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Evan S Dellon - One of the best experts on this subject based on the ideXlab platform.

  • combination therapy with elimination diet and corticosteroids is effective for adults with Eosinophilic Esophagitis
    Clinical Gastroenterology and Hepatology, 2019
    Co-Authors: Craig C Reed, Swathi Eluri, Nicholas J Shaheen, Manaswita Tappata, Evan S Dellon
    Abstract:

    Eosinophilic Esophagitis (EoE) is a chronic immune/antigen-mediated disorder defined by Eosinophilic-predominant inflammation and esophageal dysfunction.1,2 EoE represents an important cause of esophageal morbidity and a leading cause of Esophagitis.3.

  • normalized serum eosinophil peroxidase levels are inversely correlated with esophageal eosinophilia in Eosinophilic Esophagitis
    Diseases of The Esophagus, 2018
    Co-Authors: Benjamin L Wright, Evan S Dellon, Sergei I Ochkur, N S Olson, Kelly P Shim, Elizabeth A Jacobsen, Matthew A Rank, James J. Lee
    Abstract:

    Eosinophil peroxidase is an eosinophil-specific, cytoplasmic protein stored in the secondary granules of eosinophils. While eosinophil peroxidase deposition is increased in the esophagus in Eosinophilic Esophagitis (EOE), its potential role as a peripheral marker is unknown. This study aims to examine the relationship between serum eosinophil peroxidase and esophageal eosinophilia in Eosinophilic Esophagitis. Prospectively collected serum from 19 subjects with incident EoE prior to treatment and 20 non-EoE controls were tested for serum eosinophil peroxidase, Eosinophilic cationic protein, and eosinophil derived neurotoxin using ELISA. Matching esophageal tissue sections were stained and assessed for eosinophil peroxidase deposition using a histopathologic scoring algorithm. Mean peripheral blood absolute eosinophil counts in Eosinophilic Esophagitis subjects were significantly elevated compared to controls (363 vs. 195 cells/μL, P = 0.008). Absolute median serum eosinophil peroxidase, eosinophil cationic protein, and eosinophil derived neurotoxin did not differ between groups; however, when normalized for absolute eosinophil counts, Eosinophilic Esophagitis subjects had significantly lower median eosinophil peroxidase levels (2.56 vs. 6.96 ng/mL per eos/μL, P = 0.002, AUC 0.79 (0.64, 0.94 95% CI)). Multivariate analysis demonstrated this relationship persisted after controlling for atopy. Esophageal biopsies from Eosinophilic Esophagitis subjects demonstrated marked eosinophil peroxidase deposition (median score 46 vs. 0, P < 0.0001). Normalized eosinophil peroxidase levels inversely correlated with esophageal eosinophil density (r = -0.41, P = 0.009). In contrast to marked tissue eosinophil degranulation, circulating eosinophils appear to retain their granule proteins in EoE. Investigations of normalized serum eosinophil peroxidase levels as a biomarker of EoE are ongoing.

  • pathophysiology of Eosinophilic Esophagitis
    Gastroenterology, 2018
    Co-Authors: Kelly M Oshea, Jonathan M Spergel, Glenn T Furuta, Evan S Dellon, Seema S Aceves, Sandeep K Gupta, Marc E Rothenberg
    Abstract:

    Eosinophilic Esophagitis is an emerging disease that is distinguished from gastroesophageal reflux disease by the expression of a unique esophageal transcriptome and the interplay of early life environmental factors with distinct genetic susceptibility elements at 5q22 (TSLP) and 2p23 (CAPN14). Rare genetic syndromes have uncovered the contribution of barrier disruption, mediated in part by defective desmosomes and dysregulated transforming growth factor beta production and signaling, to Eosinophilic Esophagitis pathophysiology. Experimental modeling has defined a cooperative role of activated eosinophils, mast cells, and the cytokines IL-5 and IL-13, mediated by allergic sensitization to multiple foods. Understanding these processes is opening the way to better treatment based on disrupting allergic inflammatory and type 2 cytokine–mediated responses, including anti-cytokine therapeutics and dietary therapy.

  • lack of knowledge and low readiness for health care transition in Eosinophilic Esophagitis and Eosinophilic gastroenteritis
    Journal of Pediatric Gastroenterology and Nutrition, 2017
    Co-Authors: Swathi Eluri, Jessica H Gebhart, Wendy Book, Ellyn Kodroff, Mary Jo Strobel, Patricia D Jones, Paul Menardkatcher, Maria E Ferris, Evan S Dellon
    Abstract:

    ABSTRACTObjectives:A growing population of adolescents/young adults with Eosinophilic Esophagitis (EoE) and Eosinophilic gastroenteritis (EGE) will need to transition from pediatric to adult health providers. Measuring health care transition (HCT) readiness is critical, but no studies have evaluated

  • diminishing effectiveness of long term maintenance topical steroid therapy in ppi non responsive Eosinophilic Esophagitis
    Clinical and translational gastroenterology, 2017
    Co-Authors: Swathi Eluri, John T Woosley, Nicholas J Shaheen, Thomas M Runge, Jason Hansen, Bharati Kochar, Craig C Reed, Benjamin Robey, Evan S Dellon
    Abstract:

    Diminishing Effectiveness of Long-Term Maintenance Topical Steroid Therapy in PPI Non-Responsive Eosinophilic Esophagitis

Nicholas J Shaheen - One of the best experts on this subject based on the ideXlab platform.

John T Woosley - One of the best experts on this subject based on the ideXlab platform.

Xiaoxin Chen - One of the best experts on this subject based on the ideXlab platform.

Swathi Eluri - One of the best experts on this subject based on the ideXlab platform.