The Experts below are selected from a list of 489 Experts worldwide ranked by ideXlab platform

Allan E. Johnson - One of the best experts on this subject based on the ideXlab platform.

  • neurochemical changes in the Entopeduncular Nucleus and increased oral behavior in rats treated subchronically with clozapine or haloperidol
    Synapse, 1999
    Co-Authors: Lillemor Kallstrom, F A Wiesel, Allan E. Johnson
    Abstract:

    Neurochemical changes in the Entopeduncular Nucleus and increased oral behavior in rats treated subchronically with clozapine or haloperidol

  • differential distribution of glutamate decarboxylase 65 and glutamate decarboxylase 67 messenger rnas in the Entopeduncular Nucleus of the rat
    Neuroscience, 1997
    Co-Authors: P.-q Yuan, C Grånäs, L Källström, Kim L. Huhman, Dan Larhammar, H. E. Albers, Allan E. Johnson
    Abstract:

    The Entopeduncular Nucleus is one of the major output nuclei of the basal ganglia, with topographically organized projections to both motor and limbic structures. Neurons of the Entopeduncular Nucleus use GABA as the principal transmitter, and glutamic acid decarboxylase (the GABA synthetic enzyme) is widely distributed throughout the region. Previous studies have shown that glutamate decarboxylase exists in two forms (glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67), and that the messenger RNAs for these different enzymes are widely distributed in rat brain. The purpose of the present experiment was to describe the distribution of glutamic acid decarboxylase-65 and glutamic decarboxylase-67 messenger RNAs throughout the Entopeduncular Nucleus using recently developed oligodeoxynucleotide probes and in situ hybridization histochemical methods. In agreement with previous studies, northern analysis of rat brain poly(A)+ messenger RNA preparations showed that the glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 probes used in the present study hybridized to messenger RNAs of approximately 5.7 and 3.7 kb, respectively. Film autoradiographic analysis revealed large region-dependent, isoform-specific differences in the levels of expression of the two messenger RNAs, with glutamic acid decarboxylase-65 messenger RNA predominating in rostral and medial regions of the Entopeduncular Nucleus and glutamic acid decarboxylase-67 messenger RNA most abundant in the caudal region. Cellular analysis showed that these region-dependent differences in labelling were due to differences in the relative amounts of glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 messenger RNAs expressed per cell rather than the number of cells expressing each form of glutamic acid decarboxylase messenger RNA. The differences in the distribution of glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 messenger RNAs are closely related to the organization of limbic and motor circuits of the Entopeduncular Nucleus, suggesting that GABAergic transmission through the limbic pathway is regulated predominantly by glutamic acid decarboxylase-65, whereas glutamic acid decarboxylase-67 is of principal importance in the motor pathway. These data provide additional evidence that the neurons of the limbic and motor subregions of the Entopeduncular Nucleus are neurochemically distinct.

  • Differential distribution of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs in the Entopeduncular Nucleus of the rat
    Neuroscience, 1997
    Co-Authors: P.-q Yuan, C Grånäs, L Källström, Kim L. Huhman, Dan Larhammar, H. E. Albers, Allan E. Johnson
    Abstract:

    Abstract The Entopeduncular Nucleus is one of the major output nuclei of the basal ganglia, with topographically organized projections to both motor and limbic structures. Neurons of the Entopeduncular Nucleus use GABA as the principal transmitter, and glutamate decarboxylase (the GABA synthetic enzyme) is widely distributed throughout the region. Previous studies have shown that glutamate decarboxylase exists in two forms (glutamate decarboxylase-65 and glutamate decarboxylase-67), and that the messenger RNAs for these different enzymes are widely distributed in rat brain. The purpose of the present experiment was to describe the distribution of glutamate decarboxylase-65 and glutamic decarboxylase-67 messenger RNAs throughout the Entopeduncular Nucleus using recently developed oligodeoxynucleotide probes and in situ hybridization histochemical methods. In agreement with previous studies, northern analysis of rat brain poly(A) + messenger RNA preparations showed that the glutamate decarboxylase-65 and glutamate decarboxylase-67 probes used in the present study hybridized to messenger RNAs of approximately 5.7 and 3.7 kb, respectively. Film autoradiographic analysis revealed large region-dependent, isoform-specific differences in the levels of expression of the two messenger RNAs, with glutamate decarboxylase-65 messenger RNA predominating in rostral and medial regions of the Entopeduncular Nucleus and glutamate decarboxylase-67 messenger RNA most abundant in the caudal region. Cellular analysis showed that these region-dependent differences in labelling were due to differences in the relative amounts of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs expressed per cell rather than the number of cells expressing each form of glutamate decarboxylase messenger RNA. The differences in the distribution of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs are closely related to the organization of limbic and motor circuits of the Entopeduncular Nucleus, suggesting that GABAergic transmission through the limbic pathway is regulated predominantly by glutamate decarboxylase-65, whereas glutamate decarboxylase-67 is of principal importance in the motor pathway. These data provide additional evidence that the neurons of the limbic and motor subregions of the Entopeduncular Nucleus are neurochemically distinct.

P.-q Yuan - One of the best experts on this subject based on the ideXlab platform.

  • differential distribution of glutamate decarboxylase 65 and glutamate decarboxylase 67 messenger rnas in the Entopeduncular Nucleus of the rat
    Neuroscience, 1997
    Co-Authors: P.-q Yuan, C Grånäs, L Källström, Kim L. Huhman, Dan Larhammar, H. E. Albers, Allan E. Johnson
    Abstract:

    The Entopeduncular Nucleus is one of the major output nuclei of the basal ganglia, with topographically organized projections to both motor and limbic structures. Neurons of the Entopeduncular Nucleus use GABA as the principal transmitter, and glutamic acid decarboxylase (the GABA synthetic enzyme) is widely distributed throughout the region. Previous studies have shown that glutamate decarboxylase exists in two forms (glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67), and that the messenger RNAs for these different enzymes are widely distributed in rat brain. The purpose of the present experiment was to describe the distribution of glutamic acid decarboxylase-65 and glutamic decarboxylase-67 messenger RNAs throughout the Entopeduncular Nucleus using recently developed oligodeoxynucleotide probes and in situ hybridization histochemical methods. In agreement with previous studies, northern analysis of rat brain poly(A)+ messenger RNA preparations showed that the glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 probes used in the present study hybridized to messenger RNAs of approximately 5.7 and 3.7 kb, respectively. Film autoradiographic analysis revealed large region-dependent, isoform-specific differences in the levels of expression of the two messenger RNAs, with glutamic acid decarboxylase-65 messenger RNA predominating in rostral and medial regions of the Entopeduncular Nucleus and glutamic acid decarboxylase-67 messenger RNA most abundant in the caudal region. Cellular analysis showed that these region-dependent differences in labelling were due to differences in the relative amounts of glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 messenger RNAs expressed per cell rather than the number of cells expressing each form of glutamic acid decarboxylase messenger RNA. The differences in the distribution of glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 messenger RNAs are closely related to the organization of limbic and motor circuits of the Entopeduncular Nucleus, suggesting that GABAergic transmission through the limbic pathway is regulated predominantly by glutamic acid decarboxylase-65, whereas glutamic acid decarboxylase-67 is of principal importance in the motor pathway. These data provide additional evidence that the neurons of the limbic and motor subregions of the Entopeduncular Nucleus are neurochemically distinct.

  • Differential distribution of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs in the Entopeduncular Nucleus of the rat
    Neuroscience, 1997
    Co-Authors: P.-q Yuan, C Grånäs, L Källström, Kim L. Huhman, Dan Larhammar, H. E. Albers, Allan E. Johnson
    Abstract:

    Abstract The Entopeduncular Nucleus is one of the major output nuclei of the basal ganglia, with topographically organized projections to both motor and limbic structures. Neurons of the Entopeduncular Nucleus use GABA as the principal transmitter, and glutamate decarboxylase (the GABA synthetic enzyme) is widely distributed throughout the region. Previous studies have shown that glutamate decarboxylase exists in two forms (glutamate decarboxylase-65 and glutamate decarboxylase-67), and that the messenger RNAs for these different enzymes are widely distributed in rat brain. The purpose of the present experiment was to describe the distribution of glutamate decarboxylase-65 and glutamic decarboxylase-67 messenger RNAs throughout the Entopeduncular Nucleus using recently developed oligodeoxynucleotide probes and in situ hybridization histochemical methods. In agreement with previous studies, northern analysis of rat brain poly(A) + messenger RNA preparations showed that the glutamate decarboxylase-65 and glutamate decarboxylase-67 probes used in the present study hybridized to messenger RNAs of approximately 5.7 and 3.7 kb, respectively. Film autoradiographic analysis revealed large region-dependent, isoform-specific differences in the levels of expression of the two messenger RNAs, with glutamate decarboxylase-65 messenger RNA predominating in rostral and medial regions of the Entopeduncular Nucleus and glutamate decarboxylase-67 messenger RNA most abundant in the caudal region. Cellular analysis showed that these region-dependent differences in labelling were due to differences in the relative amounts of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs expressed per cell rather than the number of cells expressing each form of glutamate decarboxylase messenger RNA. The differences in the distribution of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs are closely related to the organization of limbic and motor circuits of the Entopeduncular Nucleus, suggesting that GABAergic transmission through the limbic pathway is regulated predominantly by glutamate decarboxylase-65, whereas glutamate decarboxylase-67 is of principal importance in the motor pathway. These data provide additional evidence that the neurons of the limbic and motor subregions of the Entopeduncular Nucleus are neurochemically distinct.

H. E. Albers - One of the best experts on this subject based on the ideXlab platform.

  • differential distribution of glutamate decarboxylase 65 and glutamate decarboxylase 67 messenger rnas in the Entopeduncular Nucleus of the rat
    Neuroscience, 1997
    Co-Authors: P.-q Yuan, C Grånäs, L Källström, Kim L. Huhman, Dan Larhammar, H. E. Albers, Allan E. Johnson
    Abstract:

    The Entopeduncular Nucleus is one of the major output nuclei of the basal ganglia, with topographically organized projections to both motor and limbic structures. Neurons of the Entopeduncular Nucleus use GABA as the principal transmitter, and glutamic acid decarboxylase (the GABA synthetic enzyme) is widely distributed throughout the region. Previous studies have shown that glutamate decarboxylase exists in two forms (glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67), and that the messenger RNAs for these different enzymes are widely distributed in rat brain. The purpose of the present experiment was to describe the distribution of glutamic acid decarboxylase-65 and glutamic decarboxylase-67 messenger RNAs throughout the Entopeduncular Nucleus using recently developed oligodeoxynucleotide probes and in situ hybridization histochemical methods. In agreement with previous studies, northern analysis of rat brain poly(A)+ messenger RNA preparations showed that the glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 probes used in the present study hybridized to messenger RNAs of approximately 5.7 and 3.7 kb, respectively. Film autoradiographic analysis revealed large region-dependent, isoform-specific differences in the levels of expression of the two messenger RNAs, with glutamic acid decarboxylase-65 messenger RNA predominating in rostral and medial regions of the Entopeduncular Nucleus and glutamic acid decarboxylase-67 messenger RNA most abundant in the caudal region. Cellular analysis showed that these region-dependent differences in labelling were due to differences in the relative amounts of glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 messenger RNAs expressed per cell rather than the number of cells expressing each form of glutamic acid decarboxylase messenger RNA. The differences in the distribution of glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 messenger RNAs are closely related to the organization of limbic and motor circuits of the Entopeduncular Nucleus, suggesting that GABAergic transmission through the limbic pathway is regulated predominantly by glutamic acid decarboxylase-65, whereas glutamic acid decarboxylase-67 is of principal importance in the motor pathway. These data provide additional evidence that the neurons of the limbic and motor subregions of the Entopeduncular Nucleus are neurochemically distinct.

  • Differential distribution of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs in the Entopeduncular Nucleus of the rat
    Neuroscience, 1997
    Co-Authors: P.-q Yuan, C Grånäs, L Källström, Kim L. Huhman, Dan Larhammar, H. E. Albers, Allan E. Johnson
    Abstract:

    Abstract The Entopeduncular Nucleus is one of the major output nuclei of the basal ganglia, with topographically organized projections to both motor and limbic structures. Neurons of the Entopeduncular Nucleus use GABA as the principal transmitter, and glutamate decarboxylase (the GABA synthetic enzyme) is widely distributed throughout the region. Previous studies have shown that glutamate decarboxylase exists in two forms (glutamate decarboxylase-65 and glutamate decarboxylase-67), and that the messenger RNAs for these different enzymes are widely distributed in rat brain. The purpose of the present experiment was to describe the distribution of glutamate decarboxylase-65 and glutamic decarboxylase-67 messenger RNAs throughout the Entopeduncular Nucleus using recently developed oligodeoxynucleotide probes and in situ hybridization histochemical methods. In agreement with previous studies, northern analysis of rat brain poly(A) + messenger RNA preparations showed that the glutamate decarboxylase-65 and glutamate decarboxylase-67 probes used in the present study hybridized to messenger RNAs of approximately 5.7 and 3.7 kb, respectively. Film autoradiographic analysis revealed large region-dependent, isoform-specific differences in the levels of expression of the two messenger RNAs, with glutamate decarboxylase-65 messenger RNA predominating in rostral and medial regions of the Entopeduncular Nucleus and glutamate decarboxylase-67 messenger RNA most abundant in the caudal region. Cellular analysis showed that these region-dependent differences in labelling were due to differences in the relative amounts of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs expressed per cell rather than the number of cells expressing each form of glutamate decarboxylase messenger RNA. The differences in the distribution of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs are closely related to the organization of limbic and motor circuits of the Entopeduncular Nucleus, suggesting that GABAergic transmission through the limbic pathway is regulated predominantly by glutamate decarboxylase-65, whereas glutamate decarboxylase-67 is of principal importance in the motor pathway. These data provide additional evidence that the neurons of the limbic and motor subregions of the Entopeduncular Nucleus are neurochemically distinct.

Dan Larhammar - One of the best experts on this subject based on the ideXlab platform.

  • differential distribution of glutamate decarboxylase 65 and glutamate decarboxylase 67 messenger rnas in the Entopeduncular Nucleus of the rat
    Neuroscience, 1997
    Co-Authors: P.-q Yuan, C Grånäs, L Källström, Kim L. Huhman, Dan Larhammar, H. E. Albers, Allan E. Johnson
    Abstract:

    The Entopeduncular Nucleus is one of the major output nuclei of the basal ganglia, with topographically organized projections to both motor and limbic structures. Neurons of the Entopeduncular Nucleus use GABA as the principal transmitter, and glutamic acid decarboxylase (the GABA synthetic enzyme) is widely distributed throughout the region. Previous studies have shown that glutamate decarboxylase exists in two forms (glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67), and that the messenger RNAs for these different enzymes are widely distributed in rat brain. The purpose of the present experiment was to describe the distribution of glutamic acid decarboxylase-65 and glutamic decarboxylase-67 messenger RNAs throughout the Entopeduncular Nucleus using recently developed oligodeoxynucleotide probes and in situ hybridization histochemical methods. In agreement with previous studies, northern analysis of rat brain poly(A)+ messenger RNA preparations showed that the glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 probes used in the present study hybridized to messenger RNAs of approximately 5.7 and 3.7 kb, respectively. Film autoradiographic analysis revealed large region-dependent, isoform-specific differences in the levels of expression of the two messenger RNAs, with glutamic acid decarboxylase-65 messenger RNA predominating in rostral and medial regions of the Entopeduncular Nucleus and glutamic acid decarboxylase-67 messenger RNA most abundant in the caudal region. Cellular analysis showed that these region-dependent differences in labelling were due to differences in the relative amounts of glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 messenger RNAs expressed per cell rather than the number of cells expressing each form of glutamic acid decarboxylase messenger RNA. The differences in the distribution of glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 messenger RNAs are closely related to the organization of limbic and motor circuits of the Entopeduncular Nucleus, suggesting that GABAergic transmission through the limbic pathway is regulated predominantly by glutamic acid decarboxylase-65, whereas glutamic acid decarboxylase-67 is of principal importance in the motor pathway. These data provide additional evidence that the neurons of the limbic and motor subregions of the Entopeduncular Nucleus are neurochemically distinct.

  • Differential distribution of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs in the Entopeduncular Nucleus of the rat
    Neuroscience, 1997
    Co-Authors: P.-q Yuan, C Grånäs, L Källström, Kim L. Huhman, Dan Larhammar, H. E. Albers, Allan E. Johnson
    Abstract:

    Abstract The Entopeduncular Nucleus is one of the major output nuclei of the basal ganglia, with topographically organized projections to both motor and limbic structures. Neurons of the Entopeduncular Nucleus use GABA as the principal transmitter, and glutamate decarboxylase (the GABA synthetic enzyme) is widely distributed throughout the region. Previous studies have shown that glutamate decarboxylase exists in two forms (glutamate decarboxylase-65 and glutamate decarboxylase-67), and that the messenger RNAs for these different enzymes are widely distributed in rat brain. The purpose of the present experiment was to describe the distribution of glutamate decarboxylase-65 and glutamic decarboxylase-67 messenger RNAs throughout the Entopeduncular Nucleus using recently developed oligodeoxynucleotide probes and in situ hybridization histochemical methods. In agreement with previous studies, northern analysis of rat brain poly(A) + messenger RNA preparations showed that the glutamate decarboxylase-65 and glutamate decarboxylase-67 probes used in the present study hybridized to messenger RNAs of approximately 5.7 and 3.7 kb, respectively. Film autoradiographic analysis revealed large region-dependent, isoform-specific differences in the levels of expression of the two messenger RNAs, with glutamate decarboxylase-65 messenger RNA predominating in rostral and medial regions of the Entopeduncular Nucleus and glutamate decarboxylase-67 messenger RNA most abundant in the caudal region. Cellular analysis showed that these region-dependent differences in labelling were due to differences in the relative amounts of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs expressed per cell rather than the number of cells expressing each form of glutamate decarboxylase messenger RNA. The differences in the distribution of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs are closely related to the organization of limbic and motor circuits of the Entopeduncular Nucleus, suggesting that GABAergic transmission through the limbic pathway is regulated predominantly by glutamate decarboxylase-65, whereas glutamate decarboxylase-67 is of principal importance in the motor pathway. These data provide additional evidence that the neurons of the limbic and motor subregions of the Entopeduncular Nucleus are neurochemically distinct.

Kim L. Huhman - One of the best experts on this subject based on the ideXlab platform.

  • differential distribution of glutamate decarboxylase 65 and glutamate decarboxylase 67 messenger rnas in the Entopeduncular Nucleus of the rat
    Neuroscience, 1997
    Co-Authors: P.-q Yuan, C Grånäs, L Källström, Kim L. Huhman, Dan Larhammar, H. E. Albers, Allan E. Johnson
    Abstract:

    The Entopeduncular Nucleus is one of the major output nuclei of the basal ganglia, with topographically organized projections to both motor and limbic structures. Neurons of the Entopeduncular Nucleus use GABA as the principal transmitter, and glutamic acid decarboxylase (the GABA synthetic enzyme) is widely distributed throughout the region. Previous studies have shown that glutamate decarboxylase exists in two forms (glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67), and that the messenger RNAs for these different enzymes are widely distributed in rat brain. The purpose of the present experiment was to describe the distribution of glutamic acid decarboxylase-65 and glutamic decarboxylase-67 messenger RNAs throughout the Entopeduncular Nucleus using recently developed oligodeoxynucleotide probes and in situ hybridization histochemical methods. In agreement with previous studies, northern analysis of rat brain poly(A)+ messenger RNA preparations showed that the glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 probes used in the present study hybridized to messenger RNAs of approximately 5.7 and 3.7 kb, respectively. Film autoradiographic analysis revealed large region-dependent, isoform-specific differences in the levels of expression of the two messenger RNAs, with glutamic acid decarboxylase-65 messenger RNA predominating in rostral and medial regions of the Entopeduncular Nucleus and glutamic acid decarboxylase-67 messenger RNA most abundant in the caudal region. Cellular analysis showed that these region-dependent differences in labelling were due to differences in the relative amounts of glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 messenger RNAs expressed per cell rather than the number of cells expressing each form of glutamic acid decarboxylase messenger RNA. The differences in the distribution of glutamic acid decarboxylase-65 and glutamic acid decarboxylase-67 messenger RNAs are closely related to the organization of limbic and motor circuits of the Entopeduncular Nucleus, suggesting that GABAergic transmission through the limbic pathway is regulated predominantly by glutamic acid decarboxylase-65, whereas glutamic acid decarboxylase-67 is of principal importance in the motor pathway. These data provide additional evidence that the neurons of the limbic and motor subregions of the Entopeduncular Nucleus are neurochemically distinct.

  • Differential distribution of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs in the Entopeduncular Nucleus of the rat
    Neuroscience, 1997
    Co-Authors: P.-q Yuan, C Grånäs, L Källström, Kim L. Huhman, Dan Larhammar, H. E. Albers, Allan E. Johnson
    Abstract:

    Abstract The Entopeduncular Nucleus is one of the major output nuclei of the basal ganglia, with topographically organized projections to both motor and limbic structures. Neurons of the Entopeduncular Nucleus use GABA as the principal transmitter, and glutamate decarboxylase (the GABA synthetic enzyme) is widely distributed throughout the region. Previous studies have shown that glutamate decarboxylase exists in two forms (glutamate decarboxylase-65 and glutamate decarboxylase-67), and that the messenger RNAs for these different enzymes are widely distributed in rat brain. The purpose of the present experiment was to describe the distribution of glutamate decarboxylase-65 and glutamic decarboxylase-67 messenger RNAs throughout the Entopeduncular Nucleus using recently developed oligodeoxynucleotide probes and in situ hybridization histochemical methods. In agreement with previous studies, northern analysis of rat brain poly(A) + messenger RNA preparations showed that the glutamate decarboxylase-65 and glutamate decarboxylase-67 probes used in the present study hybridized to messenger RNAs of approximately 5.7 and 3.7 kb, respectively. Film autoradiographic analysis revealed large region-dependent, isoform-specific differences in the levels of expression of the two messenger RNAs, with glutamate decarboxylase-65 messenger RNA predominating in rostral and medial regions of the Entopeduncular Nucleus and glutamate decarboxylase-67 messenger RNA most abundant in the caudal region. Cellular analysis showed that these region-dependent differences in labelling were due to differences in the relative amounts of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs expressed per cell rather than the number of cells expressing each form of glutamate decarboxylase messenger RNA. The differences in the distribution of glutamate decarboxylase-65 and glutamate decarboxylase-67 messenger RNAs are closely related to the organization of limbic and motor circuits of the Entopeduncular Nucleus, suggesting that GABAergic transmission through the limbic pathway is regulated predominantly by glutamate decarboxylase-65, whereas glutamate decarboxylase-67 is of principal importance in the motor pathway. These data provide additional evidence that the neurons of the limbic and motor subregions of the Entopeduncular Nucleus are neurochemically distinct.