The Experts below are selected from a list of 60 Experts worldwide ranked by ideXlab platform

Yasuhide Hayashi - One of the best experts on this subject based on the ideXlab platform.

  • Eosinophilic Gastrointestinal Disorder in an infant with feeding dysfunction
    International Archives of Allergy and Immunology, 2012
    Co-Authors: Yoshiyuki Yamada, Masahiko Kato, Fumiaki Toki, Mio Watanabe, Akira Nishi, Ikue Matsushita, Junko Hirato, Yasuhide Hayashi
    Abstract:

    Feeding dysfunction (FD) has recently been considered to comprise a prevalent set of symptoms in Eosinophilic Gastrointestinal Disorders (EGIDs) in young children. We report the case of an 8-month-old

  • Eosinophilic Gastrointestinal Disorder in an infant with feeding dysfunction.
    International archives of allergy and immunology, 2012
    Co-Authors: Yoshiyuki Yamada, Masahiko Kato, Fumiaki Toki, Mio Watanabe, Akira Nishi, Ikue Matsushita, Junko Hirato, Yasuhide Hayashi
    Abstract:

    Feeding dysfunction (FD) has recently been considered to comprise a prevalent set of symptoms in Eosinophilic Gastrointestinal Disorders (EGIDs) in young children. We report the case of an 8-month-old girl with an EGID who visited our hospital due to vomiting, poor weight gain and feeding difficulties; her condition was discovered during the examination of the symptoms including FD. Tracheal aspiration and reduced esophageal clearance showed up in a barium swallow test and upper Gastrointestinal contrast radiography, respectively. Delayed clearance from the stomach was also detected on Gastrointestinal scintigraphy. Gastrointestinal endoscopy and biopsies revealed esophagitis with some eosinophils and duodenitis with Eosinophilic inflammation. She was not a likely candidate for Eosinophilic esophagitis. On administration of an elemental diet, the patient gained weight. Esophageal and stomach clearance subsequently improved, although the vomiting and FD persisted to some extent. We conclude that it is important to consider other EGIDs as well as Eosinophilic esophagitis in the differential diagnosis of FD.

Yoshiyuki Yamada - One of the best experts on this subject based on the ideXlab platform.

  • Eosinophilic Gastrointestinal Disorder in an infant with feeding dysfunction
    International Archives of Allergy and Immunology, 2012
    Co-Authors: Yoshiyuki Yamada, Masahiko Kato, Fumiaki Toki, Mio Watanabe, Akira Nishi, Ikue Matsushita, Junko Hirato, Yasuhide Hayashi
    Abstract:

    Feeding dysfunction (FD) has recently been considered to comprise a prevalent set of symptoms in Eosinophilic Gastrointestinal Disorders (EGIDs) in young children. We report the case of an 8-month-old

  • Eosinophilic Gastrointestinal Disorder in an infant with feeding dysfunction.
    International archives of allergy and immunology, 2012
    Co-Authors: Yoshiyuki Yamada, Masahiko Kato, Fumiaki Toki, Mio Watanabe, Akira Nishi, Ikue Matsushita, Junko Hirato, Yasuhide Hayashi
    Abstract:

    Feeding dysfunction (FD) has recently been considered to comprise a prevalent set of symptoms in Eosinophilic Gastrointestinal Disorders (EGIDs) in young children. We report the case of an 8-month-old girl with an EGID who visited our hospital due to vomiting, poor weight gain and feeding difficulties; her condition was discovered during the examination of the symptoms including FD. Tracheal aspiration and reduced esophageal clearance showed up in a barium swallow test and upper Gastrointestinal contrast radiography, respectively. Delayed clearance from the stomach was also detected on Gastrointestinal scintigraphy. Gastrointestinal endoscopy and biopsies revealed esophagitis with some eosinophils and duodenitis with Eosinophilic inflammation. She was not a likely candidate for Eosinophilic esophagitis. On administration of an elemental diet, the patient gained weight. Esophageal and stomach clearance subsequently improved, although the vomiting and FD persisted to some extent. We conclude that it is important to consider other EGIDs as well as Eosinophilic esophagitis in the differential diagnosis of FD.

Pierre Ellul - One of the best experts on this subject based on the ideXlab platform.

  • Eosinophilic Gastrointestinal Disorder is it what it seems to be
    Annals of Gastroenterology, 2018
    Co-Authors: Stefania Chetcuti Zammit, Monique Cachia, Karen Sapiano, Julia Gauci, Stephen Montefort, Pierre Ellul
    Abstract:

    Background: Eosinophilic gastroenteropathy is an uncommon condition whose causes can be numerous and non-specific. The aim of the study was to characterize the presence of Gastrointestinal Disorders in the adult Maltese population and assess the degree of association with atopic diseases. Methods: Adult patients with Gastrointestinal eosinophilia in the Gastrointestinal tract on histology were identified and their clinical case notes were reviewed. Patients were interviewed and asked questions regarding asthma, allergic rhinitis, and eczema. Results: Sixty-six patients (39 female) were recruited. The most common clinical symptoms were diarrhea (42.4%) and abdominal pain (33.3%). The sites involved were stomach (10.6%), colon (56.1%), small bowel (10.6%), small bowel and colon (18.2%), esophagus (1.5%), and esophagus and colon (1.5%). Forty percent had persistent lower Gastrointestinal symptoms and a repeat ileocolonoscopy was performed within 12 months. These patients were diagnosed with ulcerative colitis (n=10; 47.6%), Crohn's disease (n=6; 28.6%), indeterminate colitis (n=1; 4.8%) or microscopic colitis (n=4; 19%). Allergic rhinitis was present in 39.4% of the study group, eczema in 26.1%, and asthma in 19.7%. These findings were compared with local data for atopic conditions and the study group was found to have a significantly higher prevalence of allergic rhinitis (P=0.002), but not of asthma (P=0.62) or eczema (P=0.19). Conclusions: A high proportion of patients with Eosinophilic Gastrointestinal infiltration were subsequently diagnosed with inflammatory bowel disease. Patients persistently symptomatic or who do not respond to treatment should be reassessed to exclude inflammatory bowel disease, given its high prevalence in this group of patients.

  • Eosinophilic Gastrointestinal Disorder: is it what it seems to be?
    Annals of Gastroenterology, 2018
    Co-Authors: Stefania Chetcuti Zammit, Monique Cachia, Karen Sapiano, Julia Gauci, Stephen Montefort, Pierre Ellul
    Abstract:

    Background: Eosinophilic gastroenteropathy is an uncommon condition whose causes can be numerous and non-specific. The aim of the study was to characterize the presence of Gastrointestinal Disorders in the adult Maltese population and assess the degree of association with atopic diseases. Methods: Adult patients with Gastrointestinal eosinophilia in the Gastrointestinal tract on histology were identified and their clinical case notes were reviewed. Patients were interviewed and asked questions regarding asthma, allergic rhinitis, and eczema. Results: Sixty-six patients (39 female) were recruited. The most common clinical symptoms were diarrhea (42.4%) and abdominal pain (33.3%). The sites involved were stomach (10.6%), colon (56.1%), small bowel (10.6%), small bowel and colon (18.2%), esophagus (1.5%), and esophagus and colon (1.5%). Forty percent had persistent lower Gastrointestinal symptoms and a repeat ileocolonoscopy was performed within 12 months. These patients were diagnosed with ulcerative colitis (n=10; 47.6%), Crohn's disease (n=6; 28.6%), indeterminate colitis (n=1; 4.8%) or microscopic colitis (n=4; 19%). Allergic rhinitis was present in 39.4% of the study group, eczema in 26.1%, and asthma in 19.7%. These findings were compared with local data for atopic conditions and the study group was found to have a significantly higher prevalence of allergic rhinitis (P=0.002), but not of asthma (P=0.62) or eczema (P=0.19). Conclusions: A high proportion of patients with Eosinophilic Gastrointestinal infiltration were subsequently diagnosed with inflammatory bowel disease. Patients persistently symptomatic or who do not respond to treatment should be reassessed to exclude inflammatory bowel disease, given its high prevalence in this group of patients.

Eldon A. Shaffer - One of the best experts on this subject based on the ideXlab platform.

  • Eosinophilic colitis an update on pathophysiology and treatment
    British Medical Bulletin, 2011
    Co-Authors: Abdulrahman A Alfadda, Martin Storr, Eldon A. Shaffer
    Abstract:

    Background: Primary Eosinophilic Gastrointestinal Disorders, a spectrum of inflammatory conditions, occurs when eosinophils selectively infiltrate the gut in the absence of known causes for such tissue eosinophilia. These may be classified into Eosinophilic esophagitis, Eosinophilic gastroenteritis and Eosinophilic colitis (EC). This review focuses on EC: its pathogenesis, epidemiology, clinical presentation, diagnosis and current approach to treatment. Sources of data: A literature review published in English was performed using Pubmed, Ovid, Google scholar search engines with the following keywords: Eosinophilic Gastrointestinal Disorder, EC, eosinophils, colitis and Gastrointestinal. Areas of agreement: The basis for primary EC appears related to increased sensitivity to allergens, principally as a food allergy in infants and a T lymphocyte-mediated event in adults. Endoscopic changes are generally modest, featuring edema and patchy granularity. Areas of controversy: Clear clinical and pathological diagnostic criteria of EC and its management strategy. Growing points: Intestinal involvement of EC is primarily mucosal, presenting as a mild self-limited proctitis in infants and self-limited colitis in young adults. Therapeutic approaches based on case reports tend to use either elimination diets to avoid a presumed allergen; agents traditionally used in inflammatory disease or targeted drugs like anti-histamines or leukotriene receptor antagonists. Areas timely for developing research: Prospective randomized controlled trials addressing the disease natural history, possible preventive methods and effective medical approach and long-term prognosis are required.

Martin Storr - One of the best experts on this subject based on the ideXlab platform.

  • Eosinophilic colitis an update on pathophysiology and treatment
    British Medical Bulletin, 2011
    Co-Authors: Abdulrahman A Alfadda, Martin Storr, Eldon A. Shaffer
    Abstract:

    Background: Primary Eosinophilic Gastrointestinal Disorders, a spectrum of inflammatory conditions, occurs when eosinophils selectively infiltrate the gut in the absence of known causes for such tissue eosinophilia. These may be classified into Eosinophilic esophagitis, Eosinophilic gastroenteritis and Eosinophilic colitis (EC). This review focuses on EC: its pathogenesis, epidemiology, clinical presentation, diagnosis and current approach to treatment. Sources of data: A literature review published in English was performed using Pubmed, Ovid, Google scholar search engines with the following keywords: Eosinophilic Gastrointestinal Disorder, EC, eosinophils, colitis and Gastrointestinal. Areas of agreement: The basis for primary EC appears related to increased sensitivity to allergens, principally as a food allergy in infants and a T lymphocyte-mediated event in adults. Endoscopic changes are generally modest, featuring edema and patchy granularity. Areas of controversy: Clear clinical and pathological diagnostic criteria of EC and its management strategy. Growing points: Intestinal involvement of EC is primarily mucosal, presenting as a mild self-limited proctitis in infants and self-limited colitis in young adults. Therapeutic approaches based on case reports tend to use either elimination diets to avoid a presumed allergen; agents traditionally used in inflammatory disease or targeted drugs like anti-histamines or leukotriene receptor antagonists. Areas timely for developing research: Prospective randomized controlled trials addressing the disease natural history, possible preventive methods and effective medical approach and long-term prognosis are required.