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Karyn M. Dinovo - One of the best experts on this subject based on the ideXlab platform.

  • Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response.
    Frontiers in Neuroanatomy, 2018
    Co-Authors: Paul F Mcculloch, Kenneth A. Lahrman, Benjamin Delprete, Karyn M. Dinovo
    Abstract:

    Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea, and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Consequently the primary objective of this research was to determine the central terminal projections of Nerves innervating the external nose, nasal vestibule, and nasal passages of rats. We injected Wheat Germ Agglutinin (WGA) into specific external nasal locations, into the internal nasal passages, and directly into trigeminal Nerves innervating the nose and nasal region. The immunohistological pattern of WGA labeling from the nasal passages, from rats with and without intact anterior Ethmoidal Nerves (AENs), were compared to WGA labeling patterns from specific trigeminal Nerves. After injecting WGA into the nasal passages, central projections were found prominently within the ventral tip of the medullary dorsal horn (MDH), between pyramidal decussation and obex, especially along the transition with spinal trigeminal nucleus interpolaris. This pattern of labeling was very similar to when WGA was directly injected into either the AEN or nasopalatine nerve. WGA labeling from the infraorbital nerve (ION) showed partial overlap with WGA labeling from the nasal passages, while more peripheral branches of the ION did not. Thus both the internal nasal branch of the ophthalmic AEN and the maxillary nasopalatine nerve are primarily responsible for innervating the nasal passages. We conclude that innervation of the anterior nasal passages by the AEN and nasopalatine nerve is likely to provide the afferent information responsible for the activation of secondary neurons within MDH during voluntary diving in rats

  • Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response
    Frontiers Media S.A., 2018
    Co-Authors: Paul F Mcculloch, Kenneth A. Lahrman, Benjamin Delprete, Karyn M. Dinovo
    Abstract:

    Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Consequently, the primary objective of this research was to determine the central terminal projections of Nerves innervating the external nose, nasal vestibule and nasal passages of rats. We injected wheat germ agglutinin (WGA) into specific external nasal locations, into the internal nasal passages of rats both with and without intact anterior Ethmoidal Nerves (AENs), and directly into trigeminal Nerves innervating the nose and nasal region. The central terminations of these projections within the medulla were then precisely mapped. Results indicate that the internal nasal branch of the AEN and the nasopalatine nerve, but not the infraorbital nerve (ION), provide primary innervation of the internal nasal passages. The results also suggest afferent fibers from the internal nasal passages, but not external nasal region, project to the medullary dorsal horn (MDH) in an appropriate anatomical way to cause the activation of secondary neurons within the ventral MDH that express Fos protein during diving. We conclude that innervation of the anterior nasal passages by the AEN and nasopalatine nerve is likely to provide the afferent information responsible for the activation of secondary neurons within MDH during voluntary diving in rats

  • Bilateral sectioning of the anterior Ethmoidal Nerves does not eliminate the diving response in voluntarily diving rats
    Physiological reports, 2013
    Co-Authors: Jill S. Chotiyanonta, Karyn M. Dinovo, Paul F Mcculloch
    Abstract:

    The diving response is characterized by bradycardia, apnea, and increased peripheral resistance. This reflex response is initiated by immersing the nose in water. Because the anterior Ethmoidal nerve (AEN) innervates the nose, our hypothesis was that intact AENs are essential for initiating the diving response in voluntarily diving rats. Heart rate (HR) and arterial blood pressure (BPa) were monitored using implanted biotransmitters. Sprague-Dawley rats were trained to voluntarily swim 5 m underwater. During diving, HR decreased from 480 15 to 99 5 bpm and BPa increased from 136 2t o 187 3 mmHg. Experimental rats (N = 9) then received bilateral AEN sectioning, while Sham rats (N = 8) did not. During diving in Experimental rats 7 days after AEN surgery, HR decreased from 478 13 to 76 4 bpm and BPa increased from 134 3 to 186 4 mmHg. Responses were similar in Sham rats. Then, during nasal stimulation with ammonia vapors in urethaneanesthetized Experimental rats, HR decreased from 368 7t o 83 4 bpm, and BPa increased from 126 7 to 175 4 mmHg. Responses were similar in Sham rats. Thus, 1 week after being sectioned the AENs are not essential for initiating a full cardiorespiratory response during both voluntary diving and nasal stimulation. We conclude that other nerve(s) innervating the nose are able to provide an afferent signal sufficient to initiate the diving response, although neuronal plasticity within the medullary dorsal horn may be necessary for this to occur.

Paul F Mcculloch - One of the best experts on this subject based on the ideXlab platform.

  • Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response.
    Frontiers in Neuroanatomy, 2018
    Co-Authors: Paul F Mcculloch, Kenneth A. Lahrman, Benjamin Delprete, Karyn M. Dinovo
    Abstract:

    Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea, and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Consequently the primary objective of this research was to determine the central terminal projections of Nerves innervating the external nose, nasal vestibule, and nasal passages of rats. We injected Wheat Germ Agglutinin (WGA) into specific external nasal locations, into the internal nasal passages, and directly into trigeminal Nerves innervating the nose and nasal region. The immunohistological pattern of WGA labeling from the nasal passages, from rats with and without intact anterior Ethmoidal Nerves (AENs), were compared to WGA labeling patterns from specific trigeminal Nerves. After injecting WGA into the nasal passages, central projections were found prominently within the ventral tip of the medullary dorsal horn (MDH), between pyramidal decussation and obex, especially along the transition with spinal trigeminal nucleus interpolaris. This pattern of labeling was very similar to when WGA was directly injected into either the AEN or nasopalatine nerve. WGA labeling from the infraorbital nerve (ION) showed partial overlap with WGA labeling from the nasal passages, while more peripheral branches of the ION did not. Thus both the internal nasal branch of the ophthalmic AEN and the maxillary nasopalatine nerve are primarily responsible for innervating the nasal passages. We conclude that innervation of the anterior nasal passages by the AEN and nasopalatine nerve is likely to provide the afferent information responsible for the activation of secondary neurons within MDH during voluntary diving in rats

  • Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response
    Frontiers Media S.A., 2018
    Co-Authors: Paul F Mcculloch, Kenneth A. Lahrman, Benjamin Delprete, Karyn M. Dinovo
    Abstract:

    Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Consequently, the primary objective of this research was to determine the central terminal projections of Nerves innervating the external nose, nasal vestibule and nasal passages of rats. We injected wheat germ agglutinin (WGA) into specific external nasal locations, into the internal nasal passages of rats both with and without intact anterior Ethmoidal Nerves (AENs), and directly into trigeminal Nerves innervating the nose and nasal region. The central terminations of these projections within the medulla were then precisely mapped. Results indicate that the internal nasal branch of the AEN and the nasopalatine nerve, but not the infraorbital nerve (ION), provide primary innervation of the internal nasal passages. The results also suggest afferent fibers from the internal nasal passages, but not external nasal region, project to the medullary dorsal horn (MDH) in an appropriate anatomical way to cause the activation of secondary neurons within the ventral MDH that express Fos protein during diving. We conclude that innervation of the anterior nasal passages by the AEN and nasopalatine nerve is likely to provide the afferent information responsible for the activation of secondary neurons within MDH during voluntary diving in rats

  • Bilateral sectioning of the anterior Ethmoidal Nerves does not eliminate the diving response in voluntarily diving rats
    Physiological reports, 2013
    Co-Authors: Jill S. Chotiyanonta, Karyn M. Dinovo, Paul F Mcculloch
    Abstract:

    The diving response is characterized by bradycardia, apnea, and increased peripheral resistance. This reflex response is initiated by immersing the nose in water. Because the anterior Ethmoidal nerve (AEN) innervates the nose, our hypothesis was that intact AENs are essential for initiating the diving response in voluntarily diving rats. Heart rate (HR) and arterial blood pressure (BPa) were monitored using implanted biotransmitters. Sprague-Dawley rats were trained to voluntarily swim 5 m underwater. During diving, HR decreased from 480 15 to 99 5 bpm and BPa increased from 136 2t o 187 3 mmHg. Experimental rats (N = 9) then received bilateral AEN sectioning, while Sham rats (N = 8) did not. During diving in Experimental rats 7 days after AEN surgery, HR decreased from 478 13 to 76 4 bpm and BPa increased from 134 3 to 186 4 mmHg. Responses were similar in Sham rats. Then, during nasal stimulation with ammonia vapors in urethaneanesthetized Experimental rats, HR decreased from 368 7t o 83 4 bpm, and BPa increased from 126 7 to 175 4 mmHg. Responses were similar in Sham rats. Thus, 1 week after being sectioned the AENs are not essential for initiating a full cardiorespiratory response during both voluntary diving and nasal stimulation. We conclude that other nerve(s) innervating the nose are able to provide an afferent signal sufficient to initiate the diving response, although neuronal plasticity within the medullary dorsal horn may be necessary for this to occur.

Kenneth A. Lahrman - One of the best experts on this subject based on the ideXlab platform.

  • Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response.
    Frontiers in Neuroanatomy, 2018
    Co-Authors: Paul F Mcculloch, Kenneth A. Lahrman, Benjamin Delprete, Karyn M. Dinovo
    Abstract:

    Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea, and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Consequently the primary objective of this research was to determine the central terminal projections of Nerves innervating the external nose, nasal vestibule, and nasal passages of rats. We injected Wheat Germ Agglutinin (WGA) into specific external nasal locations, into the internal nasal passages, and directly into trigeminal Nerves innervating the nose and nasal region. The immunohistological pattern of WGA labeling from the nasal passages, from rats with and without intact anterior Ethmoidal Nerves (AENs), were compared to WGA labeling patterns from specific trigeminal Nerves. After injecting WGA into the nasal passages, central projections were found prominently within the ventral tip of the medullary dorsal horn (MDH), between pyramidal decussation and obex, especially along the transition with spinal trigeminal nucleus interpolaris. This pattern of labeling was very similar to when WGA was directly injected into either the AEN or nasopalatine nerve. WGA labeling from the infraorbital nerve (ION) showed partial overlap with WGA labeling from the nasal passages, while more peripheral branches of the ION did not. Thus both the internal nasal branch of the ophthalmic AEN and the maxillary nasopalatine nerve are primarily responsible for innervating the nasal passages. We conclude that innervation of the anterior nasal passages by the AEN and nasopalatine nerve is likely to provide the afferent information responsible for the activation of secondary neurons within MDH during voluntary diving in rats

  • Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response
    Frontiers Media S.A., 2018
    Co-Authors: Paul F Mcculloch, Kenneth A. Lahrman, Benjamin Delprete, Karyn M. Dinovo
    Abstract:

    Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Consequently, the primary objective of this research was to determine the central terminal projections of Nerves innervating the external nose, nasal vestibule and nasal passages of rats. We injected wheat germ agglutinin (WGA) into specific external nasal locations, into the internal nasal passages of rats both with and without intact anterior Ethmoidal Nerves (AENs), and directly into trigeminal Nerves innervating the nose and nasal region. The central terminations of these projections within the medulla were then precisely mapped. Results indicate that the internal nasal branch of the AEN and the nasopalatine nerve, but not the infraorbital nerve (ION), provide primary innervation of the internal nasal passages. The results also suggest afferent fibers from the internal nasal passages, but not external nasal region, project to the medullary dorsal horn (MDH) in an appropriate anatomical way to cause the activation of secondary neurons within the ventral MDH that express Fos protein during diving. We conclude that innervation of the anterior nasal passages by the AEN and nasopalatine nerve is likely to provide the afferent information responsible for the activation of secondary neurons within MDH during voluntary diving in rats

Benjamin Delprete - One of the best experts on this subject based on the ideXlab platform.

  • Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response.
    Frontiers in Neuroanatomy, 2018
    Co-Authors: Paul F Mcculloch, Kenneth A. Lahrman, Benjamin Delprete, Karyn M. Dinovo
    Abstract:

    Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea, and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Consequently the primary objective of this research was to determine the central terminal projections of Nerves innervating the external nose, nasal vestibule, and nasal passages of rats. We injected Wheat Germ Agglutinin (WGA) into specific external nasal locations, into the internal nasal passages, and directly into trigeminal Nerves innervating the nose and nasal region. The immunohistological pattern of WGA labeling from the nasal passages, from rats with and without intact anterior Ethmoidal Nerves (AENs), were compared to WGA labeling patterns from specific trigeminal Nerves. After injecting WGA into the nasal passages, central projections were found prominently within the ventral tip of the medullary dorsal horn (MDH), between pyramidal decussation and obex, especially along the transition with spinal trigeminal nucleus interpolaris. This pattern of labeling was very similar to when WGA was directly injected into either the AEN or nasopalatine nerve. WGA labeling from the infraorbital nerve (ION) showed partial overlap with WGA labeling from the nasal passages, while more peripheral branches of the ION did not. Thus both the internal nasal branch of the ophthalmic AEN and the maxillary nasopalatine nerve are primarily responsible for innervating the nasal passages. We conclude that innervation of the anterior nasal passages by the AEN and nasopalatine nerve is likely to provide the afferent information responsible for the activation of secondary neurons within MDH during voluntary diving in rats

  • Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response
    Frontiers Media S.A., 2018
    Co-Authors: Paul F Mcculloch, Kenneth A. Lahrman, Benjamin Delprete, Karyn M. Dinovo
    Abstract:

    Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Consequently, the primary objective of this research was to determine the central terminal projections of Nerves innervating the external nose, nasal vestibule and nasal passages of rats. We injected wheat germ agglutinin (WGA) into specific external nasal locations, into the internal nasal passages of rats both with and without intact anterior Ethmoidal Nerves (AENs), and directly into trigeminal Nerves innervating the nose and nasal region. The central terminations of these projections within the medulla were then precisely mapped. Results indicate that the internal nasal branch of the AEN and the nasopalatine nerve, but not the infraorbital nerve (ION), provide primary innervation of the internal nasal passages. The results also suggest afferent fibers from the internal nasal passages, but not external nasal region, project to the medullary dorsal horn (MDH) in an appropriate anatomical way to cause the activation of secondary neurons within the ventral MDH that express Fos protein during diving. We conclude that innervation of the anterior nasal passages by the AEN and nasopalatine nerve is likely to provide the afferent information responsible for the activation of secondary neurons within MDH during voluntary diving in rats

Liu Qiang-he - One of the best experts on this subject based on the ideXlab platform.

  • Clinical applications of radiofrequency thermo-coagulation to vidian and anterior Ethmoidal Nerves via nasal endoscope
    Chinese Journal of Otorhinolaryngology-skull Base Surgery, 2006
    Co-Authors: Liu Qiang-he
    Abstract:

    Objective To explore a simple and safe surgical procedure for the treatment of allergic or vasomotor rhinitis.Methods Radiofrequency thermo-coagulation via nasal endoscope was applied in 65 allergic or vasomotor rhinitis patients to the areas in bilateral nasal cavities where vidian and anterior Ethmoidal Nerves concentrated.The postoperative symptoms' score was compared with the preoperative one.Results The remarkable effective rates were(84.61%),(82.97%),and(61.76%) after follow-up for 1 month,6 months and 1 year postoperatively.Conclusion This surgical procedure,owing to its good vision,simplicity,safety and remarkbale effectiveness,can be one of the treatment choices for allergic and/or vasomotor rhinitis.

  • Treatment of perennial rhinitis by radiofrequency thermo-coagulations to vidian and antirior Ethmoidal Nerves under rhinoendoscope
    2006
    Co-Authors: Liu Qiang-he
    Abstract:

    Objective:To explore an simple,easy,safety surgical procedure in treatment of allergicalvasomotor rhinitis and evaluate the results.Methods:By means of radiofrequency thermo-coagulation under rhinoendoscope to the area of nasal cavity where vidian and antirior Ethmoidal nerve concentrated in 65 cases, to reduce the excitibility and sensitivity of the Nerves.Comparation of symptom scorings prepost-operation of the patients was made.Results:operation could effectively eliminate or relieve symptoms of the patients in this group. In 1～6months, 6～12months,1～2year follow-up after operation,the remarkbale effectiveness rates were 84.61%, 82.97%, 61.76%,respctively.Conclusion:This surgical procedure,with its good vision, simplification, safety and remarkbale effectiveness, can be one of the treatment choices in allergical and or vasomotor rhinitis patients.