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Ali H Rajput - One of the best experts on this subject based on the ideXlab platform.

  • Parkinsonism in Essential Tremor cases: A clinicopathological study.
    Movement Disorders, 2019
    Co-Authors: Ali H Rajput, Emma F. Rajput, Sarah Bocking, Roland N. Auer, Alex Rajput
    Abstract:

    BACKGROUND Essential Tremor and Parkinson's syndrome are two common movement disorders that may co-occur in some individuals. There is no diagnostic neuropathology for Essential Tremor, but in PD and other Parkinson's syndrome variants, the neuropathology is well known. The spectrum of Parkinson's syndrome variants associated with Essential Tremor, their clinical features, and course have not been determined in autopsy-confirmed cases. OBJECTIVES To identify: diagnostic features of Essential Tremor/Parkinson's syndrome, different Parkinson's syndrome variants, and long-term clinical profile in such cases. METHODS Patients that had an Essential Tremor diagnosis and a subsequent clinical or pathological diagnosis of Parkinson's syndrome seen in our clinic during 50 years were included. The diagnosis of parkinsonism was made when bradykinesia, rigidity, and resting Tremor were all clinically evident. RESULTS Twenty-one cases were included. All the common variants of parkinsonism co-occurred with Essential Tremor. The most common was PD (67%) followed by PSP. The pathological findings were not predicted clinically in 2 cases that had Essential Tremor/PD and in all 5 Essential Tremor/PSP cases. CONCLUSION In most Essential Tremor/Parkinson's syndrome patients, the main motor features of parkinsonism-bradykinesia, rigidity, and resting Tremor-were identifiable. All known degenerative Parkinson's syndrome variants co-occurred in Essential Tremor patients. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

  • defective dentate nucleus gaba receptors in Essential Tremor
    Brain, 2012
    Co-Authors: Sarah Parisrobidas, Elodie Brochu, Marion Sintes, Vincent Emond, Mélanie Bousquet, Milène Vandal, Mireille Pilote, Cyntia Tremblay, Thérèse Di Paolo, Ali H Rajput
    Abstract:

    The development of new treatments for Essential Tremor, the most frequent movement disorder, is limited by a poor understanding of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABAA (35% reduction) and GABAB (22–31% reduction) receptors in the dentate nucleus of the cerebellum from individuals with Essential Tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding autoradiography. Concentrations of GABAB receptors in the dentate nucleus were inversely correlated with the duration of Essential Tremor symptoms ( r 2 = 0.44, P <  0.05), suggesting that the loss of GABAB receptors follows the progression of the disease. In situ hybridization experiments also revealed a diminution of GABAB(1a+b) receptor messenger RNA in Essential Tremor (↓27%). In contrast, no significant changes of GABAA and GABAB receptors (protein and messenger RNA), GluN2B receptors, cytochrome oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that a decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagating along the cerebello-thalamo-cortical pathways to generate Tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in Essential Tremor. * Abbreviations : GABA : γ-aminobutyric acid

  • Defective dentate nucleus GABA receptors in Essential Tremor.
    Brain : a journal of neurology, 2011
    Co-Authors: Sarah Paris-robidas, Elodie Brochu, Marion Sintes, Vincent Emond, Mélanie Bousquet, Milène Vandal, Mireille Pilote, Cyntia Tremblay, Thérèse Di Paolo, Ali H Rajput
    Abstract:

    The development of new treatments for Essential Tremor, the most frequent movement disorder, is limited by a poor understanding of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABA(A) (35% reduction) and GABA(B) (22-31% reduction) receptors in the dentate nucleus of the cerebellum from individuals with Essential Tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding autoradiography. Concentrations of GABA(B) receptors in the dentate nucleus were inversely correlated with the duration of Essential Tremor symptoms (r(2) = 0.44, P 

  • Significance of parkinsonian manifestations in Essential Tremor.
    Canadian Journal of Neurological Sciences Journal Canadien des Sciences Neurologiques, 1993
    Co-Authors: Ali H Rajput, Bohdan Rozdilsky, Lee-cyn Ang, Alex Rajput
    Abstract:

    Parkinsonian features, notably resting Tremor may be seen in some Essential Tremor patients but the significance of those is unknown. The reported risk of parkinsonism in Essential Tremor patients varies from being unchanged to 35 times higher than expected. We studied 9 patients with Essential Tremor who had autopsies. In 6 of the 9 (66%) resting Tremor was noted and in 3 (33%) cases fully developed parkinsonism was noted. The parkinsonism was consequent to neuroleptic usage in 2 and to basal ganglia status lacunaris and cribrosus in one case but no consistent abnormalities were noted in 3 Essential Tremor only and 3 Essential Tremor plus resting Tremor cases. We conclude that resting Tremor is an age-related natural evolution in some Essential Tremor patients. We recommend that the additional diagnosis of parkinsonism in the Essential Tremor be made only when resting Tremor, bradykinesia and rigidity are all evident. The risk of ideopathic Parkinson's disease in Essential Tremor cases is similar to the general population.

Sarah Parisrobidas - One of the best experts on this subject based on the ideXlab platform.

  • defective dentate nucleus gaba receptors in Essential Tremor
    Brain, 2012
    Co-Authors: Sarah Parisrobidas, Elodie Brochu, Marion Sintes, Vincent Emond, Mélanie Bousquet, Milène Vandal, Mireille Pilote, Cyntia Tremblay, Thérèse Di Paolo, Ali H Rajput
    Abstract:

    The development of new treatments for Essential Tremor, the most frequent movement disorder, is limited by a poor understanding of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABAA (35% reduction) and GABAB (22–31% reduction) receptors in the dentate nucleus of the cerebellum from individuals with Essential Tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding autoradiography. Concentrations of GABAB receptors in the dentate nucleus were inversely correlated with the duration of Essential Tremor symptoms ( r 2 = 0.44, P <  0.05), suggesting that the loss of GABAB receptors follows the progression of the disease. In situ hybridization experiments also revealed a diminution of GABAB(1a+b) receptor messenger RNA in Essential Tremor (↓27%). In contrast, no significant changes of GABAA and GABAB receptors (protein and messenger RNA), GluN2B receptors, cytochrome oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that a decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagating along the cerebello-thalamo-cortical pathways to generate Tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in Essential Tremor. * Abbreviations : GABA : γ-aminobutyric acid

Mélanie Bousquet - One of the best experts on this subject based on the ideXlab platform.

  • defective dentate nucleus gaba receptors in Essential Tremor
    Brain, 2012
    Co-Authors: Sarah Parisrobidas, Elodie Brochu, Marion Sintes, Vincent Emond, Mélanie Bousquet, Milène Vandal, Mireille Pilote, Cyntia Tremblay, Thérèse Di Paolo, Ali H Rajput
    Abstract:

    The development of new treatments for Essential Tremor, the most frequent movement disorder, is limited by a poor understanding of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABAA (35% reduction) and GABAB (22–31% reduction) receptors in the dentate nucleus of the cerebellum from individuals with Essential Tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding autoradiography. Concentrations of GABAB receptors in the dentate nucleus were inversely correlated with the duration of Essential Tremor symptoms ( r 2 = 0.44, P <  0.05), suggesting that the loss of GABAB receptors follows the progression of the disease. In situ hybridization experiments also revealed a diminution of GABAB(1a+b) receptor messenger RNA in Essential Tremor (↓27%). In contrast, no significant changes of GABAA and GABAB receptors (protein and messenger RNA), GluN2B receptors, cytochrome oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that a decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagating along the cerebello-thalamo-cortical pathways to generate Tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in Essential Tremor. * Abbreviations : GABA : γ-aminobutyric acid

  • Defective dentate nucleus GABA receptors in Essential Tremor.
    Brain : a journal of neurology, 2011
    Co-Authors: Sarah Paris-robidas, Elodie Brochu, Marion Sintes, Vincent Emond, Mélanie Bousquet, Milène Vandal, Mireille Pilote, Cyntia Tremblay, Thérèse Di Paolo, Ali H Rajput
    Abstract:

    The development of new treatments for Essential Tremor, the most frequent movement disorder, is limited by a poor understanding of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABA(A) (35% reduction) and GABA(B) (22-31% reduction) receptors in the dentate nucleus of the cerebellum from individuals with Essential Tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding autoradiography. Concentrations of GABA(B) receptors in the dentate nucleus were inversely correlated with the duration of Essential Tremor symptoms (r(2) = 0.44, P 

Thérèse Di Paolo - One of the best experts on this subject based on the ideXlab platform.

  • defective dentate nucleus gaba receptors in Essential Tremor
    Brain, 2012
    Co-Authors: Sarah Parisrobidas, Elodie Brochu, Marion Sintes, Vincent Emond, Mélanie Bousquet, Milène Vandal, Mireille Pilote, Cyntia Tremblay, Thérèse Di Paolo, Ali H Rajput
    Abstract:

    The development of new treatments for Essential Tremor, the most frequent movement disorder, is limited by a poor understanding of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABAA (35% reduction) and GABAB (22–31% reduction) receptors in the dentate nucleus of the cerebellum from individuals with Essential Tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding autoradiography. Concentrations of GABAB receptors in the dentate nucleus were inversely correlated with the duration of Essential Tremor symptoms ( r 2 = 0.44, P <  0.05), suggesting that the loss of GABAB receptors follows the progression of the disease. In situ hybridization experiments also revealed a diminution of GABAB(1a+b) receptor messenger RNA in Essential Tremor (↓27%). In contrast, no significant changes of GABAA and GABAB receptors (protein and messenger RNA), GluN2B receptors, cytochrome oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that a decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagating along the cerebello-thalamo-cortical pathways to generate Tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in Essential Tremor. * Abbreviations : GABA : γ-aminobutyric acid

  • Defective dentate nucleus GABA receptors in Essential Tremor.
    Brain : a journal of neurology, 2011
    Co-Authors: Sarah Paris-robidas, Elodie Brochu, Marion Sintes, Vincent Emond, Mélanie Bousquet, Milène Vandal, Mireille Pilote, Cyntia Tremblay, Thérèse Di Paolo, Ali H Rajput
    Abstract:

    The development of new treatments for Essential Tremor, the most frequent movement disorder, is limited by a poor understanding of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABA(A) (35% reduction) and GABA(B) (22-31% reduction) receptors in the dentate nucleus of the cerebellum from individuals with Essential Tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding autoradiography. Concentrations of GABA(B) receptors in the dentate nucleus were inversely correlated with the duration of Essential Tremor symptoms (r(2) = 0.44, P 

Mireille Pilote - One of the best experts on this subject based on the ideXlab platform.

  • defective dentate nucleus gaba receptors in Essential Tremor
    Brain, 2012
    Co-Authors: Sarah Parisrobidas, Elodie Brochu, Marion Sintes, Vincent Emond, Mélanie Bousquet, Milène Vandal, Mireille Pilote, Cyntia Tremblay, Thérèse Di Paolo, Ali H Rajput
    Abstract:

    The development of new treatments for Essential Tremor, the most frequent movement disorder, is limited by a poor understanding of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABAA (35% reduction) and GABAB (22–31% reduction) receptors in the dentate nucleus of the cerebellum from individuals with Essential Tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding autoradiography. Concentrations of GABAB receptors in the dentate nucleus were inversely correlated with the duration of Essential Tremor symptoms ( r 2 = 0.44, P <  0.05), suggesting that the loss of GABAB receptors follows the progression of the disease. In situ hybridization experiments also revealed a diminution of GABAB(1a+b) receptor messenger RNA in Essential Tremor (↓27%). In contrast, no significant changes of GABAA and GABAB receptors (protein and messenger RNA), GluN2B receptors, cytochrome oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that a decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagating along the cerebello-thalamo-cortical pathways to generate Tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in Essential Tremor. * Abbreviations : GABA : γ-aminobutyric acid

  • Defective dentate nucleus GABA receptors in Essential Tremor.
    Brain : a journal of neurology, 2011
    Co-Authors: Sarah Paris-robidas, Elodie Brochu, Marion Sintes, Vincent Emond, Mélanie Bousquet, Milène Vandal, Mireille Pilote, Cyntia Tremblay, Thérèse Di Paolo, Ali H Rajput
    Abstract:

    The development of new treatments for Essential Tremor, the most frequent movement disorder, is limited by a poor understanding of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABA(A) (35% reduction) and GABA(B) (22-31% reduction) receptors in the dentate nucleus of the cerebellum from individuals with Essential Tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding autoradiography. Concentrations of GABA(B) receptors in the dentate nucleus were inversely correlated with the duration of Essential Tremor symptoms (r(2) = 0.44, P