--Epigallocatechin 3-Gallate

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Pawan Kumar Maurya - One of the best experts on this subject based on the ideXlab platform.

  • Epigallocatechin-3-Gallate Protects Erythrocyte Ca(2+)-ATPase and Na(+)/K(+)-ATPase Against Oxidative Induced Damage During Aging in Humans.
    Advanced Pharmaceutical Bulletin, 2014
    Co-Authors: Prabhanshu Kumar, Pawan Kumar Maurya
    Abstract:

    Purpose: The main purpose of this study was to investigate the protective role of epigallocatechin-3-Gallate on tertiary butyl hydroperoxide induced oxidative damage in erythrocyte during aging in humans. Methods: Human erythrocyte membrane bound Ca2+-ATPase and Na+/K+-ATPase activities were determined as a function of human age. Protective role of epigallocatechin-3-Gallate was evaluated by in vitro experiments by adding epigallocatechin-3-Gallate in concentration dependent manner (final concentration range 10-7M to 10-4M) to the enzyme assay medium. Oxidative stress was induced in vitro by incubating washed erythrocyte ghosts with tertiary butyl hydroperoxide (10-5 M final concentration). Results: We have reported concentration dependent effect of epigallocatechin-3-Gallate on tertiary butyl hydroperoxide induced damage on activities of Ca2+-ATPase and Na+/K+-ATPase during aging in humans. We have detected a significant (p < 0.001) decreased activity of Ca2+-ATPase and Na+/K+ -ATPase as a function of human age. Epigallocatechin-3-Gallate protected ATPases against tertiary butyl hydroperoxide induced damage in concentration dependent manner during aging in humans. Conclusion: Epigallocatechin-3-Gallate is a powerful antioxidant that is capable of protecting erythrocyte Ca2+-ATPase and Na+/K+ -ATPase against oxidative stress during aging in humans. We may propose hypothesis that a high intake of catechin rich diet may provide some protection against development of aging and age related diseases.

  • Epigallocatechin-3-Gallate Protects Erythrocyte Ca(2+)-ATPase and Na(+)/K(+)-ATPase Against Oxidative Induced Damage During Aging in Humans.
    Advanced pharmaceutical bulletin, 2014
    Co-Authors: Prabhanshu Kumar, Pawan Kumar Maurya
    Abstract:

    The main purpose of this study was to investigate the protective role of epigallocatechin-3-Gallate on tertiary butyl hydroperoxide induced oxidative damage in erythrocyte during aging in humans. Human erythrocyte membrane bound Ca(2+)-ATPase and Na(+)/K(+)-ATPase activities were determined as a function of human age. Protective role of epigallocatechin-3-Gallate was evaluated by in vitro experiments by adding epigallocatechin-3-Gallate in concentration dependent manner (final concentration range 10(-7)M to 10(-4)M) to the enzyme assay medium. Oxidative stress was induced in vitro by incubating washed erythrocyte ghosts with tertiary butyl hydroperoxide (10(-5) M final concentration). We have reported concentration dependent effect of epigallocatechin-3-Gallate on tertiary butyl hydroperoxide induced damage on activities of Ca(2+)-ATPase and Na(+)/K(+)-ATPase during aging in humans. We have detected a significant (p < 0.001) decreased activity of Ca(2+)-ATPase and Na(+)/K(+) -ATPase as a function of human age. Epigallocatechin-3-Gallate protected ATPases against tertiary butyl hydroperoxide induced damage in concentration dependent manner during aging in humans. Epigallocatechin-3-Gallate is a powerful antioxidant that is capable of protecting erythrocyte Ca(2+)-ATPase and Na(+)/K(+) -ATPase against oxidative stress during aging in humans. We may propose hypothesis that a high intake of catechin rich diet may provide some protection against development of aging and age related diseases.

Hasan Mukhtar - One of the best experts on this subject based on the ideXlab platform.

Prabhanshu Kumar - One of the best experts on this subject based on the ideXlab platform.

  • Epigallocatechin-3-Gallate Protects Erythrocyte Ca(2+)-ATPase and Na(+)/K(+)-ATPase Against Oxidative Induced Damage During Aging in Humans.
    Advanced Pharmaceutical Bulletin, 2014
    Co-Authors: Prabhanshu Kumar, Pawan Kumar Maurya
    Abstract:

    Purpose: The main purpose of this study was to investigate the protective role of epigallocatechin-3-Gallate on tertiary butyl hydroperoxide induced oxidative damage in erythrocyte during aging in humans. Methods: Human erythrocyte membrane bound Ca2+-ATPase and Na+/K+-ATPase activities were determined as a function of human age. Protective role of epigallocatechin-3-Gallate was evaluated by in vitro experiments by adding epigallocatechin-3-Gallate in concentration dependent manner (final concentration range 10-7M to 10-4M) to the enzyme assay medium. Oxidative stress was induced in vitro by incubating washed erythrocyte ghosts with tertiary butyl hydroperoxide (10-5 M final concentration). Results: We have reported concentration dependent effect of epigallocatechin-3-Gallate on tertiary butyl hydroperoxide induced damage on activities of Ca2+-ATPase and Na+/K+-ATPase during aging in humans. We have detected a significant (p < 0.001) decreased activity of Ca2+-ATPase and Na+/K+ -ATPase as a function of human age. Epigallocatechin-3-Gallate protected ATPases against tertiary butyl hydroperoxide induced damage in concentration dependent manner during aging in humans. Conclusion: Epigallocatechin-3-Gallate is a powerful antioxidant that is capable of protecting erythrocyte Ca2+-ATPase and Na+/K+ -ATPase against oxidative stress during aging in humans. We may propose hypothesis that a high intake of catechin rich diet may provide some protection against development of aging and age related diseases.

  • Epigallocatechin-3-Gallate Protects Erythrocyte Ca(2+)-ATPase and Na(+)/K(+)-ATPase Against Oxidative Induced Damage During Aging in Humans.
    Advanced pharmaceutical bulletin, 2014
    Co-Authors: Prabhanshu Kumar, Pawan Kumar Maurya
    Abstract:

    The main purpose of this study was to investigate the protective role of epigallocatechin-3-Gallate on tertiary butyl hydroperoxide induced oxidative damage in erythrocyte during aging in humans. Human erythrocyte membrane bound Ca(2+)-ATPase and Na(+)/K(+)-ATPase activities were determined as a function of human age. Protective role of epigallocatechin-3-Gallate was evaluated by in vitro experiments by adding epigallocatechin-3-Gallate in concentration dependent manner (final concentration range 10(-7)M to 10(-4)M) to the enzyme assay medium. Oxidative stress was induced in vitro by incubating washed erythrocyte ghosts with tertiary butyl hydroperoxide (10(-5) M final concentration). We have reported concentration dependent effect of epigallocatechin-3-Gallate on tertiary butyl hydroperoxide induced damage on activities of Ca(2+)-ATPase and Na(+)/K(+)-ATPase during aging in humans. We have detected a significant (p < 0.001) decreased activity of Ca(2+)-ATPase and Na(+)/K(+) -ATPase as a function of human age. Epigallocatechin-3-Gallate protected ATPases against tertiary butyl hydroperoxide induced damage in concentration dependent manner during aging in humans. Epigallocatechin-3-Gallate is a powerful antioxidant that is capable of protecting erythrocyte Ca(2+)-ATPase and Na(+)/K(+) -ATPase against oxidative stress during aging in humans. We may propose hypothesis that a high intake of catechin rich diet may provide some protection against development of aging and age related diseases.

Nihal Ahmad - One of the best experts on this subject based on the ideXlab platform.

Maria Luisa García - One of the best experts on this subject based on the ideXlab platform.

  • Epigallocatechin-3-Gallate loaded PEGylated-PLGA nanoparticles: A new anti-seizure strategy for temporal lobe epilepsy
    Nanomedicine : nanotechnology biology and medicine, 2018
    Co-Authors: Amanda Cano, Miren Ettcheto, Marta Espina, C. Auladell, Ana C. Calpena, Jaume Folch, Marta Barenys, Elena Sánchez-lópez, Antoni Camins, Maria Luisa García
    Abstract:

    Abstract Temporal lobe epilepsy is the most common type of pharmacoresistant epilepsy in adults. Epigallocatechin-3-Gallate has aroused much interest because of its multiple therapeutic effects, but its instability compromises the potential effectiveness. PEGylated-PLGA nanoparticles of Epigallocatechin-3-Gallate were designed to protect the drug and to increase the brain delivery. Nanoparticles were prepared by the double emulsion method and cytotoxicity, behavioral, Fluoro-Jade C, Iba1 and GFAP immunohistochemistry studies were carried out to determine their effectiveness. Nanoparticles showed an average size of 169 nm, monodisperse population, negative surface charge, encapsulation efficiency of 95% and sustained release profile. Cytotoxicity assays exhibited that these nanocarriers were non-toxic. Behavioral test showed that nanoparticles reduced most than free drug the number of epileptic episodes and their intensity. Neurotoxicity and immunohistochemistry studies confirmed a decrease in neuronal death and neuroinflammation. In conclusion, Epigallocatechin-3-Gallate PEGylated-PLGA nanoparticles could be a suitable strategy for the treatment of temporal lobe epilepsy.