The Experts below are selected from a list of 69507 Experts worldwide ranked by ideXlab platform
Congxin Huang - One of the best experts on this subject based on the ideXlab platform.
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action potential duration restitution and the potential association with ventricular arrhythmia in langEndorff perfused chronic heart failure rabbit hearts
Chinese journal of cardiovascular diseases, 2012Co-Authors: Tao Liu, Mu Qin, Zhen Chen, He Huang, Congxin HuangAbstract:OBJECTIVE To observe the action potential duration restitution (APDR) change and potential association with ventricular arrhythmia (VA) in LangEndorff-perfused chronic heart failure rabbit hearts. METHODS Male rabbits were randomly divided into two groups: control (CTL, n=15) group and chronic heart failure (CHF, n=15) group. CHF was induced by injecting isoproterenol (300 µg×kg(-1) ×d(-1)) for 14 days. Four weeks later, cardiac function and structure change of both groups were assessed by echocardiography. In the whole LangEndorff-perfused hearts, the monophasic action potential (MAP) and the effective refractory period (ERP) were recorded from left anterior basal ventricle, left anterior free wall, left anterior apex and left posterior basal ventricle, left posterior free wall and left posterior apex, the APD curves were also constructed in both groups; at the six sites of every isolated heart, the programmed electrical stimulation and burst pacing were used to induce action potential duration (APD) alternans and VA, respectively. RESULTS Left ventricular ejection was reduced and End-Dimension was enlarged in rabbits of CHF group. Compared with the same sites of CTL group, the 90% of MAP duration (MAPD90), the ERP, the max slope (Smax) of APDR curves, the pacing cycle length of inducing the APD alternans and the VAs were significantly increased (all P<0.05) in CHF group; the spatial dispersions of MAPD90, ERP and Smax of APDR curves in CHF group were also greater than in CTL group (all P<0.05). CONCLUSION The ventricular APD alternans might be linked with occurrence of the VA in CHF rabbits. Increase of the Smax from APDR curves and the spatial dispersions of Smax in this CHF model might facilitate the development of ventricular arrhythmia.
Tao Liu - One of the best experts on this subject based on the ideXlab platform.
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action potential duration restitution and the potential association with ventricular arrhythmia in langEndorff perfused chronic heart failure rabbit hearts
Chinese journal of cardiovascular diseases, 2012Co-Authors: Tao Liu, Mu Qin, Zhen Chen, He Huang, Congxin HuangAbstract:OBJECTIVE To observe the action potential duration restitution (APDR) change and potential association with ventricular arrhythmia (VA) in LangEndorff-perfused chronic heart failure rabbit hearts. METHODS Male rabbits were randomly divided into two groups: control (CTL, n=15) group and chronic heart failure (CHF, n=15) group. CHF was induced by injecting isoproterenol (300 µg×kg(-1) ×d(-1)) for 14 days. Four weeks later, cardiac function and structure change of both groups were assessed by echocardiography. In the whole LangEndorff-perfused hearts, the monophasic action potential (MAP) and the effective refractory period (ERP) were recorded from left anterior basal ventricle, left anterior free wall, left anterior apex and left posterior basal ventricle, left posterior free wall and left posterior apex, the APD curves were also constructed in both groups; at the six sites of every isolated heart, the programmed electrical stimulation and burst pacing were used to induce action potential duration (APD) alternans and VA, respectively. RESULTS Left ventricular ejection was reduced and End-Dimension was enlarged in rabbits of CHF group. Compared with the same sites of CTL group, the 90% of MAP duration (MAPD90), the ERP, the max slope (Smax) of APDR curves, the pacing cycle length of inducing the APD alternans and the VAs were significantly increased (all P<0.05) in CHF group; the spatial dispersions of MAPD90, ERP and Smax of APDR curves in CHF group were also greater than in CTL group (all P<0.05). CONCLUSION The ventricular APD alternans might be linked with occurrence of the VA in CHF rabbits. Increase of the Smax from APDR curves and the spatial dispersions of Smax in this CHF model might facilitate the development of ventricular arrhythmia.
Mu Qin - One of the best experts on this subject based on the ideXlab platform.
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action potential duration restitution and the potential association with ventricular arrhythmia in langEndorff perfused chronic heart failure rabbit hearts
Chinese journal of cardiovascular diseases, 2012Co-Authors: Tao Liu, Mu Qin, Zhen Chen, He Huang, Congxin HuangAbstract:OBJECTIVE To observe the action potential duration restitution (APDR) change and potential association with ventricular arrhythmia (VA) in LangEndorff-perfused chronic heart failure rabbit hearts. METHODS Male rabbits were randomly divided into two groups: control (CTL, n=15) group and chronic heart failure (CHF, n=15) group. CHF was induced by injecting isoproterenol (300 µg×kg(-1) ×d(-1)) for 14 days. Four weeks later, cardiac function and structure change of both groups were assessed by echocardiography. In the whole LangEndorff-perfused hearts, the monophasic action potential (MAP) and the effective refractory period (ERP) were recorded from left anterior basal ventricle, left anterior free wall, left anterior apex and left posterior basal ventricle, left posterior free wall and left posterior apex, the APD curves were also constructed in both groups; at the six sites of every isolated heart, the programmed electrical stimulation and burst pacing were used to induce action potential duration (APD) alternans and VA, respectively. RESULTS Left ventricular ejection was reduced and End-Dimension was enlarged in rabbits of CHF group. Compared with the same sites of CTL group, the 90% of MAP duration (MAPD90), the ERP, the max slope (Smax) of APDR curves, the pacing cycle length of inducing the APD alternans and the VAs were significantly increased (all P<0.05) in CHF group; the spatial dispersions of MAPD90, ERP and Smax of APDR curves in CHF group were also greater than in CTL group (all P<0.05). CONCLUSION The ventricular APD alternans might be linked with occurrence of the VA in CHF rabbits. Increase of the Smax from APDR curves and the spatial dispersions of Smax in this CHF model might facilitate the development of ventricular arrhythmia.
Zhen Chen - One of the best experts on this subject based on the ideXlab platform.
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action potential duration restitution and the potential association with ventricular arrhythmia in langEndorff perfused chronic heart failure rabbit hearts
Chinese journal of cardiovascular diseases, 2012Co-Authors: Tao Liu, Mu Qin, Zhen Chen, He Huang, Congxin HuangAbstract:OBJECTIVE To observe the action potential duration restitution (APDR) change and potential association with ventricular arrhythmia (VA) in LangEndorff-perfused chronic heart failure rabbit hearts. METHODS Male rabbits were randomly divided into two groups: control (CTL, n=15) group and chronic heart failure (CHF, n=15) group. CHF was induced by injecting isoproterenol (300 µg×kg(-1) ×d(-1)) for 14 days. Four weeks later, cardiac function and structure change of both groups were assessed by echocardiography. In the whole LangEndorff-perfused hearts, the monophasic action potential (MAP) and the effective refractory period (ERP) were recorded from left anterior basal ventricle, left anterior free wall, left anterior apex and left posterior basal ventricle, left posterior free wall and left posterior apex, the APD curves were also constructed in both groups; at the six sites of every isolated heart, the programmed electrical stimulation and burst pacing were used to induce action potential duration (APD) alternans and VA, respectively. RESULTS Left ventricular ejection was reduced and End-Dimension was enlarged in rabbits of CHF group. Compared with the same sites of CTL group, the 90% of MAP duration (MAPD90), the ERP, the max slope (Smax) of APDR curves, the pacing cycle length of inducing the APD alternans and the VAs were significantly increased (all P<0.05) in CHF group; the spatial dispersions of MAPD90, ERP and Smax of APDR curves in CHF group were also greater than in CTL group (all P<0.05). CONCLUSION The ventricular APD alternans might be linked with occurrence of the VA in CHF rabbits. Increase of the Smax from APDR curves and the spatial dispersions of Smax in this CHF model might facilitate the development of ventricular arrhythmia.
He Huang - One of the best experts on this subject based on the ideXlab platform.
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action potential duration restitution and the potential association with ventricular arrhythmia in langEndorff perfused chronic heart failure rabbit hearts
Chinese journal of cardiovascular diseases, 2012Co-Authors: Tao Liu, Mu Qin, Zhen Chen, He Huang, Congxin HuangAbstract:OBJECTIVE To observe the action potential duration restitution (APDR) change and potential association with ventricular arrhythmia (VA) in LangEndorff-perfused chronic heart failure rabbit hearts. METHODS Male rabbits were randomly divided into two groups: control (CTL, n=15) group and chronic heart failure (CHF, n=15) group. CHF was induced by injecting isoproterenol (300 µg×kg(-1) ×d(-1)) for 14 days. Four weeks later, cardiac function and structure change of both groups were assessed by echocardiography. In the whole LangEndorff-perfused hearts, the monophasic action potential (MAP) and the effective refractory period (ERP) were recorded from left anterior basal ventricle, left anterior free wall, left anterior apex and left posterior basal ventricle, left posterior free wall and left posterior apex, the APD curves were also constructed in both groups; at the six sites of every isolated heart, the programmed electrical stimulation and burst pacing were used to induce action potential duration (APD) alternans and VA, respectively. RESULTS Left ventricular ejection was reduced and End-Dimension was enlarged in rabbits of CHF group. Compared with the same sites of CTL group, the 90% of MAP duration (MAPD90), the ERP, the max slope (Smax) of APDR curves, the pacing cycle length of inducing the APD alternans and the VAs were significantly increased (all P<0.05) in CHF group; the spatial dispersions of MAPD90, ERP and Smax of APDR curves in CHF group were also greater than in CTL group (all P<0.05). CONCLUSION The ventricular APD alternans might be linked with occurrence of the VA in CHF rabbits. Increase of the Smax from APDR curves and the spatial dispersions of Smax in this CHF model might facilitate the development of ventricular arrhythmia.