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Pitchairaj Geraldine - One of the best experts on this subject based on the ideXlab platform.
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protective role of chrysin against oxidative stress in d galactose induced aging in an Experimental Rat model
Geriatrics & Gerontology International, 2012Co-Authors: Kalaiselvi Velayutham Anand, Mohamed Sultan Mohamed Jaabir, Philip A. Thomas, Pitchairaj GeraldineAbstract:Aim: To evaluate the putative protective role of chrysin, an isoflavone, on d-galactose-induced aging in an Experimental Rat model. Methods: Rats were divided into five groups of five each. Group I received 0.9% saline only. Groups II, III and IV received d-galactose (50 mg/kg bodyweight) intraperitoneally, additionally group III and group IV received chrysin (20 mg/kg bodyweight) and α-tocopherol acetate (200 mg/kg bodyweight), respectively. Group V received chrysin alone. The experiment period was for a period of 8 weeks. After the Rats were killed, the tissue samples were analyzed for mean activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, glucose-6-phosphate dehydrogenase, reduced glutathione, vitamin C, vitamin E, malondialdehyde and protein carbonyl. Histopathological studies were also carried out for morphological conformation. Results: Tissue samples from d-galactose-exposed untreated Rats showed significantly (P < 0.05) lower levels of enzymatic and non-enzymatic anti-oxidants, and significantly (P < 0.05) higher levels of malondialdehyde and protein carbonyl when compared with group I and group III Rats. Oral administRation of chrysin for a period of 8 weeks, concomitant with the exposure to d-galactose, appeared to protect against oxidative damage and maintained all parameters at near normal levels. Histopathological studies confirmed the oxidative damage caused by d-galactose alone in tissues and also showed the tissue protective role of chrysin in Rats receiving d-galactose and chrysin. Conclusion: These results suggest that chrysin protects against oxidative stress-induced tissue damage in d-galactose-induced aging in an Experimental Rat model. Geriatr Gerontol Int 2012; ••: ••–••.
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Protective role of chrysin against oxidative stress in d-galactose-induced aging in an Experimental Rat model.
Geriatrics & gerontology international, 2012Co-Authors: Kalaiselvi Velayutham Anand, Mohamed Sultan Mohamed Jaabir, Philip A. Thomas, Pitchairaj GeraldineAbstract:Aim: To evaluate the putative protective role of chrysin, an isoflavone, on d-galactose-induced aging in an Experimental Rat model. Methods: Rats were divided into five groups of five each. Group I received 0.9% saline only. Groups II, III and IV received d-galactose (50 mg/kg bodyweight) intraperitoneally, additionally group III and group IV received chrysin (20 mg/kg bodyweight) and α-tocopherol acetate (200 mg/kg bodyweight), respectively. Group V received chrysin alone. The experiment period was for a period of 8 weeks. After the Rats were killed, the tissue samples were analyzed for mean activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, glucose-6-phosphate dehydrogenase, reduced glutathione, vitamin C, vitamin E, malondialdehyde and protein carbonyl. Histopathological studies were also carried out for morphological conformation. Results: Tissue samples from d-galactose-exposed untreated Rats showed significantly (P
Kalaiselvi Velayutham Anand - One of the best experts on this subject based on the ideXlab platform.
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protective role of chrysin against oxidative stress in d galactose induced aging in an Experimental Rat model
Geriatrics & Gerontology International, 2012Co-Authors: Kalaiselvi Velayutham Anand, Mohamed Sultan Mohamed Jaabir, Philip A. Thomas, Pitchairaj GeraldineAbstract:Aim: To evaluate the putative protective role of chrysin, an isoflavone, on d-galactose-induced aging in an Experimental Rat model. Methods: Rats were divided into five groups of five each. Group I received 0.9% saline only. Groups II, III and IV received d-galactose (50 mg/kg bodyweight) intraperitoneally, additionally group III and group IV received chrysin (20 mg/kg bodyweight) and α-tocopherol acetate (200 mg/kg bodyweight), respectively. Group V received chrysin alone. The experiment period was for a period of 8 weeks. After the Rats were killed, the tissue samples were analyzed for mean activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, glucose-6-phosphate dehydrogenase, reduced glutathione, vitamin C, vitamin E, malondialdehyde and protein carbonyl. Histopathological studies were also carried out for morphological conformation. Results: Tissue samples from d-galactose-exposed untreated Rats showed significantly (P < 0.05) lower levels of enzymatic and non-enzymatic anti-oxidants, and significantly (P < 0.05) higher levels of malondialdehyde and protein carbonyl when compared with group I and group III Rats. Oral administRation of chrysin for a period of 8 weeks, concomitant with the exposure to d-galactose, appeared to protect against oxidative damage and maintained all parameters at near normal levels. Histopathological studies confirmed the oxidative damage caused by d-galactose alone in tissues and also showed the tissue protective role of chrysin in Rats receiving d-galactose and chrysin. Conclusion: These results suggest that chrysin protects against oxidative stress-induced tissue damage in d-galactose-induced aging in an Experimental Rat model. Geriatr Gerontol Int 2012; ••: ••–••.
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Protective role of chrysin against oxidative stress in d-galactose-induced aging in an Experimental Rat model.
Geriatrics & gerontology international, 2012Co-Authors: Kalaiselvi Velayutham Anand, Mohamed Sultan Mohamed Jaabir, Philip A. Thomas, Pitchairaj GeraldineAbstract:Aim: To evaluate the putative protective role of chrysin, an isoflavone, on d-galactose-induced aging in an Experimental Rat model. Methods: Rats were divided into five groups of five each. Group I received 0.9% saline only. Groups II, III and IV received d-galactose (50 mg/kg bodyweight) intraperitoneally, additionally group III and group IV received chrysin (20 mg/kg bodyweight) and α-tocopherol acetate (200 mg/kg bodyweight), respectively. Group V received chrysin alone. The experiment period was for a period of 8 weeks. After the Rats were killed, the tissue samples were analyzed for mean activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, glucose-6-phosphate dehydrogenase, reduced glutathione, vitamin C, vitamin E, malondialdehyde and protein carbonyl. Histopathological studies were also carried out for morphological conformation. Results: Tissue samples from d-galactose-exposed untreated Rats showed significantly (P
Ahmet Ozet - One of the best experts on this subject based on the ideXlab platform.
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Pazopanib-Induced Hepatotoxicity in an Experimental Rat Model
Chemotherapy, 2018Co-Authors: Bulent Cetin, Ozge Gumusay, Ozlem Gulbahar, Ahmet Ozet, Guldal Yilmaz, Berkan Armagan, Baris Afsar, Umut Demirci, Irem Bilgetekin, Aytug UnerAbstract:Pazopanib is an effective treatment for advanced renal cell carcinoma and soft tissue sarcoma. Besides classical adverse events of this drug class, hepatotoxicity has been described as a frequent side effect. The aim of the present study was to evaluate the effect of pazopanib on the liver in an Experimental Rat model. Sixteen Wistar albino Rats were divided into 3 groups: Experimental toxicity was induced with pazopanib (10 mg/kg) administered for 28 days (group 2) or 56 days (group 3) orally by gavage. Group 1 (control group) received only distilled water. Rats in groups 2 and 3 were sacrificed after the collection of blood and tissue samples on the 28th and 56th days, respectively. We found significant differences in bilirubin, alkaline phosphatase, lactate dehydrogenase, glucose, triglyceride, very-low-density lipoprotein, and iron values (p < 0.050 for all) but none in any other parameter (p > 0.050). All Rats in the control group had normal histological features; however, none of the Rats in groups 2 and 3 showed normal histology. In group 2, we observed mild sinusoidal dilatation, congestion, enlarged Kupffer cells, accumulation of yellow-brown-black pigment in the Kupffer cells and the accumulation of hemosiderin with Prussian blue reaction in the hepatocytes. In group 3, the findings mentioned above were more prominent, and besides these findings focal acinar transformation and macrovesicular steatosis were also observed. In group 3, mild inflammation within the portal areas was observed consisting of lymphocytes, neutrophils, and eosinophils. This study is the first that reports the biochemical and histopathological evaluation of pazopanib-related hepatic toxicity.
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Pazopanib-Induced Hepatotoxicity in an Experimental Rat Model.
Chemotherapy, 2018Co-Authors: Bulent Cetin, Ozge Gumusay, Ozlem Gulbahar, Ahmet Ozet, Guldal Yilmaz, Berkan Armagan, Baris Afsar, Umut Demirci, Irem Bilgetekin, Aytug UnerAbstract:Pazopanib is an effective treatment for advanced renal cell carcinoma and soft tissue sarcoma. Besides classical adverse events of this drug class, hepatotoxicity has been described as a frequent side effect. The aim of the present study was to evaluate the effect of pazopanib on the liver in an Experimental Rat model. Sixteen Wistar albino Rats were divided into 3 groups: Experimental toxicity was induced with pazopanib (10 mg/kg) administered for 28 days (group 2) or 56 days (group 3) orally by gavage. Group 1 (control group) received only distilled water. Rats in groups 2 and 3 were sacrificed after the collection of blood and tissue samples on the 28th and 56th days, respectively. We found significant differences in bilirubin, alkaline phosphatase, lactate dehydrogenase, glucose, triglyceride, very-low-density lipoprotein, and iron values (p 0.050). All Rats in the control group had normal histological features; however, none of the Rats in groups 2 and 3 showed normal histology. In group 2, we observed mild sinusoidal dilatation, congestion, enlarged Kupffer cells, accumulation of yellow-brown-black pigment in the Kupffer cells and the accumulation of hemosiderin with Prussian blue reaction in the hepatocytes. In group 3, the findings mentioned above were more prominent, and besides these findings focal acinar transformation and macrovesicular steatosis were also observed. In group 3, mild inflammation within the portal areas was observed consisting of lymphocytes, neutrophils, and eosinophils. This study is the first that reports the biochemical and histopathological evaluation of pazopanib-related hepatic toxicity.
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Crizotinib-induced toxicity in an Experimental Rat model
Wiener klinische Wochenschrift, 2016Co-Authors: Ozge Gumusay, Guldal Esendagli-yilmaz, Aytug Uner, Bulent Cetin, Suleyman Buyukberber, Mustafa Benekli, Mustafa N. Ilhan, Ugur Coskun, Ozlem Gulbahar, Ahmet OzetAbstract:Aim The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an Experimental Rat model. Methods Eighteen Wistar albino Rats were divided into three groups: Experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively. Results Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas. Conclusion This study is the first to evaluate the histopathological features of toxicity of crizotinib in a Rat model.
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Crizotinib-induced toxicity in an Experimental Rat model.
Wiener Klinische Wochenschrift, 2016Co-Authors: Ozge Gumusay, Guldal Esendagli-yilmaz, Aytug Uner, Bulent Cetin, Suleyman Buyukberber, Mustafa Benekli, Mustafa N. Ilhan, Ugur Coskun, Ozlem Gulbahar, Ahmet OzetAbstract:Aim The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an Experimental Rat model.
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Crizotinib-induced toxicity in an Experimental Rat model.
Wiener klinische Wochenschrift, 2016Co-Authors: Ozge Gumusay, Guldal Esendagli-yilmaz, Aytug Uner, Bulent Cetin, Suleyman Buyukberber, Mustafa Benekli, Mustafa N. Ilhan, Ugur Coskun, Ozlem Gulbahar, Ahmet OzetAbstract:The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an Experimental Rat model. Eighteen Wistar albino Rats were divided into three groups: Experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively. Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas. This study is the first to evaluate the histopathological features of toxicity of crizotinib in a Rat model.
Aytug Uner - One of the best experts on this subject based on the ideXlab platform.
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Pazopanib-Induced Hepatotoxicity in an Experimental Rat Model
Chemotherapy, 2018Co-Authors: Bulent Cetin, Ozge Gumusay, Ozlem Gulbahar, Ahmet Ozet, Guldal Yilmaz, Berkan Armagan, Baris Afsar, Umut Demirci, Irem Bilgetekin, Aytug UnerAbstract:Pazopanib is an effective treatment for advanced renal cell carcinoma and soft tissue sarcoma. Besides classical adverse events of this drug class, hepatotoxicity has been described as a frequent side effect. The aim of the present study was to evaluate the effect of pazopanib on the liver in an Experimental Rat model. Sixteen Wistar albino Rats were divided into 3 groups: Experimental toxicity was induced with pazopanib (10 mg/kg) administered for 28 days (group 2) or 56 days (group 3) orally by gavage. Group 1 (control group) received only distilled water. Rats in groups 2 and 3 were sacrificed after the collection of blood and tissue samples on the 28th and 56th days, respectively. We found significant differences in bilirubin, alkaline phosphatase, lactate dehydrogenase, glucose, triglyceride, very-low-density lipoprotein, and iron values (p < 0.050 for all) but none in any other parameter (p > 0.050). All Rats in the control group had normal histological features; however, none of the Rats in groups 2 and 3 showed normal histology. In group 2, we observed mild sinusoidal dilatation, congestion, enlarged Kupffer cells, accumulation of yellow-brown-black pigment in the Kupffer cells and the accumulation of hemosiderin with Prussian blue reaction in the hepatocytes. In group 3, the findings mentioned above were more prominent, and besides these findings focal acinar transformation and macrovesicular steatosis were also observed. In group 3, mild inflammation within the portal areas was observed consisting of lymphocytes, neutrophils, and eosinophils. This study is the first that reports the biochemical and histopathological evaluation of pazopanib-related hepatic toxicity.
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Pazopanib-Induced Hepatotoxicity in an Experimental Rat Model.
Chemotherapy, 2018Co-Authors: Bulent Cetin, Ozge Gumusay, Ozlem Gulbahar, Ahmet Ozet, Guldal Yilmaz, Berkan Armagan, Baris Afsar, Umut Demirci, Irem Bilgetekin, Aytug UnerAbstract:Pazopanib is an effective treatment for advanced renal cell carcinoma and soft tissue sarcoma. Besides classical adverse events of this drug class, hepatotoxicity has been described as a frequent side effect. The aim of the present study was to evaluate the effect of pazopanib on the liver in an Experimental Rat model. Sixteen Wistar albino Rats were divided into 3 groups: Experimental toxicity was induced with pazopanib (10 mg/kg) administered for 28 days (group 2) or 56 days (group 3) orally by gavage. Group 1 (control group) received only distilled water. Rats in groups 2 and 3 were sacrificed after the collection of blood and tissue samples on the 28th and 56th days, respectively. We found significant differences in bilirubin, alkaline phosphatase, lactate dehydrogenase, glucose, triglyceride, very-low-density lipoprotein, and iron values (p 0.050). All Rats in the control group had normal histological features; however, none of the Rats in groups 2 and 3 showed normal histology. In group 2, we observed mild sinusoidal dilatation, congestion, enlarged Kupffer cells, accumulation of yellow-brown-black pigment in the Kupffer cells and the accumulation of hemosiderin with Prussian blue reaction in the hepatocytes. In group 3, the findings mentioned above were more prominent, and besides these findings focal acinar transformation and macrovesicular steatosis were also observed. In group 3, mild inflammation within the portal areas was observed consisting of lymphocytes, neutrophils, and eosinophils. This study is the first that reports the biochemical and histopathological evaluation of pazopanib-related hepatic toxicity.
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Crizotinib-induced toxicity in an Experimental Rat model
Wiener klinische Wochenschrift, 2016Co-Authors: Ozge Gumusay, Guldal Esendagli-yilmaz, Aytug Uner, Bulent Cetin, Suleyman Buyukberber, Mustafa Benekli, Mustafa N. Ilhan, Ugur Coskun, Ozlem Gulbahar, Ahmet OzetAbstract:Aim The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an Experimental Rat model. Methods Eighteen Wistar albino Rats were divided into three groups: Experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively. Results Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas. Conclusion This study is the first to evaluate the histopathological features of toxicity of crizotinib in a Rat model.
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Crizotinib-induced toxicity in an Experimental Rat model.
Wiener Klinische Wochenschrift, 2016Co-Authors: Ozge Gumusay, Guldal Esendagli-yilmaz, Aytug Uner, Bulent Cetin, Suleyman Buyukberber, Mustafa Benekli, Mustafa N. Ilhan, Ugur Coskun, Ozlem Gulbahar, Ahmet OzetAbstract:Aim The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an Experimental Rat model.
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Crizotinib-induced toxicity in an Experimental Rat model.
Wiener klinische Wochenschrift, 2016Co-Authors: Ozge Gumusay, Guldal Esendagli-yilmaz, Aytug Uner, Bulent Cetin, Suleyman Buyukberber, Mustafa Benekli, Mustafa N. Ilhan, Ugur Coskun, Ozlem Gulbahar, Ahmet OzetAbstract:The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an Experimental Rat model. Eighteen Wistar albino Rats were divided into three groups: Experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively. Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas. This study is the first to evaluate the histopathological features of toxicity of crizotinib in a Rat model.
Ozge Gumusay - One of the best experts on this subject based on the ideXlab platform.
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Pazopanib-Induced Hepatotoxicity in an Experimental Rat Model
Chemotherapy, 2018Co-Authors: Bulent Cetin, Ozge Gumusay, Ozlem Gulbahar, Ahmet Ozet, Guldal Yilmaz, Berkan Armagan, Baris Afsar, Umut Demirci, Irem Bilgetekin, Aytug UnerAbstract:Pazopanib is an effective treatment for advanced renal cell carcinoma and soft tissue sarcoma. Besides classical adverse events of this drug class, hepatotoxicity has been described as a frequent side effect. The aim of the present study was to evaluate the effect of pazopanib on the liver in an Experimental Rat model. Sixteen Wistar albino Rats were divided into 3 groups: Experimental toxicity was induced with pazopanib (10 mg/kg) administered for 28 days (group 2) or 56 days (group 3) orally by gavage. Group 1 (control group) received only distilled water. Rats in groups 2 and 3 were sacrificed after the collection of blood and tissue samples on the 28th and 56th days, respectively. We found significant differences in bilirubin, alkaline phosphatase, lactate dehydrogenase, glucose, triglyceride, very-low-density lipoprotein, and iron values (p < 0.050 for all) but none in any other parameter (p > 0.050). All Rats in the control group had normal histological features; however, none of the Rats in groups 2 and 3 showed normal histology. In group 2, we observed mild sinusoidal dilatation, congestion, enlarged Kupffer cells, accumulation of yellow-brown-black pigment in the Kupffer cells and the accumulation of hemosiderin with Prussian blue reaction in the hepatocytes. In group 3, the findings mentioned above were more prominent, and besides these findings focal acinar transformation and macrovesicular steatosis were also observed. In group 3, mild inflammation within the portal areas was observed consisting of lymphocytes, neutrophils, and eosinophils. This study is the first that reports the biochemical and histopathological evaluation of pazopanib-related hepatic toxicity.
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Pazopanib-Induced Hepatotoxicity in an Experimental Rat Model.
Chemotherapy, 2018Co-Authors: Bulent Cetin, Ozge Gumusay, Ozlem Gulbahar, Ahmet Ozet, Guldal Yilmaz, Berkan Armagan, Baris Afsar, Umut Demirci, Irem Bilgetekin, Aytug UnerAbstract:Pazopanib is an effective treatment for advanced renal cell carcinoma and soft tissue sarcoma. Besides classical adverse events of this drug class, hepatotoxicity has been described as a frequent side effect. The aim of the present study was to evaluate the effect of pazopanib on the liver in an Experimental Rat model. Sixteen Wistar albino Rats were divided into 3 groups: Experimental toxicity was induced with pazopanib (10 mg/kg) administered for 28 days (group 2) or 56 days (group 3) orally by gavage. Group 1 (control group) received only distilled water. Rats in groups 2 and 3 were sacrificed after the collection of blood and tissue samples on the 28th and 56th days, respectively. We found significant differences in bilirubin, alkaline phosphatase, lactate dehydrogenase, glucose, triglyceride, very-low-density lipoprotein, and iron values (p 0.050). All Rats in the control group had normal histological features; however, none of the Rats in groups 2 and 3 showed normal histology. In group 2, we observed mild sinusoidal dilatation, congestion, enlarged Kupffer cells, accumulation of yellow-brown-black pigment in the Kupffer cells and the accumulation of hemosiderin with Prussian blue reaction in the hepatocytes. In group 3, the findings mentioned above were more prominent, and besides these findings focal acinar transformation and macrovesicular steatosis were also observed. In group 3, mild inflammation within the portal areas was observed consisting of lymphocytes, neutrophils, and eosinophils. This study is the first that reports the biochemical and histopathological evaluation of pazopanib-related hepatic toxicity.
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Crizotinib-induced toxicity in an Experimental Rat model
Wiener klinische Wochenschrift, 2016Co-Authors: Ozge Gumusay, Guldal Esendagli-yilmaz, Aytug Uner, Bulent Cetin, Suleyman Buyukberber, Mustafa Benekli, Mustafa N. Ilhan, Ugur Coskun, Ozlem Gulbahar, Ahmet OzetAbstract:Aim The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an Experimental Rat model. Methods Eighteen Wistar albino Rats were divided into three groups: Experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively. Results Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas. Conclusion This study is the first to evaluate the histopathological features of toxicity of crizotinib in a Rat model.
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Crizotinib-induced toxicity in an Experimental Rat model.
Wiener Klinische Wochenschrift, 2016Co-Authors: Ozge Gumusay, Guldal Esendagli-yilmaz, Aytug Uner, Bulent Cetin, Suleyman Buyukberber, Mustafa Benekli, Mustafa N. Ilhan, Ugur Coskun, Ozlem Gulbahar, Ahmet OzetAbstract:Aim The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an Experimental Rat model.
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Crizotinib-induced toxicity in an Experimental Rat model.
Wiener klinische Wochenschrift, 2016Co-Authors: Ozge Gumusay, Guldal Esendagli-yilmaz, Aytug Uner, Bulent Cetin, Suleyman Buyukberber, Mustafa Benekli, Mustafa N. Ilhan, Ugur Coskun, Ozlem Gulbahar, Ahmet OzetAbstract:The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an Experimental Rat model. Eighteen Wistar albino Rats were divided into three groups: Experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively. Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas. This study is the first to evaluate the histopathological features of toxicity of crizotinib in a Rat model.
