The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform

Danny Ghazarian - One of the best experts on this subject based on the ideXlab platform.

  • ectopic hamartomatous thymoma a case demonstrating skin adnexal differentiation with positivity for Epithelial Membrane Antigen androgen receptors and brst 2 by immunohistochemistry
    Human Pathology, 2007
    Co-Authors: Ilan Weinreb, Frances P Omalley, Danny Ghazarian
    Abstract:

    Summary Ectopic hamartomatous thymoma is a rare tumor of the lower neck occurring in adult men, which follows a benign course. They are triphasic with Epithelial, adipocytic, and spindled elements in variable amounts. The origin of this tumor has been debated, but it is now believed to arise from remnants of the cervical sinus of His from early development. We describe a case of ectopic hamartomatous thymoma with typical features, as well as multifocal areas of skin adnexal differentiation. These included sebaceous, eccrine, and apocrine elements. We highlighted these by using immunohistochemistry to Epithelial Membrane Antigen, BRST-2, and androgen receptors (AR). Epithelial Membrane Antigen stained sebaceous cells and the luminal borders of eccrine and apocrine ducts. BRST-2 and AR stained apocrine elements in a cytoplasmic and a nuclear pattern, respectively. The spindled component also expressed nuclear AR. AR positivity has not been described previously and may explain the occurrence primarily in men in postpubertal life.

Vincenzo Eusebi - One of the best experts on this subject based on the ideXlab platform.

  • alcian blue and Epithelial Membrane Antigen are useful markers in differentiating benign from malignant papillae in thyroid lesions
    Virchows Archiv, 1991
    Co-Authors: Stefania Damiani, Floriana Fratamico, G Lapertosa, Roberto Dina, Vincenzo Eusebi
    Abstract:

    Immunohistochemistry for Epithelial Membrane Antigen (EMA) and histochemistry for alcianophilic substances were performed in 17 cases of papillary thyroid carcinoma (PTC) and 11 cases of benign thyroid lesions showing papillary changes (7 diffuse hyperplastic goitres-Graves'disease; 4 colloid cystic goitres). In all PTCs the glycocalix of the cells lining the papillary structures was stronly positive with anti-EMA antiserum. Alcian blue pH 2.5 stain (AB 2.5) was also positive in 15 of these cases. In contrast, no cases of benign thyroid lesions showed AB 2.5 positivity in the cells lining the papillary structures and the positivity with anti-EMA antiserum, present in only 5 out the 11 cases, was focal and very weak. These results indicate that the presence and distribution of EMA and alcianophilic substances may be useful in distinguishing benign from malignant thyroid lesions containing papillae.

J Martín De Las Mulas - One of the best experts on this subject based on the ideXlab platform.

  • Bilateral retiform Sertoli-Leydig cell tumour in a bitch. Alpha-inhibin and Epithelial Membrane Antigen as useful tools for differential diagnosis.
    Journal of comparative pathology, 2008
    Co-Authors: J Gómez-laguna, Y Millan, C Reymundo, V Domingo, J Martín De Las Mulas
    Abstract:

    Sertoli-Leydig cell tumours with a retiform pattern similar to the pattern of the rete testis are a subtype of sex cord-stromal tumours recognized in the human WHO histological classification of ovarian tumours but not in the equivalent classification for domestic animals. The morphology of the tumour may be confused with that of the more common ovarian Epithelial tumours. The gross, microscopical and immunohistochemical features of a canine retiform Sertoli-Leydig cell tumour and its comparison with the human counterpart are presented in this report. Both ovaries were enlarged and cystic. Microscopically, the tumour was cystic with tubulopapillary growth characterized by narrow, elongated branching tubules. Immunohistochemically, the tumour cells expressed alpha-inhibin, while Epithelial Membrane Antigen was not detected, indicating a sex cord-stromal origin of the tumour. Additionally, the tumour cells expressed cytokeratin and vimentin in addition to oestrogen receptor alpha and progesterone receptor.

Zsombor Melegh - One of the best experts on this subject based on the ideXlab platform.

  • gastrointestinal stromal tumours can express cd10 and Epithelial Membrane Antigen but not oestrogen receptor or hmb45
    Histopathology, 2011
    Co-Authors: Newton A C S Wong, Zsombor Melegh
    Abstract:

    Wong N A C S & Melegh Z (2011) Histopathology59, 781–785 Gastrointestinal stromal tumours can express CD10 and Epithelial Membrane Antigen but not oestrogen receptor or HMB45 Aims:  Gastrointestinal stromal tumour (GIST) may share morphological and/or immunohistochemical features with various intra-abdominal neoplasms, including endometrial stromal sarcoma, perivascular epithelioid cell tumour (PEComa), melanoma and synovial sarcoma. Each of these various neoplasms has characteristic immunohistochemical markers, including Epithelial Membrane Antigen (EMA), CD10, oestrogen receptor alpha (ERa) and/or HMB45, and therefore the primary aim of this study was to determine whether these markers are also expressed by GISTs. Methods and results:  Standard size sections of 52 GISTs were immunostained for EMA, CD10, ERa and a melanoma marker cocktail (targeting HMB45 and melan-A). Ten GISTs (19%) showed CD10 immunopositivity. This positivity was confined almost completely to small intestinal GISTs, and was seen among spindle cell GISTs but not epithelioid or mixed cell-type GISTs. Five of the 52 GISTs (9.6%) showed EMA immunopositivity. This positivity was always focal and usually seen in a perivascular location. None of the GISTs showed immunopositivity for ERa or the melanoma marker cocktail. Conclusions:  GISTs occasionally show CD10 immunopositivity (especially small intestinal spindle cell GISTs), and infrequently show focal EMA positivity. GISTs do not show immunopositivity for ERa or HMB45.

J M Theaker - One of the best experts on this subject based on the ideXlab platform.

  • ber ep4 and Epithelial Membrane Antigen aid distinction of basal cell squamous cell and basosquamous carcinomas of the skin
    Histopathology, 2000
    Co-Authors: Trevor W Beer, P Shepherd, J M Theaker
    Abstract:

    Aims : Seventy-five skin tumours were studied to investigate the value of immunohistochemistry in differentiating basal cell, squamous cell and basosquamous carcinomas of the skin. Methods and results : Archived paraffin-embedded tissue samples of basal cell carcinomas (n = 39), squamous cell carcinomas (n = 23) and basosquamous carcinomas (n = 13) were stained immunohistochemically using a panel of antibodies. All of the basal cell carcinomas stained positively for Ber EP4, in contrast to the group of squamous cell carcinomas, that showed no staining. Basosquamous carcinomas all showed at least some areas of Ber EP4 positivity. None of the basal cell carcinomas, but most of the squamous cell carcinomas (22 of 23) expressed Epithelial Membrane Antigen (EMA). Only one of the basosquamous carcinomas expressed EMA positivity focally. CAM 5.2, carcinoembryonic Antigen (CEA) and 34βE12 antibodies lacked specificity in relation to the different tumour types. Conclusion : Distinction of basal and squamous cell carcinomas of the skin can be readily achieved with routine immunohistochemistry using Ber EP4 and EMA. Identification of basosquamous carcinoma is also facilitated with this method.