Green Tea

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Hirota Fujiki - One of the best experts on this subject based on the ideXlab platform.

  • Primary cancer prevention by Green Tea, and tertiary cancer prevention by the combination of Green Tea catechins and anticancer compounds.
    Journal of cancer prevention, 2015
    Co-Authors: Hirota Fujiki, Eisaburo Sueoka, Tatsuro Watanabe, Masami Suganuma
    Abstract:

    Green Tea is a daily beverage, a non-oxidized non-fermented product containing at least four Green Tea catechins. Considering our first results when repeated applications of (-)-epigallocatechin gallate (EGCG) prevented tumor promotion in mouse skin, we have continued to look at Green Tea as a possible cancer preventive agent. 1) The 10-year prospective cohort study by Drs. K. Nakachi and K. Imai revealed that drinking 10 Japanese-size cups (120 mL/cup) of Green Tea per day delayed cancer onset in humans by 7.3 years among females and by 3.2 years among males. The delay of cancer onset is of course significant evidence of primary cancer prevention in humans. 2) In collaboration with Dr. H. Moriwaki's group we successfully presented a prototype of tertiary cancer prevention showing that 10 Japanese-size cups of Green Tea daily, supplemented with tablets of Green Tea extract (G.T.E), reduced recurrence of colorectal adenomas in polypectomy patients by 51.6% (from 31% to 15%). 3) In 1999, we first reported that the combination of Green Tea catechins and non-steroidal anti-inflammatory drugs showed synergistic anticancer effects in both in vitro and in vivo experiments, along with elucidation of the mechanism. 4) Further studies by other investigators have revealed that various combinations of EGCG or Green Tea extract and anticancer compounds inhibit tumor volume in xenograft mouse models implanted with various human cancer cell lines. Green Tea is a cancer preventive, and Green Tea catechins act as synergists with anticancer compounds.

  • Green Tea: cancer preventive beverage and/or drug
    Cancer Letters, 2002
    Co-Authors: Hirota Fujiki, Masami Suganuma, Kazue Imai, Kei Nakachi
    Abstract:

    Green Tea and (-)-epigallocatechin gallate (EGCG) are now acknowledged cancer preventives in Japan and has made it possible for us to establish the concept of a cancer preventive beverage. For the general population, we recommend 10 cups of Green Tea daily supplemented with Green Tea tablets. For cancer patients following treatment, we here present new evidence that Green Tea and a cancer preventive drug, sulindac, have synergistic preventive effects. An approach to develop Green Tea capsules as a cancer preventive drug in the US is discussed, aiming at taking full advantage of this cancer preventive beverage.

  • Green Tea and cancer prevention
    Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences, 2002
    Co-Authors: Hirota Fujiki, Masami Suganuma
    Abstract:

    We found that (-)-epigallocatechin gallate (EGCG), the main constituent of Green Tea and Green Tea extract, the lyophilized form of Green Tea infusion, inhibited both activation of protein kinase C and tumor promotion on mouse skin: The results led us to suggest Green Tea as a cancer preventive for humans. Inhibition of chemical carcinogenesis in rodents, inhibition of cell growth and induction of apoptosis on human cancer cell lines, organ distribution of 3H-EGCG in mice, multifunctional actions, and the synergistic cancer preventive activity of Green Tea with sulindac were studied. All our results show that Green Tea is a promising beverage for the purpose of cancer prevention in humans.

  • 1.2 – Green Tea as a Cancer Preventive
    Dietary Anticarcinogens and Antimutagens, 2000
    Co-Authors: Hirota Fujiki, Masami Suganuma, Sachiko Okabe, Eisaburo Sueoka, Naoko Sueoka, Satoru Matsuyama, Kazue Imai, Kei Nakachi
    Abstract:

    1 Abstract Green Tea is now an acknowledged cancer preventive in Japan and will possibly soon be recognized as such in other countries. Initially, we found that (—)- epigallocatechin gallate (EGCG), the main constituent of Green Tea inhibited tumor promotion on mouse skin in a two-stage carcinogenesis experiment. Numerous additional studies revealed the anticarcinogenic effects of EGCG and Green Tea on various organs in rodent experiments. This paper reviews the unique role of Green Tea in cancer chemoprevention, its anticarcinogenic effects and other preventive activities, bioavailability of Tea polyphenols and epidemiological studies with Green Tea. Of particular interest are studies which showed that daily consumption of Green Tea delayed clinical onset of various cancers and led to more hopeful prognoses for breast cancer patients in Stage I and II following treatment. Based on these results, I propose two stages of cancer prevention with Green Tea: prevention before cancer onset, and following cancer treatment. Since Green Tea is a common beverage, the knowledge that it inhibits cancer will be a great comfort to, especially, aging folk concerned with cancer prevention and any high risk population.

  • Cancer inhibition by Green Tea
    Mutation Research, 1998
    Co-Authors: Hirota Fujiki, Masami Suganuma, Sachiko Okabe, Eisaburo Sueoka, Naoko Sueoka, Atsumasa Komori, Tomoko Kozu, Yukiko Tada, Kenji Suga, Kazue Imai
    Abstract:

    Green Tea is now an acknowledged cancer preventive in Japan. This paper discusses several important features of (−)-epigallocatechin gallate (EGCG), the main constituent of Green Tea and Tea polyphenols. EGCG and other Tea polyphenols inhibited growth of human lung cancer cell line, PC-9 cells with G2/M arrest. 3H-EGCG administered by p.o. intubation into mouse stomach revealed that small amounts of 3H-activity were found in various organs where EGCG and Green Tea extract had previously demonstrated their anticarcinogenic effects, such as skin, stomach, duodenum, colon, liver, lung and pancreas. Cancer onset of patients who had consumed over 10 cups of Green Tea per day was 8.7 years later among females and 3.0 years later among males, compared with patients who had consumed under three cups per day. The mechanisms of action of EGCG were briefly discussed with regard to inhibition of tumor necrosis factor-α (TNF-α) release.

Hasan Mukhtar - One of the best experts on this subject based on the ideXlab platform.

  • Green Tea and Skin
    Archives of dermatology, 2000
    Co-Authors: Santosh K Katiyar, Nihal Ahmad, Hasan Mukhtar
    Abstract:

    Objective To discuss the current knowledge of polyphenolic compounds present in Green Tea as anti-inflammatory, antioxidant, and anticarcinogenic in skin. Data Sources References identified from bibliographies of pertinent articles, including our work in related fields. Study Selection and Data Extraction Articles were selected based on the use of Green Tea or its polyphenolic constituents for prevention against inflammation and cancer in the skin. Also discussed is the possible use of Green Tea to treat various inflammatory dermatoses. Data Synthesis The polyphenolic compounds from Green Tea were tested against chemical carcinogenesis and photocarcinogenesis in murine skin. These Green Tea polyphenols were found to afford protection against chemical carcinogenesis as well as photocarcinogenesis in mouse skin. A few experimental studies were conducted in human skin in our laboratory. Analysis of published studies demonstrates that Green Tea polyphenols have anti-inflammatory and anticarcinogenic properties. These effects appear to correlate with antioxidant properties of Green Tea polyphenols. Conclusions The outcome of the several experimental studies suggests that Green Tea possess anti-inflammatory and anticarcinogenic potential, which can be exploited against a variety of skin disorders. Although more clinical studies are needed, supplementation of skin care products with Green Tea may have a profound impact on various skin disorders in the years to come.

  • Green Tea in chemoprevention of cancer.
    Toxicological Sciences, 1999
    Co-Authors: Hasan Mukhtar, Nihal Ahmad
    Abstract:

    The concept of prevention of cancer using naturally occurring substances that could be included in the diet consumed by the human population is gaining increasing attention. Tea, next to water, is the most popularly consumed beverage in the world and it is grown in about 30 countries. Abundant data, amassed from several laboratories around the world in the last ten years, provided convincing evidence that polyphenolic antioxidants present in Tea afford protection against cancer risk in many animal-tumor bioassay systems. The epidemiological studies, though inconclusive, have also suggested that the consumption of Tea is associated with a lowered risk of cancer. Much of this work has been done on Green Tea; less is known about black Tea. Green Tea contains many polyphenolic antioxidants, and (‐)-epigallocatechin-3-gallate (EGCG) is the key polyphenolic antioxidant believed to be responsible for most of the cancer chemopreventive properties of Green Tea. This review will discuss these effects and the molecular mechanisms associated with the biological response to Green-Tea polyphenols.

  • Green Tea and skin--anticarcinogenic effects.
    The Journal of investigative dermatology, 1994
    Co-Authors: Hasan Mukhtar, Santosh K Katiyar, Rajesh Agarwal
    Abstract:

    Because of its special aroma, Green Tea is a popular beverage consumed by some human populations worldwide. In recent years, many laboratory studies have shown that in a variety of animal tumor bioassay systems the administration of Green Tea, specifically the polyphenolic fraction isolated from Green Tea leaves (Green Tea polyphenols), affords protection against cancer induction. In mouse skin tumor bioassay systems, topical application of Green Tea polyphenols to skin has been shown to result in protection against a) 3-methylcholanthrene-induced skin tumorigenicity, b) 7,12-dimethylbenz(a)anthracene (DMBA) -induced skin tumor initiation, c) 1 2-O-tetradecanoylphorbol-13-acetate and other tumor promoters caused tumor promotion in DMBA-initiated skin, and d) benzoyl peroxide- and 4-nitroquinoline N-oxide caused enhanced malignant progression of nonmalignant lesions. Green Tea extract has also been shown to cause partial regression of established skin papillomas in mouse. Similarly, chronic oral feeding of Green Tea polyphenols or water extract of Green Tea has also been shown to result in the protection against both chemical carcinogen- and ultraviolet B radiation-induced skin tumorigenicity. Collectively these data suggest that Green Tea possesses significant chemopreventive effect against each stage of carcinogenesis, and that it may be useful against inflammatory responses associated with the exposure of skin to chemical tumor promoters as well as to solar radiation. Available data regarding the mechanism by which Green Tea affords these diversified effects is discussed.

Santosh K Katiyar - One of the best experts on this subject based on the ideXlab platform.

  • Green Tea polyphenolic antioxidants and skin photoprotection review
    International Journal of Oncology, 2001
    Co-Authors: Santosh K Katiyar, Craig A. Elmets
    Abstract:

    : Green Tea is consumed as a popular beverage worldwide particularly in Asian countries like China, Korea, Japan and India. It contains polyphenolic compounds also known as epicatechins, which are antioxidant in nature. Many laboratories have shown that topical treatment or oral consumption of Green Tea polyphenols inhibits chemical carcinogen- or ultraviolet radiation-induced skin tumorigenesis in different animal models. Studies have shown that Green Tea extract also possesses anti-inflammatory activity. These anti-inflammatory and anti-carcinogenic properties of Green Tea are due to their polyphenolic constituents present therein. The major and most chemopreventive constituent in Green Tea responsible for these biochemical or pharmacological effects is (-)-epigallocatechin-3-gallate (EGCG). Understanding the molecular mechanisms of these effects of Green Tea is a subject of investigation in many laboratories. Treatment of Green Tea polyphenols to skin has been shown to modulate the biochemical pathways involved in inflammatory responses, cell proliferation and responses of chemical tumor promoters as well as ultraviolet (UV) light-induced inflammatory markers of skin inflammation. Topical treatment with EGCG on mouse skin also results in prevention of UVB-induced immunosuppression, and oxidative stress. The protective effects of Green Tea treatment on human skin either topically or consumed orally against UV light-induced inflammatory or carcinogenic responses are not well understood. Based on documented extensive beneficial effects of Green Tea on mouse skin models and very little in human skin, many pharmaceutical and cosmetic companies are supplementing their skin care products with Green Tea extracts. Therefore, the focus of this communication is to review and analyze the photoprotective effects of Green Tea polyphenols to skin.

  • Green Tea and Skin
    Archives of dermatology, 2000
    Co-Authors: Santosh K Katiyar, Nihal Ahmad, Hasan Mukhtar
    Abstract:

    Objective To discuss the current knowledge of polyphenolic compounds present in Green Tea as anti-inflammatory, antioxidant, and anticarcinogenic in skin. Data Sources References identified from bibliographies of pertinent articles, including our work in related fields. Study Selection and Data Extraction Articles were selected based on the use of Green Tea or its polyphenolic constituents for prevention against inflammation and cancer in the skin. Also discussed is the possible use of Green Tea to treat various inflammatory dermatoses. Data Synthesis The polyphenolic compounds from Green Tea were tested against chemical carcinogenesis and photocarcinogenesis in murine skin. These Green Tea polyphenols were found to afford protection against chemical carcinogenesis as well as photocarcinogenesis in mouse skin. A few experimental studies were conducted in human skin in our laboratory. Analysis of published studies demonstrates that Green Tea polyphenols have anti-inflammatory and anticarcinogenic properties. These effects appear to correlate with antioxidant properties of Green Tea polyphenols. Conclusions The outcome of the several experimental studies suggests that Green Tea possess anti-inflammatory and anticarcinogenic potential, which can be exploited against a variety of skin disorders. Although more clinical studies are needed, supplementation of skin care products with Green Tea may have a profound impact on various skin disorders in the years to come.

  • Green Tea and skin--anticarcinogenic effects.
    The Journal of investigative dermatology, 1994
    Co-Authors: Hasan Mukhtar, Santosh K Katiyar, Rajesh Agarwal
    Abstract:

    Because of its special aroma, Green Tea is a popular beverage consumed by some human populations worldwide. In recent years, many laboratory studies have shown that in a variety of animal tumor bioassay systems the administration of Green Tea, specifically the polyphenolic fraction isolated from Green Tea leaves (Green Tea polyphenols), affords protection against cancer induction. In mouse skin tumor bioassay systems, topical application of Green Tea polyphenols to skin has been shown to result in protection against a) 3-methylcholanthrene-induced skin tumorigenicity, b) 7,12-dimethylbenz(a)anthracene (DMBA) -induced skin tumor initiation, c) 1 2-O-tetradecanoylphorbol-13-acetate and other tumor promoters caused tumor promotion in DMBA-initiated skin, and d) benzoyl peroxide- and 4-nitroquinoline N-oxide caused enhanced malignant progression of nonmalignant lesions. Green Tea extract has also been shown to cause partial regression of established skin papillomas in mouse. Similarly, chronic oral feeding of Green Tea polyphenols or water extract of Green Tea has also been shown to result in the protection against both chemical carcinogen- and ultraviolet B radiation-induced skin tumorigenicity. Collectively these data suggest that Green Tea possesses significant chemopreventive effect against each stage of carcinogenesis, and that it may be useful against inflammatory responses associated with the exposure of skin to chemical tumor promoters as well as to solar radiation. Available data regarding the mechanism by which Green Tea affords these diversified effects is discussed.

Masami Suganuma - One of the best experts on this subject based on the ideXlab platform.

  • Primary cancer prevention by Green Tea, and tertiary cancer prevention by the combination of Green Tea catechins and anticancer compounds.
    Journal of cancer prevention, 2015
    Co-Authors: Hirota Fujiki, Eisaburo Sueoka, Tatsuro Watanabe, Masami Suganuma
    Abstract:

    Green Tea is a daily beverage, a non-oxidized non-fermented product containing at least four Green Tea catechins. Considering our first results when repeated applications of (-)-epigallocatechin gallate (EGCG) prevented tumor promotion in mouse skin, we have continued to look at Green Tea as a possible cancer preventive agent. 1) The 10-year prospective cohort study by Drs. K. Nakachi and K. Imai revealed that drinking 10 Japanese-size cups (120 mL/cup) of Green Tea per day delayed cancer onset in humans by 7.3 years among females and by 3.2 years among males. The delay of cancer onset is of course significant evidence of primary cancer prevention in humans. 2) In collaboration with Dr. H. Moriwaki's group we successfully presented a prototype of tertiary cancer prevention showing that 10 Japanese-size cups of Green Tea daily, supplemented with tablets of Green Tea extract (G.T.E), reduced recurrence of colorectal adenomas in polypectomy patients by 51.6% (from 31% to 15%). 3) In 1999, we first reported that the combination of Green Tea catechins and non-steroidal anti-inflammatory drugs showed synergistic anticancer effects in both in vitro and in vivo experiments, along with elucidation of the mechanism. 4) Further studies by other investigators have revealed that various combinations of EGCG or Green Tea extract and anticancer compounds inhibit tumor volume in xenograft mouse models implanted with various human cancer cell lines. Green Tea is a cancer preventive, and Green Tea catechins act as synergists with anticancer compounds.

  • Green Tea: cancer preventive beverage and/or drug
    Cancer Letters, 2002
    Co-Authors: Hirota Fujiki, Masami Suganuma, Kazue Imai, Kei Nakachi
    Abstract:

    Green Tea and (-)-epigallocatechin gallate (EGCG) are now acknowledged cancer preventives in Japan and has made it possible for us to establish the concept of a cancer preventive beverage. For the general population, we recommend 10 cups of Green Tea daily supplemented with Green Tea tablets. For cancer patients following treatment, we here present new evidence that Green Tea and a cancer preventive drug, sulindac, have synergistic preventive effects. An approach to develop Green Tea capsules as a cancer preventive drug in the US is discussed, aiming at taking full advantage of this cancer preventive beverage.

  • Green Tea and cancer prevention
    Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences, 2002
    Co-Authors: Hirota Fujiki, Masami Suganuma
    Abstract:

    We found that (-)-epigallocatechin gallate (EGCG), the main constituent of Green Tea and Green Tea extract, the lyophilized form of Green Tea infusion, inhibited both activation of protein kinase C and tumor promotion on mouse skin: The results led us to suggest Green Tea as a cancer preventive for humans. Inhibition of chemical carcinogenesis in rodents, inhibition of cell growth and induction of apoptosis on human cancer cell lines, organ distribution of 3H-EGCG in mice, multifunctional actions, and the synergistic cancer preventive activity of Green Tea with sulindac were studied. All our results show that Green Tea is a promising beverage for the purpose of cancer prevention in humans.

  • 1.2 – Green Tea as a Cancer Preventive
    Dietary Anticarcinogens and Antimutagens, 2000
    Co-Authors: Hirota Fujiki, Masami Suganuma, Sachiko Okabe, Eisaburo Sueoka, Naoko Sueoka, Satoru Matsuyama, Kazue Imai, Kei Nakachi
    Abstract:

    1 Abstract Green Tea is now an acknowledged cancer preventive in Japan and will possibly soon be recognized as such in other countries. Initially, we found that (—)- epigallocatechin gallate (EGCG), the main constituent of Green Tea inhibited tumor promotion on mouse skin in a two-stage carcinogenesis experiment. Numerous additional studies revealed the anticarcinogenic effects of EGCG and Green Tea on various organs in rodent experiments. This paper reviews the unique role of Green Tea in cancer chemoprevention, its anticarcinogenic effects and other preventive activities, bioavailability of Tea polyphenols and epidemiological studies with Green Tea. Of particular interest are studies which showed that daily consumption of Green Tea delayed clinical onset of various cancers and led to more hopeful prognoses for breast cancer patients in Stage I and II following treatment. Based on these results, I propose two stages of cancer prevention with Green Tea: prevention before cancer onset, and following cancer treatment. Since Green Tea is a common beverage, the knowledge that it inhibits cancer will be a great comfort to, especially, aging folk concerned with cancer prevention and any high risk population.

  • Cancer inhibition by Green Tea
    Mutation Research, 1998
    Co-Authors: Hirota Fujiki, Masami Suganuma, Sachiko Okabe, Eisaburo Sueoka, Naoko Sueoka, Atsumasa Komori, Tomoko Kozu, Yukiko Tada, Kenji Suga, Kazue Imai
    Abstract:

    Green Tea is now an acknowledged cancer preventive in Japan. This paper discusses several important features of (−)-epigallocatechin gallate (EGCG), the main constituent of Green Tea and Tea polyphenols. EGCG and other Tea polyphenols inhibited growth of human lung cancer cell line, PC-9 cells with G2/M arrest. 3H-EGCG administered by p.o. intubation into mouse stomach revealed that small amounts of 3H-activity were found in various organs where EGCG and Green Tea extract had previously demonstrated their anticarcinogenic effects, such as skin, stomach, duodenum, colon, liver, lung and pancreas. Cancer onset of patients who had consumed over 10 cups of Green Tea per day was 8.7 years later among females and 3.0 years later among males, compared with patients who had consumed under three cups per day. The mechanisms of action of EGCG were briefly discussed with regard to inhibition of tumor necrosis factor-α (TNF-α) release.

Ngoc B. Huynh - One of the best experts on this subject based on the ideXlab platform.

  • The Immunological Benefits of Green Tea (Camellia sinensis)
    International Journal of Biology, 2016
    Co-Authors: Ngoc B. Huynh
    Abstract:

    This paper explores the health benefits of Green Tea ( Camellia sinensis ). Green Tea is known for its health benefits. Its primary impact is through the immune system. The paper begins with an overview of Tea’s properties according to Chinese traditional medicine, and outlines the main impacts of Green Tea on T-cells. By reviewing more contemporary studies using Green Tea extract, the health impacts are quantifiable and epidemiological studies also indicate the link to improved health outcomes in terms of chronic ailments such as diabetes. This paper examines some of the ways in which Tea is currently consumed, with an emphasis on how Green Tea is processed in order to maximize its health benefits. Focusing on EGCG found in Green Tea, this paper discsses some of the dosages and their impacts, as well as some of the negative impacts of other caffeinated beverages. While further research in this area would reveal more in terms of the limitations on safe consumption associated with these benefits, and exploring the mechanisms through which they take place. This paper concludes that drinking Green Tea regularly is a safe and inexpensive way for most people to maintain good health.