The Experts below are selected from a list of 58074 Experts worldwide ranked by ideXlab platform

Hong-bing Shu - One of the best experts on this subject based on the ideXlab platform.

  • MLL1/WDR5 complex in leukemogenesis and Epigenetic Regulation.
    Chinese journal of cancer, 2011
    Co-Authors: Hong-bing Shu
    Abstract:

    MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional Regulation, and leukemogenesis. MLL1 -fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLL1-WDR5 histone H3Lys4 methyltransferase complex demonstrate that Epigenetic Regulation is one of the key steps in development and human diseases.

  • mll1 wdr5 complex in leukemogenesis and Epigenetic Regulation
    Chinese Journal of Cancer, 2011
    Co-Authors: Hong-bing Shu
    Abstract:

    MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional Regulation, and leukemogenesis. MLL1 -fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLL1-WDR5 histone H3Lys4 methyltransferase complex demonstrate that Epigenetic Regulation is one of the key steps in development and human diseases.

Marianne E. Bronner - One of the best experts on this subject based on the ideXlab platform.

  • Epigenetic Regulation in neural crest development.
    Developmental biology, 2014
    Co-Authors: Pablo H. Strobl-mazzulla, Marianne E. Bronner
    Abstract:

    The neural crest is a migratory and multipotent cell population that plays a crucial role in many aspects of embryonic development. In all vertebrate embryos, these cells emerge from the dorsal neural tube then migrate long distances to different regions of the body, where they contribute to formation of many cell types and structures. These include much of the peripheral nervous system, craniofacial skeleton, smooth muscle, and pigmentation of the skin. The best-studied regulatory events guiding neural crest development are mediated by transcription factors and signaling molecules. In recent years, however, growing evidence supports an important role for Epigenetic Regulation as an additional mechanism for controlling the timing and level of gene expression at different stages of neural crest development. Here, we summarize the process of neural crest formation, with focus on the role of Epigenetic Regulation in neural crest specification, migration, and differentiation as well as in neural crest related birth defects and diseases.

Aldo Merotto - One of the best experts on this subject based on the ideXlab platform.

  • Epigenetic Regulation contribution to herbicide resistance in weeds
    Pest Management Science, 2018
    Co-Authors: Catarine Markus, Jacob N Barney, Ratna Karan, Ales Pecinka, Aldo Merotto
    Abstract:

    : Continuous use of herbicides has resulted in the evolution of resistance to all major herbicide modes of action worldwide. Besides the well-documented cases of newly acquired resistance through genetic changes, Epigenetic Regulation may also contribute to herbicide resistance in weeds. Epigenetics involves processes that modify the expression of specific genetic elements without changes in the DNA sequence, and play an important role in re-programming gene expression. Epigenetic modifications can be induced spontaneously, genetically or environmentally. Stress-induced Epigenetic changes are normally reverted soon after stress exposure, although in specific cases they can also be carried over multiple generations, thereby having a selective benefit. Here, we provide an overview of the basis of Epigenetic Regulation in plants and discuss the possible effect of Epigenetic changes on herbicide resistance. The understanding of these Epigenetic changes would add a new perspective to our knowledge of environmental and management stresses and their effects on the evolution of herbicide resistance in weeds. © 2017 Society of Chemical Industry.

  • Epigenetic Regulation contribution to herbicide resistance in weeds
    Pest Management Science, 2018
    Co-Authors: Catarine Markus, Jacob N Barney, Ratna Karan, Ales Pecinka, Aldo Merotto
    Abstract:

    : Continuous use of herbicides has resulted in the evolution of resistance to all major herbicide modes of action worldwide. Besides the well-documented cases of newly acquired resistance through genetic changes, Epigenetic Regulation may also contribute to herbicide resistance in weeds. Epigenetics involves processes that modify the expression of specific genetic elements without changes in the DNA sequence, and play an important role in re-programming gene expression. Epigenetic modifications can be induced spontaneously, genetically or environmentally. Stress-induced Epigenetic changes are normally reverted soon after stress exposure, although in specific cases they can also be carried over multiple generations, thereby having a selective benefit. Here, we provide an overview of the basis of Epigenetic Regulation in plants and discuss the possible effect of Epigenetic changes on herbicide resistance. The understanding of these Epigenetic changes would add a new perspective to our knowledge of environmental and management stresses and their effects on the evolution of herbicide resistance in weeds. © 2017 Society of Chemical Industry.

Pablo H. Strobl-mazzulla - One of the best experts on this subject based on the ideXlab platform.

  • Epigenetic Regulation in neural crest development.
    Developmental biology, 2014
    Co-Authors: Pablo H. Strobl-mazzulla, Marianne E. Bronner
    Abstract:

    The neural crest is a migratory and multipotent cell population that plays a crucial role in many aspects of embryonic development. In all vertebrate embryos, these cells emerge from the dorsal neural tube then migrate long distances to different regions of the body, where they contribute to formation of many cell types and structures. These include much of the peripheral nervous system, craniofacial skeleton, smooth muscle, and pigmentation of the skin. The best-studied regulatory events guiding neural crest development are mediated by transcription factors and signaling molecules. In recent years, however, growing evidence supports an important role for Epigenetic Regulation as an additional mechanism for controlling the timing and level of gene expression at different stages of neural crest development. Here, we summarize the process of neural crest formation, with focus on the role of Epigenetic Regulation in neural crest specification, migration, and differentiation as well as in neural crest related birth defects and diseases.

Catarine Markus - One of the best experts on this subject based on the ideXlab platform.

  • Epigenetic Regulation contribution to herbicide resistance in weeds
    Pest Management Science, 2018
    Co-Authors: Catarine Markus, Jacob N Barney, Ratna Karan, Ales Pecinka, Aldo Merotto
    Abstract:

    : Continuous use of herbicides has resulted in the evolution of resistance to all major herbicide modes of action worldwide. Besides the well-documented cases of newly acquired resistance through genetic changes, Epigenetic Regulation may also contribute to herbicide resistance in weeds. Epigenetics involves processes that modify the expression of specific genetic elements without changes in the DNA sequence, and play an important role in re-programming gene expression. Epigenetic modifications can be induced spontaneously, genetically or environmentally. Stress-induced Epigenetic changes are normally reverted soon after stress exposure, although in specific cases they can also be carried over multiple generations, thereby having a selective benefit. Here, we provide an overview of the basis of Epigenetic Regulation in plants and discuss the possible effect of Epigenetic changes on herbicide resistance. The understanding of these Epigenetic changes would add a new perspective to our knowledge of environmental and management stresses and their effects on the evolution of herbicide resistance in weeds. © 2017 Society of Chemical Industry.

  • Epigenetic Regulation contribution to herbicide resistance in weeds
    Pest Management Science, 2018
    Co-Authors: Catarine Markus, Jacob N Barney, Ratna Karan, Ales Pecinka, Aldo Merotto
    Abstract:

    : Continuous use of herbicides has resulted in the evolution of resistance to all major herbicide modes of action worldwide. Besides the well-documented cases of newly acquired resistance through genetic changes, Epigenetic Regulation may also contribute to herbicide resistance in weeds. Epigenetics involves processes that modify the expression of specific genetic elements without changes in the DNA sequence, and play an important role in re-programming gene expression. Epigenetic modifications can be induced spontaneously, genetically or environmentally. Stress-induced Epigenetic changes are normally reverted soon after stress exposure, although in specific cases they can also be carried over multiple generations, thereby having a selective benefit. Here, we provide an overview of the basis of Epigenetic Regulation in plants and discuss the possible effect of Epigenetic changes on herbicide resistance. The understanding of these Epigenetic changes would add a new perspective to our knowledge of environmental and management stresses and their effects on the evolution of herbicide resistance in weeds. © 2017 Society of Chemical Industry.