Erythrocyte Deformability

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Çomu, Faruk Metİn - One of the best experts on this subject based on the ideXlab platform.

  • The Effects of Esmolol on Erythrocyte Deformability in Rat Liver Ischemia-Reperfusion Injury
    'Gazi University', 2021
    Co-Authors: Kİp GÜlay, Arslan Mustafa, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Ünal Yusuf, Sabuncu Ulku, Salman Nevriye
    Abstract:

    Background: Esmolol has protective effects in ischemia reperfusion (IR) injury. The purpose of our study was to look into the effects of this which esmolol on Erythrocyte Deformability in rat liver IR injury model

  • The Effect of Hydrogen-Rich Saline Solution on Erythrocyte Deformability in Lower Limb Ischemia Reperfusion Injury in Rats
    'Gazi University', 2021
    Co-Authors: Oktar, GÜrsel Levent, Arslan Mustafa, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Mardİn BariŞ, Özer Abdullah, KoÇak BaŞak
    Abstract:

    Aim: We aimed to investigate the effects of HRSS on Erythrocyte Deformability in lower limb ischemia reperfusion (IR) injury in rats

  • Effect of Fullerenol C60 on Erythrocyte Deformability During Ischaemia-Reperfusion Injury of Lower Extremity in Diabetic Rats
    'Gazi University', 2019
    Co-Authors: Kİp GÜlay, Arslan Mustafa, Çomu, Faruk Metİn, Kartal Hakan, Polat Yucel, KÜÇÜk AyŞegÜl
    Abstract:

    KARTAL, HAKAN/0000-0003-4539-0228WOS: 000495961100010Background: Fullerenol, a water-soluble C60-fullerene derivative synthesized by Chiang et al, has been demonstrated to be able to scavenge free radicals in vitro and in vivo. Although its protective effects have been already studied and shown in ischemia reperfusion (IR) injury, additional investigation is necessary for its effect on Erythrocyte Deformability. The purpose of our study was to look into the effects of fullerenol C60 on Erythrocyte Deformability in rat lower extremity ischemia reperfusion injury model. Materials and Methods: After approval of the Ethics Committee, 30 Wistar Albino rat were divided into 5 groups (n:6) as; Control (C), Diabetes (group D), diabetes+ fullerenol C60 group (DF), diabetes+ IR (group DIR) and diabetes IR+ fullerenol C60 (DIRF). 55 mg/kg streptozotocin was administered to the rats for diabetes. After the period of 72 hour, blood glucose concentration was mesured, 250 mg/dl and above were considered as diabetic rat. Four week after the formation of diabetes, rats were subjected to 2 hour ischemia and 2 hour reperfusion. Erythrocyte packs were prepared from heparinized blood samples and Deformability measurements were performed. Results: The Deformability index was significantly increased in diabetic rats; however, it was similar in group D, DF and DIRF. It was significantly increased in group DIR when compared to group C, D, DF and DIRF. The relative resistance was increased in I/R models. Conclusion: This study aimed to investigate the effects of IR on Erythrocyte Deformability which may lead to disturbance in blood flow and hence tissue perfusion in infrarenal rat aorta. We found that fullerenol C60 had beneficial effects by reversing undesirable effects of IR. In our opinion, further studies with larger volume are required to support our promising results

  • The Effects of HES 130/0.4 Application on Erythrocyte Deformability in Ureteral Obstructed Rats
    'Gazi University', 2018
    Co-Authors: GÜneŞ Işın, Şivgin Volkan, Arslan Mustafa, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Alkan Metİn, Ünal Yusuf
    Abstract:

    Arslan, Mustafa/0000-0003-4882-5063;WOS: 000437527600005Aim: The administration of plasma expanders is crucial for managing critically ill patients across a range of clinical conditions, including major surgery, hemorrhagic shock, and trauma. However, the effects of hydroxyethyl starch (HES) on Erythrocyte aggregation remain controversial. For this reason, we aimed to investigate the effects of HES 130/0.4, performed renal insufficiency by experimentally unilateral ureteral obstruction, on Erythrocyte Deformability. Materials and Methods: A total of 24 rats were divided into 4 groups; Control, HES 130/0.4, Ureter Obstruction (UO) and UO-HES130/0.4. Urethral obstruction groups were treated with ketamine anesthesia with a low abdominal incision and reached to the distal of right ureter and sutured with 2.0 mersilen then waited for 3 weeks for late term renal insufficiency. 20 mL.kg(-1) of HES 130/0.4 (Voluven) were infused intravenously to the HES 130/0.4 and UO-HES130/0.4 group. After 24-hour, rats were sacrificed. Deformability measurements were performed using 5% haematocrit in a phosphate-buffered saline (PBS) buffer. Results and Discussion: Relative resistance was increased in all groups compared to the control group (p

  • Effect of Levosimendan and Nigella Sativa on Erythrocyte Deformability During Myocardial Ischaemia-Reperfusion Injury in Rats
    'Gazi University', 2018
    Co-Authors: Özer Abdullah, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Mardİn BariŞ, Alkan Metİn, Kilic Yigit, Ünal Yusuf
    Abstract:

    Arslan, Mustafa/0000-0003-4882-5063WOS: 000437527600007Objective: Ischaemia-reperfusion (IR) injury is a chain of events put in place by tissue ischaemia. Reperfusion following the cellular damage causes an active inflammatory response. Erythrocyte Deformability and plasma viscosity play a critical role in tissue and organ perfusion. In this study we aimed to evaluate the effect of levosimendan and nigella sativa on Erythrocyte Deformability during myocardial IR injury in rats. Methods: Twenty-four Wistar albino rats were included in the study. The animals were randomly divided into four experimental groups. The coronary arteries of rats in Group C (control group) were not occluded or reperfused. Myocardial IR was performed by ligating the left anterior descending coronary artery for 30 min, followed by 2 h of reperfusion in the IR (IR), IR-levosimendan (24 mu g/kg) (IRL) group and IR-nigella sativa (0.2 mL/kg) (IRNS) group. Erythrocyte suspensions formed with a PBS buffer solution containing 5% htc were used to measure the Deformability. Results: As a result compared to control group, IR increased the relative resistance, a marker of Erythrocyte Deformability, significantly (p

KÜÇÜk AyŞegÜl - One of the best experts on this subject based on the ideXlab platform.

  • The Effect of Hydrogen-Rich Saline Solution on Erythrocyte Deformability in Lower Limb Ischemia Reperfusion Injury in Rats
    'Gazi University', 2021
    Co-Authors: Oktar, GÜrsel Levent, Arslan Mustafa, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Mardİn BariŞ, Özer Abdullah, KoÇak BaŞak
    Abstract:

    Aim: We aimed to investigate the effects of HRSS on Erythrocyte Deformability in lower limb ischemia reperfusion (IR) injury in rats

  • The Effects of Esmolol on Erythrocyte Deformability in Rat Liver Ischemia-Reperfusion Injury
    'Gazi University', 2021
    Co-Authors: Kİp GÜlay, Arslan Mustafa, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Ünal Yusuf, Sabuncu Ulku, Salman Nevriye
    Abstract:

    Background: Esmolol has protective effects in ischemia reperfusion (IR) injury. The purpose of our study was to look into the effects of this which esmolol on Erythrocyte Deformability in rat liver IR injury model

  • Effect of Fullerenol C60 on Erythrocyte Deformability During Ischaemia-Reperfusion Injury of Lower Extremity in Diabetic Rats
    'Gazi University', 2019
    Co-Authors: Kİp GÜlay, Arslan Mustafa, Çomu, Faruk Metİn, Kartal Hakan, Polat Yucel, KÜÇÜk AyŞegÜl
    Abstract:

    KARTAL, HAKAN/0000-0003-4539-0228WOS: 000495961100010Background: Fullerenol, a water-soluble C60-fullerene derivative synthesized by Chiang et al, has been demonstrated to be able to scavenge free radicals in vitro and in vivo. Although its protective effects have been already studied and shown in ischemia reperfusion (IR) injury, additional investigation is necessary for its effect on Erythrocyte Deformability. The purpose of our study was to look into the effects of fullerenol C60 on Erythrocyte Deformability in rat lower extremity ischemia reperfusion injury model. Materials and Methods: After approval of the Ethics Committee, 30 Wistar Albino rat were divided into 5 groups (n:6) as; Control (C), Diabetes (group D), diabetes+ fullerenol C60 group (DF), diabetes+ IR (group DIR) and diabetes IR+ fullerenol C60 (DIRF). 55 mg/kg streptozotocin was administered to the rats for diabetes. After the period of 72 hour, blood glucose concentration was mesured, 250 mg/dl and above were considered as diabetic rat. Four week after the formation of diabetes, rats were subjected to 2 hour ischemia and 2 hour reperfusion. Erythrocyte packs were prepared from heparinized blood samples and Deformability measurements were performed. Results: The Deformability index was significantly increased in diabetic rats; however, it was similar in group D, DF and DIRF. It was significantly increased in group DIR when compared to group C, D, DF and DIRF. The relative resistance was increased in I/R models. Conclusion: This study aimed to investigate the effects of IR on Erythrocyte Deformability which may lead to disturbance in blood flow and hence tissue perfusion in infrarenal rat aorta. We found that fullerenol C60 had beneficial effects by reversing undesirable effects of IR. In our opinion, further studies with larger volume are required to support our promising results

  • Effect of Levosimendan and Nigella Sativa on Erythrocyte Deformability During Myocardial Ischaemia-Reperfusion Injury in Rats
    'Gazi University', 2018
    Co-Authors: Özer Abdullah, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Mardİn BariŞ, Alkan Metİn, Kilic Yigit, Ünal Yusuf
    Abstract:

    Arslan, Mustafa/0000-0003-4882-5063WOS: 000437527600007Objective: Ischaemia-reperfusion (IR) injury is a chain of events put in place by tissue ischaemia. Reperfusion following the cellular damage causes an active inflammatory response. Erythrocyte Deformability and plasma viscosity play a critical role in tissue and organ perfusion. In this study we aimed to evaluate the effect of levosimendan and nigella sativa on Erythrocyte Deformability during myocardial IR injury in rats. Methods: Twenty-four Wistar albino rats were included in the study. The animals were randomly divided into four experimental groups. The coronary arteries of rats in Group C (control group) were not occluded or reperfused. Myocardial IR was performed by ligating the left anterior descending coronary artery for 30 min, followed by 2 h of reperfusion in the IR (IR), IR-levosimendan (24 mu g/kg) (IRL) group and IR-nigella sativa (0.2 mL/kg) (IRNS) group. Erythrocyte suspensions formed with a PBS buffer solution containing 5% htc were used to measure the Deformability. Results: As a result compared to control group, IR increased the relative resistance, a marker of Erythrocyte Deformability, significantly (p

  • Effect of cerium oxide on Erythrocyte Deformability in rat lower extremity ischemia reperfusion injury
    'AEPress s.r.o.', 2018
    Co-Authors: Kartal H, Arslan Mustafa, KÜÇÜk AyŞegÜl, Tatar Tolga, Polat Y, Çomu, Faruk Metİn
    Abstract:

    BACKGROUND: Cerium oxide is the oxide form of cerium, which has protective effects in ischemia reperfusion (I/R) injury. The purpose of our study was to look into the effects of this rare-earth metal on Erythrocyte Deformability in rat lower extremity I/R injury model

Arslan Mustafa - One of the best experts on this subject based on the ideXlab platform.

Özer Abdullah - One of the best experts on this subject based on the ideXlab platform.

  • The Effect of Hydrogen-Rich Saline Solution on Erythrocyte Deformability in Lower Limb Ischemia Reperfusion Injury in Rats
    'Gazi University', 2021
    Co-Authors: Oktar, GÜrsel Levent, Arslan Mustafa, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Mardİn BariŞ, Özer Abdullah, KoÇak BaŞak
    Abstract:

    Aim: We aimed to investigate the effects of HRSS on Erythrocyte Deformability in lower limb ischemia reperfusion (IR) injury in rats

  • Effect of Levosimendan and Nigella Sativa on Erythrocyte Deformability During Myocardial Ischaemia-Reperfusion Injury in Rats
    'Gazi University', 2018
    Co-Authors: Özer Abdullah, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Mardİn BariŞ, Alkan Metİn, Kilic Yigit, Ünal Yusuf
    Abstract:

    Arslan, Mustafa/0000-0003-4882-5063WOS: 000437527600007Objective: Ischaemia-reperfusion (IR) injury is a chain of events put in place by tissue ischaemia. Reperfusion following the cellular damage causes an active inflammatory response. Erythrocyte Deformability and plasma viscosity play a critical role in tissue and organ perfusion. In this study we aimed to evaluate the effect of levosimendan and nigella sativa on Erythrocyte Deformability during myocardial IR injury in rats. Methods: Twenty-four Wistar albino rats were included in the study. The animals were randomly divided into four experimental groups. The coronary arteries of rats in Group C (control group) were not occluded or reperfused. Myocardial IR was performed by ligating the left anterior descending coronary artery for 30 min, followed by 2 h of reperfusion in the IR (IR), IR-levosimendan (24 mu g/kg) (IRL) group and IR-nigella sativa (0.2 mL/kg) (IRNS) group. Erythrocyte suspensions formed with a PBS buffer solution containing 5% htc were used to measure the Deformability. Results: As a result compared to control group, IR increased the relative resistance, a marker of Erythrocyte Deformability, significantly (p

  • Protective effect of erdosteine on Erythrocyte Deformability in a rat model of lower limb ischemia/reperfusion injury
    'The Scientific and Technological Research Council of Turkey', 2018
    Co-Authors: Özer Abdullah, Çomu, Faruk Metİn, Mardİn BariŞ, Erer Dİlek, Kilic Yigit, Demirtas Huseyin, Oktar, GÜrsel Levent
    Abstract:

    Arslan, Mustafa/0000-0003-4882-5063WOS: 000425902900030PubMed: 29479982Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been well documented but its effect on Erythrocyte Deformability needs further investigation. Our aim was to investigate the effect of erdosteine on Erythrocyte Deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion. Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized control group (group 'control', n = 6), an ischemia/reperfusion group without erdosteine (group 'ischemia/reperfusion', n = 6), and an ischemia/reperfusion group with erdosteine at 150 mg kg(-1), intraperitoneally (group 'ischemia/reperfusion - erdosteine', n = 6). Packs of Erythrocytes were prepared from heparinized blood samples and Deformability measurements were conducted. Results: Comparisons of the control and ischemia/reperfusion - erdosteine groups revealed similar results (P = 0.051). The values of the ischemia/reperfusion group were significantly higher than those of the control and ischemia/reperfusion - erdosteine groups (P < 0.0001 and P = 0.024, respectively). Relative resistance, a marker of Erythrocyte Deformability, was increased significantly by ischemia/reperfusion compared to the control and ischemia/reperfusion - erdosteine groups (P < 0.05). Conclusion: We detected unfavorable effects of ischemia/reperfusion on Erythrocyte Deformability, which may lead to disturbance in blood flow and hence tissue perfusion in the infrarenal rat aorta. We also found that erdosteine had beneficial effects by reversing undesirable effects of ischemia/reperfusion. However, these promising results should be further supported by more detailed studies with larger volumes

  • Protective effect of erdosteine on Erythrocyte Deformability in a rat model of lower limb ischemia/reperfusion injury
    'The Scientific and Technological Research Council of Turkey', 2017
    Co-Authors: Mardİn BariŞ, Arslan Mustafa, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Kılıç Y, Özer Abdullah, Erer Dİlek, Oktar, GÜrsel Levent, Demirtaş H
    Abstract:

    Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been well documented but its effect on Erythrocyte Deformability needs further investigation. Our aim was to investigate the effect of erdosteine on Erythrocyte Deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion

  • Effect of Levosimendan and Nigella Sativa on Erythrocyte Deformability During Myocardial Ischaemia-Reperfusion Injury in Rats
    'Gazi University', 2017
    Co-Authors: Arslan Mustafa, Çomu, Faruk Metİn, KÜÇÜk AyŞegÜl, Mardİn BariŞ, Özer Abdullah, Oktar, GÜrsel Levent, Alkan Metİn, Ünal Yusuf, Kılıç Y
    Abstract:

    Objective: Ischaemia-reperfusion (IR) injury is a chain of events put in place by tissue ischaemia. Reperfusion following the cellular damage causes an active inflammatory response. Erythrocyte Deformability and plasma viscosity play a critical role in tissue and organ perfusion. In this study we aimed to evaluate the effect of levosimendan and nigella sativa on Erythrocyte Deformability during myocardial IR injury in rats

Kucuk A. - One of the best experts on this subject based on the ideXlab platform.

  • Investigation of the effects of thymoquinone on Erythrocyte Deformability in sepsis treatment which created by cecal perforation in rat
    'AEPress s.r.o.', 2018
    Co-Authors: Bostanci H., Dikmen K., Comu F. M., Arslan M., Kucuk A.
    Abstract:

    Arslan, Mustafa/0000-0003-4882-5063WOS: 000428649600005PubMed: 29536743AIM: We aimed to study the effects of thymoquinone on Erythrocyte Deformability in an experimental model of sepsis given before or after the initiation of the sepsis model. METHOD: The animals were grouped as (n = 6) control, nigella sativa, sepsis, sepsis group with administration of nigella sativa before sepsis development and sepsis group with nigella sativa administration after sepsis development. Cecal ligation and puncture model (CLP) was used to induce sepsis in the animals. The thymoquinone was given 1 hour before or after the CLP in the study groups with a dose of 500 mg.kg(-1). Erythrocyte Deformability and relative resistance was calculated. RESULT: Relative resistance was increased in the sepsis groups when compared to the control group (p < 0.0001). Deformability index was increased in the sepsis group when compared to the other groups (p < 0.0001 in all groups). Sepsis group with after nigella sativa groups Deformability index was significantly different from the Deformability index in control group (p = 0.002). The use of nigella sativa before the initiation of sepsis corrected the Deformability index significantly and the results were comparable to the control group (p = 0.078). CONCLUSION: Thymoquinone administration before induction of CLP was observed to have protective effects on these alterations in CLP sepsis (Tab. 1, Fig. 1, Ref. 26). Text in PDF www.elis.sk

  • Effects of dexmedetomidine and thymoquinone on Erythrocyte Deformability in lower limb ischemia reperfusion injury in streptozotocin-induced diabetic rats
    'AEPress s.r.o.', 2018
    Co-Authors: Özer A, Comu F. M., Kucuk A., Kılıç Y, Alkan M., Oktar L., Öztürk L
    Abstract:

    Arslan, Mustafa/0000-0003-4882-5063WOS: 000451638900006PubMed: 30345772OBJECTIVE: In this study we aimed to evaluate the effect of dexmedetomidine and thymoquinone on Erythrocyte Deformability in lower limb ischaemia-reperfusion (IR) injury in streptozotocin-induced diabetic rats. MATERIAL AND METHODS: Thirty Wistar albino rats were equally divided into 5 groups (n = 6); randomized control group (Group C), diabetes control group (Group DC), DIR group (Group DIR), DIR group with thymoquinone 25 mg.kg(-1) intraperitoneally (Group DIRT) and Group DIR with dexmedetomidine 100 mu g.kg(-1) intraperitoneally (Group DIRD). Erythrocyte packs were prepared from heparinized blood samples and Deformability measurements were performed. RESULTS: IR significantly increased the relative resistance, a marker of Erythrocyte Deformability when compared to control group (p < 0.05). There were significant differences among the groups in comparisons with ANOVA test (p < 0.0001). Comparisons of the groups DIRD and DIRT revealed similar results (p = 0.824). The values of Group DIR were significantly higher than those of the control, DC, DIRD and DIRT groups (p < 0.0001, p = 0.001, p = 0.004, p = 0.002, respectively). The values of the DC, DIR, DIRD and DIRT groups were significantly higher than those of the control group (p < 0.0001, all). CONCLUSION: Erythrocyte Deformability may cause more problems in microcirculation. Dexmedetomidine and thymoquinone may be useful in reducing the adverse effects of this type of injury

  • Effect of cerium oxide on Erythrocyte Deformability in rat lower extremity ischemia reperfusion injury
    'AEPress s.r.o.', 2018
    Co-Authors: Tatar T., Comu F. M., Arslan M., Kartal H, Polat Y, Kucuk A.
    Abstract:

    Arslan, Mustafa/0000-0003-4882-5063; KARTAL, HAKAN/0000-0003-4539-0228WOS: 000440978000008PubMed: 30160134BACKGROUND: Cerium oxide is the oxide form of cerium, which has protective effects in ischemia reperfusion (I/R) injury. The purpose of our study was to look into the effects of this rare-earth metal on Erythrocyte Deformability in rat lower extremity I/R injury model. MATERIALS AND METHODS: We used 24 Wistar albino rats as subjects in our study. They were divided into 4 groups; randomized control group (group C; n = 6), cerium oxide group 0.5 mg.kg(-1), intraperitoneal (group CO; n = 6), I/R group (group I/R; n = 6) and I/R group with cerium oxide 0.5 mg.kg(-1) intraperitoneally (group I/R-CO; n = 6). Erythrocyte packs were prepared from heparinized blood samples and Deformability measurements were performed. RESULTS: We obtained similar results from the control and I/R-CO groups (p = 0.158). The results in I/R group were evidently higher than those of the control, CO, and IR-CO groups (p < 0.0001, p < 0.0001, p = 0.001, respectively). CONCLUSION: We detected unfavorable effects of I/R on Erythrocyte Deformability, which may impair blood flow and hence tissue perfusion in infrarenal rat aorta. We also found that cerium oxide had beneficial effects by reversing undesirable effects of I/R. Further studies with larger volume are required to support our promising results (Fig. 1, Ref. 24). Text in PDF www.elis.sk

  • Effect of Different Doses of Pregabalin on Erythrocyte Deformability in Rats with Lower Limb Ischemia Reperfusion Injury
    2017
    Co-Authors: Özer A, Arslan M., Kılıç Y, Demirtaş H, Mardin B, Öztürk L, Iriz E, Kucuk A.
    Abstract:

    Aim/Introduction: Acute ischemia reperfusion (IR) injury observed in the lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Preoperative pregabalin has been used as a part of multimodal analgesia in postoperative pain treatment in recent years. Pregabalin has become one of the increasingly common agents in postoperative analgesia. In this study, we aimed to investigate the effect of pregabalin on Erythrocyte Deformability in rats undergoing IR. Materials and Methods: 24 male Wistar albino rats weighing between 200-250 g were used in the study. Rats were randomly divided into 4 groups of 6 rats each (Control, Ischemia-Reperfusion (IR), IR-Pregabalin 50 mg (50 mg.kg-1), IRPregabalin 200 mg (200 mg.kg-1). Pregabalin was administered intraperitoneally 30 min before the procedure. An atraumatic microvascular clamp was placed across the infrarenal abdominal aorta in the IR groups. Following 120 min of ischemia, the clamp was removed and reperfusion was continued for 120 min. All rats were euthanized by intraperitoneal administration of ketamine (100 mg•kg−1) and taking blood from the abdominal aorta. Erythrocytes were seperated from heparinized whole blood samples. Deformability measurements were made in Erythrocyte suspensions in phosphate buffered saline. A constant flow filtrometer system was used to measure Erythrocyte Deformability and relative resistance was calculated. Results: It was found that the formation of ischemia reperfusion increases the relative resistance according to the control group (p < 0.0001). It was determined that application of pregabalin 50 or 200 mg did not change Erythrocyte Deformability in ischemia reperfusion-induced rats (p = 0.632, p = 0.811). Conclusion: The administration of 50 or 200 mg of pregabalin has no negative effect on the Erythrocyte Deformability in ischemia reperfusion-induced rats. We think that pregabalin can be safely used for analgesia in the cases of IR. However, these findings should be supported by clinical and experimental studies carried out in more detailed and broader series

  • Effect of apelin-13 on Erythrocyte Deformability during ischaemia-reperfusion injury of heart in diabetic rats
    'AEPress s.r.o.', 2017
    Co-Authors: Kartal H, Comu F. M., Kucuk A., Polat Y, Dursun A. D., Arslan M.
    Abstract:

    KARTAL, HAKAN/0000-0003-4539-0228; Arslan, Mustafa/0000-0003-4882-5063; DURSUN, ALI DOGAN/0000-0001-9056-0025WOS: 000398005800001PubMed: 28319406OBJECTIVES: Erythrocyte Deformability and plasma viscosity are of crucial importance for the perfusion of tissues and organs. The aim of this study was to evaluate the effect of apelin-13 on Erythrocyte Deformability during IR heart injury in diabetic rats. METHODS: Eighteen Wistar Albino rats were included in the study after streptozotocin (55 mg/kg) treatment for four weeks of observation for diabetes existence. The animals were randomly assigned to one of five experimental groups. In the Group C, DC (sham-control group) and DCA (sham control group apelin-13), the coronary artery was not occluded or re-perfused. In the Group DIR, a branch of the left coronary artery was occluded for 30 minutes followed by 90 minutes of re-perfusion to produce IR. In the Group DIRA, a branch of the left coronary artery was occluded for 30 minutes followed by 90 minutes of re-perfusion to produce IR, and apelin-13 was administrated via 10 pg.kg(-1) IP route 30 minutes before ligating the left coronary artery. Deformability measurements were performed in Erythrocyte suspensions containing Htc 5% in a PBS buffer. RESULTS: The Deformability index was significantly increased in diabetic rats; however, it was similar in Group DC, DCA and DIRA. It was significantly increased in the Group DIR when compared to the Group C, DIRA, DCA and DC. The relative resistance was increased in IR models. CONCLUSION: Erythrocyte Deformability was decreased in rats having diabetes and IR injury. This injury might lead to further problems in microcirculation. It was shown that apeline-13 may be useful in enhancing the adverse effects of this type of injury (Fig. 1, Ref. 35). Text in PDF www.elis.sk

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