The Experts below are selected from a list of 12015 Experts worldwide ranked by ideXlab platform

François Paquet - One of the best experts on this subject based on the ideXlab platform.

  • Parental exposure to Enriched Uranium induced delayed hyperactivity in rat offspring
    Neurotoxicology, 2007
    Co-Authors: P. Houpert, P. Gourmelon, Sandrine Frelon, Philippe Lestaevel, Cyrill Bussy, François Paquet
    Abstract:

    Several recent reports suggest that chronic exposure to Uranium could induce behavioural effects in adult rats. As the immature brains are known to be more susceptible to toxic effects, rats were observed in an open field, in a Y-maze and in an elevated plus-maze at 2, 5 and 9 months old after exposure to Enriched Uranium (40 mg l-1) during gestation and lactation. The rats exposed to Enriched Uranium showed a significant decrease in alternation in the Y-maze at 2 months old which reflects a slight decrease in the spatial working memory capacities as previously described in adult rats. However, the main result was a delayed hyperactivity in the rats exposed to Enriched Uranium, which appeared to a slight extent at 5 months old and was more evident at 9 months old. Although this effect could not be directly explained by some Uranium accumulation in the target organs, this experiment showed that early exposure to Enriched Uranium can induce a very late effect on the rat behaviour and that such studies should not be restricted to the effects observed on young rats. © 2006 Elsevier Inc. All rights reserved.

  • Parental exposure to Enriched Uranium induced delayed hyperactivity in rat offspring.
    Neurotoxicology, 2006
    Co-Authors: P. Houpert, Sandrine Frelon, Philippe Lestaevel, Cyrill Bussy, Patrick Gourmelon, François Paquet
    Abstract:

    Several recent reports suggest that chronic exposure to Uranium could induce behavioural effects in adult rats. As the immature brains are known to be more susceptible to toxic effects, rats were observed in an open field, in a Y-maze and in an elevated plus-maze at 2, 5 and 9 months old after exposure to Enriched Uranium (40 mg l-1) during gestation and lactation. The rats exposed to Enriched Uranium showed a significant decrease in alternation in the Y-maze at 2 months old which reflects a slight decrease in the spatial working memory capacities as previously described in adult rats. However, the main result was a delayed hyperactivity in the rats exposed to Enriched Uranium, which appeared to a slight extent at 5 months old and was more evident at 9 months old. Although this effect could not be directly explained by some Uranium accumulation in the target organs, this experiment showed that early exposure to Enriched Uranium can induce a very late effect on the rat behaviour and that such studies should not be restricted to the effects observed on young rats.

P. Houpert - One of the best experts on this subject based on the ideXlab platform.

  • Parental exposure to Enriched Uranium induced delayed hyperactivity in rat offspring
    Neurotoxicology, 2007
    Co-Authors: P. Houpert, P. Gourmelon, Sandrine Frelon, Philippe Lestaevel, Cyrill Bussy, François Paquet
    Abstract:

    Several recent reports suggest that chronic exposure to Uranium could induce behavioural effects in adult rats. As the immature brains are known to be more susceptible to toxic effects, rats were observed in an open field, in a Y-maze and in an elevated plus-maze at 2, 5 and 9 months old after exposure to Enriched Uranium (40 mg l-1) during gestation and lactation. The rats exposed to Enriched Uranium showed a significant decrease in alternation in the Y-maze at 2 months old which reflects a slight decrease in the spatial working memory capacities as previously described in adult rats. However, the main result was a delayed hyperactivity in the rats exposed to Enriched Uranium, which appeared to a slight extent at 5 months old and was more evident at 9 months old. Although this effect could not be directly explained by some Uranium accumulation in the target organs, this experiment showed that early exposure to Enriched Uranium can induce a very late effect on the rat behaviour and that such studies should not be restricted to the effects observed on young rats. © 2006 Elsevier Inc. All rights reserved.

  • Parental exposure to Enriched Uranium induced delayed hyperactivity in rat offspring.
    Neurotoxicology, 2006
    Co-Authors: P. Houpert, Sandrine Frelon, Philippe Lestaevel, Cyrill Bussy, Patrick Gourmelon, François Paquet
    Abstract:

    Several recent reports suggest that chronic exposure to Uranium could induce behavioural effects in adult rats. As the immature brains are known to be more susceptible to toxic effects, rats were observed in an open field, in a Y-maze and in an elevated plus-maze at 2, 5 and 9 months old after exposure to Enriched Uranium (40 mg l-1) during gestation and lactation. The rats exposed to Enriched Uranium showed a significant decrease in alternation in the Y-maze at 2 months old which reflects a slight decrease in the spatial working memory capacities as previously described in adult rats. However, the main result was a delayed hyperactivity in the rats exposed to Enriched Uranium, which appeared to a slight extent at 5 months old and was more evident at 9 months old. Although this effect could not be directly explained by some Uranium accumulation in the target organs, this experiment showed that early exposure to Enriched Uranium can induce a very late effect on the rat behaviour and that such studies should not be restricted to the effects observed on young rats.

Sandrine Frelon - One of the best experts on this subject based on the ideXlab platform.

  • Parental exposure to Enriched Uranium induced delayed hyperactivity in rat offspring
    Neurotoxicology, 2007
    Co-Authors: P. Houpert, P. Gourmelon, Sandrine Frelon, Philippe Lestaevel, Cyrill Bussy, François Paquet
    Abstract:

    Several recent reports suggest that chronic exposure to Uranium could induce behavioural effects in adult rats. As the immature brains are known to be more susceptible to toxic effects, rats were observed in an open field, in a Y-maze and in an elevated plus-maze at 2, 5 and 9 months old after exposure to Enriched Uranium (40 mg l-1) during gestation and lactation. The rats exposed to Enriched Uranium showed a significant decrease in alternation in the Y-maze at 2 months old which reflects a slight decrease in the spatial working memory capacities as previously described in adult rats. However, the main result was a delayed hyperactivity in the rats exposed to Enriched Uranium, which appeared to a slight extent at 5 months old and was more evident at 9 months old. Although this effect could not be directly explained by some Uranium accumulation in the target organs, this experiment showed that early exposure to Enriched Uranium can induce a very late effect on the rat behaviour and that such studies should not be restricted to the effects observed on young rats. © 2006 Elsevier Inc. All rights reserved.

  • Parental exposure to Enriched Uranium induced delayed hyperactivity in rat offspring.
    Neurotoxicology, 2006
    Co-Authors: P. Houpert, Sandrine Frelon, Philippe Lestaevel, Cyrill Bussy, Patrick Gourmelon, François Paquet
    Abstract:

    Several recent reports suggest that chronic exposure to Uranium could induce behavioural effects in adult rats. As the immature brains are known to be more susceptible to toxic effects, rats were observed in an open field, in a Y-maze and in an elevated plus-maze at 2, 5 and 9 months old after exposure to Enriched Uranium (40 mg l-1) during gestation and lactation. The rats exposed to Enriched Uranium showed a significant decrease in alternation in the Y-maze at 2 months old which reflects a slight decrease in the spatial working memory capacities as previously described in adult rats. However, the main result was a delayed hyperactivity in the rats exposed to Enriched Uranium, which appeared to a slight extent at 5 months old and was more evident at 9 months old. Although this effect could not be directly explained by some Uranium accumulation in the target organs, this experiment showed that early exposure to Enriched Uranium can induce a very late effect on the rat behaviour and that such studies should not be restricted to the effects observed on young rats.

Philippe Lestaevel - One of the best experts on this subject based on the ideXlab platform.

  • Parental exposure to Enriched Uranium induced delayed hyperactivity in rat offspring
    Neurotoxicology, 2007
    Co-Authors: P. Houpert, P. Gourmelon, Sandrine Frelon, Philippe Lestaevel, Cyrill Bussy, François Paquet
    Abstract:

    Several recent reports suggest that chronic exposure to Uranium could induce behavioural effects in adult rats. As the immature brains are known to be more susceptible to toxic effects, rats were observed in an open field, in a Y-maze and in an elevated plus-maze at 2, 5 and 9 months old after exposure to Enriched Uranium (40 mg l-1) during gestation and lactation. The rats exposed to Enriched Uranium showed a significant decrease in alternation in the Y-maze at 2 months old which reflects a slight decrease in the spatial working memory capacities as previously described in adult rats. However, the main result was a delayed hyperactivity in the rats exposed to Enriched Uranium, which appeared to a slight extent at 5 months old and was more evident at 9 months old. Although this effect could not be directly explained by some Uranium accumulation in the target organs, this experiment showed that early exposure to Enriched Uranium can induce a very late effect on the rat behaviour and that such studies should not be restricted to the effects observed on young rats. © 2006 Elsevier Inc. All rights reserved.

  • Parental exposure to Enriched Uranium induced delayed hyperactivity in rat offspring.
    Neurotoxicology, 2006
    Co-Authors: P. Houpert, Sandrine Frelon, Philippe Lestaevel, Cyrill Bussy, Patrick Gourmelon, François Paquet
    Abstract:

    Several recent reports suggest that chronic exposure to Uranium could induce behavioural effects in adult rats. As the immature brains are known to be more susceptible to toxic effects, rats were observed in an open field, in a Y-maze and in an elevated plus-maze at 2, 5 and 9 months old after exposure to Enriched Uranium (40 mg l-1) during gestation and lactation. The rats exposed to Enriched Uranium showed a significant decrease in alternation in the Y-maze at 2 months old which reflects a slight decrease in the spatial working memory capacities as previously described in adult rats. However, the main result was a delayed hyperactivity in the rats exposed to Enriched Uranium, which appeared to a slight extent at 5 months old and was more evident at 9 months old. Although this effect could not be directly explained by some Uranium accumulation in the target organs, this experiment showed that early exposure to Enriched Uranium can induce a very late effect on the rat behaviour and that such studies should not be restricted to the effects observed on young rats.

Cyrill Bussy - One of the best experts on this subject based on the ideXlab platform.

  • Parental exposure to Enriched Uranium induced delayed hyperactivity in rat offspring
    Neurotoxicology, 2007
    Co-Authors: P. Houpert, P. Gourmelon, Sandrine Frelon, Philippe Lestaevel, Cyrill Bussy, François Paquet
    Abstract:

    Several recent reports suggest that chronic exposure to Uranium could induce behavioural effects in adult rats. As the immature brains are known to be more susceptible to toxic effects, rats were observed in an open field, in a Y-maze and in an elevated plus-maze at 2, 5 and 9 months old after exposure to Enriched Uranium (40 mg l-1) during gestation and lactation. The rats exposed to Enriched Uranium showed a significant decrease in alternation in the Y-maze at 2 months old which reflects a slight decrease in the spatial working memory capacities as previously described in adult rats. However, the main result was a delayed hyperactivity in the rats exposed to Enriched Uranium, which appeared to a slight extent at 5 months old and was more evident at 9 months old. Although this effect could not be directly explained by some Uranium accumulation in the target organs, this experiment showed that early exposure to Enriched Uranium can induce a very late effect on the rat behaviour and that such studies should not be restricted to the effects observed on young rats. © 2006 Elsevier Inc. All rights reserved.

  • Parental exposure to Enriched Uranium induced delayed hyperactivity in rat offspring.
    Neurotoxicology, 2006
    Co-Authors: P. Houpert, Sandrine Frelon, Philippe Lestaevel, Cyrill Bussy, Patrick Gourmelon, François Paquet
    Abstract:

    Several recent reports suggest that chronic exposure to Uranium could induce behavioural effects in adult rats. As the immature brains are known to be more susceptible to toxic effects, rats were observed in an open field, in a Y-maze and in an elevated plus-maze at 2, 5 and 9 months old after exposure to Enriched Uranium (40 mg l-1) during gestation and lactation. The rats exposed to Enriched Uranium showed a significant decrease in alternation in the Y-maze at 2 months old which reflects a slight decrease in the spatial working memory capacities as previously described in adult rats. However, the main result was a delayed hyperactivity in the rats exposed to Enriched Uranium, which appeared to a slight extent at 5 months old and was more evident at 9 months old. Although this effect could not be directly explained by some Uranium accumulation in the target organs, this experiment showed that early exposure to Enriched Uranium can induce a very late effect on the rat behaviour and that such studies should not be restricted to the effects observed on young rats.