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Axel Steiger - One of the best experts on this subject based on the ideXlab platform.

  • Sleep and Endocrine Regulation
    Frontiers in bioscience : a journal and virtual library, 2003
    Co-Authors: Axel Steiger
    Abstract:

    Abstract A bidirectional interaction exists between sleep electroencephalogram (EEG) and Endocrine activity in various species including humans. Various hormones (peptides, steroids) were shown to participate in sleep Regulation. A keyrole was shown for the reciprocal interaction between sleep-promoting growth hormone-releasing hormone (GHRH) and sleep-impairing corticotropin-releasing hormone (CRH). Changes in the GHRH:CRH ratio result in changes of sleep-Endocrine activity. There is good evidence that the change of this ratio in favor of CRH contributes to aberrances of sleep during aging and depression. Besides of GHRH ghrelin and galanin promote SWS, whereas somatostatin is another sleep-impairing factor. NPY acts as a CRH antagonist and induces sleep onset. Prolactin enhances rapid eve-movement sleep (REMS) in rats. SWS is enhanced in patients with prolactinoma. Other studies on the influence of prolactin of human sleep are lacking. There is a controversy whether CRH promotes REMS. In humans vasocactive intestinal polypeptide (VIP) appears to play a role in the temporal organization of sleep, since after VIP administration the NREMS-REMS cycle decelerated. Several neuroactive steroids (pregnenolone, progesterone, allopregnanolone, dehydroepiandrosterone) exert specific effects on sleep EEG via GABAA receptors. Cortisol appears to enhance REMS. Finally gonadal hormones participate in sleep Regulation. Estrogen replacement therapy and CRH-1 receptor antagonism in depression are beneficial clinical applications of the basic research presented here.

  • On the Gender Differences in Sleep-Endocrine Regulation in Young Normal Humans
    Neuroendocrinology, 1999
    Co-Authors: Irina A. Antonijevic, Harald Murck, Ralf-michael Frieboes, Florian Holsboer, Axel Steiger
    Abstract:

    Sleep-Endocrine Regulation in humans involves high activity of the somatotropic axis at the beginning of the night and an increase in the hypothalamic-pituitary-adrenocortical (HPA) system during the

  • On the Gender Differences in Sleep-Endocrine Regulation in Young Normal Humans
    Neuroendocrinology, 1999
    Co-Authors: Irina A. Antonijevic, Harald Murck, Ralf-michael Frieboes, Florian Holsboer, Axel Steiger
    Abstract:

    Sleep-Endocrine Regulation in humans involves high activity of the somatotropic axis at the beginning of the night and an increase in the hypothalamic-pituitary-adrenocortical (HPA) system during the night. Gender differences were examined with regard to sleep-Endocrine Regulation in young healthy controls (10 men, 9 women). The sleep EEG was recorded (23:00-07:00 h) and plasma samples were collected and analyzed for GH, cortisol and ACTH at 20-min intervals. Cortisol secretion was significantly higher in females during the first half of the night (F = 9.9, p < 0.05), while ACTH was not different. In women, sleep-EEG analysis showed less slow wave sleep (SWS) during the second half of the night (F = 4.5, p < 0.05) and a significantly greater decrease in SWS and delta activity from the first to the second half of the night (F = 3.7 and 7.4, respectively, p < 0.05). Sigma activity increased during the night in women only (F = 3.7, p < 0.05). Our data are compatible with the hypothesis that in women compared to men activity of hypothalamic CRH neurons and central CRH release is greater, but is not reflected by greater HPA activity.

Tracy Horton - One of the best experts on this subject based on the ideXlab platform.

  • Endocrine Regulation of exercise substrate utilization in women compared to men.
    Exercise and Sport Sciences Reviews, 2001
    Co-Authors: Barry Braun, Tracy Horton
    Abstract:

    BRAUN, B., AND T. HORTON. Endocrine Regulation of exercise substrate utilization in women compared to men. Exerc. Sport Sci. Rev. Vol. 29, No. 4, pp 149–154, 2001. During low to moderate intensity exercise, women utilize proportionally more lipid and less carbohydrate compared to men. Estrogen and progesterone may have direct effects on these differences by increasing lipolysis and/or constraining glucose production and utilization. Furthermore, sex steroids may have indirect effects through interactions with other hormones, especially catecholamines.

  • Endocrine Regulation of exercise substrate utilization in women compared to men.
    Exercise and Sport Sciences Reviews, 2001
    Co-Authors: Barry Braun, Tracy Horton
    Abstract:

    BRAUN, B., AND T. HORTON. Endocrine Regulation of exercise substrate utilization in women compared to men. Exerc. Sport Sci. Rev. Vol. 29, No. 4, pp 149–154, 2001. During low to moderate intensity exercise, women utilize proportionally more lipid and less carbohydrate compared to men. Estrogen and progesterone may have direct effects on these differences by increasing lipolysis and/or constraining glucose production and utilization. Furthermore, sex steroids may have indirect effects through interactions with other hormones, especially catecholamines.

Irina A. Antonijevic - One of the best experts on this subject based on the ideXlab platform.

  • On the Gender Differences in Sleep-Endocrine Regulation in Young Normal Humans
    Neuroendocrinology, 1999
    Co-Authors: Irina A. Antonijevic, Harald Murck, Ralf-michael Frieboes, Florian Holsboer, Axel Steiger
    Abstract:

    Sleep-Endocrine Regulation in humans involves high activity of the somatotropic axis at the beginning of the night and an increase in the hypothalamic-pituitary-adrenocortical (HPA) system during the

  • On the Gender Differences in Sleep-Endocrine Regulation in Young Normal Humans
    Neuroendocrinology, 1999
    Co-Authors: Irina A. Antonijevic, Harald Murck, Ralf-michael Frieboes, Florian Holsboer, Axel Steiger
    Abstract:

    Sleep-Endocrine Regulation in humans involves high activity of the somatotropic axis at the beginning of the night and an increase in the hypothalamic-pituitary-adrenocortical (HPA) system during the night. Gender differences were examined with regard to sleep-Endocrine Regulation in young healthy controls (10 men, 9 women). The sleep EEG was recorded (23:00-07:00 h) and plasma samples were collected and analyzed for GH, cortisol and ACTH at 20-min intervals. Cortisol secretion was significantly higher in females during the first half of the night (F = 9.9, p < 0.05), while ACTH was not different. In women, sleep-EEG analysis showed less slow wave sleep (SWS) during the second half of the night (F = 4.5, p < 0.05) and a significantly greater decrease in SWS and delta activity from the first to the second half of the night (F = 3.7 and 7.4, respectively, p < 0.05). Sigma activity increased during the night in women only (F = 3.7, p < 0.05). Our data are compatible with the hypothesis that in women compared to men activity of hypothalamic CRH neurons and central CRH release is greater, but is not reflected by greater HPA activity.

Barry Braun - One of the best experts on this subject based on the ideXlab platform.

  • Endocrine Regulation of exercise substrate utilization in women compared to men.
    Exercise and Sport Sciences Reviews, 2001
    Co-Authors: Barry Braun, Tracy Horton
    Abstract:

    BRAUN, B., AND T. HORTON. Endocrine Regulation of exercise substrate utilization in women compared to men. Exerc. Sport Sci. Rev. Vol. 29, No. 4, pp 149–154, 2001. During low to moderate intensity exercise, women utilize proportionally more lipid and less carbohydrate compared to men. Estrogen and progesterone may have direct effects on these differences by increasing lipolysis and/or constraining glucose production and utilization. Furthermore, sex steroids may have indirect effects through interactions with other hormones, especially catecholamines.

  • Endocrine Regulation of exercise substrate utilization in women compared to men.
    Exercise and Sport Sciences Reviews, 2001
    Co-Authors: Barry Braun, Tracy Horton
    Abstract:

    BRAUN, B., AND T. HORTON. Endocrine Regulation of exercise substrate utilization in women compared to men. Exerc. Sport Sci. Rev. Vol. 29, No. 4, pp 149–154, 2001. During low to moderate intensity exercise, women utilize proportionally more lipid and less carbohydrate compared to men. Estrogen and progesterone may have direct effects on these differences by increasing lipolysis and/or constraining glucose production and utilization. Furthermore, sex steroids may have indirect effects through interactions with other hormones, especially catecholamines.

Florian Holsboer - One of the best experts on this subject based on the ideXlab platform.

  • On the Gender Differences in Sleep-Endocrine Regulation in Young Normal Humans
    Neuroendocrinology, 1999
    Co-Authors: Irina A. Antonijevic, Harald Murck, Ralf-michael Frieboes, Florian Holsboer, Axel Steiger
    Abstract:

    Sleep-Endocrine Regulation in humans involves high activity of the somatotropic axis at the beginning of the night and an increase in the hypothalamic-pituitary-adrenocortical (HPA) system during the

  • On the Gender Differences in Sleep-Endocrine Regulation in Young Normal Humans
    Neuroendocrinology, 1999
    Co-Authors: Irina A. Antonijevic, Harald Murck, Ralf-michael Frieboes, Florian Holsboer, Axel Steiger
    Abstract:

    Sleep-Endocrine Regulation in humans involves high activity of the somatotropic axis at the beginning of the night and an increase in the hypothalamic-pituitary-adrenocortical (HPA) system during the night. Gender differences were examined with regard to sleep-Endocrine Regulation in young healthy controls (10 men, 9 women). The sleep EEG was recorded (23:00-07:00 h) and plasma samples were collected and analyzed for GH, cortisol and ACTH at 20-min intervals. Cortisol secretion was significantly higher in females during the first half of the night (F = 9.9, p < 0.05), while ACTH was not different. In women, sleep-EEG analysis showed less slow wave sleep (SWS) during the second half of the night (F = 4.5, p < 0.05) and a significantly greater decrease in SWS and delta activity from the first to the second half of the night (F = 3.7 and 7.4, respectively, p < 0.05). Sigma activity increased during the night in women only (F = 3.7, p < 0.05). Our data are compatible with the hypothesis that in women compared to men activity of hypothalamic CRH neurons and central CRH release is greater, but is not reflected by greater HPA activity.