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Robert J. Collins - One of the best experts on this subject based on the ideXlab platform.

  • Fine needle aspiration cytology of Epithelial-myoEpithelial Carcinoma of salivary glands. A report of three cases.
    Acta Cytologica, 1999
    Co-Authors: Wai-kuen Ng, Carolyn Choy, Philip P.c. Ip, Wai-hung Shek, Robert J. Collins
    Abstract:

    BACKGROUND: Epithelial-myoEpithelial Carcinoma is a rare, low grade malignant tumor of the salivary glands. Histologically, it has a biphasic cellular composition and exhibits a high degree of differentiation. The fine needle aspiration cytology of this rare tumor is rarely described in the literature. CASES: We report the fine needle aspiration cytology of three Epithelial-myoEpithelial Carcinomas, arising in the right parotid, left parotid and minor salivary gland of the hard palate. Cytology showed a biphasic population consisting of cells of ductal Epithelial and myoEpithelial origin arranged in small clusters and sheets. The myoEpithelial cells had small, uniform nuclei; ample, clear cytoplasm and distinct cell borders, while the ductal Epithelial cells had larger, mildly pleomorphic nuclei and scanty cytoplasm. These ductal cells tended to form tubules among background sheets of clear myoEpithelial cells. This feature, if present, was an important diagnostic clue. Hyaline material surrounding cell clusters and focal adenoid cystic Carcinoma-like areas with orangeophilic globules were also not uncommon. CONCLUSION: While the cytologic appearance of Epithelial-myoEpithelial Carcinoma may closely mimic that of other salivary gland tumors, such as adenoid cystic Carcinoma, pleomorphic adenoma and basal cell adenoma, certain peculiar cytologic features may allow a distinction to be made on fine needle aspiration biopsy.

Wai-kuen Ng - One of the best experts on this subject based on the ideXlab platform.

  • Fine needle aspiration cytology of Epithelial-myoEpithelial Carcinoma of salivary glands. A report of three cases.
    Acta Cytologica, 1999
    Co-Authors: Wai-kuen Ng, Carolyn Choy, Philip P.c. Ip, Wai-hung Shek, Robert J. Collins
    Abstract:

    BACKGROUND: Epithelial-myoEpithelial Carcinoma is a rare, low grade malignant tumor of the salivary glands. Histologically, it has a biphasic cellular composition and exhibits a high degree of differentiation. The fine needle aspiration cytology of this rare tumor is rarely described in the literature. CASES: We report the fine needle aspiration cytology of three Epithelial-myoEpithelial Carcinomas, arising in the right parotid, left parotid and minor salivary gland of the hard palate. Cytology showed a biphasic population consisting of cells of ductal Epithelial and myoEpithelial origin arranged in small clusters and sheets. The myoEpithelial cells had small, uniform nuclei; ample, clear cytoplasm and distinct cell borders, while the ductal Epithelial cells had larger, mildly pleomorphic nuclei and scanty cytoplasm. These ductal cells tended to form tubules among background sheets of clear myoEpithelial cells. This feature, if present, was an important diagnostic clue. Hyaline material surrounding cell clusters and focal adenoid cystic Carcinoma-like areas with orangeophilic globules were also not uncommon. CONCLUSION: While the cytologic appearance of Epithelial-myoEpithelial Carcinoma may closely mimic that of other salivary gland tumors, such as adenoid cystic Carcinoma, pleomorphic adenoma and basal cell adenoma, certain peculiar cytologic features may allow a distinction to be made on fine needle aspiration biopsy.

Feng Wang - One of the best experts on this subject based on the ideXlab platform.

  • clinical and pathological analysis of 10 cases of salivary gland Epithelial myoEpithelial Carcinoma
    Medicine, 2020
    Co-Authors: Feng Wang, Yufan Wang, Yuehong Shen, Hongyu Yang
    Abstract:

    Epithelial-myoEpithelial Carcinoma (EMC) is a rare neoplasm of the salivary glands. The aim of this study is to review and evaluate clinicopathological features and treatment of EMC of salivary gland for better sensitivity and specificity of the diagnosis.The clinical and pathological data of the 10 salivary gland EMC cases from 2008 to 2017 were analyzed.Six cases of EMC were diagnosed to be originated from parotid gland and 4 cases were from the minor salivary gland including palate, tongue, and oropharynx. Seven cases were performed radical surgery and 3 cases had radiotherapy postoperation, 2 cases had a local recurrence. The follow-up period was 4 to 104 months and the survival rate was 100%. Histopathology showed the tumors had a dominant prototypical biphasic tubular structure consisting of inner, cuboidal ductal cells and an outer layer of clear, myoEpithelial cells, which grew infiltratively. The immunohistochemistry (IHC) showed the marker proteins CK, S-100, CD117, and Calponin were strongly positive in most EMC.EMC is a rare and low-grade malignant tumor with good overall survival but relatively high tendency for local recurrence. Surgery is the priority choice for EMC therapy. Complete surgical excision and negative margins are necessary for good prognosis. Imaging techniques should be used to assess the neck dissection and it is unclear whether adjuvant radiotherapy is beneficial. To ensure the sensitivity and specificity of the EMC diagnosis, we should perform both pathological and IHC analysis.

  • Epithelial myoEpithelial Carcinoma with high grade transformation of parotid gland a case report and literature review
    Medicine, 2017
    Co-Authors: Hongyu Yang, Xia Hong, Yufan Wang, Feng Wang
    Abstract:

    Rationale Epithelial-myoEpithelial Carcinoma (EMC) is regarded as a rare low-grade malignant tumor of the salivary gland, accounting for 0.4% to 1% of all salivary gland tumors. However, Epithelial-myoEpithelial Carcinoma with high-grade transformation (EMC with HGT) is extremely rare, therefore it is easily to be inappropriately diagnosed and treated. Herein, we report an unusual case of EMC with HGT involving the parotid gland and discuss the clinical features and histological characteristic of EMC with HGT, in order to remind the doctors to take appropriate diagnosis and treatment. Patient concerns A 77-year-old female sought for treatment in our hospital due to pain mass in the left parotid gland for 6 months with rapid growth recently. Diagnoses EMC with HGT was confirmed by final pathology, and then the result showed there were 2 distinctly different areas in the tumor, including the typical EMC component and intensive spindle cells component. Interventions The extensive resection surgery was performed. Outcomes The patient was uneventful after surgery and no recurrence or metastasis has been observed after follow-up of 4 years. Lessons A review of literature suggested that EMC with HGT patients trend to be more aged, more aggressive and poorer prognosis than typical EMC patients. In order to avoid misdiagnosis and inappropriate treatment, it is necessary to accurately recognize the differences between the EMC with HGT and typical EMC.

Hongyu Yang - One of the best experts on this subject based on the ideXlab platform.

  • clinical and pathological analysis of 10 cases of salivary gland Epithelial myoEpithelial Carcinoma
    Medicine, 2020
    Co-Authors: Feng Wang, Yufan Wang, Yuehong Shen, Hongyu Yang
    Abstract:

    Epithelial-myoEpithelial Carcinoma (EMC) is a rare neoplasm of the salivary glands. The aim of this study is to review and evaluate clinicopathological features and treatment of EMC of salivary gland for better sensitivity and specificity of the diagnosis.The clinical and pathological data of the 10 salivary gland EMC cases from 2008 to 2017 were analyzed.Six cases of EMC were diagnosed to be originated from parotid gland and 4 cases were from the minor salivary gland including palate, tongue, and oropharynx. Seven cases were performed radical surgery and 3 cases had radiotherapy postoperation, 2 cases had a local recurrence. The follow-up period was 4 to 104 months and the survival rate was 100%. Histopathology showed the tumors had a dominant prototypical biphasic tubular structure consisting of inner, cuboidal ductal cells and an outer layer of clear, myoEpithelial cells, which grew infiltratively. The immunohistochemistry (IHC) showed the marker proteins CK, S-100, CD117, and Calponin were strongly positive in most EMC.EMC is a rare and low-grade malignant tumor with good overall survival but relatively high tendency for local recurrence. Surgery is the priority choice for EMC therapy. Complete surgical excision and negative margins are necessary for good prognosis. Imaging techniques should be used to assess the neck dissection and it is unclear whether adjuvant radiotherapy is beneficial. To ensure the sensitivity and specificity of the EMC diagnosis, we should perform both pathological and IHC analysis.

  • Epithelial myoEpithelial Carcinoma with high grade transformation of parotid gland a case report and literature review
    Medicine, 2017
    Co-Authors: Hongyu Yang, Xia Hong, Yufan Wang, Feng Wang
    Abstract:

    Rationale Epithelial-myoEpithelial Carcinoma (EMC) is regarded as a rare low-grade malignant tumor of the salivary gland, accounting for 0.4% to 1% of all salivary gland tumors. However, Epithelial-myoEpithelial Carcinoma with high-grade transformation (EMC with HGT) is extremely rare, therefore it is easily to be inappropriately diagnosed and treated. Herein, we report an unusual case of EMC with HGT involving the parotid gland and discuss the clinical features and histological characteristic of EMC with HGT, in order to remind the doctors to take appropriate diagnosis and treatment. Patient concerns A 77-year-old female sought for treatment in our hospital due to pain mass in the left parotid gland for 6 months with rapid growth recently. Diagnoses EMC with HGT was confirmed by final pathology, and then the result showed there were 2 distinctly different areas in the tumor, including the typical EMC component and intensive spindle cells component. Interventions The extensive resection surgery was performed. Outcomes The patient was uneventful after surgery and no recurrence or metastasis has been observed after follow-up of 4 years. Lessons A review of literature suggested that EMC with HGT patients trend to be more aged, more aggressive and poorer prognosis than typical EMC patients. In order to avoid misdiagnosis and inappropriate treatment, it is necessary to accurately recognize the differences between the EMC with HGT and typical EMC.

Mitchell R. Gore - One of the best experts on this subject based on the ideXlab platform.

  • Epithelial-myoEpithelial Carcinoma: a population-based survival analysis
    BMC Ear Nose and Throat Disorders, 2018
    Co-Authors: Mitchell R. Gore
    Abstract:

    Epithelial-myoEpithelial Carcinoma is an uncommon malignant neoplasm seen most frequently in the salivary glands, representing approximately 1 to 2% of salivary gland tumors. Less than 600 cases have been reported in the literature since its initial description in 1972. The aim of this study was to examine demographic, site, stage, and survival factors in patients with Epithelial-myoEpithelial Carcinoma. The 1973–2014 SEER (Surveillance, Epidemiology, and End Results) cancer database was queried for patients treated for Epithelial-myoEpithelial Carcinoma. The data was analyzed for patient T (tumor), N (nodal), and M (metastasis) stage, tumor site, and demographic characteristics. The Kaplan-Meier model was used to estimate actuarial survival. A total of 468 patients were identified. White patients represented 78.0% of the total. There were 291 female patients and 177 male patients. Overall 5-, 10-, and 20-year survival was 72.7%, 59.5%, and 38.3%, respectively. Mean survival time was 165.5 months. Parotid gland was the most common site with 57.7% of patients, with submandibular gland representing 9.8% of patients. Distant metastasis (M) status was unknown in 33.3%, with 2.6% being M1, 3.0% being MX, and 61.1% M0. Nodal metastasis (N) status was unknown in 33.3%, while 4.4% were N+, 4.7% were NX, and 57.5% were N0. 88.2% of patients had surgery as part or all of the treatment regimen. Univariate Kaplan-Meier analysis showed that AJCC overall stage, primary tumor (T) stage, nodal (N) stage, presence of distant metastasis (M1), age at diagnosis, race, and non-surgical treatment significantly affected survival. On multivariate analysis age, race, AJCC stage, T, N, M stage, and treatment type were significant. Epithelial-myoEpithelial Carcinoma is a malignant, histologically biphasic neoplasm most frequently seen in the parotid gland. The nodal and distant metastasis rates are low. Age at diagnosis, race, AJCC stage, T, N, M stage, and treatment type all significantly affected survival.

  • Epithelial-myoEpithelial Carcinoma: a population-based survival analysis
    BMC, 2018
    Co-Authors: Mitchell R. Gore
    Abstract:

    Abstract Background Epithelial-myoEpithelial Carcinoma is an uncommon malignant neoplasm seen most frequently in the salivary glands, representing approximately 1 to 2% of salivary gland tumors. Less than 600 cases have been reported in the literature since its initial description in 1972. The aim of this study was to examine demographic, site, stage, and survival factors in patients with Epithelial-myoEpithelial Carcinoma. Methods The 1973–2014 SEER (Surveillance, Epidemiology, and End Results) cancer database was queried for patients treated for Epithelial-myoEpithelial Carcinoma. The data was analyzed for patient T (tumor), N (nodal), and M (metastasis) stage, tumor site, and demographic characteristics. The Kaplan-Meier model was used to estimate actuarial survival. Results A total of 468 patients were identified. White patients represented 78.0% of the total. There were 291 female patients and 177 male patients. Overall 5-, 10-, and 20-year survival was 72.7%, 59.5%, and 38.3%, respectively. Mean survival time was 165.5 months. Parotid gland was the most common site with 57.7% of patients, with submandibular gland representing 9.8% of patients. Distant metastasis (M) status was unknown in 33.3%, with 2.6% being M1, 3.0% being MX, and 61.1% M0. Nodal metastasis (N) status was unknown in 33.3%, while 4.4% were N+, 4.7% were NX, and 57.5% were N0. 88.2% of patients had surgery as part or all of the treatment regimen. Univariate Kaplan-Meier analysis showed that AJCC overall stage, primary tumor (T) stage, nodal (N) stage, presence of distant metastasis (M1), age at diagnosis, race, and non-surgical treatment significantly affected survival. On multivariate analysis age, race, AJCC stage, T, N, M stage, and treatment type were significant. Conclusions Epithelial-myoEpithelial Carcinoma is a malignant, histologically biphasic neoplasm most frequently seen in the parotid gland. The nodal and distant metastasis rates are low. Age at diagnosis, race, AJCC stage, T, N, M stage, and treatment type all significantly affected survival