The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Christen Lykkegaard Andersen - One of the best experts on this subject based on the ideXlab platform.
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Epstein Barr Virus and its association with disease a review of relevance to general practice
BMC Family Practice, 2019Co-Authors: Anders Fugl, Christen Lykkegaard AndersenAbstract:General practitioners encounter the vast majority of patients with Epstein-Barr Virus-related disease, i.e. infectious mononucleosis in children and adolescents. With the expanding knowledge regarding the multifaceted role of Epstein-Barr Virus in both benign and malignant disease we chose to focus this review on Epstein-Barr Virus-related conditions with relevance to the general practitioners. A PubMed and Google Scholar literature search was performed using PubMed’s MeSH terms of relevance to Epstein-Barr Virus/infectious mononucleosis in regard to complications and associated conditions. In the present review, these included three early complications; hepatitis, splenic rupture and airway compromise, as well as possible late conditions; lymphoproliferative cancers, multiple sclerosis, rheumatoid arthritis, and chronic active Epstein-Barr Virus infection. This review thus highlights recent advances in the understanding of Epstein-Barr Virus pathogenesis, focusing on management, acute complications, referral indications and potentially associated conditions. Hepatitis is a common and self-limiting early complication to infectious mononucleosis and should be monitored with liver tests in more symptomatic cases. Splenic rupture is rare. Most cases are seen within 3 weeks after diagnosis of infectious mononucleosis and may occur spontaneously. There is no consensus on the safe return to physical activities, and ultrasonic assessment of spleen size may provide the best estimate of risk. Airway compromise due to tonsil enlargement is encountered in a minority of patients and should be treated with systemic corticosteroids during hospitalization. Association between lymphoproliferative cancers, especially Hodgkin lymphoma and Burkitt lymphoma, and infectious mononucleosis are well-established. Epstein-Barr Virus infection/infectious mononucleosis as a risk factor for multiple sclerosis has been documented and may be linked to genetic susceptibility. Chronic active Epstein-Barr Virus infection is rare. However, a general practitioner should be aware of this as a differential diagnosis in patients with persisting symptoms of infectious mononucleosis for more than 3 months.
Ben J Glasgow - One of the best experts on this subject based on the ideXlab platform.
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Epstein Barr Virus associated smooth muscle tumor of the iris in a patient with transplant a case report and review of the literature
Archives of Pathology & Laboratory Medicine, 2009Co-Authors: Anthony J Aldave, Ben J GlasgowAbstract:Abstract Epstein-Barr Virus infection has been linked to the development of smooth muscle tumors in immunocompromised patients with organ transplants and acquired immunodeficiency syndrome. A 52-year-old female recipient of a renal transplant presented with enlarging masses of the left iris. Incisional biopsy of the mass revealed a smooth muscle tumor of the iris. Epstein-Barr Virus infection was confirmed by in situ hybridization for Epstein-Barr Virus–encoded, small RNA in tumor cells. Eight months after total iridectomy the patient was free of disease. Although the prognosis and classification of Epstein-Barr Virus–associated smooth muscle tumors are controversial, mortalities caused by these tumors are rare.
Benigno C. Valdez - One of the best experts on this subject based on the ideXlab platform.
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expression of p40 Epstein Barr Virus nuclear antigen 1 binding protein 2
Biochemical and Biophysical Research Communications, 2001Co-Authors: Dale Henning, Benigno C. ValdezAbstract:Abstract Nucleolar protein p40/EBP2 is a proliferation-associated antigen that interacts with Epstein–Barr Virus nuclear antigen 1 (EBNA1) to maintain the Epstein–Barr Virus (EBV) episomes. The yeast p40/EBP2 functions in the processing of 27S-A into 27S-B ribosomal RNA. The present study reports high evolutionary conservation of the cDNA-derived amino acid sequences of p40/EBP2 from frog, chicken, pig, rat, mouse, bovine, and human. p40/EBP2 is ubiquitously expressed in human tissues. It is highly expressed in myelogenous leukemia K-562 compared to other cell lines tested. The human p40/EBP2 gene is located in chromosome 1 with nine exons and eight introns. The minimal promoter region resides 300 nucleotides upstream of a putative ATG initiation codon preceded by a pyrimidine-rich region. These two regions contain eight Sp1 and four c-Ets-1 putative binding sites. Analysis of the p40/EBP2 gene and its promoter region will facilitate studies on the regulation of its expression in EBV-infected and noninfected cells.
B Corrin - One of the best experts on this subject based on the ideXlab platform.
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lymphomatoid granulomatosis evidence that some cases represent Epstein Barr Virus associated b cell lymphoma
Histopathology, 1996Co-Authors: A G Nicholson, A C Wotherspoon, T C Diss, N Singh, D N Butcher, L Pan, P G Isaacson, B CorrinAbstract:Lymphomatoid granulomatosis is currently classified as part of a spectrum of angiocentric immunoproliferative lesions. These were initially thought to be of T-cell phenotype, but recent papers have shown that some cases are B-cell proliferations, sometimes associated with Epstein-Barr Virus infection. We reviewed the clinicopathological features of 16 patients with pulmonary lymphomatoid granulomatosis, using immunohistochemistry to assess the phenotype of the infiltrate, the polymerase chain reaction to look for immunoglobulin heavy chain and T-cell receptor gene rearrangements, and in-situ-hybridization to look for Epstein-Barr Virus infection. In seven of seven cases the atypical lymphoid population was of B-cell phenotype, with four cases showing evidence of either monoclonality or oligoclonality. All seven cases, including those that lacked unequivocal proof of malignancy, behaved aggressively. Epstein-Barr Virus RNA was detected in four cases. We conclude that some cases of lymphomatoid granulomatosis are B-cell lymphomas, sometimes associated with Epstein-Barr Virus infection.
Bayardo Perezordonez - One of the best experts on this subject based on the ideXlab platform.
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an update on Epstein Barr Virus and nasopharyngeal carcinogenesis
Head and Neck Pathology, 2007Co-Authors: Bayardo PerezordonezAbstract:Epstein-Barr Virus (EBV) is a double stranded DNA cherpesVirus with widespread distribution in all human populations. EBV is associated with a variety of diseases including infectious mononucleosis, hairy leukoplakia, inflammatory pseudotumors, nasopharyngeal carcinoma (NPC), Burkitt’s lymphoma, Hodgkin lymphoma, posttransplant lymphoproliferative disorders, HIV-associated B-cell lymphomas, some T-cell lymphomas particularly extranodal NK/T cell lymphomas of the nasal-type, and a subset of gastric and breast carcinomas. EBV preferentially infects B-lymphocytes through the binding of the major envelop glycoprotein gp350 to the CD21 receptor on the surface of B-cells and through the binding of a second glycoprotein, gp42, to human leukocyte antigen (HLA) class II molecules as a co-receptor [1]. EBV has the capacity to transform resting B-cells into permanent latently infected lymphoblastoid cell lines. Epstein-Barr Virus-transformed lymphoblastoid cell lines express a set of viral gene products referred to as latent proteins which include six EBV nuclear antigens (EBNAs 1, 2, 3A, 3B, 3C, -LP) and three latent membrane proteins (LMPs 1, 2A, and 2B). Transformed lymphoblastoid cells also show abundant expression of small, nonpolyadenylated, non-coding RNAs (EBER1 and EBER2) which are expressed in all forms of latent EBV infection. Transcripts from the BamHIA viral genome known as BART-transcripts are also detected in lymphoblastoid cells [2]. EBNA2, EBNA3C and LMP1 are key in the transformation of EBV-infected cells [3, 4]. LMP1 is the main transforming protein of EBV and functions as a classic oncogene in fibroblast transformation assay [5]. LMP1 functions as an activated member of the tumor receptor (TNFR) superfamily, and activates several signaling pathways [6, 7].
