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Aletta E. Schutte - One of the best experts on this subject based on the ideXlab platform.
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Nitric oxide synthesis capacity, ambulatory blood pressure and End Organ Damage in a black and white population: the SABPA study
Amino Acids, 2016Co-Authors: Catharina M. C. Mels, Ilisma Loots, Edzard Schwedhelm, Dorothee Atzler, Rainer H. Böger, Aletta E. SchutteAbstract:Nitric oxide (NO) synthesis capacity is determined by the availability of substrate(s) such as l -arginine and the influence of nitric oxide synthase (NOS) inhibitors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). These factors may be important in black South Africans with a very high prevalence of hypertension. We compared ambulatory blood pressure (BP), markers of End Organ Damage and NO synthesis capacity markers [ l -arginine, l -homoarginine, l -citrulline, l -arginine:ADMA, ADMA, SDMA and dimethylarginine (DMA)], between black and white teachers ( n = 390). Associations of nighttime BP and markers of End Organ Damage with NO synthesis capacity markers were also investigated. Although black men and women had higher BP and albumin-to-creatinine ratio (ACR) (all p
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nitric oxide synthesis capacity ambulatory blood pressure and End Organ Damage in a black and white population the sabpa study
Amino Acids, 2016Co-Authors: Catharina M. C. Mels, Ilisma Loots, Edzard Schwedhelm, Dorothee Atzler, Rainer H. Böger, Aletta E. SchutteAbstract:Nitric oxide (NO) synthesis capacity is determined by the availability of substrate(s) such as l-arginine and the influence of nitric oxide synthase (NOS) inhibitors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). These factors may be important in black South Africans with a very high prevalence of hypertension. We compared ambulatory blood pressure (BP), markers of End Organ Damage and NO synthesis capacity markers [l-arginine, l-homoarginine, l-citrulline, l-arginine:ADMA, ADMA, SDMA and dimethylarginine (DMA)], between black and white teachers (n = 390). Associations of nighttime BP and markers of End Organ Damage with NO synthesis capacity markers were also investigated. Although black men and women had higher BP and albumin-to-creatinine ratio (ACR) (all p < 0.001), they also had higher l-arginine, l-homoarginine, l-arginine:ADMA and lower SDMA and DMA levels (all p < 0.05). Only in white men ADMA concentrations associated positively with nighttime systolic blood pressure (R2 = 0.20, β = 0.26, p = 0.009), nighttime diastolic blood pressure (R2 = 0.23, β = 0.27, p = 0.007), carotid intima media thickness (cIMT) (R2 = 0.36, β = 0.22, p = 0.008) and ACR (R2 = 0.14, β = 0.32, p = 0.001). Our findings suggest that despite an adverse cardiovascular profile in blacks, their NO synthesis capacity profile seems favourable, and that other factors, such as NO inactivation, may prove to be more important.
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End Organ Damage in urbanized africans with low plasma renin levels the sabpa study
Clinical and Experimental Hypertension, 2014Co-Authors: Johannes M Van Rooyen, Aletta E. Schutte, Rudolph Schutte, H W Huisman, Carla M T Fourie, N T Malan, Leone MalanAbstract:AbstractThe purpose of this study was to evaluate whether active renin concentration is associated with markers of End-Organ Damage in urbanized Africans. This study forms part of the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. For this study, 81 men and 74 women were divided into low- and high-renin groups. Ambulatory blood pressure measurements were conducted. A resting 12-lead ECG was determined in order to determine the gEnder-specific Cornell voltage. Cardiovascular variables were continuously recorded with the Finometer. Carotid-dorsalis pedis pulse wave velocity was obtained with the Complior acquisition system. The carotid intima-media thickness (CIMT) was obtained with the SonoSite MicroMaxx. Blood samples were collected; serum and plasma were stored at −80 °C for analysis. Anthropometric measurements were taken using standard methods. A general health questionnaire was also completed. The urinary creatinine was determined with a calorimetric method and albumin w...
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Double product and End-Organ Damage in African and Caucasian men: the SABPA study.
International Journal of Cardiology, 2012Co-Authors: A.j. Schultz, Aletta E. Schutte, Rudolph SchutteAbstract:Abstract Background Increasing urbanisation in sub-Saharan African countries is causing a rapid increase in cardiovascular disease. Evidence suggests that Africans have higher blood pressures and a higher prevalence of hypertension-related cardiovascular morbidity and mortality, compared to Caucasians. We investigated double product (systolic blood pressure×heart rate), a substantial measure of cardiac workload, as a possible cardiovascular risk factor in African and Caucasian men. Material and methods The study consisted of 101 urbanised African and 101 Caucasian male school teachers. We measured 24h ambulatory blood pressure and the carotid cross-sectional wall area, and determined left ventricular hypertrophy electrocardiographically by means of the Cornell product. Urinary albumin and creatinine were analysed to obtain the albumin-to-creatinine ratio. Results Africans had higher 24h, daytime and nighttime systolic- and diastolic blood pressure, heart rate and resultant double product compared to the Caucasians. In addition, markers of End-Organ Damage, albumin-to-creatinine ratio and left ventricular hypertrophy were higher in the Africans while cross-sectional wall area did not differ. In Africans after single partial and multiple regression analysis, 24h systolic blood pressure, but not double product or heart rate, correlated positively with markers of End-Organ Damage (cross-sectional wall area: β=0.398, P=0.005; left ventricular hypertrophy: β=0.455, P Conclusions Double product may not be a good marker of increased cardiovascular risk when compared to systolic blood pressure in African and Caucasian men.
Dorothee Atzler - One of the best experts on this subject based on the ideXlab platform.
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Nitric oxide synthesis capacity, ambulatory blood pressure and End Organ Damage in a black and white population: the SABPA study
Amino Acids, 2016Co-Authors: Catharina M. C. Mels, Ilisma Loots, Edzard Schwedhelm, Dorothee Atzler, Rainer H. Böger, Aletta E. SchutteAbstract:Nitric oxide (NO) synthesis capacity is determined by the availability of substrate(s) such as l -arginine and the influence of nitric oxide synthase (NOS) inhibitors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). These factors may be important in black South Africans with a very high prevalence of hypertension. We compared ambulatory blood pressure (BP), markers of End Organ Damage and NO synthesis capacity markers [ l -arginine, l -homoarginine, l -citrulline, l -arginine:ADMA, ADMA, SDMA and dimethylarginine (DMA)], between black and white teachers ( n = 390). Associations of nighttime BP and markers of End Organ Damage with NO synthesis capacity markers were also investigated. Although black men and women had higher BP and albumin-to-creatinine ratio (ACR) (all p
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nitric oxide synthesis capacity ambulatory blood pressure and End Organ Damage in a black and white population the sabpa study
Amino Acids, 2016Co-Authors: Catharina M. C. Mels, Ilisma Loots, Edzard Schwedhelm, Dorothee Atzler, Rainer H. Böger, Aletta E. SchutteAbstract:Nitric oxide (NO) synthesis capacity is determined by the availability of substrate(s) such as l-arginine and the influence of nitric oxide synthase (NOS) inhibitors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). These factors may be important in black South Africans with a very high prevalence of hypertension. We compared ambulatory blood pressure (BP), markers of End Organ Damage and NO synthesis capacity markers [l-arginine, l-homoarginine, l-citrulline, l-arginine:ADMA, ADMA, SDMA and dimethylarginine (DMA)], between black and white teachers (n = 390). Associations of nighttime BP and markers of End Organ Damage with NO synthesis capacity markers were also investigated. Although black men and women had higher BP and albumin-to-creatinine ratio (ACR) (all p < 0.001), they also had higher l-arginine, l-homoarginine, l-arginine:ADMA and lower SDMA and DMA levels (all p < 0.05). Only in white men ADMA concentrations associated positively with nighttime systolic blood pressure (R2 = 0.20, β = 0.26, p = 0.009), nighttime diastolic blood pressure (R2 = 0.23, β = 0.27, p = 0.007), carotid intima media thickness (cIMT) (R2 = 0.36, β = 0.22, p = 0.008) and ACR (R2 = 0.14, β = 0.32, p = 0.001). Our findings suggest that despite an adverse cardiovascular profile in blacks, their NO synthesis capacity profile seems favourable, and that other factors, such as NO inactivation, may prove to be more important.
Catharina M. C. Mels - One of the best experts on this subject based on the ideXlab platform.
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Nitric oxide synthesis capacity, ambulatory blood pressure and End Organ Damage in a black and white population: the SABPA study
Amino Acids, 2016Co-Authors: Catharina M. C. Mels, Ilisma Loots, Edzard Schwedhelm, Dorothee Atzler, Rainer H. Böger, Aletta E. SchutteAbstract:Nitric oxide (NO) synthesis capacity is determined by the availability of substrate(s) such as l -arginine and the influence of nitric oxide synthase (NOS) inhibitors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). These factors may be important in black South Africans with a very high prevalence of hypertension. We compared ambulatory blood pressure (BP), markers of End Organ Damage and NO synthesis capacity markers [ l -arginine, l -homoarginine, l -citrulline, l -arginine:ADMA, ADMA, SDMA and dimethylarginine (DMA)], between black and white teachers ( n = 390). Associations of nighttime BP and markers of End Organ Damage with NO synthesis capacity markers were also investigated. Although black men and women had higher BP and albumin-to-creatinine ratio (ACR) (all p
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nitric oxide synthesis capacity ambulatory blood pressure and End Organ Damage in a black and white population the sabpa study
Amino Acids, 2016Co-Authors: Catharina M. C. Mels, Ilisma Loots, Edzard Schwedhelm, Dorothee Atzler, Rainer H. Böger, Aletta E. SchutteAbstract:Nitric oxide (NO) synthesis capacity is determined by the availability of substrate(s) such as l-arginine and the influence of nitric oxide synthase (NOS) inhibitors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). These factors may be important in black South Africans with a very high prevalence of hypertension. We compared ambulatory blood pressure (BP), markers of End Organ Damage and NO synthesis capacity markers [l-arginine, l-homoarginine, l-citrulline, l-arginine:ADMA, ADMA, SDMA and dimethylarginine (DMA)], between black and white teachers (n = 390). Associations of nighttime BP and markers of End Organ Damage with NO synthesis capacity markers were also investigated. Although black men and women had higher BP and albumin-to-creatinine ratio (ACR) (all p < 0.001), they also had higher l-arginine, l-homoarginine, l-arginine:ADMA and lower SDMA and DMA levels (all p < 0.05). Only in white men ADMA concentrations associated positively with nighttime systolic blood pressure (R2 = 0.20, β = 0.26, p = 0.009), nighttime diastolic blood pressure (R2 = 0.23, β = 0.27, p = 0.007), carotid intima media thickness (cIMT) (R2 = 0.36, β = 0.22, p = 0.008) and ACR (R2 = 0.14, β = 0.32, p = 0.001). Our findings suggest that despite an adverse cardiovascular profile in blacks, their NO synthesis capacity profile seems favourable, and that other factors, such as NO inactivation, may prove to be more important.
Tatsuya Nomoto - One of the best experts on this subject based on the ideXlab platform.
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systemic delivery of il 10 by an aav vector prevents vascular remodeling and End Organ Damage in stroke prone spontaneously hypertensive rat
Gene Therapy, 2009Co-Authors: Tatsuya Nomoto, Takashi Okada, Kuniko Shimazaki, Tooru Yoshioka, Mutsuko Nonakasarukawa, Koichi Takeuchi, Kenichiro Katsura, Hiroaki Mizukami, Akihiro KumeAbstract:Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and End-Organ Damage in stroke-prone spontaneously hypertensive rat
Ilisma Loots - One of the best experts on this subject based on the ideXlab platform.
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Nitric oxide synthesis capacity, ambulatory blood pressure and End Organ Damage in a black and white population: the SABPA study
Amino Acids, 2016Co-Authors: Catharina M. C. Mels, Ilisma Loots, Edzard Schwedhelm, Dorothee Atzler, Rainer H. Böger, Aletta E. SchutteAbstract:Nitric oxide (NO) synthesis capacity is determined by the availability of substrate(s) such as l -arginine and the influence of nitric oxide synthase (NOS) inhibitors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). These factors may be important in black South Africans with a very high prevalence of hypertension. We compared ambulatory blood pressure (BP), markers of End Organ Damage and NO synthesis capacity markers [ l -arginine, l -homoarginine, l -citrulline, l -arginine:ADMA, ADMA, SDMA and dimethylarginine (DMA)], between black and white teachers ( n = 390). Associations of nighttime BP and markers of End Organ Damage with NO synthesis capacity markers were also investigated. Although black men and women had higher BP and albumin-to-creatinine ratio (ACR) (all p
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nitric oxide synthesis capacity ambulatory blood pressure and End Organ Damage in a black and white population the sabpa study
Amino Acids, 2016Co-Authors: Catharina M. C. Mels, Ilisma Loots, Edzard Schwedhelm, Dorothee Atzler, Rainer H. Böger, Aletta E. SchutteAbstract:Nitric oxide (NO) synthesis capacity is determined by the availability of substrate(s) such as l-arginine and the influence of nitric oxide synthase (NOS) inhibitors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). These factors may be important in black South Africans with a very high prevalence of hypertension. We compared ambulatory blood pressure (BP), markers of End Organ Damage and NO synthesis capacity markers [l-arginine, l-homoarginine, l-citrulline, l-arginine:ADMA, ADMA, SDMA and dimethylarginine (DMA)], between black and white teachers (n = 390). Associations of nighttime BP and markers of End Organ Damage with NO synthesis capacity markers were also investigated. Although black men and women had higher BP and albumin-to-creatinine ratio (ACR) (all p < 0.001), they also had higher l-arginine, l-homoarginine, l-arginine:ADMA and lower SDMA and DMA levels (all p < 0.05). Only in white men ADMA concentrations associated positively with nighttime systolic blood pressure (R2 = 0.20, β = 0.26, p = 0.009), nighttime diastolic blood pressure (R2 = 0.23, β = 0.27, p = 0.007), carotid intima media thickness (cIMT) (R2 = 0.36, β = 0.22, p = 0.008) and ACR (R2 = 0.14, β = 0.32, p = 0.001). Our findings suggest that despite an adverse cardiovascular profile in blacks, their NO synthesis capacity profile seems favourable, and that other factors, such as NO inactivation, may prove to be more important.