi infection. Conclusions: Life-long immunosuppression in renal transplant recipients increases the risk of respiratory infection by E. Cuniculi. Microsporidia should be screened in respiratory samples of these patients, particularly when they have respiratory symptoms. Keywords: Encephalitozoon Cuniculi, Enterocytozoon bieneusi, Renal transplant recipients, Life-long immunosuppression, Respiratory trac
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Evidence of transplacental transmission of Encephalitozoon Cuniculi genotype II in murine model.
Experimental parasitology, 2018Co-Authors: Michaela Kotková, Lenka Hlaskova, Dana Květoňová, Bohumil Sak, Martin KvacAbstract:Abstract Microsporidia are obligate intracellurar unicellular parasite of wide range of vertebrates. Although ingestion or inhalation of microsporidian spores is the main route of infection, assumed vertical transmission was described in some mammals. The present study was focused on proof of vertical transmission in mice under experimental conditions. Mice were infected with E. Cuniculi genotype II intraperitoneally after mating, or perorally followed by mating in acute or chronic phase of infection. Fetuses were delivered by Caesarean section or mice were kept up to the parturition. Some of cubs were immediately after birth transferred to uninfected surrogate mothers. Group of cubs was immunosuppressed. All cubs were examined using polymerase chain reaction for the presence of Encephalitozoon after birth or in their age of 3 or 6 weeks, respectively. All fetuses delivered by Caesarean section, which were intraperitoneally or perorally infected were negative as well as all neonatal mice and youngsters tested in age of 6 weeks. Only immunosuppressed cubs and cubs of immunodeficient mice in age of 21 days were positive for Encephalitozoon Cuniculi genotype II. Present results provided the evidence that transplacental transmission of Encephalitozoon Cuniculi in mice occurs, but the mechanism of these transport is still unknown.
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Disseminated Infection of Encephalitozoon Cuniculi Associated With Osteolysis of Hip Periprosthetic Tissue.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018Co-Authors: Marta Kicia, Z Kopacz, Martin Kvac, Bohumil Sak, Kamil Cebulski, Andrzej B. Hendrich, Maria Wesołowska, Magdalena Sokulska, Andrzej PozowskiAbstract:Background Among patients with hip joint endoprosthesis, periprosthetic osteolysis is the most common complication following primary arthroplasty, and subsequent implant loosening is the leading cause of arthroplasty revision. Causes of stability loss, though not always evident, can be mechanical, allergic, or infectious (bacterial and fungal agents) in nature. Microsporidia, widespread opportunistic fungal pathogens that infect most human tissues, are a potential infectious cause of stability loss. Infections caused by Encephalitozoon species-one of the most common microsporidial pathogens in humans-primarily localize to intestinal and respiratory tracts, but can disseminate to tissues throughout the body. Methods We examined 53 immunocompetent patients, 23 after revision and 30 after primary hip arthroplasty, for infection by Encephalitozoon species. Periprosthetic tissue, urine sediments, and stool samples were tested by microscopic examination and genus-specific nested polymerase chain reaction followed by genotyping. Results Ten patients had Encephalitozoon-positive periprosthetic tissues, 9 (39%) after revision and 1 (3.3%) after primary hip arthroplasty. Among the tissue-positive postrevision patients, 7 had a positive urine sample and 1 had a positive stool sample. Encephalitozoon Cuniculi genotype II was identified in 88.8% (16/18) of samples. Two urine samples were positive for a novel Encephalitozoon species. Conclusions Encephalitozoon Cuniculi should be considered as a cause of osteolysis in hip periprosthetic tissue, leading to a loss of implant stability.
Marta Kicia - One of the best experts on this subject based on the ideXlab platform.
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experimental Encephalitozoon Cuniculi infection acquired from fermented meat products
Foodborne Pathogens and Disease, 2019Co-Authors: Tereza Veckova, Klara Brdickova, Pavel Smetana, Nikola Holubova, Lenka Hlaskova, John Mcevoy, Marta Kicia, Martin KvacAbstract:Abstract This study describes the prevalence and concentration of Encephalitozoon Cuniculi spores in pork meat and evaluates the effect of sausage fermentation on E. Cuniculi infectivity for immuno...
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Symptomatic respiratory Encephalitozoon Cuniculi infection in renal transplant recipients
Elsevier, 2019Co-Authors: Marta Kicia, Katarzyna Jakuszko, Magdalena Krajewska, Bohumil Sak, Magdalena Szydłowicz, Kamil Cebulski, Paweł Piesiak, Aneta Kowal, Andrzej B. Hendrich, Martin KvacAbstract:Objectives: Encephalitozoon spp. and Enterocytozoon bieneusi are intracellular parasitic fungi from the phylum Microsporidia, which initially localize to the intestine. As opportunistic pathogens, Encephalitozoon spp. in particular can disseminate to the respiratory tract, among other locations. Patients on life-long immunosuppression are at higher risk of such infections, mostly symptomatic. Methods: Sputum samples and bronchial washings from 72 renal transplant recipients and 105 patients with various respiratory diseases were screened for Encephalitozoon spp. and E. bieneusi by microscopic examination and genus-specific nested PCR followed by genotyping. Results: A total of 8.3% (6/72) of immunosuppressed renal transplant recipients and 1.9% (2/105) of patients with various respiratory diseases, both immunocompetent and immunosuppressed, were positive for respiratory microsporidial infection. All six transplant recipients were Encephalitozoon Cuniculi-positive by PCR/sequencing and five of them suffered from respiratory symptoms. The presence of microsporidial spores was also confirmed microscopically in three of the transplant recipients. Of the two immunocompetent patients with various respiratory diseases, one had an E. Cuniculi infection, while the second had an E. bieneusi infection. Conclusions: Life-long immunosuppression in renal transplant recipients increases the risk of respiratory infection by E. Cuniculi. Microsporidia should be screened in respiratory samples of these patients, particularly when they have respiratory symptoms. Keywords: Encephalitozoon Cuniculi, Enterocytozoon bieneusi, Renal transplant recipients, Life-long immunosuppression, Respiratory trac
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Disseminated Infection of Encephalitozoon Cuniculi Associated With Osteolysis of Hip Periprosthetic Tissue.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018Co-Authors: Marta Kicia, Z Kopacz, Martin Kvac, Bohumil Sak, Kamil Cebulski, Andrzej B. Hendrich, Maria Wesołowska, Magdalena Sokulska, Andrzej PozowskiAbstract:Background Among patients with hip joint endoprosthesis, periprosthetic osteolysis is the most common complication following primary arthroplasty, and subsequent implant loosening is the leading cause of arthroplasty revision. Causes of stability loss, though not always evident, can be mechanical, allergic, or infectious (bacterial and fungal agents) in nature. Microsporidia, widespread opportunistic fungal pathogens that infect most human tissues, are a potential infectious cause of stability loss. Infections caused by Encephalitozoon species-one of the most common microsporidial pathogens in humans-primarily localize to intestinal and respiratory tracts, but can disseminate to tissues throughout the body. Methods We examined 53 immunocompetent patients, 23 after revision and 30 after primary hip arthroplasty, for infection by Encephalitozoon species. Periprosthetic tissue, urine sediments, and stool samples were tested by microscopic examination and genus-specific nested polymerase chain reaction followed by genotyping. Results Ten patients had Encephalitozoon-positive periprosthetic tissues, 9 (39%) after revision and 1 (3.3%) after primary hip arthroplasty. Among the tissue-positive postrevision patients, 7 had a positive urine sample and 1 had a positive stool sample. Encephalitozoon Cuniculi genotype II was identified in 88.8% (16/18) of samples. Two urine samples were positive for a novel Encephalitozoon species. Conclusions Encephalitozoon Cuniculi should be considered as a cause of osteolysis in hip periprosthetic tissue, leading to a loss of implant stability.
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concurrent infection of the urinary tract with Encephalitozoon Cuniculi and enterocytozoon bieneusi in a renal transplant recipient
Journal of Clinical Microbiology, 2014Co-Authors: Marta Kicia, Maria Wesolowska, Katarzyna Jakuszko, Z Kopacz, Dana Květonova, Magdalena Krajewska, Martin KvacAbstract:ABSTRACT A urinary tract coinfection, caused by Encephalitozoon Cuniculi genotype II and Enterocytozoon bieneusi genotype D, was identified in an HIV-seronegative renal transplant recipient kept under lifelong immunosuppression. To our knowledge, this is the first report describing concurrent infection with these two microsporidia species in organ transplant recipients.
Louis M. Weiss - One of the best experts on this subject based on the ideXlab platform.
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Short communication A new vesicular compartment in Encephalitozoon Cuniculi
2012Co-Authors: Kaya Ghosh, Patrick J. Keeling, Edward Nieves, Ann Cali, Louis M. WeissAbstract:The microsporidia are emerging human and veterinary pathogens known to infect every tissue type and organ system. Their infectious spore possesses a number of peculiar organelles, including the diagnostic polar tube. In a proteomics-driven effort to find novel components of this organelle in the human-pathogenic species Encephalitozoon Cuniculi, we unexpectedly discovered a protein which localizes to punctate structures consistent with the appearance of relic mitochondria, or mitosomes. However, this novel protein did not colocalize with ferredoxin, a mitochondrial ironesulfur cluster protein which shows a similar localization pattern by light microscopy. The distribution pattern of this protein thus suggests either a novel vesicular compartment that is similar to mitosomes in size and distribution, the presence of subdomains or branching architecture within mitosomes, or heterogeneity in the protein composition of E. Cuniculi mitosomes.
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A new vesicular compartment in Encephalitozoon Cuniculi.
Microbes and Infection, 2011Co-Authors: Kaya Ghosh, Patrick J. Keeling, Edward Nieves, Ann Cali, Louis M. WeissAbstract:Abstract The microsporidia are emerging human and veterinary pathogens known to infect every tissue type and organ system. Their infectious spore possesses a number of peculiar organelles, including the diagnostic polar tube. In a proteomics-driven effort to find novel components of this organelle in the human-pathogenic species Encephalitozoon Cuniculi , we unexpectedly discovered a protein which localizes to punctate structures consistent with the appearance of relic mitochondria, or mitosomes. However, this novel protein did not colocalize with ferredoxin, a mitochondrial iron–sulfur cluster protein which shows a similar localization pattern by light microscopy. The distribution pattern of this protein thus suggests either a novel vesicular compartment that is similar to mitosomes in size and distribution, the presence of subdomains or branching architecture within mitosomes, or heterogeneity in the protein composition of E . Cuniculi mitosomes.
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interactions of Encephalitozoon Cuniculi polar tube proteins
Infection and Immunity, 2010Co-Authors: Boumediene Bouzahzah, Kaya Ghosh, Ann Cali, Peter M. Takvorian, Fnu Nagajyothi, Herbert B Tanowitz, Louis M. WeissAbstract:Microsporidia are eukaryotic, obligate intracellular organisms defined by small spores that contain a single invasion organelle, the polar tube, which coils around the interior of the spore. When these parasites infect host cells, the polar tube is discharged from the anterior pole of the spore, pierces the cell, and transfers sporoplasm into the cytoplasm of the host. Three polar tube proteins (PTP1, PTP2, and PTP3) have been identified in this structure. The interactions of these proteins in the assembly and function of the polar tube are not known. This study was undertaken to examine the protein interactions of the Encephalitozoon Cuniculi polar tube proteins (EcPTPs). Immunofluorescence and immunoelectron microscopy confirmed the colocalization of EcPTP1, EcPTP2, and EcPTP3 to the polar tube. Experiments using cross-linkers indicated that EcPTP1, EcPTP2, and EcPTP3 form a complex in the polar tube, which was confirmed by immunoprecipitation using EcPTP1 antiserum. Yeast two-hybrid analysis revealed that full-length EcPTP1, EcPTP2, and EcPTP3 interact with each other in vivo. Both the N and C termini of EcPTP1 were involved in these interactions, but the central region of this protein, which contains a repetitive motif, was not. Further studies of polar tube proteins and their structural interactions may help elucidate the formation of the polar tube during the invasion process.
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Immune response to Encephalitozoon Cuniculi infection
Microbes and infection, 2001Co-Authors: Imtiaz A. Khan, Magali Moretto, Louis M. WeissAbstract:Microsporidia are obligate intracellular parasites, which can cause complications in immunocompromised individuals. Very little is known about the host immune response generated against these infectious agents. Encephalitozoon Cuniculi is the best studied microsporidian and the protective immune response against this parasite is mediated by cytotoxic CD8+ T cells.
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Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon Cuniculi.
The Journal of eukaryotic microbiology, 2001Co-Authors: Cyrus J. Bacchi, Louis M. Weiss, Schennella Lane, Nigel Yarlett, Peter M. Takvorian, Murray WittnerAbstract:Abstract Polyamines are small cationic molecules necessary for growth and differentiation in all cells. Although mammalian cells have been studied extensively, particularly as targets of polyamine antagonists, i.e. antitumor agents, polyamine metabolism has also been studied as a potential drug target in microorganisms. Since little is known concerning polyamine metabolism in the microsporidia, we investigated it in Encephalitozoon Cuniculi, a microspordian associated with disseminated infections in humans. Organisms were grown in RK-13 cells and harvested using Percoll gradients. Electron microscopy indicated that the fractions banding at 1.051–1.059/g/ml in a microgradient procedure, and 1.102–1.119/g/ml in a scaled-up procedure were nearly homogenous, consisting of pre-emergent (immature) spores which showed large arrays of ribosomes near polar filament coils. Intact purified pre-emergent spores incubated with [3H] ornithine and methionine synthesized putrescine, spermidine, and spermine, while [14C]sp...
Bohumil Sak - One of the best experts on this subject based on the ideXlab platform.
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Encephalitozoon Cuniculi Genotype III Evinces a Resistance to Albendazole Treatment in both Immunodeficient and Immunocompetent Mice.
Antimicrobial agents and chemotherapy, 2020Co-Authors: Bohumil Sak, Klara Brdickova, Nikola Holubova, Lenka Hlaskova, Dana Květoňová, Martin KvacAbstract:Of four genotypes of Encephalitozoon Cuniculi, E. Cuniculi genotype II is considered to represent a parasite that occurs in many host species in a latent asymptomatic form, whereas E. Cuniculi genotype III seems to be more aggressive, and infections caused by this strain can lead to the death of even immunocompetent hosts. Although albendazole has been considered suitable for treatment of Encephalitozoon species, its failure in control of E. Cuniculi genotype III infection has been reported. This study determined the effect of a 100× recommended daily dose of albendazole on an Encephalitozoon Cuniculi genotype III course of infection in immunocompetent and immunodeficient mice and compared the results with those from experiments performed with a lower dose of albendazole and E. Cuniculi genotype II. The administration of the regular dose of abendazole during the acute phase of infection reduced the number of affected organs in all strains of mice and absolute counts of spores in screened organs. However, the effect on genotype III was minor. Surprisingly, no substantial effect was recorded after the use of a 100× dose of albendazole, with larger reductions seen only in the number of affected organs and absolute counts of spores in all strains of mice, implying variations in albendazole resistance between these Encephalitozoon Cuniculi genotypes. These results imply that differences in the course of infection and the response to treatment depend not only on the immunological status of the host but also on the genotype causing the infection. Understanding how microsporidia survive in hosts despite targeted antimicrosporidial treatment could significantly contribute to research related to human health.
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Symptomatic respiratory Encephalitozoon Cuniculi infection in renal transplant recipients
Elsevier, 2019Co-Authors: Marta Kicia, Katarzyna Jakuszko, Magdalena Krajewska, Bohumil Sak, Magdalena Szydłowicz, Kamil Cebulski, Paweł Piesiak, Aneta Kowal, Andrzej B. Hendrich, Martin KvacAbstract:Objectives: Encephalitozoon spp. and Enterocytozoon bieneusi are intracellular parasitic fungi from the phylum Microsporidia, which initially localize to the intestine. As opportunistic pathogens, Encephalitozoon spp. in particular can disseminate to the respiratory tract, among other locations. Patients on life-long immunosuppression are at higher risk of such infections, mostly symptomatic. Methods: Sputum samples and bronchial washings from 72 renal transplant recipients and 105 patients with various respiratory diseases were screened for Encephalitozoon spp. and E. bieneusi by microscopic examination and genus-specific nested PCR followed by genotyping. Results: A total of 8.3% (6/72) of immunosuppressed renal transplant recipients and 1.9% (2/105) of patients with various respiratory diseases, both immunocompetent and immunosuppressed, were positive for respiratory microsporidial infection. All six transplant recipients were Encephalitozoon Cuniculi-positive by PCR/sequencing and five of them suffered from respiratory symptoms. The presence of microsporidial spores was also confirmed microscopically in three of the transplant recipients. Of the two immunocompetent patients with various respiratory diseases, one had an E. Cuniculi infection, while the second had an E. bieneusi infection. Conclusions: Life-long immunosuppression in renal transplant recipients increases the risk of respiratory infection by E. Cuniculi. Microsporidia should be screened in respiratory samples of these patients, particularly when they have respiratory symptoms. Keywords: Encephalitozoon Cuniculi, Enterocytozoon bieneusi, Renal transplant recipients, Life-long immunosuppression, Respiratory trac
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Evidence of transplacental transmission of Encephalitozoon Cuniculi genotype II in murine model.
Experimental parasitology, 2018Co-Authors: Michaela Kotková, Lenka Hlaskova, Dana Květoňová, Bohumil Sak, Martin KvacAbstract:Abstract Microsporidia are obligate intracellurar unicellular parasite of wide range of vertebrates. Although ingestion or inhalation of microsporidian spores is the main route of infection, assumed vertical transmission was described in some mammals. The present study was focused on proof of vertical transmission in mice under experimental conditions. Mice were infected with E. Cuniculi genotype II intraperitoneally after mating, or perorally followed by mating in acute or chronic phase of infection. Fetuses were delivered by Caesarean section or mice were kept up to the parturition. Some of cubs were immediately after birth transferred to uninfected surrogate mothers. Group of cubs was immunosuppressed. All cubs were examined using polymerase chain reaction for the presence of Encephalitozoon after birth or in their age of 3 or 6 weeks, respectively. All fetuses delivered by Caesarean section, which were intraperitoneally or perorally infected were negative as well as all neonatal mice and youngsters tested in age of 6 weeks. Only immunosuppressed cubs and cubs of immunodeficient mice in age of 21 days were positive for Encephalitozoon Cuniculi genotype II. Present results provided the evidence that transplacental transmission of Encephalitozoon Cuniculi in mice occurs, but the mechanism of these transport is still unknown.
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Disseminated Infection of Encephalitozoon Cuniculi Associated With Osteolysis of Hip Periprosthetic Tissue.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018Co-Authors: Marta Kicia, Z Kopacz, Martin Kvac, Bohumil Sak, Kamil Cebulski, Andrzej B. Hendrich, Maria Wesołowska, Magdalena Sokulska, Andrzej PozowskiAbstract:Background Among patients with hip joint endoprosthesis, periprosthetic osteolysis is the most common complication following primary arthroplasty, and subsequent implant loosening is the leading cause of arthroplasty revision. Causes of stability loss, though not always evident, can be mechanical, allergic, or infectious (bacterial and fungal agents) in nature. Microsporidia, widespread opportunistic fungal pathogens that infect most human tissues, are a potential infectious cause of stability loss. Infections caused by Encephalitozoon species-one of the most common microsporidial pathogens in humans-primarily localize to intestinal and respiratory tracts, but can disseminate to tissues throughout the body. Methods We examined 53 immunocompetent patients, 23 after revision and 30 after primary hip arthroplasty, for infection by Encephalitozoon species. Periprosthetic tissue, urine sediments, and stool samples were tested by microscopic examination and genus-specific nested polymerase chain reaction followed by genotyping. Results Ten patients had Encephalitozoon-positive periprosthetic tissues, 9 (39%) after revision and 1 (3.3%) after primary hip arthroplasty. Among the tissue-positive postrevision patients, 7 had a positive urine sample and 1 had a positive stool sample. Encephalitozoon Cuniculi genotype II was identified in 88.8% (16/18) of samples. Two urine samples were positive for a novel Encephalitozoon species. Conclusions Encephalitozoon Cuniculi should be considered as a cause of osteolysis in hip periprosthetic tissue, leading to a loss of implant stability.
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Encephalitozoon Cuniculi, Cryptosporidium spp., Enterocytozoon bieneusi and Giardia spp. in orangutans under different levels of human contact.
2016Co-Authors: Anna Mynářová, Martin Kvac, Ivona Foitová, Dana Květoňová, Michael Rost, Helen Morrogh-bernard, Wisnu Nurcahyo, Cathleen Nguyen, Supriyadi Supriyadi, Bohumil SakAbstract:Encephalitozoon Cuniculi, Cryptosporidium spp., Enterocytozoon bieneusi and Giardia spp. in orangutans under different levels of human contact.
Jean Menotti - One of the best experts on this subject based on the ideXlab platform.
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Disseminated Infection with a New Genovar of Encephalitozoon Cuniculi in a Renal Transplant Recipient
Journal of clinical microbiology, 2010Co-Authors: Hana Talabani, Claudine Sarfati, E. Pillebout, Tom Van Gool, Francis Derouin, Jean MenottiAbstract:Disseminated microsporidiosis is a life-threatening opportunistic infection. Here, we report about a previously undescribed genovar of Encephalitozoon Cuniculi causing disseminated infection in a non-HIV-infected renal transplant recipient. Disseminated microsporidiosis must be considered in the differential diagnosis of chronic fever in renal allograft recipients, even those without urinary symptoms.