The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
M H J Van Oers - One of the best experts on this subject based on the ideXlab platform.
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coagulation abnormalities in type 1 gaucher disease are due to low grade activation and can be partly restored by Enzyme Supplementation therapy
British Journal of Haematology, 1997Co-Authors: C E M Hollak, Marcel Levi, F Berends, Johannes M F G Aerts, M H J Van OersAbstract:In type 1 Gaucher disease a bleeding tendency occurs which is partly caused by thrombocytopenia due to massive splenomegaly. In addition, low levels of factors IX and XI have been described. The mechanism responsible for these clotting factor abnormalities is unknown. We performed a detailed study of parameters of coagulation and fibrinolysis in 30 type 1 Gaucher disease patients (14 splenectomized) before and after treatment with Enzyme Supplementation therapy. Pre-treatment aPTT and PT were prolonged in 42% and 38% of patients, respectively. In 30-60% serious deficiencies (< 50%) of coagulation factors XI, XII, VII, X, V and II were observed. The low levels of factor V correlated with platelet count and were inversely associated with splenic volume. Levels of inhibitors were mildly decreased. Markers for activation of coagulation (thrombin-antithrombin (TAT) complex) and fibrinolysis (PAP complex, fibrin cleavage product D-dimer) were significantly elevated, especially in the splenectomized patients, indicating ongoing activation of these processes. After 12 months of Enzyme Supplementation therapy partial correction occurred. Thus, severe disorders of the coagulation system occur in Gaucher disease, contributing to the bleeding tendency. The deficiencies may be the result of consumption of coagulation factors caused by ongoing low-level coagulation activation. possibly due to mononuclear cell activation.
Hans Aerts - One of the best experts on this subject based on the ideXlab platform.
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dixon quantitative chemical shift imaging is a sensitive tool for the evaluation of bone marrow responses to individualized doses of Enzyme Supplementation therapy in type 1 gaucher disease
Blood Cells Molecules and Diseases, 2001Co-Authors: Carla E M Hollak, Mario Maas, Erik M Akkerman, Ard Den Heeten, Hans AertsAbstract:Type 1 Gaucher disease can be effectively treated with Enzyme Supplementation therapy. Bone disease is a debilitating feature of the disorder and results from infiltration of the bone marrow by Gaucher cells. The effect of treatment on bone marrow infiltration is difficult to measure, necessitating the development of sensitive techniques to allow adequate dosing. Dixon quantitative chemical shift imaging (Dixon-QCSI) is a MRI technique to measure displacement of fatty marrow by Gaucher cells. Low bone marrow fat fractions have been found in Gaucher disease. We studied the effect of individualized low doses of Enzyme therapy on the fat fractions of the lumbar spine in 12 adult Gaucher disease patients before and during treatment and in 9 untreated Gaucher controls. Fat fractions were decreased in 9/12 patients (median 0.20, range 0.08–0.40) and equally low in the untreated Gaucher controls compared to age-matched healthy volunteers (normal values 0.27–0.43, P < 0.01). During treatment, fat fractions increased significantly already after 1 year in 11/12 patients (P = 0.007). After 4 to 5 years, fat fractions normalized in 11/12 patients. Fat fractions remained low in the untreated Gaucher controls (P = 0.5 and 0.6 at 1 and 2 years, respectively). Six of 11 patients had a dose increase, which did not clearly affect fat fractions. Dixon-QCSI is a sensitive tool for the measurement of the response of bone marrow to Enzyme therapy.
G G Mateos - One of the best experts on this subject based on the ideXlab platform.
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influence of Enzyme Supplementation of diets and cooking flaking of maize on digestive traits and growth performance of broilers from 1 to 21 days of age
Animal Feed Science and Technology, 2009Co-Authors: M I Gracia, M A Latorre, R Lazaro, P Medel, M J Aranibar, E Jimenezmoreno, G G MateosAbstract:Abstract A trial was conducted to study the influence of cooking–flaking (C-F) of maize and Enzyme Supplementation (ES) of the diet on mucosa morphometry, digestive organ weight, dietary component digestibility and growth performance of broilers from 1 to 21 days of age. There were 4 treatments arranged factorially with 2 heat processings of maize (raw and C-F) and 2 levels (0 and 500 mg/kg) of an Enzyme complex with xylanase, protease and α-amylase activity. Dietary treatment did not affect any productive trait from 1 to 21 days of age. However, from 1 to 4 days of age, body weight gain (P
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influence of Enzyme Supplementation and heat processing of barley on digestive traits and productive performance of broilers
Poultry Science, 2008Co-Authors: M Garcia, M I Gracia, M A Latorre, R Lazaro, G G MateosAbstract:ABSTRACT We studied the influence of Enzyme Supplementation (ES) of the diet and heat processing (HP) of barley on digestive traits and productive performance of broilers from 1 to 42 d of age. There were 6 diets arranged factorially with 2 doses (0 and 500 ppm) of a fungal Enzyme complex with β-glucanase and xylanase activity and 3 HP of barley (raw, micronized, and expanded). In addition, a control diet based on raw corn without ES was also included from 1 to 21 d of age. Enzymes reduced intestinal viscosity (IV) at all ages (P ≤ 0.001) and water intake at 21 d of age (P ≤ 0.01) and increased DM of the ileal contents at 28 d (P ≤ 0.001). Also, ES increased total tract apparent retention of nutrients and BW gain and feed conversion ratio from 1 to 42 d of age (P ≤ 0.001). Heat processing of barley increased IV at 7 and at 28 d of age, and DM of ileal contents (P ≤ 0.05) at 28 d of age. In addition, HP improved feed intake (P ≤ 0.01) and BW gain (P ≤ 0.001) from 1 to 7 d of age, but the effects disappeared after 21 d of age. From 1 to 7 d of age, chicks fed micronized barley had higher IV, gained less weight, and had poorer feed conversion ratio than chicks fed expanded barley (P ≤ 0.05). It is concluded that barley with Enzymes can substitute for all of the corn in diets fed to broilers from 1 to 21 d of age. Enzymes improved digestive traits, retention of nutrients, and broiler performance from 1 to 42 d of age, and HP of barley improved performance from 1 to 7 d of age. The effects of HP of barley on broiler performance were more evident with expansion than with micronization.
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heat processing of barley and Enzyme Supplementation of diets for broilers
Poultry Science, 2003Co-Authors: M I Gracia, M A Latorre, M Garcia, R Lazaro, G G MateosAbstract:The influence of heat processing (HP) of barley and Enzyme Supplementation (ES) of the diet on digestive and performance traits of broilers to 21 d was studied. There were four treatments arranged factorially with two barley-processing treatments (raw or heated), two levels of ES (0 or 500 ppm), and five replicates per treatment. Chicks fed HP barley grew faster than broilers fed raw barley until 8 d of age, but the effect disappeared thereafter. In general, ES improved broiler performance at all ages. Intestinal viscosity was increased by HP of barley (P < or = 0.05) and reduced by ES (P < or = 0.001), and the decrease in viscosity caused by ES was greater for HP than for raw barley diets (HP x ES; P < or = 0.05). Heat processing of barley and ES of the diet improved apparent retention of nutrients (P < or = 0.001). Age affected apparent retention of nutrients differently. For starch and neutral detergent fiber, retention increased linearly with age (P < or = 0.01), but for the remaining nutrients the retention decreased from d 4 to 8 and then increased until d 21 (P < or = 0.001). Also, the beneficial effects of HP on retention of nutrients were more pronounced at younger ages (HP x age; P < or = 0.05). Both HP (P < or = 0.001) and ES (P < or = 0.01) increased liver weight, and Enzymes reduced the weights of pancreas (P < or = 0.05) and small intestine (P < or = 0.001). Villus height was improved by HP (P < or = 0.001) and ES (P < or = 0.01), but villus surface area was only improved by Enzymes (P < or = 0.01). It was concluded that broiler performance is improved by HP of barley at early ages and by ES of the diet throughout the trial. Also, HP and ES increased apparent retention of nutrients, AMEn of the diet, and villus height.
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processing of barley and Enzyme Supplementation in diets for young pigs
Animal Feed Science and Technology, 2002Co-Authors: P Medel, M I Gracia, F Baucells, C De Blas, G G MateosAbstract:Abstract Two trials were conducted to study the influence of heat processing (HP) of barley and Enzyme Supplementation (ES) to diets for young pigs. In trial one, six treatments arranged factorially with two types of barley processing (raw or cooked-flaked) and three levels of ES (0, 600 and 1200 mg/kg) were used. Each treatment was replicated four times and five piglets caged together formed the experimental unit. The Enzyme complex contained 3100 U α-amylase/g, 400 U xylanase/g and 225 U β-glucanase/g. Growth rate, feed intake and feed conversion were measured at 14 and 28 days. Coefficient of total tract apparent digestibility (CTTAD) of organic matter (OM), energy, crude protein (CP), ether extract (EE), crude fibre and starch were assessed at 14 days. In trial two, 16 piglets were used to measure ileal viscosity (VISC), apparent ileal digestibility of starch, pH at the stomach, caecum and colon and volatile fatty acid (VFA) concentration in the caecum. Only diets containing 0 or 600 mg ES/kg were used. From 0 to 14 days after weaning, piglets fed HP barley grew faster than piglets fed raw barley (0.213 kg per day versus 0.184 kg per day, P =0.050) but the effect disappeared thereafter. Barley processing increased coefficient of apparent ileal digestibility (CIAD) of starch (0.993 versus 0.984 for HP and raw barley diets; P =0.017) but VISC, digestive pH or VFA concentration of the caecum were not affected. None of the total tract digestibility coefficients studied was affected by dietary treatment. It is concluded that HP of barley improved piglet growth during the first 14 day post-weaning and increased apparent ileal digestibility of starch, but that ES had no effect on performance of piglets.
J. Fris Jensen - One of the best experts on this subject based on the ideXlab platform.
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Enzyme Supplementation of wheat-based diets for broilers
Animal Feed Science and Technology, 1998Co-Authors: Sanna Steenfeldt, Marianne Hammershøj, Anette Müllertz, J. Fris JensenAbstract:Abstract Two experiments were conducted to determine the effect of Enzyme Supplementation on the nitrogen-corrected apparent metabolisable energy (AMEn) and apparent nutrient digestibilities in ileum and excreta from male broiler chickens fed diets containing high amounts of wheat (>80%). Four different Enzyme preparations were added to the wheat-based diets in varying levels and combinations. The difference between Experiments 1 and 2 consisted in the addition of different Enzymes and Enzyme levels. Excreta and ileal content were collected from broiler chickens at 3 and 6 weeks of age. At 3 weeks of age Enzyme Supplementation increased (P
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Enzyme Supplementation of wheat-based diets for broilers 1. Effect on growth performance and intestinal viscosity
Animal Feed Science and Technology, 1998Co-Authors: Sanna Steenfeldt, Anette Müllertz, J. Fris JensenAbstract:Abstract The influence of Enzyme Supplementation on performance and intestinal viscosity of male broiler chickens fed with diets containing high amount of wheat was examined in three experiments. In the first experiment, addition with an Enzyme preparation including different cell wall degrading Enzymes to diets containing 63 g kg −1 and 72 g kg −1 of wheat improved ( P −1 wheat diet. In addition, intestinal viscosity of chickens fed with the 72 g kg −1 wheat diet was reduced ( P −1 and four different Enzyme preparations were used (two xylanase preparations, two mixed preparations). Overall, a significant effect on performance and intestinal viscosity of chickens was obtained as a result of Enzyme Supplementation in both experiments. In the first 21 days, improvements ( P P −1 .
C E M Hollak - One of the best experts on this subject based on the ideXlab platform.
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coagulation abnormalities in type 1 gaucher disease are due to low grade activation and can be partly restored by Enzyme Supplementation therapy
British Journal of Haematology, 1997Co-Authors: C E M Hollak, Marcel Levi, F Berends, Johannes M F G Aerts, M H J Van OersAbstract:In type 1 Gaucher disease a bleeding tendency occurs which is partly caused by thrombocytopenia due to massive splenomegaly. In addition, low levels of factors IX and XI have been described. The mechanism responsible for these clotting factor abnormalities is unknown. We performed a detailed study of parameters of coagulation and fibrinolysis in 30 type 1 Gaucher disease patients (14 splenectomized) before and after treatment with Enzyme Supplementation therapy. Pre-treatment aPTT and PT were prolonged in 42% and 38% of patients, respectively. In 30-60% serious deficiencies (< 50%) of coagulation factors XI, XII, VII, X, V and II were observed. The low levels of factor V correlated with platelet count and were inversely associated with splenic volume. Levels of inhibitors were mildly decreased. Markers for activation of coagulation (thrombin-antithrombin (TAT) complex) and fibrinolysis (PAP complex, fibrin cleavage product D-dimer) were significantly elevated, especially in the splenectomized patients, indicating ongoing activation of these processes. After 12 months of Enzyme Supplementation therapy partial correction occurred. Thus, severe disorders of the coagulation system occur in Gaucher disease, contributing to the bleeding tendency. The deficiencies may be the result of consumption of coagulation factors caused by ongoing low-level coagulation activation. possibly due to mononuclear cell activation.