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Teri A Longacre - One of the best experts on this subject based on the ideXlab platform.
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inhibin and cd99 mic2 expression in uterine Stromal neoplasms with sex cord like elements
Human Pathology, 1999Co-Authors: Robin J Baker, Richard H Hildebrandt, Robert V Rouse, Michael R Hendrickson, Teri A LongacreAbstract:Abstract Uterine mesenchymal neoplasms with sex-cord-like elements are designated as Endometrial Stromal Tumor with sex-cord-like elements (ESTSCLE) or uterine Tumor resembling ovarian sex-cord Tumor (UTROSCT), depending on the extent of sex-cord-like differentiation. Occasionally, sex-cord elements similar to those in ESTSCLE and UTROSCT occur in uterine adenosarcomas. To determine whether the sex-cord-like elements in these Tumors show immunohistological evidence of sex-cord differentiation, we studied a series of uterine neoplasms for expression of inhibin, a peptide hormone expressed by normal ovarian granulosa cells and ovarian sex-cord neoplasms, and CD99, a protein also expressed by granulosa cells, Sertoli cells, and some ovarian sex-cord Tumors. Thirty uterine mesenchymal neoplasms (five epithelioid or plexiform smooth muscle Tumors, three Endometrial Stromal Tumors, two mixed Endometrial Stromal and smooth muscle Tumors, 10 ESTSCLE, five UTROSCT, and five miscellaneous Stromal processes) and five epithelial neoplasms were evaluated for expression of CD99 (clone 12E7) and inhibin (clone R1) in formalin-fixed, paraffin-embedded tissue. Three of 10 (30%) ESTSCLE and five of five (100%) UTROSCT were inhibin and CD99 immunoreactive. Inhibin staining was confined to the areas with sex-cord-like differentation, and staining was generally much stronger and more extensive in areas featuring prominent foam cells. There were no differences in the degree or intensity of staining for inhibin in premenopausal and postmenopausal women. CD99 expression tended to correlate with inhibin and was typically confined to similar cell types in the individual neoplasms. Weak CD99 immunoreactivity was seen in one additional epithelioid smooth muscle Tumor, whereas all other mesenchymal and epithelial neoplasms studied for inhibin and CD99 were negative. These results provide further immunohistological support for true sex-cord differentiation within uterine mesenchymal proliferations and suggest that the degree of sex-cord differentiation may correlate with the expression of these markers.
Robin J Baker - One of the best experts on this subject based on the ideXlab platform.
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inhibin and cd99 mic2 expression in uterine Stromal neoplasms with sex cord like elements
Human Pathology, 1999Co-Authors: Robin J Baker, Richard H Hildebrandt, Robert V Rouse, Michael R Hendrickson, Teri A LongacreAbstract:Abstract Uterine mesenchymal neoplasms with sex-cord-like elements are designated as Endometrial Stromal Tumor with sex-cord-like elements (ESTSCLE) or uterine Tumor resembling ovarian sex-cord Tumor (UTROSCT), depending on the extent of sex-cord-like differentiation. Occasionally, sex-cord elements similar to those in ESTSCLE and UTROSCT occur in uterine adenosarcomas. To determine whether the sex-cord-like elements in these Tumors show immunohistological evidence of sex-cord differentiation, we studied a series of uterine neoplasms for expression of inhibin, a peptide hormone expressed by normal ovarian granulosa cells and ovarian sex-cord neoplasms, and CD99, a protein also expressed by granulosa cells, Sertoli cells, and some ovarian sex-cord Tumors. Thirty uterine mesenchymal neoplasms (five epithelioid or plexiform smooth muscle Tumors, three Endometrial Stromal Tumors, two mixed Endometrial Stromal and smooth muscle Tumors, 10 ESTSCLE, five UTROSCT, and five miscellaneous Stromal processes) and five epithelial neoplasms were evaluated for expression of CD99 (clone 12E7) and inhibin (clone R1) in formalin-fixed, paraffin-embedded tissue. Three of 10 (30%) ESTSCLE and five of five (100%) UTROSCT were inhibin and CD99 immunoreactive. Inhibin staining was confined to the areas with sex-cord-like differentation, and staining was generally much stronger and more extensive in areas featuring prominent foam cells. There were no differences in the degree or intensity of staining for inhibin in premenopausal and postmenopausal women. CD99 expression tended to correlate with inhibin and was typically confined to similar cell types in the individual neoplasms. Weak CD99 immunoreactivity was seen in one additional epithelioid smooth muscle Tumor, whereas all other mesenchymal and epithelial neoplasms studied for inhibin and CD99 were negative. These results provide further immunohistological support for true sex-cord differentiation within uterine mesenchymal proliferations and suggest that the degree of sex-cord differentiation may correlate with the expression of these markers.
G P Sutton - One of the best experts on this subject based on the ideXlab platform.
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Hormonal treatment of an Endometrial Stromal nodule followed by local excision.
Obstetrics and gynecology, 1999Co-Authors: J M Schilder, W W Hurd, L M Roth, G P SuttonAbstract:Endometrial Stromal nodule is a rare subtype of Endometrial Stromal Tumor. Although such nodules are benign, hysterectomy has been considered the treatment of choice, because evaluation of the margin is required for diagnosis. The similarity between low-grade Stromal sarcoma and Stromal nodule suggests that Stromal nodules might respond to hormonal management. Twenty-one-year-old nulligravida, diagnosed with Endometrial Stromal nodule, which decreased in size with leuprolide acetate treatment, underwent local excision of the Tumor with preservation of reproductive function. Hormonal therapy was successful in decreasing the size of this Stromal nodule which allowed for conservative management.
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Hormonal treatment of an Endometrial Stromal nodule followed by local excision.
Obstetrics & Gynecology, 1999Co-Authors: J M Schilder, W W Hurd, L M Roth, G P SuttonAbstract:Abstract Background: Endometrial Stromal nodule is a rare subtype of Endometrial Stromal Tumor. Although such nodules are benign, hysterectomy has been considered the treatment of choice, because evaluation of the margin is required for diagnosis. The similarity between low-grade Stromal sarcoma and Stromal nodule suggests that Stromal nodules might respond to hormonal management. Case: Twenty-one-year-old nulligravida, diagnosed with Endometrial Stromal nodule, which decreased in size with leuprolide acetate treatment, underwent local excision of the Tumor with preservation of reproductive function. Conclusion: Hormonal therapy was successful in decreasing the size of this Stromal nodule which allowed for conservative management.
Shinji Itoyama - One of the best experts on this subject based on the ideXlab platform.
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A Case of Recurrent Intramural Uterine Stromal Tumor with Epithelial Differentiation Effectively Treated with Oral Low‐Dose Administration of Etoposide
Asia-Oceania Journal of Obstetrics and Gynaecology, 2010Co-Authors: Hiroyuki Seki, Akiyoshi Takagi, Shinichi Takada, Satoru Takeda, Katsuyuki Kinoshita, Atsuko Masunaga, Isamu Sugawara, Shinji ItoyamaAbstract:A 66-year-old woman was diagnosed as having myoma of the uterus and total hysterectomy with bilateral salpingo-oophorectomy was performed. The histopathological findings were puzzling, and the case was finally diagnosed as intramural uterine Stromal Tumor with epithelial differentiation. Three years after the operation, a firm Tumor developed in the pelvic cavity. Laparotomy failed to remove the Tumor and neither CAP (cyclophosphamide 500 mg, adriamycin 50 mg, CDDP 70 mg) therapy nor radiation therapy was effective. Oral administration of etoposide (25 mg/day), however, showed PR (50% decrease) as determined by CT scanning, and ultrasonography, and no me-tastatic lesions were found. This Tumor was coincident with the Endometrial Stromal Tumor with epithelial elements classified by Clement and Scully. The histological feature of the Tumors and the efficacy of oral etoposide therapy are discussed in this study.
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A case of intramural uterine Stromal Tumor with epithelial differentiation.
Pathology International, 1992Co-Authors: Atsuko Masunaga, Katsuyuki Kinoshita, Isamu Sugawara, Teruaki Oka, Hisayoshi Nakamura, Tomoyuki Yamashita, Shinji ItoyamaAbstract:A case of intrauterine Tumor in a 62-year-old Japanese woman is presented. It was thought initially that this was a case of uterine Tumor resembling an ovarian sex cord Tumor. To examine the cytological features of the Tumor cells, electron microscopical and immunohistochemical studies were done, and a hormone assay of the Tumor tissue was performed. The Tumor cells were rich in rough endoplasmic reticulum (rER), mitochondria and microfilaments. Some Tumor cells tended to form glandular patterns, but these epithelial elements were frequently scattered among fibrous Stromal elements. Though many Tumor cells with an epithelial appearance possessed a large quantity of cytokeratin and vimentin, they did not secrete estradiol, progesterone, testosterone or human chorionic gonadotropin. This case was finally diagnosed as an intramural uterine Stromal Tumor with epithelial differentiation after taking all the available data into consideration. This would be classified as an Endometrial Stromal Tumor with epithelial elements, recently proposed and named by Clement and Scully.
Michael R Hendrickson - One of the best experts on this subject based on the ideXlab platform.
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inhibin and cd99 mic2 expression in uterine Stromal neoplasms with sex cord like elements
Human Pathology, 1999Co-Authors: Robin J Baker, Richard H Hildebrandt, Robert V Rouse, Michael R Hendrickson, Teri A LongacreAbstract:Abstract Uterine mesenchymal neoplasms with sex-cord-like elements are designated as Endometrial Stromal Tumor with sex-cord-like elements (ESTSCLE) or uterine Tumor resembling ovarian sex-cord Tumor (UTROSCT), depending on the extent of sex-cord-like differentiation. Occasionally, sex-cord elements similar to those in ESTSCLE and UTROSCT occur in uterine adenosarcomas. To determine whether the sex-cord-like elements in these Tumors show immunohistological evidence of sex-cord differentiation, we studied a series of uterine neoplasms for expression of inhibin, a peptide hormone expressed by normal ovarian granulosa cells and ovarian sex-cord neoplasms, and CD99, a protein also expressed by granulosa cells, Sertoli cells, and some ovarian sex-cord Tumors. Thirty uterine mesenchymal neoplasms (five epithelioid or plexiform smooth muscle Tumors, three Endometrial Stromal Tumors, two mixed Endometrial Stromal and smooth muscle Tumors, 10 ESTSCLE, five UTROSCT, and five miscellaneous Stromal processes) and five epithelial neoplasms were evaluated for expression of CD99 (clone 12E7) and inhibin (clone R1) in formalin-fixed, paraffin-embedded tissue. Three of 10 (30%) ESTSCLE and five of five (100%) UTROSCT were inhibin and CD99 immunoreactive. Inhibin staining was confined to the areas with sex-cord-like differentation, and staining was generally much stronger and more extensive in areas featuring prominent foam cells. There were no differences in the degree or intensity of staining for inhibin in premenopausal and postmenopausal women. CD99 expression tended to correlate with inhibin and was typically confined to similar cell types in the individual neoplasms. Weak CD99 immunoreactivity was seen in one additional epithelioid smooth muscle Tumor, whereas all other mesenchymal and epithelial neoplasms studied for inhibin and CD99 were negative. These results provide further immunohistological support for true sex-cord differentiation within uterine mesenchymal proliferations and suggest that the degree of sex-cord differentiation may correlate with the expression of these markers.