The Experts below are selected from a list of 1053 Experts worldwide ranked by ideXlab platform
Ming Yao - One of the best experts on this subject based on the ideXlab platform.
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enriching the housing environment for mice enhances their nk cell antitumor immunity via sympathetic nerve dependent regulation of nkg2d and ccr5
Cancer Research, 2017Co-Authors: Yanfang Song, Yu Gan, Qing Wang, Zihong Meng, Yuling Shen, Ming YaoAbstract:Mice housed in an enriched environment display a tumor-resistant phenotype due to Eustress stimulation. However, the mechanisms underlying enriched environment-induced protection against cancers remain largely unexplained. In this study, we observed a significant antitumor effect induced by enriched environment in murine pancreatic cancer and lung cancer models. This effect remained intact in T/B lymphocyte-deficient Rag1-/- mice, but was nearly eliminated in natural killer (NK) cell-deficient Beige mice or in antibody-mediated NK-cell-depleted mice, suggesting a predominant role of NK cells in enriched environment-induced tumor inhibition. Exposure to enriched environment enhanced NK-cell activity against tumors and promoted tumoral infiltration of NK cells. Enriched environment increased the expression levels of CCR5 and NKG2D (KLRK1) in NK cells; blocking their function effectively blunted the enriched environment-induced enhancement of tumoral infiltration and cytotoxic activity of NK cells. Moreover, blockade of β-adrenergic signaling or chemical sympathectomy abolished the effects of enriched environment on NK cells and attenuated the antitumor effect of enriched environment. Taken together, our results provide new insight into the mechanism by which Eustress exerts a beneficial effect against cancer. Cancer Res; 77(7); 1611-22. ©2017 AACR.
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enriched environment housing enhances the sensitivity of mouse pancreatic cancer to chemotherapeutic agents
Biochemical and Biophysical Research Communications, 2016Co-Authors: Yu Gan, Hui Yuan, Qing Wang, Yingchao Fan, Jian Zhang, Ming YaoAbstract:Living in an enriched housing environment is an established model of Eustress and has been consistently shown to reduce the growth of transplanted tumors, including pancreatic cancer. Here, we further investigate the influence of an enriched environment (EE) on the efficacy of chemotherapy in pancreatic cancer. Male C57BL/6 mice were housed in EE or standard environment (SE) conditions and transplanted with syngeneic Panc02 pancreatic cancer cells. Tumor-bearing mice were treated with 5-fluorouracil (5-FU) or gemcitabine (GEM) to examine their sensitivities to chemotherapy. The results showed that both 5-FU and GEM exerted the dose dependent inhibition of tumor growth. The tumor inhibition rates of low-dose 5-FU and GEM were improved from 17.7% and 23.6% to 46.3% and 49.9% by EE housing. Importantly, tumor cells isolated from the pancreatic cancer xenografts of EE mice had significantly enhanced sensitivities to both 5-FU and GEM (IC50 for 5-FU: 2.8 μM versus 27.3 μM; IC50 for GEM: 0.8 μM versus 5.0 μM). Furthermore, using microarray analyses, we identified the "ATP-binding cassette (ABC) transporter" that was overrepresented among EE-induced down-regulated genes in pancreatic cancer. Particularly, the tumoral expression of ABC transporter A8b (ABCA8b) was confirmed to be significantly decreased by EE. Over-expression of ABCA8b in mouse pancreatic cancer cells led to a marked decrease in the sensitivity to chemotherapeutic drugs both in vitro and in vivo. In conclusion, our data indicate that benign stressful stimulation can synergistically boost the efficiency of chemotherapeutics in pancreatic cancer, which suggests a novel strategy for adjuvant cancer therapy.
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enriched environment inhibits mouse pancreatic cancer growth and down regulates the expression of mitochondria related genes in cancer cells
Scientific Reports, 2015Co-Authors: Yu Gan, Yingchao Fan, Hechun Lin, Yanfang Song, Xiaojin Cai, Weihong Pan, Ming YaoAbstract:Psycho-social stress has been suggested to influence the development of cancer, but it remains poorly defined with regard to pancreatic cancer, a lethal malignancy with few effective treatment modalities. In this study, we sought to investigate the impacts of enriched environment (EE) housing, a rodent model of "Eustress'', on the growth of mouse pancreatic cancer, and to explore the potential underlying mechanisms through gene expression profiling. The EE mice showed significantly reduced tumor weights in both subcutaneous (53%) and orthotopic (41%) models, while each single component of EE (inanimate stimulation, social stimulation or physical exercise) was not profound enough to achieve comparative anti-tumor effects as EE. The integrative transcriptomic and proteomic analysis revealed that in response to EE, a total of 129 genes in the tumors showed differential expression at both the mRNA and protein levels. The differentially expressed genes were mostly localized to the mitochondria and enriched in the citrate cycle and oxidative phosphorylation pathways. Interestingly, nearly all of the mitochondria-related genes were down-regulated by EE. Our data have provided experimental evidence in favor of the application of positive stress or of benign environmental stimulation in pancreatic cancer therapy.
Ake Strid - One of the best experts on this subject based on the ideXlab platform.
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integration of non target metabolomics and sensory analysis unravels vegetable plant metabolite signatures associated with sensory quality a case study using dill anethum graveolens
Food Chemistry, 2021Co-Authors: Victor Costa Castroalves, Mats Aronsson, Irina Kalbina, Asgeir Nilsen, Eva Rosenqvist, Marcel A K Jansen, Minjie Qian, Asa Ostrom, Tuulia Hyotylainen, Ake StridAbstract:Using dill (Anethum graveolens L.) as a model herb, we reveal novel associations between metabolite profile and sensory quality, by integrating non-target metabolomics with sensory data. Low night temperatures and exposure to UV-enriched light was used to modulate plant metabolism, thereby improving sensory quality. Plant age is a crucial factor associated with accumulation of dill ether and α-phellandrene, volatile compounds associated with dill flavour. However, sensory analysis showed that neither of these compounds has any strong association with dill taste. Rather, amino acids alanine, phenylalanine, glutamic acid, valine, and leucine increased in samples exposed to Eustress and were positively associated with dill and sour taste. Increases in amino acids and organic acids changed the taste from lemon/grass to a more bitter/pungent dill-related taste. Our procedure reveals a novel approach to establish links between effects of Eustressors on sensory quality and may be applicable to a broad range of crops.
Yu Gan - One of the best experts on this subject based on the ideXlab platform.
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enriching the housing environment for mice enhances their nk cell antitumor immunity via sympathetic nerve dependent regulation of nkg2d and ccr5
Cancer Research, 2017Co-Authors: Yanfang Song, Yu Gan, Qing Wang, Zihong Meng, Yuling Shen, Ming YaoAbstract:Mice housed in an enriched environment display a tumor-resistant phenotype due to Eustress stimulation. However, the mechanisms underlying enriched environment-induced protection against cancers remain largely unexplained. In this study, we observed a significant antitumor effect induced by enriched environment in murine pancreatic cancer and lung cancer models. This effect remained intact in T/B lymphocyte-deficient Rag1-/- mice, but was nearly eliminated in natural killer (NK) cell-deficient Beige mice or in antibody-mediated NK-cell-depleted mice, suggesting a predominant role of NK cells in enriched environment-induced tumor inhibition. Exposure to enriched environment enhanced NK-cell activity against tumors and promoted tumoral infiltration of NK cells. Enriched environment increased the expression levels of CCR5 and NKG2D (KLRK1) in NK cells; blocking their function effectively blunted the enriched environment-induced enhancement of tumoral infiltration and cytotoxic activity of NK cells. Moreover, blockade of β-adrenergic signaling or chemical sympathectomy abolished the effects of enriched environment on NK cells and attenuated the antitumor effect of enriched environment. Taken together, our results provide new insight into the mechanism by which Eustress exerts a beneficial effect against cancer. Cancer Res; 77(7); 1611-22. ©2017 AACR.
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enriched environment housing enhances the sensitivity of mouse pancreatic cancer to chemotherapeutic agents
Biochemical and Biophysical Research Communications, 2016Co-Authors: Yu Gan, Hui Yuan, Qing Wang, Yingchao Fan, Jian Zhang, Ming YaoAbstract:Living in an enriched housing environment is an established model of Eustress and has been consistently shown to reduce the growth of transplanted tumors, including pancreatic cancer. Here, we further investigate the influence of an enriched environment (EE) on the efficacy of chemotherapy in pancreatic cancer. Male C57BL/6 mice were housed in EE or standard environment (SE) conditions and transplanted with syngeneic Panc02 pancreatic cancer cells. Tumor-bearing mice were treated with 5-fluorouracil (5-FU) or gemcitabine (GEM) to examine their sensitivities to chemotherapy. The results showed that both 5-FU and GEM exerted the dose dependent inhibition of tumor growth. The tumor inhibition rates of low-dose 5-FU and GEM were improved from 17.7% and 23.6% to 46.3% and 49.9% by EE housing. Importantly, tumor cells isolated from the pancreatic cancer xenografts of EE mice had significantly enhanced sensitivities to both 5-FU and GEM (IC50 for 5-FU: 2.8 μM versus 27.3 μM; IC50 for GEM: 0.8 μM versus 5.0 μM). Furthermore, using microarray analyses, we identified the "ATP-binding cassette (ABC) transporter" that was overrepresented among EE-induced down-regulated genes in pancreatic cancer. Particularly, the tumoral expression of ABC transporter A8b (ABCA8b) was confirmed to be significantly decreased by EE. Over-expression of ABCA8b in mouse pancreatic cancer cells led to a marked decrease in the sensitivity to chemotherapeutic drugs both in vitro and in vivo. In conclusion, our data indicate that benign stressful stimulation can synergistically boost the efficiency of chemotherapeutics in pancreatic cancer, which suggests a novel strategy for adjuvant cancer therapy.
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enriched environment inhibits mouse pancreatic cancer growth and down regulates the expression of mitochondria related genes in cancer cells
Scientific Reports, 2015Co-Authors: Yu Gan, Yingchao Fan, Hechun Lin, Yanfang Song, Xiaojin Cai, Weihong Pan, Ming YaoAbstract:Psycho-social stress has been suggested to influence the development of cancer, but it remains poorly defined with regard to pancreatic cancer, a lethal malignancy with few effective treatment modalities. In this study, we sought to investigate the impacts of enriched environment (EE) housing, a rodent model of "Eustress'', on the growth of mouse pancreatic cancer, and to explore the potential underlying mechanisms through gene expression profiling. The EE mice showed significantly reduced tumor weights in both subcutaneous (53%) and orthotopic (41%) models, while each single component of EE (inanimate stimulation, social stimulation or physical exercise) was not profound enough to achieve comparative anti-tumor effects as EE. The integrative transcriptomic and proteomic analysis revealed that in response to EE, a total of 129 genes in the tumors showed differential expression at both the mRNA and protein levels. The differentially expressed genes were mostly localized to the mitochondria and enriched in the citrate cycle and oxidative phosphorylation pathways. Interestingly, nearly all of the mitochondria-related genes were down-regulated by EE. Our data have provided experimental evidence in favor of the application of positive stress or of benign environmental stimulation in pancreatic cancer therapy.
Victor Costa Castroalves - One of the best experts on this subject based on the ideXlab platform.
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integration of non target metabolomics and sensory analysis unravels vegetable plant metabolite signatures associated with sensory quality a case study using dill anethum graveolens
Food Chemistry, 2021Co-Authors: Victor Costa Castroalves, Mats Aronsson, Irina Kalbina, Asgeir Nilsen, Eva Rosenqvist, Marcel A K Jansen, Minjie Qian, Asa Ostrom, Tuulia Hyotylainen, Ake StridAbstract:Using dill (Anethum graveolens L.) as a model herb, we reveal novel associations between metabolite profile and sensory quality, by integrating non-target metabolomics with sensory data. Low night temperatures and exposure to UV-enriched light was used to modulate plant metabolism, thereby improving sensory quality. Plant age is a crucial factor associated with accumulation of dill ether and α-phellandrene, volatile compounds associated with dill flavour. However, sensory analysis showed that neither of these compounds has any strong association with dill taste. Rather, amino acids alanine, phenylalanine, glutamic acid, valine, and leucine increased in samples exposed to Eustress and were positively associated with dill and sour taste. Increases in amino acids and organic acids changed the taste from lemon/grass to a more bitter/pungent dill-related taste. Our procedure reveals a novel approach to establish links between effects of Eustressors on sensory quality and may be applicable to a broad range of crops.
Mats Aronsson - One of the best experts on this subject based on the ideXlab platform.
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integration of non target metabolomics and sensory analysis unravels vegetable plant metabolite signatures associated with sensory quality a case study using dill anethum graveolens
Food Chemistry, 2021Co-Authors: Victor Costa Castroalves, Mats Aronsson, Irina Kalbina, Asgeir Nilsen, Eva Rosenqvist, Marcel A K Jansen, Minjie Qian, Asa Ostrom, Tuulia Hyotylainen, Ake StridAbstract:Using dill (Anethum graveolens L.) as a model herb, we reveal novel associations between metabolite profile and sensory quality, by integrating non-target metabolomics with sensory data. Low night temperatures and exposure to UV-enriched light was used to modulate plant metabolism, thereby improving sensory quality. Plant age is a crucial factor associated with accumulation of dill ether and α-phellandrene, volatile compounds associated with dill flavour. However, sensory analysis showed that neither of these compounds has any strong association with dill taste. Rather, amino acids alanine, phenylalanine, glutamic acid, valine, and leucine increased in samples exposed to Eustress and were positively associated with dill and sour taste. Increases in amino acids and organic acids changed the taste from lemon/grass to a more bitter/pungent dill-related taste. Our procedure reveals a novel approach to establish links between effects of Eustressors on sensory quality and may be applicable to a broad range of crops.
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Integration of non-target metabolomics and sensory analysis unravels vegetable plant metabolite signatures associated with sensory quality : A case study using dill (Anethum graveolens)
'Elsevier BV', 2021Co-Authors: Castro Alves Victor, Kalbina Irina, Nilsen Asgeir, Mats Aronsson, Rosenqvist Eva, Jansen, Marcel A K, Qian Minjie, Öström Åsa, Hyötyläinen Tuulia, Strid ÅkeAbstract:Using dill (Anethum graveolens L.) as a model herb, we revealnovel associations between metabolite profile and sensory quality, by integrating non-target metabolomics with sensory data. Low night temperatures and exposure to UV-enriched light was used to modulate plant metabolism, thereby improving sensory quality. Plant age is a crucial factor associated with accumulation of dill ether and α-phellandrene, volatile compounds associated with dill flavour. However, sensory analysis showed that neither of these compounds has any strong association with dill taste. Rather, amino acids alanine, phenylalanine, glutamic acid, valine, and leucine increased in samples exposed to Eustress and were positively associated with dill and sour taste. Increases in amino acids and organic acids changed the taste from lemon/grass to a more bitter/pungent dill-related taste. Our approach reveals a novel approach to establish links between effects of Eustressors on sensory quality, and may be applicable to a broad range of crops
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Integration of non-target metabolomics and sensory analysis unravels vegetable plant metabolite signatures associated with sensory quality : A case study using dill (Anethum graveolens)
'Elsevier BV', 2021Co-Authors: Castro Alves Victor, Kalbina Irina, Nilsen Asgeir, Mats Aronsson, Rosenqvist Eva, Jansen, Marcel A K, Qian Minjie, Öström Åsa, Hyötyläinen Tuulia, Strid ÅkeAbstract:Using dill (Anethum graveolens L.) as a model herb, we revealnovel associations between metabolite profile and sensory quality, by integrating non-target metabolomics with sensory data. Low night temperatures and exposure to UV-enriched light was used to modulate plant metabolism, thereby improving sensory quality. Plant age is a crucial factor associated with accumulation of dill ether and α-phellandrene, volatile compounds associated with dill flavour. However, sensory analysis showed that neither of these compounds has any strong association with dill taste. Rather, amino acids alanine, phenylalanine, glutamic acid, valine, and leucine increased in samples exposed to Eustress and were positively associated with dill and sour taste. Increases in amino acids and organic acids changed the taste from lemon/grass to a more bitter/pungent dill-related taste. Our approach reveals a novel approach to establish links between effects of Eustressors on sensory quality, and may be applicable to a broad range of crops.Funding Agencies:Faculty for Business, Science and Technology at Örebro University Örebro University Vice Chancellor's strategic research programme on 'Food and Health' Science Foundation Ireland S16/IA/4418
