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Denis Macina - One of the best experts on this subject based on the ideXlab platform.

  • a cross sectional study of bordetella pertussis seroprevalence and Estimated Duration of vaccine protection against pertussis in st petersburg russia
    Vaccine, 2018
    Co-Authors: Natalia Kurova, Elena V. Timofeeva, Nicole Guiso, Denis Macina
    Abstract:

    BACKGROUND In Russia as in other countries introduction of infant vaccination against pertussis in 1950s led to dramatic decrease of whooping cough. The current vaccination schedule includes a 3-dose infant series and toddler booster; the pre-school booster was cancelled in 1980s and never reintroduced. Whole-cell vaccines, and in a smaller proportion acellular vaccines are used for all doses. However, pertussis incidence in urban settings is high with highest burden in school children. We conducted a study of seroprevalence of recent pertussis infection to estimate the Duration of protection from the 4-dose series. MATERIALS AND METHODS Sera sample from 395 St Petersburg children aged ≥3 years and <14 years were tested for pertussis toxin antibodies using a commercial PT ELISA test. Only children with completed 4-dose vaccination course were included in the study. Age-specific seroprevalence of recent pertussis infection was analyzed for trends. RESULTS Children fully vaccinated against pertussis at 3 years old had significant delays in infant vaccination schedule: only 83.5% received at least one dose of pertussis vaccine at 6 months of age and 25.6% received their toddler booster before 24 months-old. Overall, 10.6% of children demonstrated the serological signs of the infection in the last 12 months. A clear trend (r2 = 0.692) of increasing proportion of infection in the last 12 months was observed in children who had received their last dose of vaccine 6 years and more prior to the study. CONCLUSION Our study demonstrates that Russian children become susceptible to infection at or soon after entering school. The results confirm the waning of vaccine-elicited immunity around school-age and support the need for a booster dose at that age.

  • A cross-sectional study of Bordetella pertussis seroprevalence and Estimated Duration of vaccine protection against pertussis in St. Petersburg, Russia.
    Vaccine, 2018
    Co-Authors: Natalia Kurova, Elena V. Timofeeva, Nicole Guiso, Denis Macina
    Abstract:

    BACKGROUND In Russia as in other countries introduction of infant vaccination against pertussis in 1950s led to dramatic decrease of whooping cough. The current vaccination schedule includes a 3-dose infant series and toddler booster; the pre-school booster was cancelled in 1980s and never reintroduced. Whole-cell vaccines, and in a smaller proportion acellular vaccines are used for all doses. However, pertussis incidence in urban settings is high with highest burden in school children. We conducted a study of seroprevalence of recent pertussis infection to estimate the Duration of protection from the 4-dose series. MATERIALS AND METHODS Sera sample from 395 St Petersburg children aged ≥3 years and

F Ambrosch - One of the best experts on this subject based on the ideXlab platform.

  • Estimated persistence of anti hav antibodies after single dose and booster hepatitis a vaccination 0 6 schedule
    Acta Tropica, 1998
    Co-Authors: G Wiedermann, M Kundi, F Ambrosch
    Abstract:

    Abstract The persistence of antibodies after a single dose and booster vaccination against hepatitis A (Havrix® 1440) has not yet been assessed. By reanalysing previously published data of serum titres and application of a two-component model, we Estimated the Duration of protection. In 134 vaccinees, aged 20–39 years, the GMT 1 month after booster was 3629 mlU/ml, which would result in an Estimated Duration of protection of 34.5 years and in 66 vaccinees aged 40–62 years a GMT of 2320 mlU/ml was calculated, resulting in a Duration of protection of 31.5 years. Even when taking the minimum observed titres in the older age group into account, the Duration of protection will be more than 10 years. Considering at the same time, its good tolerability and compliance, the single dose hepatitis A vaccination appears highly recommendable in travel medicine.

  • Estimated persistence of anti hav antibodies after single dose and booster hepatitis a vaccination 0 6 schedule
    Acta Tropica, 1998
    Co-Authors: G Wiedermann, M Kundi, F Ambrosch
    Abstract:

    Abstract The persistence of antibodies after a single dose and booster vaccination against hepatitis A (Havrix® 1440) has not yet been assessed. By reanalysing previously published data of serum titres and application of a two-component model, we Estimated the Duration of protection. In 134 vaccinees, aged 20–39 years, the GMT 1 month after booster was 3629 mlU/ml, which would result in an Estimated Duration of protection of 34.5 years and in 66 vaccinees aged 40–62 years a GMT of 2320 mlU/ml was calculated, resulting in a Duration of protection of 31.5 years. Even when taking the minimum observed titres in the older age group into account, the Duration of protection will be more than 10 years. Considering at the same time, its good tolerability and compliance, the single dose hepatitis A vaccination appears highly recommendable in travel medicine.

Natalia Kurova - One of the best experts on this subject based on the ideXlab platform.

  • a cross sectional study of bordetella pertussis seroprevalence and Estimated Duration of vaccine protection against pertussis in st petersburg russia
    Vaccine, 2018
    Co-Authors: Natalia Kurova, Elena V. Timofeeva, Nicole Guiso, Denis Macina
    Abstract:

    BACKGROUND In Russia as in other countries introduction of infant vaccination against pertussis in 1950s led to dramatic decrease of whooping cough. The current vaccination schedule includes a 3-dose infant series and toddler booster; the pre-school booster was cancelled in 1980s and never reintroduced. Whole-cell vaccines, and in a smaller proportion acellular vaccines are used for all doses. However, pertussis incidence in urban settings is high with highest burden in school children. We conducted a study of seroprevalence of recent pertussis infection to estimate the Duration of protection from the 4-dose series. MATERIALS AND METHODS Sera sample from 395 St Petersburg children aged ≥3 years and <14 years were tested for pertussis toxin antibodies using a commercial PT ELISA test. Only children with completed 4-dose vaccination course were included in the study. Age-specific seroprevalence of recent pertussis infection was analyzed for trends. RESULTS Children fully vaccinated against pertussis at 3 years old had significant delays in infant vaccination schedule: only 83.5% received at least one dose of pertussis vaccine at 6 months of age and 25.6% received their toddler booster before 24 months-old. Overall, 10.6% of children demonstrated the serological signs of the infection in the last 12 months. A clear trend (r2 = 0.692) of increasing proportion of infection in the last 12 months was observed in children who had received their last dose of vaccine 6 years and more prior to the study. CONCLUSION Our study demonstrates that Russian children become susceptible to infection at or soon after entering school. The results confirm the waning of vaccine-elicited immunity around school-age and support the need for a booster dose at that age.

  • A cross-sectional study of Bordetella pertussis seroprevalence and Estimated Duration of vaccine protection against pertussis in St. Petersburg, Russia.
    Vaccine, 2018
    Co-Authors: Natalia Kurova, Elena V. Timofeeva, Nicole Guiso, Denis Macina
    Abstract:

    BACKGROUND In Russia as in other countries introduction of infant vaccination against pertussis in 1950s led to dramatic decrease of whooping cough. The current vaccination schedule includes a 3-dose infant series and toddler booster; the pre-school booster was cancelled in 1980s and never reintroduced. Whole-cell vaccines, and in a smaller proportion acellular vaccines are used for all doses. However, pertussis incidence in urban settings is high with highest burden in school children. We conducted a study of seroprevalence of recent pertussis infection to estimate the Duration of protection from the 4-dose series. MATERIALS AND METHODS Sera sample from 395 St Petersburg children aged ≥3 years and

G Wiedermann - One of the best experts on this subject based on the ideXlab platform.

  • Estimated persistence of anti hav antibodies after single dose and booster hepatitis a vaccination 0 6 schedule
    Acta Tropica, 1998
    Co-Authors: G Wiedermann, M Kundi, F Ambrosch
    Abstract:

    Abstract The persistence of antibodies after a single dose and booster vaccination against hepatitis A (Havrix® 1440) has not yet been assessed. By reanalysing previously published data of serum titres and application of a two-component model, we Estimated the Duration of protection. In 134 vaccinees, aged 20–39 years, the GMT 1 month after booster was 3629 mlU/ml, which would result in an Estimated Duration of protection of 34.5 years and in 66 vaccinees aged 40–62 years a GMT of 2320 mlU/ml was calculated, resulting in a Duration of protection of 31.5 years. Even when taking the minimum observed titres in the older age group into account, the Duration of protection will be more than 10 years. Considering at the same time, its good tolerability and compliance, the single dose hepatitis A vaccination appears highly recommendable in travel medicine.

  • Estimated persistence of anti hav antibodies after single dose and booster hepatitis a vaccination 0 6 schedule
    Acta Tropica, 1998
    Co-Authors: G Wiedermann, M Kundi, F Ambrosch
    Abstract:

    Abstract The persistence of antibodies after a single dose and booster vaccination against hepatitis A (Havrix® 1440) has not yet been assessed. By reanalysing previously published data of serum titres and application of a two-component model, we Estimated the Duration of protection. In 134 vaccinees, aged 20–39 years, the GMT 1 month after booster was 3629 mlU/ml, which would result in an Estimated Duration of protection of 34.5 years and in 66 vaccinees aged 40–62 years a GMT of 2320 mlU/ml was calculated, resulting in a Duration of protection of 31.5 years. Even when taking the minimum observed titres in the older age group into account, the Duration of protection will be more than 10 years. Considering at the same time, its good tolerability and compliance, the single dose hepatitis A vaccination appears highly recommendable in travel medicine.

Nicole Guiso - One of the best experts on this subject based on the ideXlab platform.

  • a cross sectional study of bordetella pertussis seroprevalence and Estimated Duration of vaccine protection against pertussis in st petersburg russia
    Vaccine, 2018
    Co-Authors: Natalia Kurova, Elena V. Timofeeva, Nicole Guiso, Denis Macina
    Abstract:

    BACKGROUND In Russia as in other countries introduction of infant vaccination against pertussis in 1950s led to dramatic decrease of whooping cough. The current vaccination schedule includes a 3-dose infant series and toddler booster; the pre-school booster was cancelled in 1980s and never reintroduced. Whole-cell vaccines, and in a smaller proportion acellular vaccines are used for all doses. However, pertussis incidence in urban settings is high with highest burden in school children. We conducted a study of seroprevalence of recent pertussis infection to estimate the Duration of protection from the 4-dose series. MATERIALS AND METHODS Sera sample from 395 St Petersburg children aged ≥3 years and <14 years were tested for pertussis toxin antibodies using a commercial PT ELISA test. Only children with completed 4-dose vaccination course were included in the study. Age-specific seroprevalence of recent pertussis infection was analyzed for trends. RESULTS Children fully vaccinated against pertussis at 3 years old had significant delays in infant vaccination schedule: only 83.5% received at least one dose of pertussis vaccine at 6 months of age and 25.6% received their toddler booster before 24 months-old. Overall, 10.6% of children demonstrated the serological signs of the infection in the last 12 months. A clear trend (r2 = 0.692) of increasing proportion of infection in the last 12 months was observed in children who had received their last dose of vaccine 6 years and more prior to the study. CONCLUSION Our study demonstrates that Russian children become susceptible to infection at or soon after entering school. The results confirm the waning of vaccine-elicited immunity around school-age and support the need for a booster dose at that age.

  • A cross-sectional study of Bordetella pertussis seroprevalence and Estimated Duration of vaccine protection against pertussis in St. Petersburg, Russia.
    Vaccine, 2018
    Co-Authors: Natalia Kurova, Elena V. Timofeeva, Nicole Guiso, Denis Macina
    Abstract:

    BACKGROUND In Russia as in other countries introduction of infant vaccination against pertussis in 1950s led to dramatic decrease of whooping cough. The current vaccination schedule includes a 3-dose infant series and toddler booster; the pre-school booster was cancelled in 1980s and never reintroduced. Whole-cell vaccines, and in a smaller proportion acellular vaccines are used for all doses. However, pertussis incidence in urban settings is high with highest burden in school children. We conducted a study of seroprevalence of recent pertussis infection to estimate the Duration of protection from the 4-dose series. MATERIALS AND METHODS Sera sample from 395 St Petersburg children aged ≥3 years and