The Experts below are selected from a list of 102 Experts worldwide ranked by ideXlab platform
Fernando Maluenda - One of the best experts on this subject based on the ideXlab platform.
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long term results of classic antireflux Surgery in 152 patients with barrett s Esophagus clinical radiologic endoscopic manometric and acid reflux test analysis before and late after operation
Surgery, 1998Co-Authors: Attila Csendes, Italo Braghetto, Patricio Burdiles, Guillermo Puente, Owen Korn, Juan Carlos Diaz, Fernando MaluendaAbstract:Abstract Background: The classic surgical procedure for patients with Barrett's Esophagus (BE) has been either Nissen fundoplication or posterior gastropexy with calibration of the cardia. Methods: The purpose of our study was to determine late subjective and objective results of these classic surgical techniques in a large number of patients with BE. A total of 152 patients were included in this prospective protocol. Results: There was 1 death (0.7%) after operation. The late follow-up of 100 months demonstrated a high percentage of failures among patients with noncomplicated BE (54%) and an even higher figure in patients with complicated BE (64%). In 15 patients low grade dysplasia appeared at 8 years of follow-up and an adenocarcinoma in 4 patients. Twenty-four–hour pH monitoring demonstrated a decrease in acid reflux into the Esophagus, and Bilitec studies also demonstrated a decrease of duodenoesophageal reflux, but in all cases with a higher value than the normal limit. Conclusions: Classic antireflux Surgery in patients with BE results in a high percentage of failures at very late follow-up because it cannot completely avoid acid and duodenal reflux into the Esophagus. (Surgery 1998;123:645-57.)
Attila Csendes - One of the best experts on this subject based on the ideXlab platform.
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Length of the Esophagus in patients with gastroesophageal reflux disease and Barrett's Esophagus compared to controls
Surgery, 2003Co-Authors: Owen Korn, Attila Csendes, Italo Braghetto, Patricio Burdiles, Héctor Sagastume, Leandro BiaginiAbstract:Abstract Background. It is a current opinion among surgeons that the Esophagus is shorter in patients with reflux disease and particularly in those with complicated Barrett's Esophagus. However, objective evidence of this is scarce. Therefore we attempted to determine the occurrence and magnitude of this phenomenon among our patients. Methods. One hundred ninety control subjects, 77 patients with severe erosive esophagitis, 74 with Barrett's Esophagus, and 29 with complicated Barrett's Esophagus (ulcer, stenosis) were grouped according to height. The length of the Esophagus was determined by standard manometric study, measuring the distance from the crycopharingeal sphincter to the distal limit of the lower esophageal sphincter. Values were expressed in cm as the mean ± SD. Results. The esophageal length according to height was 1 to 2 cm shorter in patients compared to controls, but these differences were not significant. Conclusions. No differences were found between patients with progressive severity of the disease. This study confirms that the presence of a so-called “short Esophagus” does not exist or is not relevant in our patients with gastroesophageal reflux disease, including those with complicated Barrett's Esophagus. (Surgery 2003;133:358-63.)
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long term results of classic antireflux Surgery in 152 patients with barrett s Esophagus clinical radiologic endoscopic manometric and acid reflux test analysis before and late after operation
Surgery, 1998Co-Authors: Attila Csendes, Italo Braghetto, Patricio Burdiles, Guillermo Puente, Owen Korn, Juan Carlos Diaz, Fernando MaluendaAbstract:Abstract Background: The classic surgical procedure for patients with Barrett's Esophagus (BE) has been either Nissen fundoplication or posterior gastropexy with calibration of the cardia. Methods: The purpose of our study was to determine late subjective and objective results of these classic surgical techniques in a large number of patients with BE. A total of 152 patients were included in this prospective protocol. Results: There was 1 death (0.7%) after operation. The late follow-up of 100 months demonstrated a high percentage of failures among patients with noncomplicated BE (54%) and an even higher figure in patients with complicated BE (64%). In 15 patients low grade dysplasia appeared at 8 years of follow-up and an adenocarcinoma in 4 patients. Twenty-four–hour pH monitoring demonstrated a decrease in acid reflux into the Esophagus, and Bilitec studies also demonstrated a decrease of duodenoesophageal reflux, but in all cases with a higher value than the normal limit. Conclusions: Classic antireflux Surgery in patients with BE results in a high percentage of failures at very late follow-up because it cannot completely avoid acid and duodenal reflux into the Esophagus. (Surgery 1998;123:645-57.)
Annarosa Arcangeli - One of the best experts on this subject based on the ideXlab platform.
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A Mouse Model for BarrettâÂÂs Esophagus: Surgery and Histology
Journal of carcinogenesis & mutagenesis, 2017Co-Authors: Antonio Taddei, Tiziano Lottini, Marilena Fazi, Maria Novella Ringressi, Elena Lastraioli, Paolo Bechi, Annarosa ArcangeliAbstract:Purpose: Barrett’s Esophagus (BE) is the sole precursor lesion of esophageal adenocarcinoma (EA) identified so far. The progression towards EA is estimated to affect 2 to 10% of BE patients, hence endoscopic surveillance of at-risk subjects is mandatory. Surveillance endoscopic procedures imply high cost, discomfort and risks for the patient, as well as the non-infrequent missing of small, focal lesions signaling progression to EA. Hence, it is important to search for new potential markers to better identify BE patients at risk of EA progression. The aim of this study was to produce a mouse model of BE, suitable for further molecular and genetic analyses. Methods: Forty-four CD1 mice were operated upon by means of an esophago-jejunal anastomosis. Five CD1 mice underwent a sham operation. The animals were sacrificed 10 months later and histological analysis was performed with Hematoxylin & Eosin and Alcian Blue staining. Results: The overall postoperative mortality rate was 11%. Of the 39 operated animals 14% developed histologically detectable intestinal metaplasia in the lower Esophagus. No histologically detectable lesions were shown in the sham group. Conclusions: The mice model we propose could be applied because of its technical feasibility and acceptable mortality and can be used in transgenic mice too, in order to better understand molecular progression from BE to esophageal adenocarcinoma.
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A Mouse Model for Barrett’s Esophagus: Surgery and Histology
Journal of carcinogenesis & mutagenesis, 2017Co-Authors: Antonio Taddei, Tiziano Lottini, Marilena Fazi, Maria Novella Ringressi, Elena Lastraioli, Paolo Bechi, Annarosa ArcangeliAbstract:Purpose: Barrett’s Esophagus (BE) is the sole precursor lesion of esophageal adenocarcinoma (EA) identified so far. The progression towards EA is estimated to affect 2 to 10% of BE patients, hence endoscopic surveillance of at-risk subjects is mandatory. Surveillance endoscopic procedures imply high cost, discomfort and risks for the patient, as well as the non-infrequent missing of small, focal lesions signaling progression to EA. Hence, it is important to search for new potential markers to better identify BE patients at risk of EA progression. The aim of this study was to produce a mouse model of BE, suitable for further molecular and genetic analyses. Methods: Forty-four CD1 mice were operated upon by means of an esophago-jejunal anastomosis. Five CD1 mice underwent a sham operation. The animals were sacrificed 10 months later and histological analysis was performed with Hematoxylin & Eosin and Alcian Blue staining. Results: The overall postoperative mortality rate was 11%. Of the 39 operated animals 14% developed histologically detectable intestinal metaplasia in the lower Esophagus. No histologically detectable lesions were shown in the sham group. Conclusions: The mice model we propose could be applied because of its technical feasibility and acceptable mortality and can be used in transgenic mice too, in order to better understand molecular progression from BE to esophageal adenocarcinoma.
Yiwang Ye - One of the best experts on this subject based on the ideXlab platform.
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Long-term survival after enucleation of a giant esophageal gastrointestinal stromal tumor
World Journal of Gastroenterology, 2014Co-Authors: Zhimin Mu, Xu-xing Peng, Hai Zhang, Hao Wu, Baokun Chen, Da Wu, Yiwang YeAbstract:Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms of the gastrointestinal tract. Less than 1% occurs in the Esophagus. Surgery is the primary treatment for patients with GISTs. We report a 29-year-old male was admitted after the detection of a posterior mediastinal mass during work-up with routine examination. He did not have any disease-related symptoms. The physical examination was unremarkable. Chest computed tomographic scan, the barium esophagogram and endoscopic esophageal ultrasound showed benign neoplasm. The patient was performed an enucleation Surgery through the right posterolateral thoracotomy. The pathology revealed a 13.0 cm × 12.0 cm × 5.0 cm mass. The tumor was CD117 (C-kit), PDGFRA and DOG1 positive. These findings were consistent with a GIST of the Esophagus. So the diagnosis of GIST of Esophagus was confirmed. The pathological diagnosis of low grade of GIST of Esophagus was confirmed. The patient has no evidence of recurrence and is in good clinical conditions up-to date, five years after Surgery.
Wenjie Jiao - One of the best experts on this subject based on the ideXlab platform.
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exclusive right thoracic approach for Esophagus Surgery
Thoracic Cancer, 2017Co-Authors: Chuan Li, Nan Ge, Yi Shen, Wenjie JiaoAbstract:: An exclusive right thoracic approach for Esophagus Surgery is rarely used, with few reports of its use in China. We retrospectively reviewed the data of 21 esophageal cancer patients from January 2010 to January 2015. Their age ranged from 74-83 years (average 76.6). All of the patients had lower pulmonary function. After multidisciplinary team discussion, sufficient preoperative preparation, and assessment of cardiopulmonary reserve, an exclusive right thoracic approach for esophageal cancer resection was performed. The Esophagus was dissected in the right chest and the stomach was separated through the esophageal hiatus. The tube stomach and the esophageal remnant were anastomosed with a stapling device at the top of the right side of the thoracic cavity. All operations were successfully completed; however, there were two early postoperative deaths resulting from pulmonary infection and pulmonary artery embolism. The one-year postoperative survival rate was 66.7%. An exclusive right thoracic approach could be selectively used for elderly patients with poor pulmonary function.