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Curtis J Nickel - One of the best experts on this subject based on the ideXlab platform.
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national institutes of health chronic prostatitis symptom index nih cpsi symptom Evaluation in multinational cohorts of patients with chronic prostatitis chronic pelvic pain syndrome
European Urology, 2013Co-Authors: Florian M E Wagenlehner, W Weidner, J Olivier W Van Till, Vittorio Magri, Gianpaolo Perletti, Jos Houbiers, Curtis J NickelAbstract:Abstract Background The assessment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in everyday practice and clinical studies relies on National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores for symptom appraisal, inclusion criteria for clinical trials, follow-up, and response Evaluation. Objective We investigated multiple databases of CP/CPPS patients to determine the prevalence and impact of pain locations and types to improve our strategy of individualized phenotypically guided treatment. Design, setting, and participants Four major databases with CPSI scores for nonselected CP/CPPS clinic patients from Canada, Germany, Italy, and the United States. Outcome measurements and statistical analysis Individual question scores and subtotal and total scores of CPSI were described and correlated with each other. Ordinal regression analysis was performed to define pain severity categories. Results and limitations A total of 1563 CP/CPPS patients were included. Perineal pain/discomfort was the most prevalent pain symptom (63%) followed by testicular pain (58%), pain in the pubic area (42%) and penis (32%); reports of pain during ejaculation and voiding were 45% and 43%, respectively. European patients had a significantly higher number of pain localizations and symptoms compared with North American patients ( p r =0.645). No specific pain localization/type was associated with more severe pain. Correlation of pain domain with quality of life (QoL) ( r =0.678) was higher than the urinary domain ( r =0.320). Individually, pain severity ( r =0.627) and pain frequency ( r =0.594) correlated better with QoL than pain localization ( r =0.354). Pain severity categories results for NIH-CPSI item 4 (0–10 numerical rating scale for average pain) were mild, 0–3; moderate, 4–6; severe, 7–10; CPSI pain domain (0–21): mild, 0–7; moderate, 8–13; and severe, 14–21. Conclusions Pain has more impact on QoL than urinary symptoms. Pain severity and frequency are more important than pain localization/type. Cut-off levels for disease severity categories have been identified that will prove valuable in symptom assessment and the development of therapeutic strategies.
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national institutes of health chronic prostatitis symptom index nih cpsi symptom Evaluation in multinational cohorts of patients with chronic prostatitis chronic pelvic pain syndrome
European Urology, 2013Co-Authors: Florian M E Wagenlehner, W Weidner, J Olivier W Van Till, Vittorio Magri, Gianpaolo Perletti, Jos Houbiers, Curtis J NickelAbstract:BACKGROUND: The assessment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in everyday practice and clinical studies relies on National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores for symptom appraisal, inclusion criteria for clinical trials, follow-up, and response Evaluation. Objective: We investigated multiple databases of CP/CPPS patients to determine the prevalence and impact of pain locations and types to improve our strategy of individualized phenotypically guided treatment. DESIGN, SETTING, AND PARTICIPANTS: Four major databases with CPSI scores for nonselected CP/CPPS clinic patients from Canada, Germany, Italy, and the United States. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Individual question scores and subtotal and total scores of CPSI were described and correlated with each other. Ordinal regression analysis was performed to define pain severity categories. RESULTS AND LIMITATIONS: A total of 1563 CP/CPPS patients were included. Perineal pain/discomfort was the most prevalent pain symptom (63%) followed by testicular pain (58%), pain in the pubic area (42%) and penis (32%); reports of pain during ejaculation and voiding were 45% and 43%, respectively. European patients had a significantly higher number of pain localizations and symptoms compared with North American patients (p<0.001). Severity of pain correlated well with frequency of pain (r = 0.645). No specific pain localization/type was associated with more severe pain. Correlation of pain domain with quality of life (QoL) (r = 0.678) was higher than the urinary domain (r = 0.320). Individually, pain severity (r = 0.627) and pain frequency (r = 0.594) correlated better with QoL than pain localization (r = 0.354). Pain severity categories results for NIH-CPSI item 4 (0-10 numerical rating scale for average pain) were mild, 0-3; moderate, 4-6; severe, 7-10; CPSI pain domain (0-21): mild, 0-7; moderate, 8-13; and severe, 14-21. CONCLUSIONS: Pain has more impact on QoL than urinary symptoms. Pain severity and frequency are more important than pain localization/type. Cut-off levels for disease severity categories have been identified that will prove valuable in symptom assessment and the development of therapeutic strategies.
Florian M E Wagenlehner - One of the best experts on this subject based on the ideXlab platform.
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national institutes of health chronic prostatitis symptom index nih cpsi symptom Evaluation in multinational cohorts of patients with chronic prostatitis chronic pelvic pain syndrome
European Urology, 2013Co-Authors: Florian M E Wagenlehner, W Weidner, J Olivier W Van Till, Vittorio Magri, Gianpaolo Perletti, Jos Houbiers, Curtis J NickelAbstract:Abstract Background The assessment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in everyday practice and clinical studies relies on National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores for symptom appraisal, inclusion criteria for clinical trials, follow-up, and response Evaluation. Objective We investigated multiple databases of CP/CPPS patients to determine the prevalence and impact of pain locations and types to improve our strategy of individualized phenotypically guided treatment. Design, setting, and participants Four major databases with CPSI scores for nonselected CP/CPPS clinic patients from Canada, Germany, Italy, and the United States. Outcome measurements and statistical analysis Individual question scores and subtotal and total scores of CPSI were described and correlated with each other. Ordinal regression analysis was performed to define pain severity categories. Results and limitations A total of 1563 CP/CPPS patients were included. Perineal pain/discomfort was the most prevalent pain symptom (63%) followed by testicular pain (58%), pain in the pubic area (42%) and penis (32%); reports of pain during ejaculation and voiding were 45% and 43%, respectively. European patients had a significantly higher number of pain localizations and symptoms compared with North American patients ( p r =0.645). No specific pain localization/type was associated with more severe pain. Correlation of pain domain with quality of life (QoL) ( r =0.678) was higher than the urinary domain ( r =0.320). Individually, pain severity ( r =0.627) and pain frequency ( r =0.594) correlated better with QoL than pain localization ( r =0.354). Pain severity categories results for NIH-CPSI item 4 (0–10 numerical rating scale for average pain) were mild, 0–3; moderate, 4–6; severe, 7–10; CPSI pain domain (0–21): mild, 0–7; moderate, 8–13; and severe, 14–21. Conclusions Pain has more impact on QoL than urinary symptoms. Pain severity and frequency are more important than pain localization/type. Cut-off levels for disease severity categories have been identified that will prove valuable in symptom assessment and the development of therapeutic strategies.
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national institutes of health chronic prostatitis symptom index nih cpsi symptom Evaluation in multinational cohorts of patients with chronic prostatitis chronic pelvic pain syndrome
European Urology, 2013Co-Authors: Florian M E Wagenlehner, W Weidner, J Olivier W Van Till, Vittorio Magri, Gianpaolo Perletti, Jos Houbiers, Curtis J NickelAbstract:BACKGROUND: The assessment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in everyday practice and clinical studies relies on National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores for symptom appraisal, inclusion criteria for clinical trials, follow-up, and response Evaluation. Objective: We investigated multiple databases of CP/CPPS patients to determine the prevalence and impact of pain locations and types to improve our strategy of individualized phenotypically guided treatment. DESIGN, SETTING, AND PARTICIPANTS: Four major databases with CPSI scores for nonselected CP/CPPS clinic patients from Canada, Germany, Italy, and the United States. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Individual question scores and subtotal and total scores of CPSI were described and correlated with each other. Ordinal regression analysis was performed to define pain severity categories. RESULTS AND LIMITATIONS: A total of 1563 CP/CPPS patients were included. Perineal pain/discomfort was the most prevalent pain symptom (63%) followed by testicular pain (58%), pain in the pubic area (42%) and penis (32%); reports of pain during ejaculation and voiding were 45% and 43%, respectively. European patients had a significantly higher number of pain localizations and symptoms compared with North American patients (p<0.001). Severity of pain correlated well with frequency of pain (r = 0.645). No specific pain localization/type was associated with more severe pain. Correlation of pain domain with quality of life (QoL) (r = 0.678) was higher than the urinary domain (r = 0.320). Individually, pain severity (r = 0.627) and pain frequency (r = 0.594) correlated better with QoL than pain localization (r = 0.354). Pain severity categories results for NIH-CPSI item 4 (0-10 numerical rating scale for average pain) were mild, 0-3; moderate, 4-6; severe, 7-10; CPSI pain domain (0-21): mild, 0-7; moderate, 8-13; and severe, 14-21. CONCLUSIONS: Pain has more impact on QoL than urinary symptoms. Pain severity and frequency are more important than pain localization/type. Cut-off levels for disease severity categories have been identified that will prove valuable in symptom assessment and the development of therapeutic strategies.
W Weidner - One of the best experts on this subject based on the ideXlab platform.
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national institutes of health chronic prostatitis symptom index nih cpsi symptom Evaluation in multinational cohorts of patients with chronic prostatitis chronic pelvic pain syndrome
European Urology, 2013Co-Authors: Florian M E Wagenlehner, W Weidner, J Olivier W Van Till, Vittorio Magri, Gianpaolo Perletti, Jos Houbiers, Curtis J NickelAbstract:BACKGROUND: The assessment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in everyday practice and clinical studies relies on National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores for symptom appraisal, inclusion criteria for clinical trials, follow-up, and response Evaluation. Objective: We investigated multiple databases of CP/CPPS patients to determine the prevalence and impact of pain locations and types to improve our strategy of individualized phenotypically guided treatment. DESIGN, SETTING, AND PARTICIPANTS: Four major databases with CPSI scores for nonselected CP/CPPS clinic patients from Canada, Germany, Italy, and the United States. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Individual question scores and subtotal and total scores of CPSI were described and correlated with each other. Ordinal regression analysis was performed to define pain severity categories. RESULTS AND LIMITATIONS: A total of 1563 CP/CPPS patients were included. Perineal pain/discomfort was the most prevalent pain symptom (63%) followed by testicular pain (58%), pain in the pubic area (42%) and penis (32%); reports of pain during ejaculation and voiding were 45% and 43%, respectively. European patients had a significantly higher number of pain localizations and symptoms compared with North American patients (p<0.001). Severity of pain correlated well with frequency of pain (r = 0.645). No specific pain localization/type was associated with more severe pain. Correlation of pain domain with quality of life (QoL) (r = 0.678) was higher than the urinary domain (r = 0.320). Individually, pain severity (r = 0.627) and pain frequency (r = 0.594) correlated better with QoL than pain localization (r = 0.354). Pain severity categories results for NIH-CPSI item 4 (0-10 numerical rating scale for average pain) were mild, 0-3; moderate, 4-6; severe, 7-10; CPSI pain domain (0-21): mild, 0-7; moderate, 8-13; and severe, 14-21. CONCLUSIONS: Pain has more impact on QoL than urinary symptoms. Pain severity and frequency are more important than pain localization/type. Cut-off levels for disease severity categories have been identified that will prove valuable in symptom assessment and the development of therapeutic strategies.
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national institutes of health chronic prostatitis symptom index nih cpsi symptom Evaluation in multinational cohorts of patients with chronic prostatitis chronic pelvic pain syndrome
European Urology, 2013Co-Authors: Florian M E Wagenlehner, W Weidner, J Olivier W Van Till, Vittorio Magri, Gianpaolo Perletti, Jos Houbiers, Curtis J NickelAbstract:Abstract Background The assessment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in everyday practice and clinical studies relies on National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores for symptom appraisal, inclusion criteria for clinical trials, follow-up, and response Evaluation. Objective We investigated multiple databases of CP/CPPS patients to determine the prevalence and impact of pain locations and types to improve our strategy of individualized phenotypically guided treatment. Design, setting, and participants Four major databases with CPSI scores for nonselected CP/CPPS clinic patients from Canada, Germany, Italy, and the United States. Outcome measurements and statistical analysis Individual question scores and subtotal and total scores of CPSI were described and correlated with each other. Ordinal regression analysis was performed to define pain severity categories. Results and limitations A total of 1563 CP/CPPS patients were included. Perineal pain/discomfort was the most prevalent pain symptom (63%) followed by testicular pain (58%), pain in the pubic area (42%) and penis (32%); reports of pain during ejaculation and voiding were 45% and 43%, respectively. European patients had a significantly higher number of pain localizations and symptoms compared with North American patients ( p r =0.645). No specific pain localization/type was associated with more severe pain. Correlation of pain domain with quality of life (QoL) ( r =0.678) was higher than the urinary domain ( r =0.320). Individually, pain severity ( r =0.627) and pain frequency ( r =0.594) correlated better with QoL than pain localization ( r =0.354). Pain severity categories results for NIH-CPSI item 4 (0–10 numerical rating scale for average pain) were mild, 0–3; moderate, 4–6; severe, 7–10; CPSI pain domain (0–21): mild, 0–7; moderate, 8–13; and severe, 14–21. Conclusions Pain has more impact on QoL than urinary symptoms. Pain severity and frequency are more important than pain localization/type. Cut-off levels for disease severity categories have been identified that will prove valuable in symptom assessment and the development of therapeutic strategies.
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varicocele and male factor infertility treatment a new meta analysis and review of the role of varicocele repair
European Urology, 2011Co-Authors: Abdulaziz Baazeem, Eric Belzile, Antonio Ciampi, Gert R Dohle, Keith Jarvi, Andrea Salonia, W Weidner, Armand ZiniAbstract:Abstract Context Varicocele is a common condition, found in many men who present for infertility Evaluation. Objective To assess the effect of varicocelectomy on male infertility. Evidence acquisition A literature search was performed using Embase and Medline. Literature reviewed included meta-analyses and randomized and nonrandomized prospective (controlled and noncontrolled) studies. In addition, a new meta-analysis was performed. Evidence synthesis Four randomized controlled trials reporting on pregnancy outcome after repair of clinical varicoceles in oligozoospermic men were identified. Using the random effect model, the combined odds ratio was 2.23 (95% confidence interval [CI], 0.86–5.78; p =0.091), indicating that varicocelectomy is moderately superior to observation, but the effect is not statistically significant. We identified 22, 17, and 5 prospective studies reporting on sperm concentration, total motility, and progressive motility, respectively, before and after repair of clinical varicocele. The random effect model combined improvement in sperm concentration was 12.32 million sperm per milliliter (95% CI, 9.45–15.19; p p p =0.003), respectively. These results indicate that varicocelectomy is associated with a significant increase in sperm concentration as well as total and progressive motility. Prospective studies also show that varicocelectomy reduces seminal oxidative stress and sperm DNA damage as well as improving sperm ultramorphology. Studies indicate that a microsurgical approach to a varicocele repair results in less recurrence and fewer complications than other techniques. Conclusions Although there is no conclusive evidence that a varicocele repair improves spontaneous pregnancy rates, varicocelectomy improves sperm parameters (count and total and progressive motility), reduces sperm DNA damage and seminal oxidative stress, and improves sperm ultramorphology. The various methods of repair are all viable options, but microsurgical repair seems to be associated with better outcomes.
J Olivier W Van Till - One of the best experts on this subject based on the ideXlab platform.
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national institutes of health chronic prostatitis symptom index nih cpsi symptom Evaluation in multinational cohorts of patients with chronic prostatitis chronic pelvic pain syndrome
European Urology, 2013Co-Authors: Florian M E Wagenlehner, W Weidner, J Olivier W Van Till, Vittorio Magri, Gianpaolo Perletti, Jos Houbiers, Curtis J NickelAbstract:Abstract Background The assessment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in everyday practice and clinical studies relies on National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores for symptom appraisal, inclusion criteria for clinical trials, follow-up, and response Evaluation. Objective We investigated multiple databases of CP/CPPS patients to determine the prevalence and impact of pain locations and types to improve our strategy of individualized phenotypically guided treatment. Design, setting, and participants Four major databases with CPSI scores for nonselected CP/CPPS clinic patients from Canada, Germany, Italy, and the United States. Outcome measurements and statistical analysis Individual question scores and subtotal and total scores of CPSI were described and correlated with each other. Ordinal regression analysis was performed to define pain severity categories. Results and limitations A total of 1563 CP/CPPS patients were included. Perineal pain/discomfort was the most prevalent pain symptom (63%) followed by testicular pain (58%), pain in the pubic area (42%) and penis (32%); reports of pain during ejaculation and voiding were 45% and 43%, respectively. European patients had a significantly higher number of pain localizations and symptoms compared with North American patients ( p r =0.645). No specific pain localization/type was associated with more severe pain. Correlation of pain domain with quality of life (QoL) ( r =0.678) was higher than the urinary domain ( r =0.320). Individually, pain severity ( r =0.627) and pain frequency ( r =0.594) correlated better with QoL than pain localization ( r =0.354). Pain severity categories results for NIH-CPSI item 4 (0–10 numerical rating scale for average pain) were mild, 0–3; moderate, 4–6; severe, 7–10; CPSI pain domain (0–21): mild, 0–7; moderate, 8–13; and severe, 14–21. Conclusions Pain has more impact on QoL than urinary symptoms. Pain severity and frequency are more important than pain localization/type. Cut-off levels for disease severity categories have been identified that will prove valuable in symptom assessment and the development of therapeutic strategies.
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national institutes of health chronic prostatitis symptom index nih cpsi symptom Evaluation in multinational cohorts of patients with chronic prostatitis chronic pelvic pain syndrome
European Urology, 2013Co-Authors: Florian M E Wagenlehner, W Weidner, J Olivier W Van Till, Vittorio Magri, Gianpaolo Perletti, Jos Houbiers, Curtis J NickelAbstract:BACKGROUND: The assessment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in everyday practice and clinical studies relies on National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores for symptom appraisal, inclusion criteria for clinical trials, follow-up, and response Evaluation. Objective: We investigated multiple databases of CP/CPPS patients to determine the prevalence and impact of pain locations and types to improve our strategy of individualized phenotypically guided treatment. DESIGN, SETTING, AND PARTICIPANTS: Four major databases with CPSI scores for nonselected CP/CPPS clinic patients from Canada, Germany, Italy, and the United States. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Individual question scores and subtotal and total scores of CPSI were described and correlated with each other. Ordinal regression analysis was performed to define pain severity categories. RESULTS AND LIMITATIONS: A total of 1563 CP/CPPS patients were included. Perineal pain/discomfort was the most prevalent pain symptom (63%) followed by testicular pain (58%), pain in the pubic area (42%) and penis (32%); reports of pain during ejaculation and voiding were 45% and 43%, respectively. European patients had a significantly higher number of pain localizations and symptoms compared with North American patients (p<0.001). Severity of pain correlated well with frequency of pain (r = 0.645). No specific pain localization/type was associated with more severe pain. Correlation of pain domain with quality of life (QoL) (r = 0.678) was higher than the urinary domain (r = 0.320). Individually, pain severity (r = 0.627) and pain frequency (r = 0.594) correlated better with QoL than pain localization (r = 0.354). Pain severity categories results for NIH-CPSI item 4 (0-10 numerical rating scale for average pain) were mild, 0-3; moderate, 4-6; severe, 7-10; CPSI pain domain (0-21): mild, 0-7; moderate, 8-13; and severe, 14-21. CONCLUSIONS: Pain has more impact on QoL than urinary symptoms. Pain severity and frequency are more important than pain localization/type. Cut-off levels for disease severity categories have been identified that will prove valuable in symptom assessment and the development of therapeutic strategies.
Vittorio Magri - One of the best experts on this subject based on the ideXlab platform.
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national institutes of health chronic prostatitis symptom index nih cpsi symptom Evaluation in multinational cohorts of patients with chronic prostatitis chronic pelvic pain syndrome
European Urology, 2013Co-Authors: Florian M E Wagenlehner, W Weidner, J Olivier W Van Till, Vittorio Magri, Gianpaolo Perletti, Jos Houbiers, Curtis J NickelAbstract:Abstract Background The assessment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in everyday practice and clinical studies relies on National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores for symptom appraisal, inclusion criteria for clinical trials, follow-up, and response Evaluation. Objective We investigated multiple databases of CP/CPPS patients to determine the prevalence and impact of pain locations and types to improve our strategy of individualized phenotypically guided treatment. Design, setting, and participants Four major databases with CPSI scores for nonselected CP/CPPS clinic patients from Canada, Germany, Italy, and the United States. Outcome measurements and statistical analysis Individual question scores and subtotal and total scores of CPSI were described and correlated with each other. Ordinal regression analysis was performed to define pain severity categories. Results and limitations A total of 1563 CP/CPPS patients were included. Perineal pain/discomfort was the most prevalent pain symptom (63%) followed by testicular pain (58%), pain in the pubic area (42%) and penis (32%); reports of pain during ejaculation and voiding were 45% and 43%, respectively. European patients had a significantly higher number of pain localizations and symptoms compared with North American patients ( p r =0.645). No specific pain localization/type was associated with more severe pain. Correlation of pain domain with quality of life (QoL) ( r =0.678) was higher than the urinary domain ( r =0.320). Individually, pain severity ( r =0.627) and pain frequency ( r =0.594) correlated better with QoL than pain localization ( r =0.354). Pain severity categories results for NIH-CPSI item 4 (0–10 numerical rating scale for average pain) were mild, 0–3; moderate, 4–6; severe, 7–10; CPSI pain domain (0–21): mild, 0–7; moderate, 8–13; and severe, 14–21. Conclusions Pain has more impact on QoL than urinary symptoms. Pain severity and frequency are more important than pain localization/type. Cut-off levels for disease severity categories have been identified that will prove valuable in symptom assessment and the development of therapeutic strategies.
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national institutes of health chronic prostatitis symptom index nih cpsi symptom Evaluation in multinational cohorts of patients with chronic prostatitis chronic pelvic pain syndrome
European Urology, 2013Co-Authors: Florian M E Wagenlehner, W Weidner, J Olivier W Van Till, Vittorio Magri, Gianpaolo Perletti, Jos Houbiers, Curtis J NickelAbstract:BACKGROUND: The assessment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in everyday practice and clinical studies relies on National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores for symptom appraisal, inclusion criteria for clinical trials, follow-up, and response Evaluation. Objective: We investigated multiple databases of CP/CPPS patients to determine the prevalence and impact of pain locations and types to improve our strategy of individualized phenotypically guided treatment. DESIGN, SETTING, AND PARTICIPANTS: Four major databases with CPSI scores for nonselected CP/CPPS clinic patients from Canada, Germany, Italy, and the United States. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Individual question scores and subtotal and total scores of CPSI were described and correlated with each other. Ordinal regression analysis was performed to define pain severity categories. RESULTS AND LIMITATIONS: A total of 1563 CP/CPPS patients were included. Perineal pain/discomfort was the most prevalent pain symptom (63%) followed by testicular pain (58%), pain in the pubic area (42%) and penis (32%); reports of pain during ejaculation and voiding were 45% and 43%, respectively. European patients had a significantly higher number of pain localizations and symptoms compared with North American patients (p<0.001). Severity of pain correlated well with frequency of pain (r = 0.645). No specific pain localization/type was associated with more severe pain. Correlation of pain domain with quality of life (QoL) (r = 0.678) was higher than the urinary domain (r = 0.320). Individually, pain severity (r = 0.627) and pain frequency (r = 0.594) correlated better with QoL than pain localization (r = 0.354). Pain severity categories results for NIH-CPSI item 4 (0-10 numerical rating scale for average pain) were mild, 0-3; moderate, 4-6; severe, 7-10; CPSI pain domain (0-21): mild, 0-7; moderate, 8-13; and severe, 14-21. CONCLUSIONS: Pain has more impact on QoL than urinary symptoms. Pain severity and frequency are more important than pain localization/type. Cut-off levels for disease severity categories have been identified that will prove valuable in symptom assessment and the development of therapeutic strategies.
