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S Aggestrup - One of the best experts on this subject based on the ideXlab platform.

  • morning or Evening Dosage of omeprazole for gastro oesophageal reflux disease
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J Hendel, L Hendel, S Aggestrup
    Abstract:

    SUMMARY Background and aims: When routinely checking patients receiving omeprazole treatment for gastro-oesophageal reflux, we have been finding patients with surprisingly low nocturnal gastric pH. The aim of this study was to evaluate the impact of timing of the 40 mg omeprazole once daily regimen. Methods: We evaluated the difference in effect of 40 mg omeprazole, given as a morning or Evening dose, in 17 patients with gastro-oesophageal reflux disease. Gastric and oesophageal pH was recorded by portable 24-h two-channel pH-metry in a cross-over design of 14 days of morning and 14 days of Evening administration. Results: In five patients pathological reflux was abolished by both regimens, four only during morning Dosage, and three only during Evening Dosage. In the remaining five patients abolition of pathological reflux was not achieved. The therapeutic outcome and patient preference for morning or Evening administration were closely related to the individual oesophageal pH curves. Patients with reflux induced by physical activity had a clear preference for morning Dosage, patients with nocturnal reflux showed a clear preference for Evening Dosage. Gastric pH profiles showed a high inter-individual variation; paired statistics, however, revealed a significant impact of Dosage timing on the gastric pH profile. After morning Dosage the work-day part (the first 7 h) of the gastric pH profile is 0.72 ± 0.91 (mean difference of pairs ± s.d.) higher than after Evening Dosage (P < 0.01). After Evening Dosage the gastric pH during the supine period is 0.64 ± 0.83 (mean difference of pairs ± s.d.) higher than after morning Dosage (P= 0.02). Conclusion: The timing of a 40 mg omeprazole Dosage regimen has a clinically significant impact on the 24-h pH profile, and that—by relating to the patient 24-hour oesophageal pH-metry in combination with the patient symptomatology—the timing of this Dosage is highly important for therapeutic efficacy.

  • Morning or Evening Dosage of omeprazole for gastro‐oesophageal reflux disease?
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J Hendel, L Hendel, S Aggestrup
    Abstract:

    SUMMARY Background and aims: When routinely checking patients receiving omeprazole treatment for gastro-oesophageal reflux, we have been finding patients with surprisingly low nocturnal gastric pH. The aim of this study was to evaluate the impact of timing of the 40 mg omeprazole once daily regimen. Methods: We evaluated the difference in effect of 40 mg omeprazole, given as a morning or Evening dose, in 17 patients with gastro-oesophageal reflux disease. Gastric and oesophageal pH was recorded by portable 24-h two-channel pH-metry in a cross-over design of 14 days of morning and 14 days of Evening administration. Results: In five patients pathological reflux was abolished by both regimens, four only during morning Dosage, and three only during Evening Dosage. In the remaining five patients abolition of pathological reflux was not achieved. The therapeutic outcome and patient preference for morning or Evening administration were closely related to the individual oesophageal pH curves. Patients with reflux induced by physical activity had a clear preference for morning Dosage, patients with nocturnal reflux showed a clear preference for Evening Dosage. Gastric pH profiles showed a high inter-individual variation; paired statistics, however, revealed a significant impact of Dosage timing on the gastric pH profile. After morning Dosage the work-day part (the first 7 h) of the gastric pH profile is 0.72 ± 0.91 (mean difference of pairs ± s.d.) higher than after Evening Dosage (P < 0.01). After Evening Dosage the gastric pH during the supine period is 0.64 ± 0.83 (mean difference of pairs ± s.d.) higher than after morning Dosage (P= 0.02). Conclusion: The timing of a 40 mg omeprazole Dosage regimen has a clinically significant impact on the 24-h pH profile, and that—by relating to the patient 24-hour oesophageal pH-metry in combination with the patient symptomatology—the timing of this Dosage is highly important for therapeutic efficacy.

J Hendel - One of the best experts on this subject based on the ideXlab platform.

  • morning or Evening Dosage of omeprazole for gastro oesophageal reflux disease
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J Hendel, L Hendel, S Aggestrup
    Abstract:

    SUMMARY Background and aims: When routinely checking patients receiving omeprazole treatment for gastro-oesophageal reflux, we have been finding patients with surprisingly low nocturnal gastric pH. The aim of this study was to evaluate the impact of timing of the 40 mg omeprazole once daily regimen. Methods: We evaluated the difference in effect of 40 mg omeprazole, given as a morning or Evening dose, in 17 patients with gastro-oesophageal reflux disease. Gastric and oesophageal pH was recorded by portable 24-h two-channel pH-metry in a cross-over design of 14 days of morning and 14 days of Evening administration. Results: In five patients pathological reflux was abolished by both regimens, four only during morning Dosage, and three only during Evening Dosage. In the remaining five patients abolition of pathological reflux was not achieved. The therapeutic outcome and patient preference for morning or Evening administration were closely related to the individual oesophageal pH curves. Patients with reflux induced by physical activity had a clear preference for morning Dosage, patients with nocturnal reflux showed a clear preference for Evening Dosage. Gastric pH profiles showed a high inter-individual variation; paired statistics, however, revealed a significant impact of Dosage timing on the gastric pH profile. After morning Dosage the work-day part (the first 7 h) of the gastric pH profile is 0.72 ± 0.91 (mean difference of pairs ± s.d.) higher than after Evening Dosage (P < 0.01). After Evening Dosage the gastric pH during the supine period is 0.64 ± 0.83 (mean difference of pairs ± s.d.) higher than after morning Dosage (P= 0.02). Conclusion: The timing of a 40 mg omeprazole Dosage regimen has a clinically significant impact on the 24-h pH profile, and that—by relating to the patient 24-hour oesophageal pH-metry in combination with the patient symptomatology—the timing of this Dosage is highly important for therapeutic efficacy.

  • Morning or Evening Dosage of omeprazole for gastro‐oesophageal reflux disease?
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J Hendel, L Hendel, S Aggestrup
    Abstract:

    SUMMARY Background and aims: When routinely checking patients receiving omeprazole treatment for gastro-oesophageal reflux, we have been finding patients with surprisingly low nocturnal gastric pH. The aim of this study was to evaluate the impact of timing of the 40 mg omeprazole once daily regimen. Methods: We evaluated the difference in effect of 40 mg omeprazole, given as a morning or Evening dose, in 17 patients with gastro-oesophageal reflux disease. Gastric and oesophageal pH was recorded by portable 24-h two-channel pH-metry in a cross-over design of 14 days of morning and 14 days of Evening administration. Results: In five patients pathological reflux was abolished by both regimens, four only during morning Dosage, and three only during Evening Dosage. In the remaining five patients abolition of pathological reflux was not achieved. The therapeutic outcome and patient preference for morning or Evening administration were closely related to the individual oesophageal pH curves. Patients with reflux induced by physical activity had a clear preference for morning Dosage, patients with nocturnal reflux showed a clear preference for Evening Dosage. Gastric pH profiles showed a high inter-individual variation; paired statistics, however, revealed a significant impact of Dosage timing on the gastric pH profile. After morning Dosage the work-day part (the first 7 h) of the gastric pH profile is 0.72 ± 0.91 (mean difference of pairs ± s.d.) higher than after Evening Dosage (P < 0.01). After Evening Dosage the gastric pH during the supine period is 0.64 ± 0.83 (mean difference of pairs ± s.d.) higher than after morning Dosage (P= 0.02). Conclusion: The timing of a 40 mg omeprazole Dosage regimen has a clinically significant impact on the 24-h pH profile, and that—by relating to the patient 24-hour oesophageal pH-metry in combination with the patient symptomatology—the timing of this Dosage is highly important for therapeutic efficacy.

Takayoshi Toyota - One of the best experts on this subject based on the ideXlab platform.

  • Effect of lansoprazole on intragastric pH
    Digestive Diseases and Sciences, 1992
    Co-Authors: Michio Hongo, Shuichi Ohara, Yorihisa Hirasawa, Shigeru Asaki, Takayoshi Toyota
    Abstract:

    Lansoprazole is a newly developed proton pump inhibitor. The purpose of this study was to determine whether morning or Evening Dosage gave better control of 24-hr intragastric pH. In this study, we examined the antisecretory effect of lansoprazole by repeated intragastric pH monitoring on four occasions in eight normal subjects and compared median 24-hr pH values and pH threshold time of pH≧4 between morning and Evening dosing, following the administration of lansoprazole 30 mg once daily in either the morning or Evening for seven days. Intragastric pH was monitored before and after seven days of treatment. Both morning and Evening dosing caused a rise in the intragastric pH. Median pH for 24 hr was 4.3 and 1.6 with and without lansoprazole morning dosing and 4.6 and 2.1 for Evening dosing, respectively. The pH threshold curve shifted to the right with lansoprazole treatment in either case. However, no differences were found between morning and Evening dosing in terms of median 24-hr pH values of pH threshold time of pH≧4. These results indicate that lansoprazole can be given once daily in either the morning or Evening because of its potent and long-lasting antisecretory activity.

  • Effect of lansoprazole on intragastric pH. Comparison between morning and Evening dosing.
    Digestive Diseases and Sciences, 1992
    Co-Authors: Michio Hongo, Shuichi Ohara, Yorihisa Hirasawa, Shigeru Asaki, Takayoshi Toyota
    Abstract:

    Lansoprazole is a newly developed proton pump inhibitor. The purpose of this study was to determine whether morning or Evening Dosage gave better control of 24-hr intragastric pH. In this study, we examined the antisecretory effect of lansoprazole by repeated intragastric pH monitoring on four occasions in eight normal subjects and compared median 24-hr pH values and pH threshold time of pH≧4 between morning and Evening dosing, following the administration of lansoprazole 30 mg once daily in either the morning or Evening for seven days. Intragastric pH was monitored before and after seven days of treatment. Both morning and Evening dosing caused a rise in the intragastric pH. Median pH for 24 hr was 4.3 and 1.6 with and without lansoprazole morning dosing and 4.6 and 2.1 for Evening dosing, respectively. The pH threshold curve shifted to the right with lansoprazole treatment in either case. However, no differences were found between morning and Evening dosing in terms of median 24-hr pH values of pH threshold time of pH≧4. These results indicate that lansoprazole can be given once daily in either the morning or Evening because of its potent and long-lasting antisecretory activity.

L Hendel - One of the best experts on this subject based on the ideXlab platform.

  • morning or Evening Dosage of omeprazole for gastro oesophageal reflux disease
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J Hendel, L Hendel, S Aggestrup
    Abstract:

    SUMMARY Background and aims: When routinely checking patients receiving omeprazole treatment for gastro-oesophageal reflux, we have been finding patients with surprisingly low nocturnal gastric pH. The aim of this study was to evaluate the impact of timing of the 40 mg omeprazole once daily regimen. Methods: We evaluated the difference in effect of 40 mg omeprazole, given as a morning or Evening dose, in 17 patients with gastro-oesophageal reflux disease. Gastric and oesophageal pH was recorded by portable 24-h two-channel pH-metry in a cross-over design of 14 days of morning and 14 days of Evening administration. Results: In five patients pathological reflux was abolished by both regimens, four only during morning Dosage, and three only during Evening Dosage. In the remaining five patients abolition of pathological reflux was not achieved. The therapeutic outcome and patient preference for morning or Evening administration were closely related to the individual oesophageal pH curves. Patients with reflux induced by physical activity had a clear preference for morning Dosage, patients with nocturnal reflux showed a clear preference for Evening Dosage. Gastric pH profiles showed a high inter-individual variation; paired statistics, however, revealed a significant impact of Dosage timing on the gastric pH profile. After morning Dosage the work-day part (the first 7 h) of the gastric pH profile is 0.72 ± 0.91 (mean difference of pairs ± s.d.) higher than after Evening Dosage (P < 0.01). After Evening Dosage the gastric pH during the supine period is 0.64 ± 0.83 (mean difference of pairs ± s.d.) higher than after morning Dosage (P= 0.02). Conclusion: The timing of a 40 mg omeprazole Dosage regimen has a clinically significant impact on the 24-h pH profile, and that—by relating to the patient 24-hour oesophageal pH-metry in combination with the patient symptomatology—the timing of this Dosage is highly important for therapeutic efficacy.

  • Morning or Evening Dosage of omeprazole for gastro‐oesophageal reflux disease?
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J Hendel, L Hendel, S Aggestrup
    Abstract:

    SUMMARY Background and aims: When routinely checking patients receiving omeprazole treatment for gastro-oesophageal reflux, we have been finding patients with surprisingly low nocturnal gastric pH. The aim of this study was to evaluate the impact of timing of the 40 mg omeprazole once daily regimen. Methods: We evaluated the difference in effect of 40 mg omeprazole, given as a morning or Evening dose, in 17 patients with gastro-oesophageal reflux disease. Gastric and oesophageal pH was recorded by portable 24-h two-channel pH-metry in a cross-over design of 14 days of morning and 14 days of Evening administration. Results: In five patients pathological reflux was abolished by both regimens, four only during morning Dosage, and three only during Evening Dosage. In the remaining five patients abolition of pathological reflux was not achieved. The therapeutic outcome and patient preference for morning or Evening administration were closely related to the individual oesophageal pH curves. Patients with reflux induced by physical activity had a clear preference for morning Dosage, patients with nocturnal reflux showed a clear preference for Evening Dosage. Gastric pH profiles showed a high inter-individual variation; paired statistics, however, revealed a significant impact of Dosage timing on the gastric pH profile. After morning Dosage the work-day part (the first 7 h) of the gastric pH profile is 0.72 ± 0.91 (mean difference of pairs ± s.d.) higher than after Evening Dosage (P < 0.01). After Evening Dosage the gastric pH during the supine period is 0.64 ± 0.83 (mean difference of pairs ± s.d.) higher than after morning Dosage (P= 0.02). Conclusion: The timing of a 40 mg omeprazole Dosage regimen has a clinically significant impact on the 24-h pH profile, and that—by relating to the patient 24-hour oesophageal pH-metry in combination with the patient symptomatology—the timing of this Dosage is highly important for therapeutic efficacy.

Michio Hongo - One of the best experts on this subject based on the ideXlab platform.

  • Effect of lansoprazole on intragastric pH
    Digestive Diseases and Sciences, 1992
    Co-Authors: Michio Hongo, Shuichi Ohara, Yorihisa Hirasawa, Shigeru Asaki, Takayoshi Toyota
    Abstract:

    Lansoprazole is a newly developed proton pump inhibitor. The purpose of this study was to determine whether morning or Evening Dosage gave better control of 24-hr intragastric pH. In this study, we examined the antisecretory effect of lansoprazole by repeated intragastric pH monitoring on four occasions in eight normal subjects and compared median 24-hr pH values and pH threshold time of pH≧4 between morning and Evening dosing, following the administration of lansoprazole 30 mg once daily in either the morning or Evening for seven days. Intragastric pH was monitored before and after seven days of treatment. Both morning and Evening dosing caused a rise in the intragastric pH. Median pH for 24 hr was 4.3 and 1.6 with and without lansoprazole morning dosing and 4.6 and 2.1 for Evening dosing, respectively. The pH threshold curve shifted to the right with lansoprazole treatment in either case. However, no differences were found between morning and Evening dosing in terms of median 24-hr pH values of pH threshold time of pH≧4. These results indicate that lansoprazole can be given once daily in either the morning or Evening because of its potent and long-lasting antisecretory activity.

  • Effect of lansoprazole on intragastric pH. Comparison between morning and Evening dosing.
    Digestive Diseases and Sciences, 1992
    Co-Authors: Michio Hongo, Shuichi Ohara, Yorihisa Hirasawa, Shigeru Asaki, Takayoshi Toyota
    Abstract:

    Lansoprazole is a newly developed proton pump inhibitor. The purpose of this study was to determine whether morning or Evening Dosage gave better control of 24-hr intragastric pH. In this study, we examined the antisecretory effect of lansoprazole by repeated intragastric pH monitoring on four occasions in eight normal subjects and compared median 24-hr pH values and pH threshold time of pH≧4 between morning and Evening dosing, following the administration of lansoprazole 30 mg once daily in either the morning or Evening for seven days. Intragastric pH was monitored before and after seven days of treatment. Both morning and Evening dosing caused a rise in the intragastric pH. Median pH for 24 hr was 4.3 and 1.6 with and without lansoprazole morning dosing and 4.6 and 2.1 for Evening dosing, respectively. The pH threshold curve shifted to the right with lansoprazole treatment in either case. However, no differences were found between morning and Evening dosing in terms of median 24-hr pH values of pH threshold time of pH≧4. These results indicate that lansoprazole can be given once daily in either the morning or Evening because of its potent and long-lasting antisecretory activity.