The Experts below are selected from a list of 338295 Experts worldwide ranked by ideXlab platform
Caesar E Ordonez - One of the best experts on this subject based on the ideXlab platform.
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technical note a fast and monolithic prototype clinical proton radiography system optimized for pencil beam scanning
arXiv: Medical Physics, 2020Co-Authors: Ethan A Dejongh, Christina Sarosiek, V Rykalin, G Coutrakon, Don F Dejongh, Igor Polnyi, Kirk L Duffin, Nicholas T Karonis, Caesar E OrdonezAbstract:Purpose: To demonstrate a proton imaging system based on well-established fast scintillator technology to achieve high performance with low cost and complexity, with the potential of a straightforward translation into clinical use. Methods: The system tracks individual protons through one (X, Y) scintillating fiber tracker plane upstream and downstream of the object and into a 13 cm-thick scintillating block residual Energy Detector. The fibers in the tracker planes are multiplexed into silicon photomultipliers (SiPMs) to reduce the number of electronics channels. The light signal from the residual Energy Detector is collected by 16 photomultiplier tubes (PMTs). Only four signals from the PMTs are output from each event, which allows for fast signal readout. A robust calibration method of the PMT signal to residual Energy has been developed to obtain accurate proton images. The development of patient-specific scan patterns using multiple input energies allows for an image to be produced with minimal excess dose delivered to the patient. Results: The calibration of signals in the Energy Detector produces accurate residual range measurements limited by intrinsic range straggling. We measured the water-equivalent thickness (WET) of a block of solid water (physical thickness of 6.10 mm) with a proton radiograph. The mean WET from all pixels in the block was 6.13 cm (SD 0.02 cm). The use of patient-specific scan patterns using multiple input energies enables imaging with a compact range Detector. Conclusions: We have developed a prototype clinical proton radiography system for pretreatment imaging in proton radiation therapy. We have optimized the system for use with pencil beam scanning systems and have achieved a reduction of size and complexity compared to previous designs.
Nicholas T Karonis - One of the best experts on this subject based on the ideXlab platform.
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technical note a fast and monolithic prototype clinical proton radiography system optimized for pencil beam scanning
arXiv: Medical Physics, 2020Co-Authors: Ethan A Dejongh, Christina Sarosiek, V Rykalin, G Coutrakon, Don F Dejongh, Igor Polnyi, Kirk L Duffin, Nicholas T Karonis, Caesar E OrdonezAbstract:Purpose: To demonstrate a proton imaging system based on well-established fast scintillator technology to achieve high performance with low cost and complexity, with the potential of a straightforward translation into clinical use. Methods: The system tracks individual protons through one (X, Y) scintillating fiber tracker plane upstream and downstream of the object and into a 13 cm-thick scintillating block residual Energy Detector. The fibers in the tracker planes are multiplexed into silicon photomultipliers (SiPMs) to reduce the number of electronics channels. The light signal from the residual Energy Detector is collected by 16 photomultiplier tubes (PMTs). Only four signals from the PMTs are output from each event, which allows for fast signal readout. A robust calibration method of the PMT signal to residual Energy has been developed to obtain accurate proton images. The development of patient-specific scan patterns using multiple input energies allows for an image to be produced with minimal excess dose delivered to the patient. Results: The calibration of signals in the Energy Detector produces accurate residual range measurements limited by intrinsic range straggling. We measured the water-equivalent thickness (WET) of a block of solid water (physical thickness of 6.10 mm) with a proton radiograph. The mean WET from all pixels in the block was 6.13 cm (SD 0.02 cm). The use of patient-specific scan patterns using multiple input energies enables imaging with a compact range Detector. Conclusions: We have developed a prototype clinical proton radiography system for pretreatment imaging in proton radiation therapy. We have optimized the system for use with pencil beam scanning systems and have achieved a reduction of size and complexity compared to previous designs.
V Rykalin - One of the best experts on this subject based on the ideXlab platform.
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proof of concept image artifact reduction by Energy modulated proton computed tomography empct
Physica Medica, 2021Co-Authors: Jannis Dickmann, Christina Sarosiek, V Rykalin, Mark Pankuch, G Coutrakon, R P Johnson, V Bashkirov, R Schulte, Katia Parodi, Guillaume LandryAbstract:Abstract Purpose To reduce imaging artifacts and improve image quality of a specific proton computed tomography (pCT) prototype scanner by combining pCT data acquired at two different incident proton energies to avoid protons stopping in sub-optimal Detector sections. Methods Image artifacts of a prototype pCT scanner are linked to protons stopping close to internal structures of the scanner’s multi-stage Energy Detector. We aimed at avoiding such protons by acquiring pCT data at two different incident energies and combining the data in post-processing from which artifact-reduced images of the relative stopping power (RSP) were calculated. Energy-modulated pCT (EMpCT) images were assessed visually and quantitatively and compared to the original mono-energetic images in terms of RSP accuracy and noise. Data were acquired for a homogeneous water phantom. Results RSP images reconstructed from the mono-energetic datasets displayed local image artifacts which were ring-shaped due to the homogeneity of the phantom. The merged EMpCT dataset achieved a superior visual image quality with reduced artifacts and only minor remaining rings. The inter-quartile range (25/75) of RSP values was reduced from 0.7 % with the current standard acquisition to 0.2 % with EMpCT due to the reduction of ring artifacts. In this study, dose was doubled compared to a standard scan, but we discuss strategies to reduce excess dose. Conclusions EMpCT allows to effectively avoid regions of the Energy Detector that cause image artifacts. Thereby, image quality is improved.
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technical note a fast and monolithic prototype clinical proton radiography system optimized for pencil beam scanning
arXiv: Medical Physics, 2020Co-Authors: Ethan A Dejongh, Christina Sarosiek, V Rykalin, G Coutrakon, Don F Dejongh, Igor Polnyi, Kirk L Duffin, Nicholas T Karonis, Caesar E OrdonezAbstract:Purpose: To demonstrate a proton imaging system based on well-established fast scintillator technology to achieve high performance with low cost and complexity, with the potential of a straightforward translation into clinical use. Methods: The system tracks individual protons through one (X, Y) scintillating fiber tracker plane upstream and downstream of the object and into a 13 cm-thick scintillating block residual Energy Detector. The fibers in the tracker planes are multiplexed into silicon photomultipliers (SiPMs) to reduce the number of electronics channels. The light signal from the residual Energy Detector is collected by 16 photomultiplier tubes (PMTs). Only four signals from the PMTs are output from each event, which allows for fast signal readout. A robust calibration method of the PMT signal to residual Energy has been developed to obtain accurate proton images. The development of patient-specific scan patterns using multiple input energies allows for an image to be produced with minimal excess dose delivered to the patient. Results: The calibration of signals in the Energy Detector produces accurate residual range measurements limited by intrinsic range straggling. We measured the water-equivalent thickness (WET) of a block of solid water (physical thickness of 6.10 mm) with a proton radiograph. The mean WET from all pixels in the block was 6.13 cm (SD 0.02 cm). The use of patient-specific scan patterns using multiple input energies enables imaging with a compact range Detector. Conclusions: We have developed a prototype clinical proton radiography system for pretreatment imaging in proton radiation therapy. We have optimized the system for use with pencil beam scanning systems and have achieved a reduction of size and complexity compared to previous designs.
G Coutrakon - One of the best experts on this subject based on the ideXlab platform.
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proof of concept image artifact reduction by Energy modulated proton computed tomography empct
Physica Medica, 2021Co-Authors: Jannis Dickmann, Christina Sarosiek, V Rykalin, Mark Pankuch, G Coutrakon, R P Johnson, V Bashkirov, R Schulte, Katia Parodi, Guillaume LandryAbstract:Abstract Purpose To reduce imaging artifacts and improve image quality of a specific proton computed tomography (pCT) prototype scanner by combining pCT data acquired at two different incident proton energies to avoid protons stopping in sub-optimal Detector sections. Methods Image artifacts of a prototype pCT scanner are linked to protons stopping close to internal structures of the scanner’s multi-stage Energy Detector. We aimed at avoiding such protons by acquiring pCT data at two different incident energies and combining the data in post-processing from which artifact-reduced images of the relative stopping power (RSP) were calculated. Energy-modulated pCT (EMpCT) images were assessed visually and quantitatively and compared to the original mono-energetic images in terms of RSP accuracy and noise. Data were acquired for a homogeneous water phantom. Results RSP images reconstructed from the mono-energetic datasets displayed local image artifacts which were ring-shaped due to the homogeneity of the phantom. The merged EMpCT dataset achieved a superior visual image quality with reduced artifacts and only minor remaining rings. The inter-quartile range (25/75) of RSP values was reduced from 0.7 % with the current standard acquisition to 0.2 % with EMpCT due to the reduction of ring artifacts. In this study, dose was doubled compared to a standard scan, but we discuss strategies to reduce excess dose. Conclusions EMpCT allows to effectively avoid regions of the Energy Detector that cause image artifacts. Thereby, image quality is improved.
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technical note a fast and monolithic prototype clinical proton radiography system optimized for pencil beam scanning
arXiv: Medical Physics, 2020Co-Authors: Ethan A Dejongh, Christina Sarosiek, V Rykalin, G Coutrakon, Don F Dejongh, Igor Polnyi, Kirk L Duffin, Nicholas T Karonis, Caesar E OrdonezAbstract:Purpose: To demonstrate a proton imaging system based on well-established fast scintillator technology to achieve high performance with low cost and complexity, with the potential of a straightforward translation into clinical use. Methods: The system tracks individual protons through one (X, Y) scintillating fiber tracker plane upstream and downstream of the object and into a 13 cm-thick scintillating block residual Energy Detector. The fibers in the tracker planes are multiplexed into silicon photomultipliers (SiPMs) to reduce the number of electronics channels. The light signal from the residual Energy Detector is collected by 16 photomultiplier tubes (PMTs). Only four signals from the PMTs are output from each event, which allows for fast signal readout. A robust calibration method of the PMT signal to residual Energy has been developed to obtain accurate proton images. The development of patient-specific scan patterns using multiple input energies allows for an image to be produced with minimal excess dose delivered to the patient. Results: The calibration of signals in the Energy Detector produces accurate residual range measurements limited by intrinsic range straggling. We measured the water-equivalent thickness (WET) of a block of solid water (physical thickness of 6.10 mm) with a proton radiograph. The mean WET from all pixels in the block was 6.13 cm (SD 0.02 cm). The use of patient-specific scan patterns using multiple input energies enables imaging with a compact range Detector. Conclusions: We have developed a prototype clinical proton radiography system for pretreatment imaging in proton radiation therapy. We have optimized the system for use with pencil beam scanning systems and have achieved a reduction of size and complexity compared to previous designs.
Christina Sarosiek - One of the best experts on this subject based on the ideXlab platform.
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proof of concept image artifact reduction by Energy modulated proton computed tomography empct
Physica Medica, 2021Co-Authors: Jannis Dickmann, Christina Sarosiek, V Rykalin, Mark Pankuch, G Coutrakon, R P Johnson, V Bashkirov, R Schulte, Katia Parodi, Guillaume LandryAbstract:Abstract Purpose To reduce imaging artifacts and improve image quality of a specific proton computed tomography (pCT) prototype scanner by combining pCT data acquired at two different incident proton energies to avoid protons stopping in sub-optimal Detector sections. Methods Image artifacts of a prototype pCT scanner are linked to protons stopping close to internal structures of the scanner’s multi-stage Energy Detector. We aimed at avoiding such protons by acquiring pCT data at two different incident energies and combining the data in post-processing from which artifact-reduced images of the relative stopping power (RSP) were calculated. Energy-modulated pCT (EMpCT) images were assessed visually and quantitatively and compared to the original mono-energetic images in terms of RSP accuracy and noise. Data were acquired for a homogeneous water phantom. Results RSP images reconstructed from the mono-energetic datasets displayed local image artifacts which were ring-shaped due to the homogeneity of the phantom. The merged EMpCT dataset achieved a superior visual image quality with reduced artifacts and only minor remaining rings. The inter-quartile range (25/75) of RSP values was reduced from 0.7 % with the current standard acquisition to 0.2 % with EMpCT due to the reduction of ring artifacts. In this study, dose was doubled compared to a standard scan, but we discuss strategies to reduce excess dose. Conclusions EMpCT allows to effectively avoid regions of the Energy Detector that cause image artifacts. Thereby, image quality is improved.
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technical note a fast and monolithic prototype clinical proton radiography system optimized for pencil beam scanning
arXiv: Medical Physics, 2020Co-Authors: Ethan A Dejongh, Christina Sarosiek, V Rykalin, G Coutrakon, Don F Dejongh, Igor Polnyi, Kirk L Duffin, Nicholas T Karonis, Caesar E OrdonezAbstract:Purpose: To demonstrate a proton imaging system based on well-established fast scintillator technology to achieve high performance with low cost and complexity, with the potential of a straightforward translation into clinical use. Methods: The system tracks individual protons through one (X, Y) scintillating fiber tracker plane upstream and downstream of the object and into a 13 cm-thick scintillating block residual Energy Detector. The fibers in the tracker planes are multiplexed into silicon photomultipliers (SiPMs) to reduce the number of electronics channels. The light signal from the residual Energy Detector is collected by 16 photomultiplier tubes (PMTs). Only four signals from the PMTs are output from each event, which allows for fast signal readout. A robust calibration method of the PMT signal to residual Energy has been developed to obtain accurate proton images. The development of patient-specific scan patterns using multiple input energies allows for an image to be produced with minimal excess dose delivered to the patient. Results: The calibration of signals in the Energy Detector produces accurate residual range measurements limited by intrinsic range straggling. We measured the water-equivalent thickness (WET) of a block of solid water (physical thickness of 6.10 mm) with a proton radiograph. The mean WET from all pixels in the block was 6.13 cm (SD 0.02 cm). The use of patient-specific scan patterns using multiple input energies enables imaging with a compact range Detector. Conclusions: We have developed a prototype clinical proton radiography system for pretreatment imaging in proton radiation therapy. We have optimized the system for use with pencil beam scanning systems and have achieved a reduction of size and complexity compared to previous designs.