The Experts below are selected from a list of 570093 Experts worldwide ranked by ideXlab platform
Carol A. Eisenberg - One of the best experts on this subject based on the ideXlab platform.
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Stem Cell plasticity Cell fusion and transdifferentiation
Birth Defects Research Part C-embryo Today-reviews, 2003Co-Authors: Leonard M Eisenberg, Carol A. EisenbergAbstract:One of the most contentious issues in biology today concerns the existence of Stem Cell plasticity. The term “plasticity” refers to the capacity of tissue-derived Stem Cells to exhibit a phenotypic potential that extends beyond the differentiated Cell phenotypes of their resident tissue. Although evidence of Stem Cell plasticity has been reported by multiple laboratories, other scientists have not found the data persuasive and have remained skeptical about these new findings. This review will provide an overview of the Stem Cell plasticity controversy. We will examine many of the major objections that have been made to challenge the Stem Cell plasticity data. This controversy will be placed in the context of the traditional view of Stem Cell potential and Cell phenotypic diversification. What the implications of Cell plasticity are, and how its existence may modulate our present understanding of Stem Cell biology, will be explored. In addition, we will examine a topic that is usually not included within a discussion of Stem Cell biology—the direct conversion of one differentiated Cell type into another. We believe that these observations on the transdifferentiation of differentiated Cells have direct bearing on the issue of Stem Cell plasticity, and may provide insights into how Cell phenotypic diversification is realized in the adult and into the origin of Cell phenotypes during evolution. Birth Defects Research (Part C) 69:209–218, 2003. © 2003 Wiley-Liss, Inc.
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Stem Cell plasticity Cell fusion and transdifferentiation
Birth Defects Research Part C-embryo Today-reviews, 2003Co-Authors: Leonard M Eisenberg, Carol A. EisenbergAbstract:One of the most contentious issues in biology today concerns the existence of Stem Cell plasticity. The term "plasticity" refers to the capacity of tissue-derived Stem Cells to exhibit a phenotypic potential that extends beyond the differentiated Cell phenotypes of their resident tissue. Although evidence of Stem Cell plasticity has been reported by multiple laboratories, other scientists have not found the data persuasive and have remained skeptical about these new findings. This review will provide an overview of the Stem Cell plasticity controversy. We will examine many of the major objections that have been made to challenge the Stem Cell plasticity data. This controversy will be placed in the context of the traditional view of Stem Cell potential and Cell phenotypic diversification. What the implications of Cell plasticity are, and how its existence may modulate our present understanding of Stem Cell biology, will be explored. In addition, we will examine a topic that is usually not included within a discussion of Stem Cell biology--the direct conversion of one differentiated Cell type into another. We believe that these observations on the transdifferentiation of differentiated Cells have direct bearing on the issue of Stem Cell plasticity, and may provide insights into how Cell phenotypic diversification is realized in the adult and into the origin of Cell phenotypes during evolution.
Leonard M Eisenberg - One of the best experts on this subject based on the ideXlab platform.
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Stem Cell plasticity Cell fusion and transdifferentiation
Birth Defects Research Part C-embryo Today-reviews, 2003Co-Authors: Leonard M Eisenberg, Carol A. EisenbergAbstract:One of the most contentious issues in biology today concerns the existence of Stem Cell plasticity. The term “plasticity” refers to the capacity of tissue-derived Stem Cells to exhibit a phenotypic potential that extends beyond the differentiated Cell phenotypes of their resident tissue. Although evidence of Stem Cell plasticity has been reported by multiple laboratories, other scientists have not found the data persuasive and have remained skeptical about these new findings. This review will provide an overview of the Stem Cell plasticity controversy. We will examine many of the major objections that have been made to challenge the Stem Cell plasticity data. This controversy will be placed in the context of the traditional view of Stem Cell potential and Cell phenotypic diversification. What the implications of Cell plasticity are, and how its existence may modulate our present understanding of Stem Cell biology, will be explored. In addition, we will examine a topic that is usually not included within a discussion of Stem Cell biology—the direct conversion of one differentiated Cell type into another. We believe that these observations on the transdifferentiation of differentiated Cells have direct bearing on the issue of Stem Cell plasticity, and may provide insights into how Cell phenotypic diversification is realized in the adult and into the origin of Cell phenotypes during evolution. Birth Defects Research (Part C) 69:209–218, 2003. © 2003 Wiley-Liss, Inc.
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Stem Cell plasticity Cell fusion and transdifferentiation
Birth Defects Research Part C-embryo Today-reviews, 2003Co-Authors: Leonard M Eisenberg, Carol A. EisenbergAbstract:One of the most contentious issues in biology today concerns the existence of Stem Cell plasticity. The term "plasticity" refers to the capacity of tissue-derived Stem Cells to exhibit a phenotypic potential that extends beyond the differentiated Cell phenotypes of their resident tissue. Although evidence of Stem Cell plasticity has been reported by multiple laboratories, other scientists have not found the data persuasive and have remained skeptical about these new findings. This review will provide an overview of the Stem Cell plasticity controversy. We will examine many of the major objections that have been made to challenge the Stem Cell plasticity data. This controversy will be placed in the context of the traditional view of Stem Cell potential and Cell phenotypic diversification. What the implications of Cell plasticity are, and how its existence may modulate our present understanding of Stem Cell biology, will be explored. In addition, we will examine a topic that is usually not included within a discussion of Stem Cell biology--the direct conversion of one differentiated Cell type into another. We believe that these observations on the transdifferentiation of differentiated Cells have direct bearing on the issue of Stem Cell plasticity, and may provide insights into how Cell phenotypic diversification is realized in the adult and into the origin of Cell phenotypes during evolution.
Nigel H. Russell - One of the best experts on this subject based on the ideXlab platform.
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The role of plerixafor in optimizing peripheral blood Stem Cell mobilization for autologous Stem Cell transplantation
Leukemia, 2011Co-Authors: Mohamad Mohty, Kai Hübel, Rafael F. Duarte, Sandra Croockewit, G Kvalheim, Nigel H. RussellAbstract:The role of plerixafor in optimizing peripheral blood Stem Cell mobilization for autologous Stem Cell transplantation
Songlin Wang - One of the best experts on this subject based on the ideXlab platform.
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Stem Cell based tooth and periodontal regeneration
Oral Diseases, 2018Co-Authors: Lei Hu, Songlin WangAbstract:Currently regeneration of tooth and periodontal damage still remains great challenge. Stem Cell-based tissue engineering raised novel therapeutic strategies for tooth and periodontal repair. Stem Cells for tooth and periodontal regeneration include dental pulp Stem Cells (DPSCs), periodontal ligament Stem Cells (PDLSCs), Stem Cells from the dental apical papilla (SCAPs), and Stem Cells from human exfoliated deciduous teeth (SHEDs), dental follicle Stem Cells (DFSCs), dental epithelial Stem Cells (DESCs), bone marrow mesenchymal Stem Cells (BMMSCs), adipose-derived Stem Cells (ADSCs), embryonic Stem Cells (ESCs) and induced pluripotent Stem Cells (iPSCs). To date, substantial advances have been made in Stem Cell-based tooth and periodontal regeneration, including dentin-pulp, whole tooth, bio-root and periodontal regeneration. Translational investigations have been performed such as dental Stem Cell banking and clinical trials. In this review, we present strategies for Stem Cell-based tissue engineering for tooth and periodontal repair, and the translational studies. This article is protected by copyright. All rights reserved.
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Stem Cell based tooth and periodontal regeneration
Oral Diseases, 2018Co-Authors: Yi Liu, Songlin WangAbstract:Currently regeneration of tooth and periodontal damage still remains great challenge. Stem Cell-based tissue engineering raised novel therapeutic strategies for tooth and periodontal repair. Stem Cells for tooth and periodontal regeneration include dental pulp Stem Cells (DPSCs), periodontal ligament Stem Cells (PDLSCs), Stem Cells from the dental apical papilla (SCAPs), and Stem Cells from human exfoliated deciduous teeth (SHEDs), dental follicle Stem Cells (DFSCs), dental epithelial Stem Cells (DESCs), bone marrow mesenchymal Stem Cells (BMMSCs), adipose-derived Stem Cells (ADSCs), embryonic Stem Cells (ESCs) and induced pluripotent Stem Cells (iPSCs). To date, substantial advances have been made in Stem Cell-based tooth and periodontal regeneration, including dentin-pulp, whole tooth, bioroot and periodontal regeneration. Translational investigations have been performed such as dental Stem Cell banking and clinical trials. In this review, we present strategies for Stem Cell-based tissue engineering for tooth and periodontal repair, and the translational studies.
Thomas Laux - One of the best experts on this subject based on the ideXlab platform.
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Plant Stem Cell Niches
Annual Review of Plant Biology, 2012Co-Authors: Ernst Aichinger, Noortje Kornet, Thomas D. Friedrich, Thomas LauxAbstract:MultiCellular organisms possess pluripotent Stem Cells to form new organs, replenish the daily loss of Cells, or regenerate organs after injury. Stem Cells are maintained in specific environments, the Stem Cell niches, that provide signals to block differentiation. In plants, Stem Cell niches are situated in the shoot, root, and vascular meriStems—self-perpetuating units of organ formation. Plants' lifelong activity—which, as in the case of trees, can extend over more than a thousand years—requires that a robust regulatory network keep the balance between pluripotent Stem Cells and differentiating descendants. In this review, we focus on current models in plant Stem Cell research elaborated during the past two decades, mainly in the model plant Arabidopsis thaliana. We address the roles of mobile signals on transcriptional modules involved in balancing Cell fates. In addition, we discuss shared features of and differences between the distinct Stem Cell niches of Arabidopsis.
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connecting the paths in plant Stem Cell regulation
Trends in Cell Biology, 2007Co-Authors: Matthew R Tucker, Thomas LauxAbstract:Stem Cell niches are specialized microenvironments where pluripotent Cells are maintained to provide undifferentiated Cells for the formation of new tissues and organs. The balance between Stem Cell maintenance within the niche and differentiation of Cells that exit it is regulated by local Cell–Cell communication, together with external cues. Recent findings have shown connections between key developmental pathways and added significant insights into the central principles of Stem Cell maintenance in plant meriStems. These insights include the convergence of important Stem Cell transcriptional regulators with cytokinin signaling in the shoot meriStem, the biochemical dissection of peptide signaling in the shoot niche and the identification of conserved regulators in shoot and root niches.
