The Experts below are selected from a list of 23169 Experts worldwide ranked by ideXlab platform

W R Green - One of the best experts on this subject based on the ideXlab platform.

  • Tumor detachments of the retinal pigment Epithelium in ocular central nervous system lymphoma
    Retina-the Journal of Retinal and Vitreous Diseases, 1996
    Co-Authors: J M Dean, M A Novak, C C Chan, W R Green
    Abstract:

    BACKGROUND: Ocular/central nervous system (CNS) lymphoma is a B-lymphocyte-derived Tumor that characteristically involves the retina, optic nerve head, vitreous, and subretinal pigment epithelial areas of the eye. METHOD: A retrospective analysis of clinical history and photography fluorescein angiography, histopathology, and immunocytochemistry of an untreated patient with ocular/CNS lymphoma was performed. RESULTS: Tumor detachments of the retinal pigment Epithelium (RPE) evolved into areas of RPE atrophy and depigmentation and disciform scars. Histopathologic studies disclosed foci of Tumor cells in the wall of and around blood vessels and between the RPE and Bruch's membrane. Immunocytochemistry identified the malignant cells as B-lymphocytes. CONCLUSIONS: The clinicopathologic features of a patient with ocular/CNS B-cell lymphoma are presented. Retinal pigment Epithelium Tumor detachments evolved to areas of RPE atrophy and depigmentation and disciform scars.

J M Dean - One of the best experts on this subject based on the ideXlab platform.

  • Tumor detachments of the retinal pigment Epithelium in ocular central nervous system lymphoma
    Retina-the Journal of Retinal and Vitreous Diseases, 1996
    Co-Authors: J M Dean, M A Novak, C C Chan, W R Green
    Abstract:

    BACKGROUND: Ocular/central nervous system (CNS) lymphoma is a B-lymphocyte-derived Tumor that characteristically involves the retina, optic nerve head, vitreous, and subretinal pigment epithelial areas of the eye. METHOD: A retrospective analysis of clinical history and photography fluorescein angiography, histopathology, and immunocytochemistry of an untreated patient with ocular/CNS lymphoma was performed. RESULTS: Tumor detachments of the retinal pigment Epithelium (RPE) evolved into areas of RPE atrophy and depigmentation and disciform scars. Histopathologic studies disclosed foci of Tumor cells in the wall of and around blood vessels and between the RPE and Bruch's membrane. Immunocytochemistry identified the malignant cells as B-lymphocytes. CONCLUSIONS: The clinicopathologic features of a patient with ocular/CNS B-cell lymphoma are presented. Retinal pigment Epithelium Tumor detachments evolved to areas of RPE atrophy and depigmentation and disciform scars.

M A Novak - One of the best experts on this subject based on the ideXlab platform.

  • Tumor detachments of the retinal pigment Epithelium in ocular central nervous system lymphoma
    Retina-the Journal of Retinal and Vitreous Diseases, 1996
    Co-Authors: J M Dean, M A Novak, C C Chan, W R Green
    Abstract:

    BACKGROUND: Ocular/central nervous system (CNS) lymphoma is a B-lymphocyte-derived Tumor that characteristically involves the retina, optic nerve head, vitreous, and subretinal pigment epithelial areas of the eye. METHOD: A retrospective analysis of clinical history and photography fluorescein angiography, histopathology, and immunocytochemistry of an untreated patient with ocular/CNS lymphoma was performed. RESULTS: Tumor detachments of the retinal pigment Epithelium (RPE) evolved into areas of RPE atrophy and depigmentation and disciform scars. Histopathologic studies disclosed foci of Tumor cells in the wall of and around blood vessels and between the RPE and Bruch's membrane. Immunocytochemistry identified the malignant cells as B-lymphocytes. CONCLUSIONS: The clinicopathologic features of a patient with ocular/CNS B-cell lymphoma are presented. Retinal pigment Epithelium Tumor detachments evolved to areas of RPE atrophy and depigmentation and disciform scars.

C C Chan - One of the best experts on this subject based on the ideXlab platform.

  • Tumor detachments of the retinal pigment Epithelium in ocular central nervous system lymphoma
    Retina-the Journal of Retinal and Vitreous Diseases, 1996
    Co-Authors: J M Dean, M A Novak, C C Chan, W R Green
    Abstract:

    BACKGROUND: Ocular/central nervous system (CNS) lymphoma is a B-lymphocyte-derived Tumor that characteristically involves the retina, optic nerve head, vitreous, and subretinal pigment epithelial areas of the eye. METHOD: A retrospective analysis of clinical history and photography fluorescein angiography, histopathology, and immunocytochemistry of an untreated patient with ocular/CNS lymphoma was performed. RESULTS: Tumor detachments of the retinal pigment Epithelium (RPE) evolved into areas of RPE atrophy and depigmentation and disciform scars. Histopathologic studies disclosed foci of Tumor cells in the wall of and around blood vessels and between the RPE and Bruch's membrane. Immunocytochemistry identified the malignant cells as B-lymphocytes. CONCLUSIONS: The clinicopathologic features of a patient with ocular/CNS B-cell lymphoma are presented. Retinal pigment Epithelium Tumor detachments evolved to areas of RPE atrophy and depigmentation and disciform scars.

Karel Smetana - One of the best experts on this subject based on the ideXlab platform.

  • epithelial stromal interaction in squamous cell Epithelium derived Tumors an important new player in the control of Tumor biological properties
    Anticancer Research, 2010
    Co-Authors: Jan Plzak, Lukas Lacina, Martin Chovanec, Barbora Dvorankova, Pavol Szabo, Zdenek Cada, Karel Smetana
    Abstract:

    Mesenchymal-epithelial interaction is important in the morphogenesis of squamous epithelia and their appendages, and in the control of the hair cycle postnatally. This review summarizes data regarding the interaction between stromal fibroblasts and Tumor cells, with an emphasis on Tumors originating from squamous Epithelium. Tumor stromal fibroblasts as important element of the cancer stem cell niche are able to participate in the control of the biological properties of Tumors. We propose these stromal cells and their products as novel targets for anticancer therapy. Nonmelanoma skin cancer (predominantly basal and squamous cell carcinoma) represents the most frequent malignant Tumor worldwide. It is generally accepted that its incidence is increasing with the ageing of the population, but also with climatic and behavioral changes. Although they are less aggressive than Tumors originating from the mucosa, their locally aggressive growth frequently mutilates the patient (Figure 1). The carcinomas originating from mucosal regions of the head and neck (predominantly of squamous type) are characterized by lymphatic and distant metastasis in addition to locally aggressive invasion, resulting in a poor prognosis. Despite the progress in both diagnosis and treatment, no significant progress has been achieved, except when the treatment is started at an advanced stage of the disease. New results from investigation of different types of Tumors indicate the importance of Tumor microenvironment on the biological properties of Tumor, such as the local aggressive growth and lymphatic or distant metastasation. This microenvironment is highly complex and includes many cell types such as fibroblasts, inflammatory and endothelial cells and their products such as cytokines and extracellular matrix. This review article summarizes data about the role of the epithelial-mesenchymal interaction in Tumor originating from squamous Epithelium.

  • Epithelial―Stromal Interaction in Squamous Cell Epithelium-derived Tumors: An Important New Player in the Control of Tumor Biological Properties
    Anticancer Research, 2010
    Co-Authors: Jan Plzak, Lukas Lacina, Martin Chovanec, Barbora Dvorankova, Pavol Szabo, Zdenek Cada, Karel Smetana
    Abstract:

    Mesenchymal-epithelial interaction is important in the morphogenesis of squamous epithelia and their appendages, and in the control of the hair cycle postnatally. This review summarizes data regarding the interaction between stromal fibroblasts and Tumor cells, with an emphasis on Tumors originating from squamous Epithelium. Tumor stromal fibroblasts as important element of the cancer stem cell niche are able to participate in the control of the biological properties of Tumors. We propose these stromal cells and their products as novel targets for anticancer therapy. Nonmelanoma skin cancer (predominantly basal and squamous cell carcinoma) represents the most frequent malignant Tumor worldwide. It is generally accepted that its incidence is increasing with the ageing of the population, but also with climatic and behavioral changes. Although they are less aggressive than Tumors originating from the mucosa, their locally aggressive growth frequently mutilates the patient (Figure 1). The carcinomas originating from mucosal regions of the head and neck (predominantly of squamous type) are characterized by lymphatic and distant metastasis in addition to locally aggressive invasion, resulting in a poor prognosis. Despite the progress in both diagnosis and treatment, no significant progress has been achieved, except when the treatment is started at an advanced stage of the disease. New results from investigation of different types of Tumors indicate the importance of Tumor microenvironment on the biological properties of Tumor, such as the local aggressive growth and lymphatic or distant metastasation. This microenvironment is highly complex and includes many cell types such as fibroblasts, inflammatory and endothelial cells and their products such as cytokines and extracellular matrix. This review article summarizes data about the role of the epithelial-mesenchymal interaction in Tumor originating from squamous Epithelium.