The Experts below are selected from a list of 1992 Experts worldwide ranked by ideXlab platform
Amos Marc Bairoch - One of the best experts on this subject based on the ideXlab platform.
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the swiss prot protein knowledgebase and ExPASy providing the plant community with high quality proteomic data and tools
2004Co-Authors: Michel Schneider, Michael Tognolli, Amos Marc BairochAbstract:The Swiss-Prot protein knowledgebase provides manually annotated entries for all species, but concentrates on the annotation of entries from model organisms to ensure the presence of high quality annotation of representative members of all protein families. A specific Plant Protein Annotation Program (PPAP) was started to cope with the increasing amount of data produced by the complete sequencing of plant genomes. Its main goal is the annotation of proteins from the model plant organism Arabidopsis thaliana. In addition to bibliographic references, experimental results, computed features and sometimes even contradictory conclusions, direct links to specialized databases connect amino acid sequences with the current knowledge in plant sciences. As protein families and groups of plant-specific proteins are regularly reviewed to keep up with current scientific findings, we hope that the wealth of information of Arabidopsis origin accumulated in our knowledgebase, and the numerous software tools provided on the Expert Protein Analysis System (ExPASy) web site might help to identify and reveal the function of proteins originating from other plants. Recently, a single, centralized, authoritative resource for protein sequences and functional information, UniProt, was created by joining the information contained in Swiss-Prot, Translation of the EMBL nucleotide sequence (TrEMBL), and the Protein Information Resource-Protein Sequence Database (PIR-PSD). A rising problem is that an increasing number of nucleotide sequences are not being submitted to the public databases, and thus the proteins inferred from such sequences will have difficulties finding their way to the Swiss-Prot or TrEMBL databases.
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the swiss prot variant page and the modsnp database a resource for sequence and structure information on human protein variants
2004Co-Authors: Yum Lina Yip, Elisabeth Gasteiger, Alexandre Gattiker, Holger Scheib, Alexander V Diemand, L Famiglietti, Amos Marc BairochAbstract:Missense mutation leading to single amino acid polymorphism (SAP) is the type of mutation most frequently related to human diseases. The Swiss-Prot protein knowledgebase records information on such mutations in various sections of a protein entry, namely in the "feature," "comment," and "reference" fields. To facilitate users in obtaining the most relevant information about each human SAP recorded in the knowledgebase, the Swiss-Prot Variant web pages were created to provide a summary of available sequence information, as well as additional structural information on each variant. In particular, the ModSNP database was set up to store information related to SAPs and to manage the modeling of SAPs onto protein structures via an automatic homology modeling pipeline. Currently, among the 16,566 human SAPs recorded in the Swiss-Prot knowledgebase (release 42.5, 21 November 2003), more than 25% have corresponding 3D-models. Of these variants, 47% are related to disease, 26% are polymorphisms, and 27% are not yet clearly classified. The ModSNP database is updated and the subsequent model construction pipeline is launched with each weekly Swiss-Prot release. Thus, the ModSNP database represents a valuable resource for the structural analysis of protein variation. The Swiss-Prot variant pages are accessible from the NiceProt view of a Swiss-Prot entry on the ExPASy server (www.ExPASy.org/), via a hyperlink created for the stable and unique identifier FTId of each human SAP.
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ExPASy the proteomics server for in depth protein knowledge and analysis
2003Co-Authors: Elisabeth Gasteiger, Christine Hoogland, Ron D. Appel, Alexandre Gattiker, Ivan Ivanyi, Amos Marc BairochAbstract:The ExPASy (the Expert Protein Analysis System) World Wide Web server (http://www.ExPASy.org), is provided as a service to the life science community by a multidisciplinary team at the Swiss Institute of Bioinformatics (SIB). It provides access to a variety of databases and analytical tools dedicated to proteins and proteomics. ExPASy databases include SWISS-PROT and TrEMBL, SWISS-2DPAGE, PROSITE, ENZYME and the SWISS-MODEL repository. Analysis tools are available for specific tasks relevant to proteomics, similarity searches, pattern and profile searches, post-translational modification prediction, topology prediction, primary, secondary and tertiary structure analysis and sequence alignment. These databases and tools are tightly interlinked: a special emphasis is placed on integration of database entries with related resources developed at the SIB and elsewhere, and the proteomics tools have been designed to read the annotations in SWISS-PROT in order to enhance their predictions. ExPASy started to operate in 1993, as the first WWW server in the field of life sciences. In addition to the main site in Switzerland, seven mirror sites in different continents currently serve the user community.
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ExPASy the proteomics server for in depth protein knowledge and analysis
2003Co-Authors: Elisabeth Gasteiger, Christine Hoogland, Ron D. Appel, Alexandre Gattiker, Ivan Ivanyi, Amos Marc BairochAbstract:The ExPASy (the Expert Protein Analysis System) World Wide Web server (http://www.ExPASy.org), is provided as a service to the life science community by a multidisciplinary team at the Swiss Institute of Bioinformatics (SIB). It provides access to a variety of databases and analytical tools dedicated to proteins and proteomics. ExPASy databases include SWISS-PROT and TrEMBL, SWISS-2DPAGE, PROSITE, ENZYME and the SWISS-MODEL repository. Analysis tools are available for specific tasks relevant to proteomics, similarity searches, pattern and profile searches, post-translational modification prediction, topology prediction, primary, secondary and tertiary structure analysis and sequence alignment. These databases and tools are tightly interlinked: a special emphasis is placed on integration of database entries with related resources developed at the SIB and elsewhere, and the proteomics tools have been designed to read the annotations in SWISS-PROT in order to enhance their predictions. ExPASy started to operate in 1993, as the first WWW server in the field of life sciences. In addition to the main site in Switzerland, seven mirror sites in different continents currently serve the user community.
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el nuevo servidor latinoamericano de biologia molecular de la ucb bo ExPASy org
2002Co-Authors: Reynaldo Vargas Altamirano, Elisabeth Gasteiger, Christine Hoogland, Ron D. Appel, Ivan Ivanyi, Amos Marc Bairoch, Jacier Roja Baldaremma, Denis F. HochstrasserAbstract:ExPASy es un servidor de biologia molecular que provee acceso a informacion en proteomica a traves de un conjunto de herramientas de analisis y bases de datos dedicadas. Este servidor, desarrollado por el Instituto Suizo de Bioinformatica (SIB), es pionero en su clase y actualmente se ha convertido en una de las refe-rencias mas consultadas por centros de investigacion e industrias de biotecnologia a nivel mundial. Sitios mirrors han sido implementados alrededor del mundo, en instituciones academicas y de investigacion, para ofrecer un acceso eficiente a los centros de investigacion y desarrollo en biologia molecular geograficamente distri-buidos. La Universidad Catolica Boliviana, mediante el Instituto de Investigacion en Informatica Aplicada (IIIA), en colaboracion con el SIB, ha implementado un nuevo servidor mirror http://bo.ExPASy.org para la region latinoamericana que ha sido puesto a disposicion de la comunidad cientifica a principios de noviembre 2002. Este articulo tiene por objetivo presentar el contenido del sitio mirror y sus posibles aplicaciones para la investigacion y la industria.
Elisabeth Gasteiger - One of the best experts on this subject based on the ideXlab platform.
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GlyConnect: Glycoproteomics Goes Visual, Interactive, and Analytical.
2019Co-Authors: Davide Alocci, Nicolle H Packer, Elisabeth Gasteiger, Julien Mariethoz, Alessandra Gastaldello, Niclas G Karlsson, Daniel Kolarich, Frederique LisacekAbstract:Knowledge of glycoproteins, their site-specific glycosylation patterns, and the glycan structures that they present to their recognition partners in health and disease is gradually being built on using a range of experimental approaches. The data from these analyses are increasingly being standardized and presented in various sources, from supplemental tables in publications to localized servers in investigator laboratories. Bioinformatics tools are now needed to collect these data and enable the user to search, display, and connect glycomics and glycoproteomics to other sources of related proteomics, genomics, and interactomics information. We here introduce GlyConnect (https://glyconnect.ExPASy.org/), the central platform of the Glycomics@ExPASy portal for glycoinformatics. GlyConnect has been developed to gather, monitor, integrate, and visualize data in a user-friendly way to facilitate the interpretation of collected glycoscience data. GlyConnect is designed to accommodate and integrate multiple data types as they are increasingly produced.
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glycomics ExPASy bridging the gap
2018Co-Authors: Julien Mariethoz, Elisabeth Gasteiger, Davide Alocci, Alessandra Gastaldello, Oliver Horlacher, Miguel A Rojasmacias, Niclas G Karlsson, Nicolle H PackerAbstract:Glycomics@ExPASy (https://www.ExPASy.org/glycomics) is the glycomics tab of ExPASy, the server of SIB Swiss Institute of Bioinformatics. It was created in 2016 to centralize web-based glycoinformatics resources developed within an international network of glycoscientists. The hosted collection currently includes mainly databases and tools created and maintained at SIB but also links to a range of reference resources popular in the glycomics community. The philosophy of our toolbox is that it should be {glycoscientist AND protein scientist}–friendly with the aim of (1) popularizing the use of bioinformatics in glycobiology and (2) emphasizing the relationship between glycobiology and protein-oriented bioinformatics resources. The scarcity of data bridging these two disciplines led us to design tools as interactive as possible based on database connectivity to facilitate data exploration and support hypothesis building. Glycomics@ExPASy was designed, and is developed, with a long-term vision in close collaboration with glycoscientists to meet as closely as possible the growing needs of the community for glycoinformatics.
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GlyConnect: Glycoproteomics Goes Visual, Interactive, and Analytical
2018Co-Authors: Davide Alocci, Nicolle H Packer, Elisabeth Gasteiger, Julien Mariethoz, Alessandra Gastaldello, Niclas G Karlsson, Daniel Kolarich, Frederique LisacekAbstract:Knowledge of glycoproteins, their site-specific glycosylation patterns, and the glycan structures that they present to their recognition partners in health and disease is gradually being built on using a range of experimental approaches. The data from these analyses are increasingly being standardized and presented in various sources, from supplemental tables in publications to localized servers in investigator laboratories. Bioinformatics tools are now needed to collect these data and enable the user to search, display, and connect glycomics and glycoproteomics to other sources of related proteomics, genomics, and interactomics information. We here introduce GlyConnect (https://glyconnect.ExPASy.org/), the central platform of the Glycomics@ExPASy portal for glycoinformatics. GlyConnect has been developed to gather, monitor, integrate, and visualize data in a user-friendly way to facilitate the interpretation of collected glycoscience data. GlyConnect is designed to accommodate and integrate multiple data types as they are increasingly produced
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unicarbkb building a knowledge platform for glycoproteomics
2014Co-Authors: Matthew Campbell, Elisabeth Gasteiger, Robyn Peterson, Julien Mariethoz, Yukie Akune, Kiyoko F Aokikinoshita, Frederique Lisacek, Nicolle H PackerAbstract:The UniCarb KnowledgeBase (UniCarbKB; http://unicarbkb.org) offers public access to a growing, curated database of information on the glycan structures of glycoproteins. UniCarbKB is an international effort that aims to further our understanding of structures, pathways and networks involved in glycosylation and glyco-mediated processes by integrating structural, experimental and functional glycoscience information. This initiative builds upon the success of the glycan structure database GlycoSuiteDB, together with the informatic standards introduced by EUROCarbDB, to provide a high-quality and updated resource to support glycomics and glycoproteomics research. UniCarbKB provides comprehensive information concerning glycan structures, and published glycoprotein information including global and site-specific attachment information. For the first release over 890 references, 3740 glycan structure entries and 400 glycoproteins have been curated. Further, 598 protein glycosylation sites have been annotated with experimentally confirmed glycan structures from the literature. Among these are 35 glycoproteins, 502 structures and 60 publications previously not included in GlycoSuiteDB. This article provides an update on the transformation of GlycoSuiteDB (featured in previous NAR Database issues and hosted by ExPASy since 2009) to UniCarbKB and its integration with UniProtKB and GlycoMod. Here, we introduce a refactored database, supported by substantial new curated data collections and intuitive user-interfaces that improve database searching.
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ExPASy: SIB bioinformatics resource portal
2012Co-Authors: Panu Artimo, Manohar Jonnalagedda, Delphine Baratin, Edouard De Castro, Volker Flegel, Arnaud Fortier, Severine Duvaud, Gabor Csardi, Konstantin Arnold, Elisabeth GasteigerAbstract:ExPASy (http://www.ExPASy.org) has worldwide reputation as one of the main bioinformatics resources for proteomics. It has now evolved, becoming an extensible and integrative portal accessing many scientific resources, databases and software tools in different areas of life sciences. Scientists can henceforth access seamlessly a wide range of resources in many different domains, such as proteomics, genomics, phylogeny/evolution, systems biology, population genetics, transcriptomics, etc. The individual resources (databases, web-based and downloadable software tools) are hosted in a 'decentralized' way by different groups of the SIB Swiss Institute of Bioinformatics and partner institutions. Specifically, a single web portal provides a common entry point to a wide range of resources developed and operated by different SIB groups and external institutions. The portal features a search function across 'selected' resources. Additionally, the availability and usage of resources are monitored. The portal is aimed for both expert users and people who are not familiar with a specific domain in life sciences. The new web interface provides, in particular, visual guidance for newcomers to ExPASy.
Ron D. Appel - One of the best experts on this subject based on the ideXlab platform.
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the world 2dpage constellation to promote and publish gel based proteomics data through the ExPASy server
2008Co-Authors: Christine Hoogland, Ron D. Appel, Khaled Mostaguir, Frederique LisacekAbstract:Since it was launched in 1993, the ExPASy server has been and is still a reference in the proteomics world. ExPASy users access various databases, many dedicated tools, and lists of resources, among other services. A significant part of resources available is devoted to two-dimensional electrophoresis data. Our latest contribution to the expansion of the pool of on-line proteomics data is the World-2DPAGE Constellation, accessible at http://world-2dpage.ExPASy.org/. It is composed of the established WORLD-2DPAGE List of 2-D PAGE database servers, the World-2DPAGE Portal that queries simultaneously world-wide proteomics databases, and the recently created World-2DPAGE Repository. The latter component is a public standards-compliant repository for gel-based proteomics data linked to protein identifications published in the literature. It has been set up using the Make2D-DB package, a software tool that helps building SWISS-2DPAGE-like databases on one's own Web site. The lack of necessary informatics infrastructure to build and run a dedicated website is no longer an obstacle to make proteomics data publicly accessible on the Internet.
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ExPASy the proteomics server for in depth protein knowledge and analysis
2003Co-Authors: Elisabeth Gasteiger, Christine Hoogland, Ron D. Appel, Alexandre Gattiker, Ivan Ivanyi, Amos Marc BairochAbstract:The ExPASy (the Expert Protein Analysis System) World Wide Web server (http://www.ExPASy.org), is provided as a service to the life science community by a multidisciplinary team at the Swiss Institute of Bioinformatics (SIB). It provides access to a variety of databases and analytical tools dedicated to proteins and proteomics. ExPASy databases include SWISS-PROT and TrEMBL, SWISS-2DPAGE, PROSITE, ENZYME and the SWISS-MODEL repository. Analysis tools are available for specific tasks relevant to proteomics, similarity searches, pattern and profile searches, post-translational modification prediction, topology prediction, primary, secondary and tertiary structure analysis and sequence alignment. These databases and tools are tightly interlinked: a special emphasis is placed on integration of database entries with related resources developed at the SIB and elsewhere, and the proteomics tools have been designed to read the annotations in SWISS-PROT in order to enhance their predictions. ExPASy started to operate in 1993, as the first WWW server in the field of life sciences. In addition to the main site in Switzerland, seven mirror sites in different continents currently serve the user community.
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ExPASy the proteomics server for in depth protein knowledge and analysis
2003Co-Authors: Elisabeth Gasteiger, Christine Hoogland, Ron D. Appel, Alexandre Gattiker, Ivan Ivanyi, Amos Marc BairochAbstract:The ExPASy (the Expert Protein Analysis System) World Wide Web server (http://www.ExPASy.org), is provided as a service to the life science community by a multidisciplinary team at the Swiss Institute of Bioinformatics (SIB). It provides access to a variety of databases and analytical tools dedicated to proteins and proteomics. ExPASy databases include SWISS-PROT and TrEMBL, SWISS-2DPAGE, PROSITE, ENZYME and the SWISS-MODEL repository. Analysis tools are available for specific tasks relevant to proteomics, similarity searches, pattern and profile searches, post-translational modification prediction, topology prediction, primary, secondary and tertiary structure analysis and sequence alignment. These databases and tools are tightly interlinked: a special emphasis is placed on integration of database entries with related resources developed at the SIB and elsewhere, and the proteomics tools have been designed to read the annotations in SWISS-PROT in order to enhance their predictions. ExPASy started to operate in 1993, as the first WWW server in the field of life sciences. In addition to the main site in Switzerland, seven mirror sites in different continents currently serve the user community.
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el nuevo servidor latinoamericano de biologia molecular de la ucb bo ExPASy org
2002Co-Authors: Reynaldo Vargas Altamirano, Elisabeth Gasteiger, Christine Hoogland, Ron D. Appel, Ivan Ivanyi, Amos Marc Bairoch, Jacier Roja Baldaremma, Denis F. HochstrasserAbstract:ExPASy es un servidor de biologia molecular que provee acceso a informacion en proteomica a traves de un conjunto de herramientas de analisis y bases de datos dedicadas. Este servidor, desarrollado por el Instituto Suizo de Bioinformatica (SIB), es pionero en su clase y actualmente se ha convertido en una de las refe-rencias mas consultadas por centros de investigacion e industrias de biotecnologia a nivel mundial. Sitios mirrors han sido implementados alrededor del mundo, en instituciones academicas y de investigacion, para ofrecer un acceso eficiente a los centros de investigacion y desarrollo en biologia molecular geograficamente distri-buidos. La Universidad Catolica Boliviana, mediante el Instituto de Investigacion en Informatica Aplicada (IIIA), en colaboracion con el SIB, ha implementado un nuevo servidor mirror http://bo.ExPASy.org para la region latinoamericana que ha sido puesto a disposicion de la comunidad cientifica a principios de noviembre 2002. Este articulo tiene por objetivo presentar el contenido del sitio mirror y sus posibles aplicaciones para la investigacion y la industria.
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Two-dimensional electrophoresis resources available from ExPASy.
1999Co-Authors: Christine Hoogland, Jean-charles Sanchez, Daniel Walther, Vincent Baujard, O. Baujard, Luisa Tonella, Denis F. Hochstrasser, Ron D. AppelAbstract:This paper describes the set of two-dimensional electrophoresis (2-DE) resources currently available from the ExPASy proteomics Web server. These resources include the SWISS-2DPAGE database, 2-DE software packages, 2-DE technical and educational services, as well as indexes and search engines for 2-DE related sites over the Internet.
Seyed Alireza Dastgheib - One of the best experts on this subject based on the ideXlab platform.
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a novel mutation in sepn1 causing rigid spine muscular dystrophy 1 a case report
2019Co-Authors: Fateme Ziyaee, Eslam Shorafa, Hassan Dastsooz, Parham Habibzadeh, Hamid Nemati, Amir Saeed, Mohammad Silawi, Mohammad Ali Farazi Fard, Mohammad Ali Faghihi, Seyed Alireza DastgheibAbstract:Muscular dystrophies are a clinically and genetically heterogeneous group of disorders characterized by variable degrees of progressive muscle degeneration and weakness. There is a wide variability in the age of onset, symptoms and rate of progression in subtypes of these disorders. Herein, we present the results of our study conducted to identify the pathogenic genetic variation involved in our patient affected by rigid spine muscular dystrophy. A 14-year-old boy, product of a first-cousin marriage, was enrolled in our study with failure to thrive, fatigue, muscular dystrophy, generalized muscular atrophy, kyphoscoliosis, and flexion contracture of the knees and elbows. Whole-exome sequencing (WES) was carried out on the DNA of the patient to investigate all coding regions and uncovered a novel, homozygous missense mutation in SEPN1 gene (c. 1379 C > T, p.Ser460Phe). This mutation has not been reported before in different public variant databases and also our database (BayanGene), so it is classified as a variation of unknown significance (VUS). Subsequently, it was confirmed that the novel variation was homozygous in our patient and heterozygous in his parents. Different bioinformatics tools showed the damaging effects of the variant on protein. Multiple sequence alignment using BLASTP on ExPASy and WebLogo, revealed the conservation of the mutated residue. We reported a novel homozygous mutation in SEPN1 gene that expands our understanding of rigid spine muscular dystrophy. Although bioinformatics analyses of results were in favor of the pathogenicity of the mutation, functional studies are needed to establish the pathogenicity of the variant.
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A novel mutation in SEPN1 causing rigid spine muscular dystrophy 1: a Case report
2019Co-Authors: Fateme Ziyaee, Eslam Shorafa, Hassan Dastsooz, Parham Habibzadeh, Hamid Nemati, Amir Saeed, Mohammad Silawi, Mohammad Ali Farazi Fard, Mohammad Ali Faghihi, Seyed Alireza DastgheibAbstract:Abstract Background Muscular dystrophies are a clinically and genetically heterogeneous group of disorders characterized by variable degrees of progressive muscle degeneration and weakness. There is a wide variability in the age of onset, symptoms and rate of progression in subtypes of these disorders. Herein, we present the results of our study conducted to identify the pathogenic genetic variation involved in our patient affected by rigid spine muscular dystrophy. Case presentation A 14-year-old boy, product of a first-cousin marriage, was enrolled in our study with failure to thrive, fatigue, muscular dystrophy, generalized muscular atrophy, kyphoscoliosis, and flexion contracture of the knees and elbows. Whole-exome sequencing (WES) was carried out on the DNA of the patient to investigate all coding regions and uncovered a novel, homozygous missense mutation in SEPN1 gene (c. 1379 C > T, p.Ser460Phe). This mutation has not been reported before in different public variant databases and also our database (BayanGene), so it is classified as a variation of unknown significance (VUS). Subsequently, it was confirmed that the novel variation was homozygous in our patient and heterozygous in his parents. Different bioinformatics tools showed the damaging effects of the variant on protein. Multiple sequence alignment using BLASTP on ExPASy and WebLogo, revealed the conservation of the mutated residue. Conclusion We reported a novel homozygous mutation in SEPN1 gene that expands our understanding of rigid spine muscular dystrophy. Although bioinformatics analyses of results were in favor of the pathogenicity of the mutation, functional studies are needed to establish the pathogenicity of the variant
Christine Hoogland - One of the best experts on this subject based on the ideXlab platform.
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the world 2dpage constellation to promote and publish gel based proteomics data through the ExPASy server
2008Co-Authors: Christine Hoogland, Ron D. Appel, Khaled Mostaguir, Frederique LisacekAbstract:Since it was launched in 1993, the ExPASy server has been and is still a reference in the proteomics world. ExPASy users access various databases, many dedicated tools, and lists of resources, among other services. A significant part of resources available is devoted to two-dimensional electrophoresis data. Our latest contribution to the expansion of the pool of on-line proteomics data is the World-2DPAGE Constellation, accessible at http://world-2dpage.ExPASy.org/. It is composed of the established WORLD-2DPAGE List of 2-D PAGE database servers, the World-2DPAGE Portal that queries simultaneously world-wide proteomics databases, and the recently created World-2DPAGE Repository. The latter component is a public standards-compliant repository for gel-based proteomics data linked to protein identifications published in the literature. It has been set up using the Make2D-DB package, a software tool that helps building SWISS-2DPAGE-like databases on one's own Web site. The lack of necessary informatics infrastructure to build and run a dedicated website is no longer an obstacle to make proteomics data publicly accessible on the Internet.
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ExPASy the proteomics server for in depth protein knowledge and analysis
2003Co-Authors: Elisabeth Gasteiger, Christine Hoogland, Ron D. Appel, Alexandre Gattiker, Ivan Ivanyi, Amos Marc BairochAbstract:The ExPASy (the Expert Protein Analysis System) World Wide Web server (http://www.ExPASy.org), is provided as a service to the life science community by a multidisciplinary team at the Swiss Institute of Bioinformatics (SIB). It provides access to a variety of databases and analytical tools dedicated to proteins and proteomics. ExPASy databases include SWISS-PROT and TrEMBL, SWISS-2DPAGE, PROSITE, ENZYME and the SWISS-MODEL repository. Analysis tools are available for specific tasks relevant to proteomics, similarity searches, pattern and profile searches, post-translational modification prediction, topology prediction, primary, secondary and tertiary structure analysis and sequence alignment. These databases and tools are tightly interlinked: a special emphasis is placed on integration of database entries with related resources developed at the SIB and elsewhere, and the proteomics tools have been designed to read the annotations in SWISS-PROT in order to enhance their predictions. ExPASy started to operate in 1993, as the first WWW server in the field of life sciences. In addition to the main site in Switzerland, seven mirror sites in different continents currently serve the user community.
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ExPASy the proteomics server for in depth protein knowledge and analysis
2003Co-Authors: Elisabeth Gasteiger, Christine Hoogland, Ron D. Appel, Alexandre Gattiker, Ivan Ivanyi, Amos Marc BairochAbstract:The ExPASy (the Expert Protein Analysis System) World Wide Web server (http://www.ExPASy.org), is provided as a service to the life science community by a multidisciplinary team at the Swiss Institute of Bioinformatics (SIB). It provides access to a variety of databases and analytical tools dedicated to proteins and proteomics. ExPASy databases include SWISS-PROT and TrEMBL, SWISS-2DPAGE, PROSITE, ENZYME and the SWISS-MODEL repository. Analysis tools are available for specific tasks relevant to proteomics, similarity searches, pattern and profile searches, post-translational modification prediction, topology prediction, primary, secondary and tertiary structure analysis and sequence alignment. These databases and tools are tightly interlinked: a special emphasis is placed on integration of database entries with related resources developed at the SIB and elsewhere, and the proteomics tools have been designed to read the annotations in SWISS-PROT in order to enhance their predictions. ExPASy started to operate in 1993, as the first WWW server in the field of life sciences. In addition to the main site in Switzerland, seven mirror sites in different continents currently serve the user community.
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el nuevo servidor latinoamericano de biologia molecular de la ucb bo ExPASy org
2002Co-Authors: Reynaldo Vargas Altamirano, Elisabeth Gasteiger, Christine Hoogland, Ron D. Appel, Ivan Ivanyi, Amos Marc Bairoch, Jacier Roja Baldaremma, Denis F. HochstrasserAbstract:ExPASy es un servidor de biologia molecular que provee acceso a informacion en proteomica a traves de un conjunto de herramientas de analisis y bases de datos dedicadas. Este servidor, desarrollado por el Instituto Suizo de Bioinformatica (SIB), es pionero en su clase y actualmente se ha convertido en una de las refe-rencias mas consultadas por centros de investigacion e industrias de biotecnologia a nivel mundial. Sitios mirrors han sido implementados alrededor del mundo, en instituciones academicas y de investigacion, para ofrecer un acceso eficiente a los centros de investigacion y desarrollo en biologia molecular geograficamente distri-buidos. La Universidad Catolica Boliviana, mediante el Instituto de Investigacion en Informatica Aplicada (IIIA), en colaboracion con el SIB, ha implementado un nuevo servidor mirror http://bo.ExPASy.org para la region latinoamericana que ha sido puesto a disposicion de la comunidad cientifica a principios de noviembre 2002. Este articulo tiene por objetivo presentar el contenido del sitio mirror y sus posibles aplicaciones para la investigacion y la industria.
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Two-dimensional electrophoresis resources available from ExPASy.
1999Co-Authors: Christine Hoogland, Jean-charles Sanchez, Daniel Walther, Vincent Baujard, O. Baujard, Luisa Tonella, Denis F. Hochstrasser, Ron D. AppelAbstract:This paper describes the set of two-dimensional electrophoresis (2-DE) resources currently available from the ExPASy proteomics Web server. These resources include the SWISS-2DPAGE database, 2-DE software packages, 2-DE technical and educational services, as well as indexes and search engines for 2-DE related sites over the Internet.
