The Experts below are selected from a list of 87 Experts worldwide ranked by ideXlab platform
Sang-sik Choi - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of continuous Epidural infusion with Epidural electric stimulation compared to that of conventional continuous Epidural infusion for acute herpes zoster management: a retrospective study
BMC Anesthesiology, 2020Co-Authors: Chung Hun Lee, Mi Kyoung Lee, Sang-sik Choi, Yeon Joo Lee, Jong Sun ParkAbstract:Background Continuous Epidural infusions are commonly used in clinical settings to reduce the likelihood of transition to postherpetic neuralgia via pain control. The purpose of this study was to compare the efficacy of conventional continuous Epidural infusion to that of continuous Epidural infusion in which the catheter is guided by electric stimulation to areas with neurological damage for the treatment of zoster-related pain and prevention of postherpetic neuralgia. Methods We analyzed the medical records of 114 patients in this study. The patients were divided into two groups: contrast (conventional continuous Epidural infusion) and stimulation (continuous Epidural infusion with Epidural electric stimulation). In the contrast group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the stimulation group, the site of herpes zoster infection was identified through electric stimulation using a guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2 and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6-month follow-up period after each procedure. Results After adjusting for confounding variables, the pain score was significantly lower in the stimulation group than in the contrast group for 6 months after the procedure. After adjustment, the odds of complete remission were 1.9-times higher in the stimulation group than in the contrast group (95% confidence interval [CI]: 0.81–4.44, P = 0.14). Patients in the contrast group were significantly more likely to require other interventions within 6 months of the procedure than patients in the stimulation group (odds ratio: 3.62, 95% CI: 1.17–11.19, P = 0.03). Conclusion Epidural Drug Administration to specific spinal segments using electric stimulation catheters may be more helpful than conventional continuous Epidural infusion for improving pain and preventing postherpetic neuralgia in the acute phase of herpes zoster.
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A new technique of Epidural and intrathecal catheterization to evaluate pharmacokinetics of Epidural Administration in dogs: a prospective study
2019Co-Authors: Myoung Hoon Kong, Jung Eun Kim, Mi Kyoung Lee, Chung Hun Lee, Yeon Joo Lee, Sang-sik ChoiAbstract:Abstract Background: Experimental research on animals should be performed before applying new treatment modalities in humans. Among experimental animal models, canine model research is a commonly used method. Injecting Drugs into the Epidural has also been commonly used in the canine animal model. In canine models, Epidural catheters are often inserted into the lumbosacral area during Epidural Drug injection. Unlike the existing canine model, we describe a new and alternative technique of Epidural and intrathecal catheterization to investigate methods of Epidural Drug Administration in dogs. Methods: Twelve adult dogs were used in this study. The Epidural procedures were performed with dogs in sternal recumbency under deep sedation. Epidural catheterization was perforemed at the T1-T2 intervertebral space with C-arm fluoroscopy guidance. After confirming the loss of resistance, a flexible Epidural catheter was passed cranially to the C2-C3 level. The intrathecal procedures were performed with dogs in lateral recumbency under deep sedation. Intrathecal catheterization was performed through the cisterna magna with the neck slightly flexed. An 18-gauge Tuohy needle was inserted into the subarachnoid space through the atlanto-occipital space. After confirming cerebrospinal fluid leakage without bleeding, a flexible intrathecal catheter was passed caudally to the C2-C3 level. Results: All Epidural and intrathecal catheterizations were successfully performed under deep sedation without any complications. Conclusion: The new technique of Epidural and intrathecal catheterization in canines is an alternative procedure for investigating Epidurally administered Drugs.
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Efficacy of continuous Epidural infusion with Epidural electric stimulation compared to conventional continuous Epidural infusion for acute herpes zoster management: A retrospective study
2019Co-Authors: Chung Hun Lee, Mi Kyoung Lee, Sang-sik Choi, Yeon Joo Lee, Jong Sun ParkAbstract:Abstract Background: A continuous Epidural infusion is commonly used in clinical settings, and reduces the likelihood of transition to postherpetic neuralgia via pain control. The purpose of the present study was to compare the efficacy of conventional continuous Epidural infusion to that of continuous Epidural infusion where the catheter is specifically guided by electric stimulation to areas with neurological damage in the treatment of zoster-related pain and prevention of postherpetic neuralgia. Methods: We analyzed the medical records of 114 patients in the present study. The patients were divided into two groups: contrast (conventional continuous Epidural infusion), and stimulation (continuous Epidural infusion with Epidural electric stimulation). In the contrast group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the stimulation group, the site of herpes zoster infection was identified through electric stimulation using a guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2, and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6-month follow-up period after each procedure. Results: After adjusting for confounding variables, the pain score was significantly lower in the stimulation group than in the contrast group for 6 months after the procedure. The adjusted odds ratio of patients included in the complete remission category was 1.9 times higher in the stimulation group than in the contrast group (95% confidence interval: 0.81-4.44, P = 0.14). The adjusted odds ratio for other interventions within 6 months after the procedure was 3.62 times higher in the contrast group than in the stimulation group (95% confidence interval: 1.17-11.19, P = 0.03). Conclusion: Epidural Drug Administration to specific spinal segments using electric stimulation catheters may be more helpful than conventional continuous Epidural infusion for improving pain and preventing postherpetic neuralgia in acute phase of herpes zoster.
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Efficacy of continuous Epidural block with Epidural electrical stimulation compared to conventional continuous Epidural block for acute herpes zoster management: A retrospective study
2019Co-Authors: Sang-sik Choi, Jong Sun ParkAbstract:Abstract Background Continuous Epidural block is commonly used in clinical settings and reduces the likelihood of transition to postherpetic neuralgia via pain control. The purpose of the present study was to compare the efficacies of conventional continuous Epidural block and continuous Epidural block involving electric stimulation-guided localization of the catheter to areas with neurological damage, in the treatment of herpes zoster pain and prevention of postherpetic neuralgia.Methods We analyzed the medical records of 114 patients in the present study. The patients were divided into two groups: esopocan (conventional continuous Epidural block) and epistim (continuous Epidural block with Epidural electric stimulation). In the esopocan group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the epistim group, the site of herpes zoster infection was identified through electric stimulation using the guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2 and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6 month follow-up period after each procedure.Results After adjusting for confounding variables, the pain score was significantly lower in the epistim group than in the esopocan group for 6 months after the procedure. The adjusted odds ratio of patients included in the complete remission category was 1.9 times higher in the epistim group than the esopocan group (95% confidence interval: 0.81-4.44, P = 0.14). The adjusted odds ratio for other interventions within 6 months after the procedure was 3.62 times higher in the esopocan group than the epistim group (95% confidence interval: 1.17-11.19, P = 0.03). Conclusion Epidural Drug Administration to specific spinal segments using electrical stimulation catheters may be more helpful than conventional continuous Epidural block in improving pain and preventing postherpetic neuralgia in acute herpes zoster.
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A new technique of Epidural and intrathecal catheterization to evaluate pharmacokinetics of Epidural Administration in dogs: a prospective study
2019Co-Authors: Myoung Hoon Kong, Sang-sik Choi, Jung Eun Kim, Mi Kyoung Lee, Chung Hun Lee, Yeon Joo LeeAbstract:Abstract Background: Compared to the conventional oral or intravenous Drug Administration, Epidural Administration of Drugs has significantly higher efficacy and safety. Experimental research on animals should be performed before applying to humans. Unlike the existing canine model, we describe a new and alternative technique of Epidural and intrathecal catheterization to investigate the efficacy and safety of Epidural Drug Administration in dogs. Methods: Twelve adult dogs were used in this study. The procedures were performed with dogs in sternal recumbency under deep sedation. Epidural catheterization was performed at the T1–T2 intervertebral space with C-arm fluoroscopy guidance. After confirming loss of resistance, a flexible Epidural catheter was passed cranially to the C2–C3 level. Intrathecal catheterization was performed through the cisterna magna with the neck slightly flexed. An 18-gauge Tuohy needle was inserted into the subarachnoid space through the atlanto-occipital space. After confirming cerebrospinal fluid leakage without bleeding, a flexible intrathecal catheter was passed caudally to the C2–C3 level. Results: All Epidural and intrathecal catheterizations were successfully performed under deep sedation without any complications. Conclusion: The new technique of Epidural and intrathecal catheterization in canines is a safe and alternative procedure for investigating the toxicity and pharmacology of Epidurally administered Drugs.
Jong Sun Park - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of continuous Epidural infusion with Epidural electric stimulation compared to that of conventional continuous Epidural infusion for acute herpes zoster management: a retrospective study
BMC Anesthesiology, 2020Co-Authors: Chung Hun Lee, Mi Kyoung Lee, Sang-sik Choi, Yeon Joo Lee, Jong Sun ParkAbstract:Background Continuous Epidural infusions are commonly used in clinical settings to reduce the likelihood of transition to postherpetic neuralgia via pain control. The purpose of this study was to compare the efficacy of conventional continuous Epidural infusion to that of continuous Epidural infusion in which the catheter is guided by electric stimulation to areas with neurological damage for the treatment of zoster-related pain and prevention of postherpetic neuralgia. Methods We analyzed the medical records of 114 patients in this study. The patients were divided into two groups: contrast (conventional continuous Epidural infusion) and stimulation (continuous Epidural infusion with Epidural electric stimulation). In the contrast group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the stimulation group, the site of herpes zoster infection was identified through electric stimulation using a guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2 and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6-month follow-up period after each procedure. Results After adjusting for confounding variables, the pain score was significantly lower in the stimulation group than in the contrast group for 6 months after the procedure. After adjustment, the odds of complete remission were 1.9-times higher in the stimulation group than in the contrast group (95% confidence interval [CI]: 0.81–4.44, P = 0.14). Patients in the contrast group were significantly more likely to require other interventions within 6 months of the procedure than patients in the stimulation group (odds ratio: 3.62, 95% CI: 1.17–11.19, P = 0.03). Conclusion Epidural Drug Administration to specific spinal segments using electric stimulation catheters may be more helpful than conventional continuous Epidural infusion for improving pain and preventing postherpetic neuralgia in the acute phase of herpes zoster.
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Efficacy of continuous Epidural infusion with Epidural electric stimulation compared to conventional continuous Epidural infusion for acute herpes zoster management: A retrospective study
2019Co-Authors: Chung Hun Lee, Mi Kyoung Lee, Sang-sik Choi, Yeon Joo Lee, Jong Sun ParkAbstract:Abstract Background: A continuous Epidural infusion is commonly used in clinical settings, and reduces the likelihood of transition to postherpetic neuralgia via pain control. The purpose of the present study was to compare the efficacy of conventional continuous Epidural infusion to that of continuous Epidural infusion where the catheter is specifically guided by electric stimulation to areas with neurological damage in the treatment of zoster-related pain and prevention of postherpetic neuralgia. Methods: We analyzed the medical records of 114 patients in the present study. The patients were divided into two groups: contrast (conventional continuous Epidural infusion), and stimulation (continuous Epidural infusion with Epidural electric stimulation). In the contrast group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the stimulation group, the site of herpes zoster infection was identified through electric stimulation using a guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2, and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6-month follow-up period after each procedure. Results: After adjusting for confounding variables, the pain score was significantly lower in the stimulation group than in the contrast group for 6 months after the procedure. The adjusted odds ratio of patients included in the complete remission category was 1.9 times higher in the stimulation group than in the contrast group (95% confidence interval: 0.81-4.44, P = 0.14). The adjusted odds ratio for other interventions within 6 months after the procedure was 3.62 times higher in the contrast group than in the stimulation group (95% confidence interval: 1.17-11.19, P = 0.03). Conclusion: Epidural Drug Administration to specific spinal segments using electric stimulation catheters may be more helpful than conventional continuous Epidural infusion for improving pain and preventing postherpetic neuralgia in acute phase of herpes zoster.
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Efficacy of continuous Epidural block with Epidural electrical stimulation compared to conventional continuous Epidural block for acute herpes zoster management: A retrospective study
2019Co-Authors: Sang-sik Choi, Jong Sun ParkAbstract:Abstract Background Continuous Epidural block is commonly used in clinical settings and reduces the likelihood of transition to postherpetic neuralgia via pain control. The purpose of the present study was to compare the efficacies of conventional continuous Epidural block and continuous Epidural block involving electric stimulation-guided localization of the catheter to areas with neurological damage, in the treatment of herpes zoster pain and prevention of postherpetic neuralgia.Methods We analyzed the medical records of 114 patients in the present study. The patients were divided into two groups: esopocan (conventional continuous Epidural block) and epistim (continuous Epidural block with Epidural electric stimulation). In the esopocan group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the epistim group, the site of herpes zoster infection was identified through electric stimulation using the guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2 and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6 month follow-up period after each procedure.Results After adjusting for confounding variables, the pain score was significantly lower in the epistim group than in the esopocan group for 6 months after the procedure. The adjusted odds ratio of patients included in the complete remission category was 1.9 times higher in the epistim group than the esopocan group (95% confidence interval: 0.81-4.44, P = 0.14). The adjusted odds ratio for other interventions within 6 months after the procedure was 3.62 times higher in the esopocan group than the epistim group (95% confidence interval: 1.17-11.19, P = 0.03). Conclusion Epidural Drug Administration to specific spinal segments using electrical stimulation catheters may be more helpful than conventional continuous Epidural block in improving pain and preventing postherpetic neuralgia in acute herpes zoster.
Yeon Joo Lee - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of continuous Epidural infusion with Epidural electric stimulation compared to that of conventional continuous Epidural infusion for acute herpes zoster management: a retrospective study
BMC Anesthesiology, 2020Co-Authors: Chung Hun Lee, Mi Kyoung Lee, Sang-sik Choi, Yeon Joo Lee, Jong Sun ParkAbstract:Background Continuous Epidural infusions are commonly used in clinical settings to reduce the likelihood of transition to postherpetic neuralgia via pain control. The purpose of this study was to compare the efficacy of conventional continuous Epidural infusion to that of continuous Epidural infusion in which the catheter is guided by electric stimulation to areas with neurological damage for the treatment of zoster-related pain and prevention of postherpetic neuralgia. Methods We analyzed the medical records of 114 patients in this study. The patients were divided into two groups: contrast (conventional continuous Epidural infusion) and stimulation (continuous Epidural infusion with Epidural electric stimulation). In the contrast group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the stimulation group, the site of herpes zoster infection was identified through electric stimulation using a guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2 and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6-month follow-up period after each procedure. Results After adjusting for confounding variables, the pain score was significantly lower in the stimulation group than in the contrast group for 6 months after the procedure. After adjustment, the odds of complete remission were 1.9-times higher in the stimulation group than in the contrast group (95% confidence interval [CI]: 0.81–4.44, P = 0.14). Patients in the contrast group were significantly more likely to require other interventions within 6 months of the procedure than patients in the stimulation group (odds ratio: 3.62, 95% CI: 1.17–11.19, P = 0.03). Conclusion Epidural Drug Administration to specific spinal segments using electric stimulation catheters may be more helpful than conventional continuous Epidural infusion for improving pain and preventing postherpetic neuralgia in the acute phase of herpes zoster.
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A new technique of Epidural and intrathecal catheterization to evaluate pharmacokinetics of Epidural Administration in dogs: a prospective study
2019Co-Authors: Myoung Hoon Kong, Jung Eun Kim, Mi Kyoung Lee, Chung Hun Lee, Yeon Joo Lee, Sang-sik ChoiAbstract:Abstract Background: Experimental research on animals should be performed before applying new treatment modalities in humans. Among experimental animal models, canine model research is a commonly used method. Injecting Drugs into the Epidural has also been commonly used in the canine animal model. In canine models, Epidural catheters are often inserted into the lumbosacral area during Epidural Drug injection. Unlike the existing canine model, we describe a new and alternative technique of Epidural and intrathecal catheterization to investigate methods of Epidural Drug Administration in dogs. Methods: Twelve adult dogs were used in this study. The Epidural procedures were performed with dogs in sternal recumbency under deep sedation. Epidural catheterization was perforemed at the T1-T2 intervertebral space with C-arm fluoroscopy guidance. After confirming the loss of resistance, a flexible Epidural catheter was passed cranially to the C2-C3 level. The intrathecal procedures were performed with dogs in lateral recumbency under deep sedation. Intrathecal catheterization was performed through the cisterna magna with the neck slightly flexed. An 18-gauge Tuohy needle was inserted into the subarachnoid space through the atlanto-occipital space. After confirming cerebrospinal fluid leakage without bleeding, a flexible intrathecal catheter was passed caudally to the C2-C3 level. Results: All Epidural and intrathecal catheterizations were successfully performed under deep sedation without any complications. Conclusion: The new technique of Epidural and intrathecal catheterization in canines is an alternative procedure for investigating Epidurally administered Drugs.
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Efficacy of continuous Epidural infusion with Epidural electric stimulation compared to conventional continuous Epidural infusion for acute herpes zoster management: A retrospective study
2019Co-Authors: Chung Hun Lee, Mi Kyoung Lee, Sang-sik Choi, Yeon Joo Lee, Jong Sun ParkAbstract:Abstract Background: A continuous Epidural infusion is commonly used in clinical settings, and reduces the likelihood of transition to postherpetic neuralgia via pain control. The purpose of the present study was to compare the efficacy of conventional continuous Epidural infusion to that of continuous Epidural infusion where the catheter is specifically guided by electric stimulation to areas with neurological damage in the treatment of zoster-related pain and prevention of postherpetic neuralgia. Methods: We analyzed the medical records of 114 patients in the present study. The patients were divided into two groups: contrast (conventional continuous Epidural infusion), and stimulation (continuous Epidural infusion with Epidural electric stimulation). In the contrast group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the stimulation group, the site of herpes zoster infection was identified through electric stimulation using a guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2, and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6-month follow-up period after each procedure. Results: After adjusting for confounding variables, the pain score was significantly lower in the stimulation group than in the contrast group for 6 months after the procedure. The adjusted odds ratio of patients included in the complete remission category was 1.9 times higher in the stimulation group than in the contrast group (95% confidence interval: 0.81-4.44, P = 0.14). The adjusted odds ratio for other interventions within 6 months after the procedure was 3.62 times higher in the contrast group than in the stimulation group (95% confidence interval: 1.17-11.19, P = 0.03). Conclusion: Epidural Drug Administration to specific spinal segments using electric stimulation catheters may be more helpful than conventional continuous Epidural infusion for improving pain and preventing postherpetic neuralgia in acute phase of herpes zoster.
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A new technique of Epidural and intrathecal catheterization to evaluate pharmacokinetics of Epidural Administration in dogs: a prospective study
2019Co-Authors: Myoung Hoon Kong, Sang-sik Choi, Jung Eun Kim, Mi Kyoung Lee, Chung Hun Lee, Yeon Joo LeeAbstract:Abstract Background: Compared to the conventional oral or intravenous Drug Administration, Epidural Administration of Drugs has significantly higher efficacy and safety. Experimental research on animals should be performed before applying to humans. Unlike the existing canine model, we describe a new and alternative technique of Epidural and intrathecal catheterization to investigate the efficacy and safety of Epidural Drug Administration in dogs. Methods: Twelve adult dogs were used in this study. The procedures were performed with dogs in sternal recumbency under deep sedation. Epidural catheterization was performed at the T1–T2 intervertebral space with C-arm fluoroscopy guidance. After confirming loss of resistance, a flexible Epidural catheter was passed cranially to the C2–C3 level. Intrathecal catheterization was performed through the cisterna magna with the neck slightly flexed. An 18-gauge Tuohy needle was inserted into the subarachnoid space through the atlanto-occipital space. After confirming cerebrospinal fluid leakage without bleeding, a flexible intrathecal catheter was passed caudally to the C2–C3 level. Results: All Epidural and intrathecal catheterizations were successfully performed under deep sedation without any complications. Conclusion: The new technique of Epidural and intrathecal catheterization in canines is a safe and alternative procedure for investigating the toxicity and pharmacology of Epidurally administered Drugs.
Chung Hun Lee - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of continuous Epidural infusion with Epidural electric stimulation compared to that of conventional continuous Epidural infusion for acute herpes zoster management: a retrospective study
BMC Anesthesiology, 2020Co-Authors: Chung Hun Lee, Mi Kyoung Lee, Sang-sik Choi, Yeon Joo Lee, Jong Sun ParkAbstract:Background Continuous Epidural infusions are commonly used in clinical settings to reduce the likelihood of transition to postherpetic neuralgia via pain control. The purpose of this study was to compare the efficacy of conventional continuous Epidural infusion to that of continuous Epidural infusion in which the catheter is guided by electric stimulation to areas with neurological damage for the treatment of zoster-related pain and prevention of postherpetic neuralgia. Methods We analyzed the medical records of 114 patients in this study. The patients were divided into two groups: contrast (conventional continuous Epidural infusion) and stimulation (continuous Epidural infusion with Epidural electric stimulation). In the contrast group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the stimulation group, the site of herpes zoster infection was identified through electric stimulation using a guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2 and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6-month follow-up period after each procedure. Results After adjusting for confounding variables, the pain score was significantly lower in the stimulation group than in the contrast group for 6 months after the procedure. After adjustment, the odds of complete remission were 1.9-times higher in the stimulation group than in the contrast group (95% confidence interval [CI]: 0.81–4.44, P = 0.14). Patients in the contrast group were significantly more likely to require other interventions within 6 months of the procedure than patients in the stimulation group (odds ratio: 3.62, 95% CI: 1.17–11.19, P = 0.03). Conclusion Epidural Drug Administration to specific spinal segments using electric stimulation catheters may be more helpful than conventional continuous Epidural infusion for improving pain and preventing postherpetic neuralgia in the acute phase of herpes zoster.
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A new technique of Epidural and intrathecal catheterization to evaluate pharmacokinetics of Epidural Administration in dogs: a prospective study
2019Co-Authors: Myoung Hoon Kong, Jung Eun Kim, Mi Kyoung Lee, Chung Hun Lee, Yeon Joo Lee, Sang-sik ChoiAbstract:Abstract Background: Experimental research on animals should be performed before applying new treatment modalities in humans. Among experimental animal models, canine model research is a commonly used method. Injecting Drugs into the Epidural has also been commonly used in the canine animal model. In canine models, Epidural catheters are often inserted into the lumbosacral area during Epidural Drug injection. Unlike the existing canine model, we describe a new and alternative technique of Epidural and intrathecal catheterization to investigate methods of Epidural Drug Administration in dogs. Methods: Twelve adult dogs were used in this study. The Epidural procedures were performed with dogs in sternal recumbency under deep sedation. Epidural catheterization was perforemed at the T1-T2 intervertebral space with C-arm fluoroscopy guidance. After confirming the loss of resistance, a flexible Epidural catheter was passed cranially to the C2-C3 level. The intrathecal procedures were performed with dogs in lateral recumbency under deep sedation. Intrathecal catheterization was performed through the cisterna magna with the neck slightly flexed. An 18-gauge Tuohy needle was inserted into the subarachnoid space through the atlanto-occipital space. After confirming cerebrospinal fluid leakage without bleeding, a flexible intrathecal catheter was passed caudally to the C2-C3 level. Results: All Epidural and intrathecal catheterizations were successfully performed under deep sedation without any complications. Conclusion: The new technique of Epidural and intrathecal catheterization in canines is an alternative procedure for investigating Epidurally administered Drugs.
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Efficacy of continuous Epidural infusion with Epidural electric stimulation compared to conventional continuous Epidural infusion for acute herpes zoster management: A retrospective study
2019Co-Authors: Chung Hun Lee, Mi Kyoung Lee, Sang-sik Choi, Yeon Joo Lee, Jong Sun ParkAbstract:Abstract Background: A continuous Epidural infusion is commonly used in clinical settings, and reduces the likelihood of transition to postherpetic neuralgia via pain control. The purpose of the present study was to compare the efficacy of conventional continuous Epidural infusion to that of continuous Epidural infusion where the catheter is specifically guided by electric stimulation to areas with neurological damage in the treatment of zoster-related pain and prevention of postherpetic neuralgia. Methods: We analyzed the medical records of 114 patients in the present study. The patients were divided into two groups: contrast (conventional continuous Epidural infusion), and stimulation (continuous Epidural infusion with Epidural electric stimulation). In the contrast group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the stimulation group, the site of herpes zoster infection was identified through electric stimulation using a guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2, and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6-month follow-up period after each procedure. Results: After adjusting for confounding variables, the pain score was significantly lower in the stimulation group than in the contrast group for 6 months after the procedure. The adjusted odds ratio of patients included in the complete remission category was 1.9 times higher in the stimulation group than in the contrast group (95% confidence interval: 0.81-4.44, P = 0.14). The adjusted odds ratio for other interventions within 6 months after the procedure was 3.62 times higher in the contrast group than in the stimulation group (95% confidence interval: 1.17-11.19, P = 0.03). Conclusion: Epidural Drug Administration to specific spinal segments using electric stimulation catheters may be more helpful than conventional continuous Epidural infusion for improving pain and preventing postherpetic neuralgia in acute phase of herpes zoster.
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A new technique of Epidural and intrathecal catheterization to evaluate pharmacokinetics of Epidural Administration in dogs: a prospective study
2019Co-Authors: Myoung Hoon Kong, Sang-sik Choi, Jung Eun Kim, Mi Kyoung Lee, Chung Hun Lee, Yeon Joo LeeAbstract:Abstract Background: Compared to the conventional oral or intravenous Drug Administration, Epidural Administration of Drugs has significantly higher efficacy and safety. Experimental research on animals should be performed before applying to humans. Unlike the existing canine model, we describe a new and alternative technique of Epidural and intrathecal catheterization to investigate the efficacy and safety of Epidural Drug Administration in dogs. Methods: Twelve adult dogs were used in this study. The procedures were performed with dogs in sternal recumbency under deep sedation. Epidural catheterization was performed at the T1–T2 intervertebral space with C-arm fluoroscopy guidance. After confirming loss of resistance, a flexible Epidural catheter was passed cranially to the C2–C3 level. Intrathecal catheterization was performed through the cisterna magna with the neck slightly flexed. An 18-gauge Tuohy needle was inserted into the subarachnoid space through the atlanto-occipital space. After confirming cerebrospinal fluid leakage without bleeding, a flexible intrathecal catheter was passed caudally to the C2–C3 level. Results: All Epidural and intrathecal catheterizations were successfully performed under deep sedation without any complications. Conclusion: The new technique of Epidural and intrathecal catheterization in canines is a safe and alternative procedure for investigating the toxicity and pharmacology of Epidurally administered Drugs.
Mi Kyoung Lee - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of continuous Epidural infusion with Epidural electric stimulation compared to that of conventional continuous Epidural infusion for acute herpes zoster management: a retrospective study
BMC Anesthesiology, 2020Co-Authors: Chung Hun Lee, Mi Kyoung Lee, Sang-sik Choi, Yeon Joo Lee, Jong Sun ParkAbstract:Background Continuous Epidural infusions are commonly used in clinical settings to reduce the likelihood of transition to postherpetic neuralgia via pain control. The purpose of this study was to compare the efficacy of conventional continuous Epidural infusion to that of continuous Epidural infusion in which the catheter is guided by electric stimulation to areas with neurological damage for the treatment of zoster-related pain and prevention of postherpetic neuralgia. Methods We analyzed the medical records of 114 patients in this study. The patients were divided into two groups: contrast (conventional continuous Epidural infusion) and stimulation (continuous Epidural infusion with Epidural electric stimulation). In the contrast group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the stimulation group, the site of herpes zoster infection was identified through electric stimulation using a guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2 and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6-month follow-up period after each procedure. Results After adjusting for confounding variables, the pain score was significantly lower in the stimulation group than in the contrast group for 6 months after the procedure. After adjustment, the odds of complete remission were 1.9-times higher in the stimulation group than in the contrast group (95% confidence interval [CI]: 0.81–4.44, P = 0.14). Patients in the contrast group were significantly more likely to require other interventions within 6 months of the procedure than patients in the stimulation group (odds ratio: 3.62, 95% CI: 1.17–11.19, P = 0.03). Conclusion Epidural Drug Administration to specific spinal segments using electric stimulation catheters may be more helpful than conventional continuous Epidural infusion for improving pain and preventing postherpetic neuralgia in the acute phase of herpes zoster.
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A new technique of Epidural and intrathecal catheterization to evaluate pharmacokinetics of Epidural Administration in dogs: a prospective study
2019Co-Authors: Myoung Hoon Kong, Jung Eun Kim, Mi Kyoung Lee, Chung Hun Lee, Yeon Joo Lee, Sang-sik ChoiAbstract:Abstract Background: Experimental research on animals should be performed before applying new treatment modalities in humans. Among experimental animal models, canine model research is a commonly used method. Injecting Drugs into the Epidural has also been commonly used in the canine animal model. In canine models, Epidural catheters are often inserted into the lumbosacral area during Epidural Drug injection. Unlike the existing canine model, we describe a new and alternative technique of Epidural and intrathecal catheterization to investigate methods of Epidural Drug Administration in dogs. Methods: Twelve adult dogs were used in this study. The Epidural procedures were performed with dogs in sternal recumbency under deep sedation. Epidural catheterization was perforemed at the T1-T2 intervertebral space with C-arm fluoroscopy guidance. After confirming the loss of resistance, a flexible Epidural catheter was passed cranially to the C2-C3 level. The intrathecal procedures were performed with dogs in lateral recumbency under deep sedation. Intrathecal catheterization was performed through the cisterna magna with the neck slightly flexed. An 18-gauge Tuohy needle was inserted into the subarachnoid space through the atlanto-occipital space. After confirming cerebrospinal fluid leakage without bleeding, a flexible intrathecal catheter was passed caudally to the C2-C3 level. Results: All Epidural and intrathecal catheterizations were successfully performed under deep sedation without any complications. Conclusion: The new technique of Epidural and intrathecal catheterization in canines is an alternative procedure for investigating Epidurally administered Drugs.
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Efficacy of continuous Epidural infusion with Epidural electric stimulation compared to conventional continuous Epidural infusion for acute herpes zoster management: A retrospective study
2019Co-Authors: Chung Hun Lee, Mi Kyoung Lee, Sang-sik Choi, Yeon Joo Lee, Jong Sun ParkAbstract:Abstract Background: A continuous Epidural infusion is commonly used in clinical settings, and reduces the likelihood of transition to postherpetic neuralgia via pain control. The purpose of the present study was to compare the efficacy of conventional continuous Epidural infusion to that of continuous Epidural infusion where the catheter is specifically guided by electric stimulation to areas with neurological damage in the treatment of zoster-related pain and prevention of postherpetic neuralgia. Methods: We analyzed the medical records of 114 patients in the present study. The patients were divided into two groups: contrast (conventional continuous Epidural infusion), and stimulation (continuous Epidural infusion with Epidural electric stimulation). In the contrast group, the position of the Epidural catheter was confirmed using contrast medium alone, whereas in the stimulation group, the site of herpes zoster infection was identified through electric stimulation using a guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2, and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6-month follow-up period after each procedure. Results: After adjusting for confounding variables, the pain score was significantly lower in the stimulation group than in the contrast group for 6 months after the procedure. The adjusted odds ratio of patients included in the complete remission category was 1.9 times higher in the stimulation group than in the contrast group (95% confidence interval: 0.81-4.44, P = 0.14). The adjusted odds ratio for other interventions within 6 months after the procedure was 3.62 times higher in the contrast group than in the stimulation group (95% confidence interval: 1.17-11.19, P = 0.03). Conclusion: Epidural Drug Administration to specific spinal segments using electric stimulation catheters may be more helpful than conventional continuous Epidural infusion for improving pain and preventing postherpetic neuralgia in acute phase of herpes zoster.
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A new technique of Epidural and intrathecal catheterization to evaluate pharmacokinetics of Epidural Administration in dogs: a prospective study
2019Co-Authors: Myoung Hoon Kong, Sang-sik Choi, Jung Eun Kim, Mi Kyoung Lee, Chung Hun Lee, Yeon Joo LeeAbstract:Abstract Background: Compared to the conventional oral or intravenous Drug Administration, Epidural Administration of Drugs has significantly higher efficacy and safety. Experimental research on animals should be performed before applying to humans. Unlike the existing canine model, we describe a new and alternative technique of Epidural and intrathecal catheterization to investigate the efficacy and safety of Epidural Drug Administration in dogs. Methods: Twelve adult dogs were used in this study. The procedures were performed with dogs in sternal recumbency under deep sedation. Epidural catheterization was performed at the T1–T2 intervertebral space with C-arm fluoroscopy guidance. After confirming loss of resistance, a flexible Epidural catheter was passed cranially to the C2–C3 level. Intrathecal catheterization was performed through the cisterna magna with the neck slightly flexed. An 18-gauge Tuohy needle was inserted into the subarachnoid space through the atlanto-occipital space. After confirming cerebrospinal fluid leakage without bleeding, a flexible intrathecal catheter was passed caudally to the C2–C3 level. Results: All Epidural and intrathecal catheterizations were successfully performed under deep sedation without any complications. Conclusion: The new technique of Epidural and intrathecal catheterization in canines is a safe and alternative procedure for investigating the toxicity and pharmacology of Epidurally administered Drugs.