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P Lind - One of the best experts on this subject based on the ideXlab platform.
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fluorine 18 fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an Endemic Goiter area
Surgery, 2003Co-Authors: E Kresnik, Peter Mikosch, Hans Jurgen Gallowitsch, Haro Stettner, Isabella Igerc, I Gomez, G Kumnig, P LindAbstract:Abstract Background. The aim of this study was to evaluate the usefulness of fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in the preoperative assessment of suspicious thyroid nodules. Methods. A total of 43 patients were examined before surgical resection. In all patients, imaging was obtained at 70 minutes after the intravenous administration of 180 MBq 18F-FDG. Standard uptake values (SUVs) were calculated. Results. A total of 16 patients with thyroid carcinomas (11 papillary, 3 follicular, 2 anaplastic), 23 thyroid adenomas (11 microfollicular, 10 Hurthle cell, 2 macrofollicular), and 4 patients with degenerative Goiter were found. 18F-FDG uptake in Hurthle cell adenoma, thyroid cancer, microfollicular adenoma, degenerative Goiter, and macrofollicular adenoma was 4.4 ± 2.2, 3.7 ± 1.9, 1.6 ± 0.3, 1.2 ± 0.2, and 0.9 ± 0.1, respectively. Significant differences were observed between thyroid carcinomas and both microfollicular adenomas and degenerative Goiters (P
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comparison between 99mtc tetrofosmin pertechnetate subtraction scintigraphy and 99mtc tetrofosmin spect for preoperative localization of parathyroid adenoma in an Endemic Goiter area
Investigative Radiology, 2000Co-Authors: Hans Jurgen Gallowitsch, Peter Mikosch, E Kresnik, O Unterweger, P LindAbstract:Gallowitsch HJ, Mikosch P, Kresnik E, Unterweger O, Lind P. Comparison between 99mTc-tetrofosmin/pertechnetate subtraction scintigraphy and 99mTc-tetrofosmin SPECT for preoperative localization of parathyroid adenoma in an Endemic Goiter area. Invest Radiol 2000;35:453–459.RATIONALE AND OBJECTIVES.T
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comparison between 99mtc tetrofosmin pertechnetate subtraction scintigraphy and 99mtc tetrofosmin spect for preoperative localization of parathyroid adenoma in an Endemic Goiter area
Investigative Radiology, 2000Co-Authors: Hans Jurgen Gallowitsch, Peter Mikosch, E Kresnik, O Unterweger, P LindAbstract:Rationale and objectives Technetium-99m-((99m)Tc-) tetrofosmin, a cationic, lipophilic complex like (99m)Tc-sestamibi, has proved to be a potential tracer for parathyroid scintigraphy despite some differences in washout behavior from the thyroid gland. Previous results comparing a double-phase technique with single-proton emission computed tomography (SPECT) or with subtraction techniques demonstrated a high detection rate, especially when SPECT and subtraction techniques were used, whereas the double-phase protocol revealed only moderate results. In this study, a direct comparison was made between (99m)Tc-tetrofosmin/pertechnetate subtraction and SPECT to elucidate the optimal protocol for tetrofosmin parathyroid imaging. Methods Twenty-three patients who were biochemically suspected of parathyroid adenoma or hyperplasia due to primary or tertiary hyperparathyroidism were included in our study. In all patients, serum calcium, phosphate, and intact parathormone levels were analyzed in a single blood sample before (99m)Tc-tetrofosmin/pertechnetate subtraction scintigraphy and SPECT. Ultrasound of the neck was performed in all patients to exclude false-positive results due to thyroid adenomas. All patients underwent parathyroidectomy with intraoperative revision of all parathyroid glands, and the histological results were compared with preoperative findings. Results Both imaging modalities, ie, subtraction scintigraphy and SPECT, correctly identified 20 of 23 (87%) histologically confirmed adenomas preoperatively. The positive predictive value was calculated to be 95% and 100%, respectively, for these two methods. Subtraction scintigraphy and SPECT showed concordant results in 19 patients (18 positive, 1 false-negative) and discordant results in 4 patients (2 positive with subtraction, 2 with SPECT). The combined use of subtraction scintigraphy and SPECT techniques revealed a sensitivity of 95.7% (22/23) and a positive predictive value of 95%. The whole procedure can be performed in less than 90 minutes per patient. Whereas subtraction scintigraphy tended to show more false-positive retentions due to thyroid adenomas, the interpretation of SPECT may be difficult in small adenomas with missing thyroid/parathyroid differential washout. Conclusions Both imaging modalities, subtraction scintigraphy with pertechnetate and SPECT, are highly sensitive methods for parathyroid adenoma localization with (99m)Tc-tetrofosmin. However, our study did demonstrate that a combination of both modalities can further improve the diagnostic accuracy. Especially in an Endemic Goiter area, additional ultrasound may be required to avoid false-positive results due to thyroid adenomas.
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thyroid hemiagenesis in an Endemic Goiter area diagnosed by ultrasonography report of sixteen patients
Thyroid, 1999Co-Authors: Peter Mikosch, E Kresnik, Hans Jurgen Gallowitsch, I Gomez, Mario Molnar, P LindAbstract:During a period of 9 years, 71,500 patients underwent thyroid investigations at our department. Sixteen patients with thyroid hemiagenesis, 13 women and 3 men, were seen during this period. Fifteen...
Hans Jurgen Gallowitsch - One of the best experts on this subject based on the ideXlab platform.
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fluorine 18 fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an Endemic Goiter area
Surgery, 2003Co-Authors: E Kresnik, Peter Mikosch, Hans Jurgen Gallowitsch, Haro Stettner, Isabella Igerc, I Gomez, G Kumnig, P LindAbstract:Abstract Background. The aim of this study was to evaluate the usefulness of fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in the preoperative assessment of suspicious thyroid nodules. Methods. A total of 43 patients were examined before surgical resection. In all patients, imaging was obtained at 70 minutes after the intravenous administration of 180 MBq 18F-FDG. Standard uptake values (SUVs) were calculated. Results. A total of 16 patients with thyroid carcinomas (11 papillary, 3 follicular, 2 anaplastic), 23 thyroid adenomas (11 microfollicular, 10 Hurthle cell, 2 macrofollicular), and 4 patients with degenerative Goiter were found. 18F-FDG uptake in Hurthle cell adenoma, thyroid cancer, microfollicular adenoma, degenerative Goiter, and macrofollicular adenoma was 4.4 ± 2.2, 3.7 ± 1.9, 1.6 ± 0.3, 1.2 ± 0.2, and 0.9 ± 0.1, respectively. Significant differences were observed between thyroid carcinomas and both microfollicular adenomas and degenerative Goiters (P
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comparison between 99mtc tetrofosmin pertechnetate subtraction scintigraphy and 99mtc tetrofosmin spect for preoperative localization of parathyroid adenoma in an Endemic Goiter area
Investigative Radiology, 2000Co-Authors: Hans Jurgen Gallowitsch, Peter Mikosch, E Kresnik, O Unterweger, P LindAbstract:Gallowitsch HJ, Mikosch P, Kresnik E, Unterweger O, Lind P. Comparison between 99mTc-tetrofosmin/pertechnetate subtraction scintigraphy and 99mTc-tetrofosmin SPECT for preoperative localization of parathyroid adenoma in an Endemic Goiter area. Invest Radiol 2000;35:453–459.RATIONALE AND OBJECTIVES.T
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comparison between 99mtc tetrofosmin pertechnetate subtraction scintigraphy and 99mtc tetrofosmin spect for preoperative localization of parathyroid adenoma in an Endemic Goiter area
Investigative Radiology, 2000Co-Authors: Hans Jurgen Gallowitsch, Peter Mikosch, E Kresnik, O Unterweger, P LindAbstract:Rationale and objectives Technetium-99m-((99m)Tc-) tetrofosmin, a cationic, lipophilic complex like (99m)Tc-sestamibi, has proved to be a potential tracer for parathyroid scintigraphy despite some differences in washout behavior from the thyroid gland. Previous results comparing a double-phase technique with single-proton emission computed tomography (SPECT) or with subtraction techniques demonstrated a high detection rate, especially when SPECT and subtraction techniques were used, whereas the double-phase protocol revealed only moderate results. In this study, a direct comparison was made between (99m)Tc-tetrofosmin/pertechnetate subtraction and SPECT to elucidate the optimal protocol for tetrofosmin parathyroid imaging. Methods Twenty-three patients who were biochemically suspected of parathyroid adenoma or hyperplasia due to primary or tertiary hyperparathyroidism were included in our study. In all patients, serum calcium, phosphate, and intact parathormone levels were analyzed in a single blood sample before (99m)Tc-tetrofosmin/pertechnetate subtraction scintigraphy and SPECT. Ultrasound of the neck was performed in all patients to exclude false-positive results due to thyroid adenomas. All patients underwent parathyroidectomy with intraoperative revision of all parathyroid glands, and the histological results were compared with preoperative findings. Results Both imaging modalities, ie, subtraction scintigraphy and SPECT, correctly identified 20 of 23 (87%) histologically confirmed adenomas preoperatively. The positive predictive value was calculated to be 95% and 100%, respectively, for these two methods. Subtraction scintigraphy and SPECT showed concordant results in 19 patients (18 positive, 1 false-negative) and discordant results in 4 patients (2 positive with subtraction, 2 with SPECT). The combined use of subtraction scintigraphy and SPECT techniques revealed a sensitivity of 95.7% (22/23) and a positive predictive value of 95%. The whole procedure can be performed in less than 90 minutes per patient. Whereas subtraction scintigraphy tended to show more false-positive retentions due to thyroid adenomas, the interpretation of SPECT may be difficult in small adenomas with missing thyroid/parathyroid differential washout. Conclusions Both imaging modalities, subtraction scintigraphy with pertechnetate and SPECT, are highly sensitive methods for parathyroid adenoma localization with (99m)Tc-tetrofosmin. However, our study did demonstrate that a combination of both modalities can further improve the diagnostic accuracy. Especially in an Endemic Goiter area, additional ultrasound may be required to avoid false-positive results due to thyroid adenomas.
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thyroid hemiagenesis in an Endemic Goiter area diagnosed by ultrasonography report of sixteen patients
Thyroid, 1999Co-Authors: Peter Mikosch, E Kresnik, Hans Jurgen Gallowitsch, I Gomez, Mario Molnar, P LindAbstract:During a period of 9 years, 71,500 patients underwent thyroid investigations at our department. Sixteen patients with thyroid hemiagenesis, 13 women and 3 men, were seen during this period. Fifteen...
E Kresnik - One of the best experts on this subject based on the ideXlab platform.
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fluorine 18 fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an Endemic Goiter area
Surgery, 2003Co-Authors: E Kresnik, Peter Mikosch, Hans Jurgen Gallowitsch, Haro Stettner, Isabella Igerc, I Gomez, G Kumnig, P LindAbstract:Abstract Background. The aim of this study was to evaluate the usefulness of fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in the preoperative assessment of suspicious thyroid nodules. Methods. A total of 43 patients were examined before surgical resection. In all patients, imaging was obtained at 70 minutes after the intravenous administration of 180 MBq 18F-FDG. Standard uptake values (SUVs) were calculated. Results. A total of 16 patients with thyroid carcinomas (11 papillary, 3 follicular, 2 anaplastic), 23 thyroid adenomas (11 microfollicular, 10 Hurthle cell, 2 macrofollicular), and 4 patients with degenerative Goiter were found. 18F-FDG uptake in Hurthle cell adenoma, thyroid cancer, microfollicular adenoma, degenerative Goiter, and macrofollicular adenoma was 4.4 ± 2.2, 3.7 ± 1.9, 1.6 ± 0.3, 1.2 ± 0.2, and 0.9 ± 0.1, respectively. Significant differences were observed between thyroid carcinomas and both microfollicular adenomas and degenerative Goiters (P
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comparison between 99mtc tetrofosmin pertechnetate subtraction scintigraphy and 99mtc tetrofosmin spect for preoperative localization of parathyroid adenoma in an Endemic Goiter area
Investigative Radiology, 2000Co-Authors: Hans Jurgen Gallowitsch, Peter Mikosch, E Kresnik, O Unterweger, P LindAbstract:Gallowitsch HJ, Mikosch P, Kresnik E, Unterweger O, Lind P. Comparison between 99mTc-tetrofosmin/pertechnetate subtraction scintigraphy and 99mTc-tetrofosmin SPECT for preoperative localization of parathyroid adenoma in an Endemic Goiter area. Invest Radiol 2000;35:453–459.RATIONALE AND OBJECTIVES.T
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comparison between 99mtc tetrofosmin pertechnetate subtraction scintigraphy and 99mtc tetrofosmin spect for preoperative localization of parathyroid adenoma in an Endemic Goiter area
Investigative Radiology, 2000Co-Authors: Hans Jurgen Gallowitsch, Peter Mikosch, E Kresnik, O Unterweger, P LindAbstract:Rationale and objectives Technetium-99m-((99m)Tc-) tetrofosmin, a cationic, lipophilic complex like (99m)Tc-sestamibi, has proved to be a potential tracer for parathyroid scintigraphy despite some differences in washout behavior from the thyroid gland. Previous results comparing a double-phase technique with single-proton emission computed tomography (SPECT) or with subtraction techniques demonstrated a high detection rate, especially when SPECT and subtraction techniques were used, whereas the double-phase protocol revealed only moderate results. In this study, a direct comparison was made between (99m)Tc-tetrofosmin/pertechnetate subtraction and SPECT to elucidate the optimal protocol for tetrofosmin parathyroid imaging. Methods Twenty-three patients who were biochemically suspected of parathyroid adenoma or hyperplasia due to primary or tertiary hyperparathyroidism were included in our study. In all patients, serum calcium, phosphate, and intact parathormone levels were analyzed in a single blood sample before (99m)Tc-tetrofosmin/pertechnetate subtraction scintigraphy and SPECT. Ultrasound of the neck was performed in all patients to exclude false-positive results due to thyroid adenomas. All patients underwent parathyroidectomy with intraoperative revision of all parathyroid glands, and the histological results were compared with preoperative findings. Results Both imaging modalities, ie, subtraction scintigraphy and SPECT, correctly identified 20 of 23 (87%) histologically confirmed adenomas preoperatively. The positive predictive value was calculated to be 95% and 100%, respectively, for these two methods. Subtraction scintigraphy and SPECT showed concordant results in 19 patients (18 positive, 1 false-negative) and discordant results in 4 patients (2 positive with subtraction, 2 with SPECT). The combined use of subtraction scintigraphy and SPECT techniques revealed a sensitivity of 95.7% (22/23) and a positive predictive value of 95%. The whole procedure can be performed in less than 90 minutes per patient. Whereas subtraction scintigraphy tended to show more false-positive retentions due to thyroid adenomas, the interpretation of SPECT may be difficult in small adenomas with missing thyroid/parathyroid differential washout. Conclusions Both imaging modalities, subtraction scintigraphy with pertechnetate and SPECT, are highly sensitive methods for parathyroid adenoma localization with (99m)Tc-tetrofosmin. However, our study did demonstrate that a combination of both modalities can further improve the diagnostic accuracy. Especially in an Endemic Goiter area, additional ultrasound may be required to avoid false-positive results due to thyroid adenomas.
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thyroid hemiagenesis in an Endemic Goiter area diagnosed by ultrasonography report of sixteen patients
Thyroid, 1999Co-Authors: Peter Mikosch, E Kresnik, Hans Jurgen Gallowitsch, I Gomez, Mario Molnar, P LindAbstract:During a period of 9 years, 71,500 patients underwent thyroid investigations at our department. Sixteen patients with thyroid hemiagenesis, 13 women and 3 men, were seen during this period. Fifteen...
Peter Mikosch - One of the best experts on this subject based on the ideXlab platform.
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fluorine 18 fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an Endemic Goiter area
Surgery, 2003Co-Authors: E Kresnik, Peter Mikosch, Hans Jurgen Gallowitsch, Haro Stettner, Isabella Igerc, I Gomez, G Kumnig, P LindAbstract:Abstract Background. The aim of this study was to evaluate the usefulness of fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in the preoperative assessment of suspicious thyroid nodules. Methods. A total of 43 patients were examined before surgical resection. In all patients, imaging was obtained at 70 minutes after the intravenous administration of 180 MBq 18F-FDG. Standard uptake values (SUVs) were calculated. Results. A total of 16 patients with thyroid carcinomas (11 papillary, 3 follicular, 2 anaplastic), 23 thyroid adenomas (11 microfollicular, 10 Hurthle cell, 2 macrofollicular), and 4 patients with degenerative Goiter were found. 18F-FDG uptake in Hurthle cell adenoma, thyroid cancer, microfollicular adenoma, degenerative Goiter, and macrofollicular adenoma was 4.4 ± 2.2, 3.7 ± 1.9, 1.6 ± 0.3, 1.2 ± 0.2, and 0.9 ± 0.1, respectively. Significant differences were observed between thyroid carcinomas and both microfollicular adenomas and degenerative Goiters (P
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comparison between 99mtc tetrofosmin pertechnetate subtraction scintigraphy and 99mtc tetrofosmin spect for preoperative localization of parathyroid adenoma in an Endemic Goiter area
Investigative Radiology, 2000Co-Authors: Hans Jurgen Gallowitsch, Peter Mikosch, E Kresnik, O Unterweger, P LindAbstract:Gallowitsch HJ, Mikosch P, Kresnik E, Unterweger O, Lind P. Comparison between 99mTc-tetrofosmin/pertechnetate subtraction scintigraphy and 99mTc-tetrofosmin SPECT for preoperative localization of parathyroid adenoma in an Endemic Goiter area. Invest Radiol 2000;35:453–459.RATIONALE AND OBJECTIVES.T
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comparison between 99mtc tetrofosmin pertechnetate subtraction scintigraphy and 99mtc tetrofosmin spect for preoperative localization of parathyroid adenoma in an Endemic Goiter area
Investigative Radiology, 2000Co-Authors: Hans Jurgen Gallowitsch, Peter Mikosch, E Kresnik, O Unterweger, P LindAbstract:Rationale and objectives Technetium-99m-((99m)Tc-) tetrofosmin, a cationic, lipophilic complex like (99m)Tc-sestamibi, has proved to be a potential tracer for parathyroid scintigraphy despite some differences in washout behavior from the thyroid gland. Previous results comparing a double-phase technique with single-proton emission computed tomography (SPECT) or with subtraction techniques demonstrated a high detection rate, especially when SPECT and subtraction techniques were used, whereas the double-phase protocol revealed only moderate results. In this study, a direct comparison was made between (99m)Tc-tetrofosmin/pertechnetate subtraction and SPECT to elucidate the optimal protocol for tetrofosmin parathyroid imaging. Methods Twenty-three patients who were biochemically suspected of parathyroid adenoma or hyperplasia due to primary or tertiary hyperparathyroidism were included in our study. In all patients, serum calcium, phosphate, and intact parathormone levels were analyzed in a single blood sample before (99m)Tc-tetrofosmin/pertechnetate subtraction scintigraphy and SPECT. Ultrasound of the neck was performed in all patients to exclude false-positive results due to thyroid adenomas. All patients underwent parathyroidectomy with intraoperative revision of all parathyroid glands, and the histological results were compared with preoperative findings. Results Both imaging modalities, ie, subtraction scintigraphy and SPECT, correctly identified 20 of 23 (87%) histologically confirmed adenomas preoperatively. The positive predictive value was calculated to be 95% and 100%, respectively, for these two methods. Subtraction scintigraphy and SPECT showed concordant results in 19 patients (18 positive, 1 false-negative) and discordant results in 4 patients (2 positive with subtraction, 2 with SPECT). The combined use of subtraction scintigraphy and SPECT techniques revealed a sensitivity of 95.7% (22/23) and a positive predictive value of 95%. The whole procedure can be performed in less than 90 minutes per patient. Whereas subtraction scintigraphy tended to show more false-positive retentions due to thyroid adenomas, the interpretation of SPECT may be difficult in small adenomas with missing thyroid/parathyroid differential washout. Conclusions Both imaging modalities, subtraction scintigraphy with pertechnetate and SPECT, are highly sensitive methods for parathyroid adenoma localization with (99m)Tc-tetrofosmin. However, our study did demonstrate that a combination of both modalities can further improve the diagnostic accuracy. Especially in an Endemic Goiter area, additional ultrasound may be required to avoid false-positive results due to thyroid adenomas.
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thyroid hemiagenesis in an Endemic Goiter area diagnosed by ultrasonography report of sixteen patients
Thyroid, 1999Co-Authors: Peter Mikosch, E Kresnik, Hans Jurgen Gallowitsch, I Gomez, Mario Molnar, P LindAbstract:During a period of 9 years, 71,500 patients underwent thyroid investigations at our department. Sixteen patients with thyroid hemiagenesis, 13 women and 3 men, were seen during this period. Fifteen...
O Unterweger - One of the best experts on this subject based on the ideXlab platform.
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comparison between 99mtc tetrofosmin pertechnetate subtraction scintigraphy and 99mtc tetrofosmin spect for preoperative localization of parathyroid adenoma in an Endemic Goiter area
Investigative Radiology, 2000Co-Authors: Hans Jurgen Gallowitsch, Peter Mikosch, E Kresnik, O Unterweger, P LindAbstract:Gallowitsch HJ, Mikosch P, Kresnik E, Unterweger O, Lind P. Comparison between 99mTc-tetrofosmin/pertechnetate subtraction scintigraphy and 99mTc-tetrofosmin SPECT for preoperative localization of parathyroid adenoma in an Endemic Goiter area. Invest Radiol 2000;35:453–459.RATIONALE AND OBJECTIVES.T
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comparison between 99mtc tetrofosmin pertechnetate subtraction scintigraphy and 99mtc tetrofosmin spect for preoperative localization of parathyroid adenoma in an Endemic Goiter area
Investigative Radiology, 2000Co-Authors: Hans Jurgen Gallowitsch, Peter Mikosch, E Kresnik, O Unterweger, P LindAbstract:Rationale and objectives Technetium-99m-((99m)Tc-) tetrofosmin, a cationic, lipophilic complex like (99m)Tc-sestamibi, has proved to be a potential tracer for parathyroid scintigraphy despite some differences in washout behavior from the thyroid gland. Previous results comparing a double-phase technique with single-proton emission computed tomography (SPECT) or with subtraction techniques demonstrated a high detection rate, especially when SPECT and subtraction techniques were used, whereas the double-phase protocol revealed only moderate results. In this study, a direct comparison was made between (99m)Tc-tetrofosmin/pertechnetate subtraction and SPECT to elucidate the optimal protocol for tetrofosmin parathyroid imaging. Methods Twenty-three patients who were biochemically suspected of parathyroid adenoma or hyperplasia due to primary or tertiary hyperparathyroidism were included in our study. In all patients, serum calcium, phosphate, and intact parathormone levels were analyzed in a single blood sample before (99m)Tc-tetrofosmin/pertechnetate subtraction scintigraphy and SPECT. Ultrasound of the neck was performed in all patients to exclude false-positive results due to thyroid adenomas. All patients underwent parathyroidectomy with intraoperative revision of all parathyroid glands, and the histological results were compared with preoperative findings. Results Both imaging modalities, ie, subtraction scintigraphy and SPECT, correctly identified 20 of 23 (87%) histologically confirmed adenomas preoperatively. The positive predictive value was calculated to be 95% and 100%, respectively, for these two methods. Subtraction scintigraphy and SPECT showed concordant results in 19 patients (18 positive, 1 false-negative) and discordant results in 4 patients (2 positive with subtraction, 2 with SPECT). The combined use of subtraction scintigraphy and SPECT techniques revealed a sensitivity of 95.7% (22/23) and a positive predictive value of 95%. The whole procedure can be performed in less than 90 minutes per patient. Whereas subtraction scintigraphy tended to show more false-positive retentions due to thyroid adenomas, the interpretation of SPECT may be difficult in small adenomas with missing thyroid/parathyroid differential washout. Conclusions Both imaging modalities, subtraction scintigraphy with pertechnetate and SPECT, are highly sensitive methods for parathyroid adenoma localization with (99m)Tc-tetrofosmin. However, our study did demonstrate that a combination of both modalities can further improve the diagnostic accuracy. Especially in an Endemic Goiter area, additional ultrasound may be required to avoid false-positive results due to thyroid adenomas.