The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform
Sverre Langård - One of the best experts on this subject based on the ideXlab platform.
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Discrimination of Smoking Status by Thiocyanate and Cotinine in Serum, and Carbon Monoxide in Expired Air
International journal of epidemiology, 1992Co-Authors: Halfrid Waage, Terje Silsand, Petter Urdal, Sverre LangårdAbstract:To develop a procedure for maximizing the discrimination of smoking status, the authors analysed parallel samples of thiocyanate and cotinine in serum, and carbon monoxide (CO) in Expired Air in a cohort of 145 male subjects aged 45-65 years. The sensitivity and specificity were 93% and 82%, 97% and 83%, and 98% and 100% for thiocyanate, cotinine, and CO respectively. The results were not significantly improved when combining two or three methods as compared with CO separately. Also, cotinine in urine was analysed in a subgroup of 21 subjects. The correlation coefficient between cotinine in serum and urine was 0.92. In a subgroup of 44 subjects with extensive information on smoking habits, CO was the only indicator significantly related to the quantity of tobacco smoked. We conclude that CO seems sufficient for validating smoking status, but as atypical smokers who are vulnerable to misclassification may be overrepresented in smoking cessation programmes, combining two methods could still be useful. Validating the amount of tobacco smoked is of limited use with the current methods.
Halfrid Waage - One of the best experts on this subject based on the ideXlab platform.
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Discrimination of Smoking Status by Thiocyanate and Cotinine in Serum, and Carbon Monoxide in Expired Air
International journal of epidemiology, 1992Co-Authors: Halfrid Waage, Terje Silsand, Petter Urdal, Sverre LangårdAbstract:To develop a procedure for maximizing the discrimination of smoking status, the authors analysed parallel samples of thiocyanate and cotinine in serum, and carbon monoxide (CO) in Expired Air in a cohort of 145 male subjects aged 45-65 years. The sensitivity and specificity were 93% and 82%, 97% and 83%, and 98% and 100% for thiocyanate, cotinine, and CO respectively. The results were not significantly improved when combining two or three methods as compared with CO separately. Also, cotinine in urine was analysed in a subgroup of 21 subjects. The correlation coefficient between cotinine in serum and urine was 0.92. In a subgroup of 44 subjects with extensive information on smoking habits, CO was the only indicator significantly related to the quantity of tobacco smoked. We conclude that CO seems sufficient for validating smoking status, but as atypical smokers who are vulnerable to misclassification may be overrepresented in smoking cessation programmes, combining two methods could still be useful. Validating the amount of tobacco smoked is of limited use with the current methods.
A. Georgiadou - One of the best experts on this subject based on the ideXlab platform.
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Analysis of Expired Air of fasting male monks at Mount Athos.
Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2006Co-Authors: M. Statheropoulos, Agapios Agapiou, A. GeorgiadouAbstract:Expired Air chemical analysis is investigated as a search and locate method for the early detection of entrapped people under the ruins of collapsed buildings after an earthquake. Fasting individuals were examined as a group that simulates the medical status of some of such victims. Exhaled Air from seven fasting male monks (after 63 h) was analysed using thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) analysis. Over 150 volatile organic compounds (VOCs) were identified and the 43 most frequent are presented. Acetone showed by far the highest "positive alveolar gradient". Other compounds included phenol, di-limonene, 2-pentanone, isoprene and acetaldehyde. Quantitative results showed a 30-fold increase of acetone concentration (5.8 ppmv) compared to control measurements of a volunteer. Breath acetone was also identified through a portable gas chromatography-ion mobility spectrometer showing possible, under certain conditions, effectiveness of the method in the field.
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Preliminary investigation of using volatile organic compounds from human Expired Air, blood and urine for locating entrapped people in earthquakes.
Journal of Chromatography B, 2005Co-Authors: M. Statheropoulos, E. Sianos, Agapios Agapiou, A. Georgiadou, A. Pappa, Nikolaos Tzamtzis, H. Giotaki, C. Papageorgiou, D. KolostoumbisAbstract:Abstract A preliminary investigation on the possibility of using volatile organic compounds (VOCs) determination of Expired Air, blood and urine, for the early location of entrapped people in earthquakes, has been carried out. A group of 15 healthy subjects has been sampled. The identification of a common “core” of substances might provide indications of human presence that can be used for the development of a real time field analytical method for the on site detection of entrapped people. Expired Air samples have been analyzed by thermal desorption GC/MS and VOCs from blood and urine by headspace SPME–GC/MS. Acetone was the only compound found common in all three matrices. Isoprene was found in both Expired Air and blood samples. Acetone and isoprene along with a number of saturated hydrocarbons were among the major constituents identified in Expired Air analysis. Various ketones (2-pentanone, 4-heptanone, 2-butanone) were also determined over urine specimens. Using the techniques and methods of field analytical chemistry and technology appears to be the proper approach for applying the results of the present study in real situations.
M. Statheropoulos - One of the best experts on this subject based on the ideXlab platform.
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Analysis of Expired Air of fasting male monks at Mount Athos.
Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2006Co-Authors: M. Statheropoulos, Agapios Agapiou, A. GeorgiadouAbstract:Expired Air chemical analysis is investigated as a search and locate method for the early detection of entrapped people under the ruins of collapsed buildings after an earthquake. Fasting individuals were examined as a group that simulates the medical status of some of such victims. Exhaled Air from seven fasting male monks (after 63 h) was analysed using thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) analysis. Over 150 volatile organic compounds (VOCs) were identified and the 43 most frequent are presented. Acetone showed by far the highest "positive alveolar gradient". Other compounds included phenol, di-limonene, 2-pentanone, isoprene and acetaldehyde. Quantitative results showed a 30-fold increase of acetone concentration (5.8 ppmv) compared to control measurements of a volunteer. Breath acetone was also identified through a portable gas chromatography-ion mobility spectrometer showing possible, under certain conditions, effectiveness of the method in the field.
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Preliminary investigation of using volatile organic compounds from human Expired Air, blood and urine for locating entrapped people in earthquakes.
Journal of Chromatography B, 2005Co-Authors: M. Statheropoulos, E. Sianos, Agapios Agapiou, A. Georgiadou, A. Pappa, Nikolaos Tzamtzis, H. Giotaki, C. Papageorgiou, D. KolostoumbisAbstract:Abstract A preliminary investigation on the possibility of using volatile organic compounds (VOCs) determination of Expired Air, blood and urine, for the early location of entrapped people in earthquakes, has been carried out. A group of 15 healthy subjects has been sampled. The identification of a common “core” of substances might provide indications of human presence that can be used for the development of a real time field analytical method for the on site detection of entrapped people. Expired Air samples have been analyzed by thermal desorption GC/MS and VOCs from blood and urine by headspace SPME–GC/MS. Acetone was the only compound found common in all three matrices. Isoprene was found in both Expired Air and blood samples. Acetone and isoprene along with a number of saturated hydrocarbons were among the major constituents identified in Expired Air analysis. Various ketones (2-pentanone, 4-heptanone, 2-butanone) were also determined over urine specimens. Using the techniques and methods of field analytical chemistry and technology appears to be the proper approach for applying the results of the present study in real situations.
Petter Urdal - One of the best experts on this subject based on the ideXlab platform.
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Discrimination of Smoking Status by Thiocyanate and Cotinine in Serum, and Carbon Monoxide in Expired Air
International journal of epidemiology, 1992Co-Authors: Halfrid Waage, Terje Silsand, Petter Urdal, Sverre LangårdAbstract:To develop a procedure for maximizing the discrimination of smoking status, the authors analysed parallel samples of thiocyanate and cotinine in serum, and carbon monoxide (CO) in Expired Air in a cohort of 145 male subjects aged 45-65 years. The sensitivity and specificity were 93% and 82%, 97% and 83%, and 98% and 100% for thiocyanate, cotinine, and CO respectively. The results were not significantly improved when combining two or three methods as compared with CO separately. Also, cotinine in urine was analysed in a subgroup of 21 subjects. The correlation coefficient between cotinine in serum and urine was 0.92. In a subgroup of 44 subjects with extensive information on smoking habits, CO was the only indicator significantly related to the quantity of tobacco smoked. We conclude that CO seems sufficient for validating smoking status, but as atypical smokers who are vulnerable to misclassification may be overrepresented in smoking cessation programmes, combining two methods could still be useful. Validating the amount of tobacco smoked is of limited use with the current methods.
