The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Marcel F. Jonkman - One of the best experts on this subject based on the ideXlab platform.
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bullous Eosinophilic Cellulitis wells syndrome associated with churg strauss syndrome
Journal of The European Academy of Dermatology and Venereology, 2003Co-Authors: Marielouise Schuttelaar, Marcel F. JonkmanAbstract:We report a patient with Churg-Strauss syndrome (CSS) with asthma, eosinophilia, nasal polyposis and ANCA-associated multisystem vasculitis, who's skin eruption started with erythematous urticarial-plaques followed by haemorrhagic bullae. Histology of the plaques revealed 'flame figures' in the dermis with no granulomatous or vasculitic process, consistent with the diagnosis of Eosinophilic Cellulitis or Wells' syndrome. The association of CSS and Wells' syndrome observed in this patient may have a common pathogenesis. CSS may induce Wells' syndrome by an unknown factor.
Marielouise Schuttelaar - One of the best experts on this subject based on the ideXlab platform.
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bullous Eosinophilic Cellulitis wells syndrome associated with churg strauss syndrome
Journal of The European Academy of Dermatology and Venereology, 2003Co-Authors: Marielouise Schuttelaar, Marcel F. JonkmanAbstract:We report a patient with Churg-Strauss syndrome (CSS) with asthma, eosinophilia, nasal polyposis and ANCA-associated multisystem vasculitis, who's skin eruption started with erythematous urticarial-plaques followed by haemorrhagic bullae. Histology of the plaques revealed 'flame figures' in the dermis with no granulomatous or vasculitic process, consistent with the diagnosis of Eosinophilic Cellulitis or Wells' syndrome. The association of CSS and Wells' syndrome observed in this patient may have a common pathogenesis. CSS may induce Wells' syndrome by an unknown factor.
Giovanni Genovese - One of the best experts on this subject based on the ideXlab platform.
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Eosinophilic Dermatoses: Recognition and Management
American Journal of Clinical Dermatology, 2020Co-Authors: Angelo Valerio Marzano, Giovanni GenoveseAbstract:Eosinophilic dermatoses encompass a broad spectrum of diseases of different etiologies hallmarked by Eosinophilic infiltration of the skin and/or mucous membranes, with or without associated blood eosinophilia. The wide range of dermatological manifestations of this spectrum, including nodules and plaques, pustules, blisters, ulcers, and urticarial lesions, is reflected in a non-univocal classification system. We identified six groups of Eosinophilic dermatoses based on the predominant anatomic level of involvement: (1) epidermal; (2) of the dermal–epidermal junction; (3) dermal; (4) of the hypodermis and muscle fascia; (5) of the pilosebaceous unit; and (6) vascular/perivascular. We review clinicopathologic features and management of diseases belonging to each group, particularly: (1) pemphigus herpetiformis and atopic dermatitis as prototypes of the epidermal group; (2) bullous pemphigoid as prototypic Eosinophilic dermatosis of the dermal–epidermal junction; (3) Eosinophilic Cellulitis (Wells syndrome), hyperEosinophilic syndromes, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, Eosinophilic dermatosis of hematologic malignancy and chronic spontaneous urticaria as paradigmatic dermal Eosinophilic dermatoses; (4) Eosinophilic fasciitis as an Eosinophilic dermatosis with predominant involvement of the hypodermis and muscle fascia; (5) Eosinophilic pustular folliculitis as a model of the pilosebaceous unit involvement; and (6) granuloma faciale, angiolymphoid hyperplasia with eosinophilia, and Eosinophilic granulomatosis with polyangiitis, belonging to the vascular/perivascular group.
Noriko Ohgou - One of the best experts on this subject based on the ideXlab platform.
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Eosinophilic Cellulitis as a cutaneous manifestation of idiopathic hyperEosinophilic syndrome
Journal of The American Academy of Dermatology, 2003Co-Authors: Kimio Fujii, Hiroshi Tanabe, Yuko Kanno, Kenji Konishi, Noriko OhgouAbstract:Three patients with Eosinophilic Cellulitis associated with sustained peripheral blood eosinophilia of unidentified cause are reported. They also presented with diversities of extracutaneous symptoms such as bronchospasm, sensory polyneuropathies, epigastralgia, and gangrenous Eosinophilic enteritis. These cases suggest that Eosinophilic Cellulitis can develop as a cutaneous manifestation of idiopathic hyperEosinophilic syndrome.
Peter Elsner - One of the best experts on this subject based on the ideXlab platform.
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treatment of Eosinophilic Cellulitis wells syndrome a systematic review
Journal of The European Academy of Dermatology and Venereology, 2016Co-Authors: F Rasler, J. Lukács, Peter ElsnerAbstract:Eosinophilic Cellulitis (Wells syndrome) is a rare inflammatory skin disease defined by erythematous, tender, sometimes urticarial plaques, possibly with vesicles and bullae, and granulomatous Eosinophilic infiltrates in the dermis. Usually the disease has a benign course with spontaneous remission within a few weeks. Nevertheless, recurrences are quite frequent and may occur for several years. The objective of this study was to review the so far reported treatment options for Wells syndrome in a systematic manner. This systematic review is based on a search on Medline, Embase and Cochrane Central Register for English and German articles from 1970 to 2015. Advices on the treatment of Wells syndrome are limited predominately to case reports or to small case series. There are no randomized controlled trials, and control groups are missing. A variety of treatment options for Wells syndrome were reported including topical and systemic corticosteroids, antihistamines, cyclosporine, dapsone, azathioprine, griseofulvin, doxycycline, minocycline, antimalarial medications, oral tacrolimus/topical tacrolimus, sulfasalazine, interferon alpha and gamma, TNF alpha inhibitors, colchicine and PUVA therapy. As well-designed, randomized controlled trials are missing, no guidelines for the treatment of this disease can be given. Due to the small number of patients and the frequent misdiagnosis of this clinical entity, the aim of this systematic overview is to call attention to this rare condition and to help clinicians to diagnose and treat Wells syndrome effectively. Due to the good prognosis and tendency to resolve, systemic treatment should be limited to cases resistant to local therapy or with widespread lesions.
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Life of lesions in Eosinophilic Cellulitis (Wells' syndrome)-a condition that may be missed at first sight.
The American Journal of dermatopathology, 2015Co-Authors: Melanie Peckruhn, Joerg Tittelbach, Sibylle Schliemann, Peter ElsnerAbstract:Eosinophilic Cellulitis is an inflammation of, until now, unknown etiology that was first described by George Wells in 1971. Its dominating histological hallmarks are so-called "flame figures" and an Eosinophilic infiltrate. Here, we report the case of a 46-year-old man who initially presented with excoriated papules that were histologically interpreted as consistent with "arthropod reactions." Later on, the clinical presentation changed to erythematous plaques, partially with cockade-like aspects. At this time, new biopsies were performed showing a superficial and deep perivascular lymphocytic and heavily Eosinophilic infiltrate and flame figures, thus allowing to establish the diagnosis of Wells' syndrome. Under treatment with oral prednisolone and dapsone, the patient showed a rapid improvement of the condition. The presented case demonstrates both the clinical and histopathologic life of lesions of Well's syndrome in the course of the disease from unspecific to distinctive. The need for repeated biopsies is discussed. Current understanding of the pathogenesis of Wells' syndrome and its correlating histological features are elucidated.