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John L. Beard - One of the best experts on this subject based on the ideXlab platform.

  • metabolic rate and thyroxine 5 deiodinase in iron deficiency effects of the Estrous Cycle
    Nutrition Research, 1992
    Co-Authors: Scott M. Smith, Daniel R. Deaver, John L. Beard
    Abstract:

    Abstract Thyroid function is severely compromised in male iron-deficient (ID) rats. Similar effects in female rats are undocumented. Therefore, we examined thyroid hormone metabolism in female iron-deficient and control (CN) rats throughout the Estrous Cycle. Overall, iron-deficient rats had significantly lower plasma concentrations of thyroxine than controls (25.1 ± 8.4 nmol/L in ID; 31.5 ± 9.3 nmol/L in CN, mean ± SD, p≤0.001), while plasma triiodothyronine concentrations were similar to those of controls (0.44 ± 0.19 nmol/L vs. 0.48 ± 0.16 nmol/L, p≥0.05). Oxygen consumption was unaffected by either iron deficiency or the Estrous Cycle. Control animals had higher liver thyroxine 5′-deiodinase activity at estrus (567 ± 260 pmoles I − produced • mg protein −1 • 20 min −1 ) while iron-deficient animals had lower activity (310 ± 145 pmoles I − • mg protein −1 • 20 min −1 ) relative to other stages of the Estrous Cycle. In contrast, the lower interscapular brown adipose tissue 5′-deiodinase activity in iron-deficiency rats (p≤0.02) was not affected by the Estrous Cycle (p≥0.05). In conclusion, iron deficiency alters the normal Estrous Cycle variation in hepatic triiodothyronine production and plasma thyroid hormone concentrations

  • Metabolic rate and thyroxine 5′-deiodinase in iron deficiency: Effects of the Estrous Cycle
    Nutrition Research, 1992
    Co-Authors: Scott M. Smith, Daniel R. Deaver, John L. Beard
    Abstract:

    Abstract Thyroid function is severely compromised in male iron-deficient (ID) rats. Similar effects in female rats are undocumented. Therefore, we examined thyroid hormone metabolism in female iron-deficient and control (CN) rats throughout the Estrous Cycle. Overall, iron-deficient rats had significantly lower plasma concentrations of thyroxine than controls (25.1 ± 8.4 nmol/L in ID; 31.5 ± 9.3 nmol/L in CN, mean ± SD, p≤0.001), while plasma triiodothyronine concentrations were similar to those of controls (0.44 ± 0.19 nmol/L vs. 0.48 ± 0.16 nmol/L, p≥0.05). Oxygen consumption was unaffected by either iron deficiency or the Estrous Cycle. Control animals had higher liver thyroxine 5′-deiodinase activity at estrus (567 ± 260 pmoles I − produced • mg protein −1 • 20 min −1 ) while iron-deficient animals had lower activity (310 ± 145 pmoles I − • mg protein −1 • 20 min −1 ) relative to other stages of the Estrous Cycle. In contrast, the lower interscapular brown adipose tissue 5′-deiodinase activity in iron-deficiency rats (p≤0.02) was not affected by the Estrous Cycle (p≥0.05). In conclusion, iron deficiency alters the normal Estrous Cycle variation in hepatic triiodothyronine production and plasma thyroid hormone concentrations

Muriel Koehl - One of the best experts on this subject based on the ideXlab platform.

  • Sleep in female mice: a strain comparison across the Estrous Cycle.
    Sleep, 2003
    Co-Authors: Muriel Koehl, Sally E. Battle, Fred W. Turek
    Abstract:

    Study Objective: Studying inbred strains of mice has proven useful in uncovering genetic variation in the expression of sleep patterns. However, although genetic influence on many behaviors has been shown to be gender specific, to date, sleep patterns in different strains of female mice have not been reported. In order to perform such studies in female mice, the Estrous Cycle must be taken into account in view of the effects of reproductive hormones on sleep. The aim of this study was thus to determine sleep patterns in female mice of different inbred strains over the Estrous Cycle. Design: Three strains of mice were used. Vaginal smears were performed to determine the Estrous Cycle stage; electroencephalographic and electromyographic activity, as well as body temperature and locomotor activity collected during a full Estrous Cycle, were analyzed. Measurements and Results: We report a major impact of the genetic background in the regulation of non-rapid eye movement sleep over a 24-hour period and clear strain differences in rapid eye movement sleep distribution over the light-dark Cycle. In contrast, the Estrous Cycle had less influence on non-rapid eye movement sleep and rapid eye movement sleep, and these effects were dependent on the genotype of the mice. Conclusions: Sleep regulation in female mice is influenced primarily by genetic background and, to a lesser extent, by hormonal variations associated with the Estrous Cycle.

  • Sleep in Female Mice: A Strain Comparison Across the Estrous Cycle
    SLEEP, 2003
    Co-Authors: Muriel Koehl, Sally Battle, Fred Turek
    Abstract:

    Studying inbred strains of mice has proven useful in uncovering genetic variation in the expression of sleep patterns. However, although genetic influence on many behaviors has been shown to be gender specific, to date, sleep patterns in different strains of female mice have not been reported. In order to perform such studies in female mice, the Estrous Cycle must be taken into account in view of the effects of reproductive hormones on sleep. The aim of this study was thus to determine sleep patterns in female mice of different inbred strains over the Estrous Cycle.

Scott M. Smith - One of the best experts on this subject based on the ideXlab platform.

  • metabolic rate and thyroxine 5 deiodinase in iron deficiency effects of the Estrous Cycle
    Nutrition Research, 1992
    Co-Authors: Scott M. Smith, Daniel R. Deaver, John L. Beard
    Abstract:

    Abstract Thyroid function is severely compromised in male iron-deficient (ID) rats. Similar effects in female rats are undocumented. Therefore, we examined thyroid hormone metabolism in female iron-deficient and control (CN) rats throughout the Estrous Cycle. Overall, iron-deficient rats had significantly lower plasma concentrations of thyroxine than controls (25.1 ± 8.4 nmol/L in ID; 31.5 ± 9.3 nmol/L in CN, mean ± SD, p≤0.001), while plasma triiodothyronine concentrations were similar to those of controls (0.44 ± 0.19 nmol/L vs. 0.48 ± 0.16 nmol/L, p≥0.05). Oxygen consumption was unaffected by either iron deficiency or the Estrous Cycle. Control animals had higher liver thyroxine 5′-deiodinase activity at estrus (567 ± 260 pmoles I − produced • mg protein −1 • 20 min −1 ) while iron-deficient animals had lower activity (310 ± 145 pmoles I − • mg protein −1 • 20 min −1 ) relative to other stages of the Estrous Cycle. In contrast, the lower interscapular brown adipose tissue 5′-deiodinase activity in iron-deficiency rats (p≤0.02) was not affected by the Estrous Cycle (p≥0.05). In conclusion, iron deficiency alters the normal Estrous Cycle variation in hepatic triiodothyronine production and plasma thyroid hormone concentrations

  • Metabolic rate and thyroxine 5′-deiodinase in iron deficiency: Effects of the Estrous Cycle
    Nutrition Research, 1992
    Co-Authors: Scott M. Smith, Daniel R. Deaver, John L. Beard
    Abstract:

    Abstract Thyroid function is severely compromised in male iron-deficient (ID) rats. Similar effects in female rats are undocumented. Therefore, we examined thyroid hormone metabolism in female iron-deficient and control (CN) rats throughout the Estrous Cycle. Overall, iron-deficient rats had significantly lower plasma concentrations of thyroxine than controls (25.1 ± 8.4 nmol/L in ID; 31.5 ± 9.3 nmol/L in CN, mean ± SD, p≤0.001), while plasma triiodothyronine concentrations were similar to those of controls (0.44 ± 0.19 nmol/L vs. 0.48 ± 0.16 nmol/L, p≥0.05). Oxygen consumption was unaffected by either iron deficiency or the Estrous Cycle. Control animals had higher liver thyroxine 5′-deiodinase activity at estrus (567 ± 260 pmoles I − produced • mg protein −1 • 20 min −1 ) while iron-deficient animals had lower activity (310 ± 145 pmoles I − • mg protein −1 • 20 min −1 ) relative to other stages of the Estrous Cycle. In contrast, the lower interscapular brown adipose tissue 5′-deiodinase activity in iron-deficiency rats (p≤0.02) was not affected by the Estrous Cycle (p≥0.05). In conclusion, iron deficiency alters the normal Estrous Cycle variation in hepatic triiodothyronine production and plasma thyroid hormone concentrations

Fred Turek - One of the best experts on this subject based on the ideXlab platform.

  • Sleep in Female Mice: A Strain Comparison Across the Estrous Cycle
    SLEEP, 2003
    Co-Authors: Muriel Koehl, Sally Battle, Fred Turek
    Abstract:

    Studying inbred strains of mice has proven useful in uncovering genetic variation in the expression of sleep patterns. However, although genetic influence on many behaviors has been shown to be gender specific, to date, sleep patterns in different strains of female mice have not been reported. In order to perform such studies in female mice, the Estrous Cycle must be taken into account in view of the effects of reproductive hormones on sleep. The aim of this study was thus to determine sleep patterns in female mice of different inbred strains over the Estrous Cycle.

Fred W. Turek - One of the best experts on this subject based on the ideXlab platform.

  • Sleep in female mice: a strain comparison across the Estrous Cycle.
    Sleep, 2003
    Co-Authors: Muriel Koehl, Sally E. Battle, Fred W. Turek
    Abstract:

    Study Objective: Studying inbred strains of mice has proven useful in uncovering genetic variation in the expression of sleep patterns. However, although genetic influence on many behaviors has been shown to be gender specific, to date, sleep patterns in different strains of female mice have not been reported. In order to perform such studies in female mice, the Estrous Cycle must be taken into account in view of the effects of reproductive hormones on sleep. The aim of this study was thus to determine sleep patterns in female mice of different inbred strains over the Estrous Cycle. Design: Three strains of mice were used. Vaginal smears were performed to determine the Estrous Cycle stage; electroencephalographic and electromyographic activity, as well as body temperature and locomotor activity collected during a full Estrous Cycle, were analyzed. Measurements and Results: We report a major impact of the genetic background in the regulation of non-rapid eye movement sleep over a 24-hour period and clear strain differences in rapid eye movement sleep distribution over the light-dark Cycle. In contrast, the Estrous Cycle had less influence on non-rapid eye movement sleep and rapid eye movement sleep, and these effects were dependent on the genotype of the mice. Conclusions: Sleep regulation in female mice is influenced primarily by genetic background and, to a lesser extent, by hormonal variations associated with the Estrous Cycle.