The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform
R. Lalonde - One of the best experts on this subject based on the ideXlab platform.
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subchronic memantine administration on spatial learning Exploratory Activity and nest building in an app ps1 mouse model of alzheimer s disease
Neuropharmacology, 2011Co-Authors: Mohammed Filali, R. Lalonde, Serge RivestAbstract:Glutamate neurotoxicity has been proposed to be involved in Alzheimer pathogenesis, with clinical data supporting succesful treatment with the NMDA receptor antagonist memantine. In the present study, the effects of subchronic memantine administration were assessed on spatial and non-spatial learning as well as Exploratory Activity and nest-building in APP/PS1 mutant mice. Memantine (10 mg/kg, i.p.) was better than placebo during the reversal phase of left-right discrimination, though equivalent to saline for Morris water maze and passive avoidance learning. The drug had no effect on non-learned behaviors in elevated plus-maze exploration and nest-building. These results support a specific action of the NMDA receptor antagonist on behavioral flexibility in mutant mice with amyloid pathology.
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Subchronic memantine administration on spatial learning, Exploratory Activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease.
Neuropharmacology, 2011Co-Authors: Mohammed Filali, R. Lalonde, Serge RivestAbstract:Glutamate neurotoxicity has been proposed to be involved in Alzheimer pathogenesis, with clinical data supporting succesful treatment with the NMDA receptor antagonist memantine. In the present study, the effects of subchronic memantine administration were assessed on spatial and non-spatial learning as well as Exploratory Activity and nest-building in APP/PS1 mutant mice. Memantine (10 mg/kg, i.p.) was better than placebo during the reversal phase of left-right discrimination, though equivalent to saline for Morris water maze and passive avoidance learning. The drug had no effect on non-learned behaviors in elevated plus-maze exploration and nest-building. These results support a specific action of the NMDA receptor antagonist on behavioral flexibility in mutant mice with amyloid pathology.
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Exploratory Activity and motor coordination in old versus middle-aged C57BL/6J mice.
Archives of gerontology and geriatrics, 2008Co-Authors: R. Lalonde, C. StrazielleAbstract:Aged mice were compared to middle-aged mice in two tests of Exploratory Activity and two tests of motor coordination. The 16-month-old mice had more ambulatory and rearing movements than 24-month-old mice, but fewer sterotyped movements. In contrast, no difference was found in the emergence test. The 16-month-old group outperformed the 24-month-old group on the stationary beam and coat-hanger tests. Regression analyses indicate that the number of falls from the stationary beam was positively correlated with movement times (MTs) before reaching the end of the horizontal bar. However, there was no significant correlation between open-field measures and emergence latencies, indicating that the two tests of Exploratory Activity estimate separate aspects of behavior.
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Exploratory Activity and spatial learning in 12-month-old APP695SWE/co+PS1/ΔE9 mice with amyloid plaques
Neuroscience letters, 2005Co-Authors: R. Lalonde, Hong Duck Kim, J.a. Maxwell, Ken Ichiro FukuchiAbstract:APP(695)SWE/co+PS1/DeltaE9 mice with Abeta plaques in neocortex and hippocampus were evaluated in tests of Exploratory Activity and spatial learning. On the initial testing day, 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze. The bigenic group also travelled farther in the central region of the open-field without spending more time there. Only the bigenic group alternated above chance in the T-maze. In the Morris water maze, APP(695)SWE/co+PS1/DeltaE9 mice were impaired during acquisition of the hidden platform sub-task and the probe trial but not in the visible platform test. These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology.
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Exploratory Activity and spatial learning in 12 month old app695swe co ps1 δe9 mice with amyloid plaques
Neuroscience Letters, 2005Co-Authors: R. Lalonde, Hong Duck Kim, Ken Ichiro Fukuchi, J.a. MaxwellAbstract:APP(695)SWE/co+PS1/DeltaE9 mice with Abeta plaques in neocortex and hippocampus were evaluated in tests of Exploratory Activity and spatial learning. On the initial testing day, 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze. The bigenic group also travelled farther in the central region of the open-field without spending more time there. Only the bigenic group alternated above chance in the T-maze. In the Morris water maze, APP(695)SWE/co+PS1/DeltaE9 mice were impaired during acquisition of the hidden platform sub-task and the probe trial but not in the visible platform test. These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology.
Ken Ichiro Fukuchi - One of the best experts on this subject based on the ideXlab platform.
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Exploratory Activity and spatial learning in 12-month-old APP695SWE/co+PS1/ΔE9 mice with amyloid plaques
Neuroscience letters, 2005Co-Authors: R. Lalonde, Hong Duck Kim, J.a. Maxwell, Ken Ichiro FukuchiAbstract:APP(695)SWE/co+PS1/DeltaE9 mice with Abeta plaques in neocortex and hippocampus were evaluated in tests of Exploratory Activity and spatial learning. On the initial testing day, 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze. The bigenic group also travelled farther in the central region of the open-field without spending more time there. Only the bigenic group alternated above chance in the T-maze. In the Morris water maze, APP(695)SWE/co+PS1/DeltaE9 mice were impaired during acquisition of the hidden platform sub-task and the probe trial but not in the visible platform test. These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology.
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Exploratory Activity and spatial learning in 12 month old app695swe co ps1 δe9 mice with amyloid plaques
Neuroscience Letters, 2005Co-Authors: R. Lalonde, Hong Duck Kim, Ken Ichiro Fukuchi, J.a. MaxwellAbstract:APP(695)SWE/co+PS1/DeltaE9 mice with Abeta plaques in neocortex and hippocampus were evaluated in tests of Exploratory Activity and spatial learning. On the initial testing day, 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze. The bigenic group also travelled farther in the central region of the open-field without spending more time there. Only the bigenic group alternated above chance in the T-maze. In the Morris water maze, APP(695)SWE/co+PS1/DeltaE9 mice were impaired during acquisition of the hidden platform sub-task and the probe trial but not in the visible platform test. These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology.
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Exploratory Activity, anxiety, and motor coordination in bigenic APPswe + PS1/ΔE9 mice
Neuroscience letters, 2004Co-Authors: R. Lalonde, Hong Duck Kim, Ken Ichiro FukuchiAbstract:Bigenic APPswe + PS1/DeltaE9 mice with Abeta plaque formation in neocortex and hippocampus were evaluated in three tests measuring Exploratory Activity. By comparison to a non-transgenic group controlled for age and gender, 7-month-old APPswe + PS1/DeltaE9 mice spent more time in the open arms and had higher open/total entries and duration in the elevated plus-maze, indicative of disinhibitory tendencies. On the contrary, the groups did not differ in T-maze and open-field tests. Moreover, the motor coordination of the bigenic group was equivalent to that of controls in stationary beam, coat-hanger, rotorod, and grip strength tests. No mouse displayed neurological signs, such as pathological reflexes, myoclonus, or convulsions. The results in the elevated plus-maze test are akin to the loss of inhibitory control observed in some patients with Alzheimer's disease.
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Exploratory Activity anxiety and motor coordination in bigenic appswe ps1 δe9 mice
Neuroscience Letters, 2004Co-Authors: R. Lalonde, Hong Duck Kim, Ken Ichiro FukuchiAbstract:Bigenic APPswe + PS1/ΔE9 mice with Aβ plaque formation in neocortex and hippocampus were evaluated in three tests measuring Exploratory Activity. By comparison to a non-transgenic group controlled for age and gender, 7-month-old APPswe + PS1/ΔE9 mice spent more time in the open arms and had higher open/total entries and duration in the elevated plus-maze, indicative of disinhibitory tendencies. On the contrary, the groups did not differ in T-maze and open-field tests. Moreover, the motor coordination of the bigenic group was equivalent to that of controls in stationary beam, coat-hanger, rotorod, and grip strength tests. No mouse displayed neurological signs, such as pathological reflexes, myoclonus, or convulsions. The results in the elevated plus-maze test are akin to the loss of inhibitory control observed in some patients with Alzheimer's disease.
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Transgenic mice expressing the βAPP695SWE mutation: effects on Exploratory Activity, anxiety, and motor coordination
Brain research, 2003Co-Authors: R. Lalonde, C. Strazielle, Hong Duck Kim, Terry L. Lewis, Ken Ichiro FukuchiAbstract:Abstract The functional consequences of the βAPP transgene with the Swedish mutation in mice were assessed in tests of Exploratory Activity and motor coordination. The βAPP695SWE (Tg2576) transgenic mice are characterized by Aβ plaque formation in the neocortex and hippocampus. By comparison to non-transgenic mice controlled for age and gender, 17-month-old βAPP695SWE transgenic mice displayed impaired spontaneous alternation, increased Activity levels in the peripheral part of the open-field, and reduced anxiety in the elevated plus-maze. These results are similar to the loss of inhibitory control observed in some patients with Alzheimer’s disease. These measures may be added to cognitive dysfunctions as testing ground for Aβ vaccination and other attempts at experimental therapies.
Serge Rivest - One of the best experts on this subject based on the ideXlab platform.
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subchronic memantine administration on spatial learning Exploratory Activity and nest building in an app ps1 mouse model of alzheimer s disease
Neuropharmacology, 2011Co-Authors: Mohammed Filali, R. Lalonde, Serge RivestAbstract:Glutamate neurotoxicity has been proposed to be involved in Alzheimer pathogenesis, with clinical data supporting succesful treatment with the NMDA receptor antagonist memantine. In the present study, the effects of subchronic memantine administration were assessed on spatial and non-spatial learning as well as Exploratory Activity and nest-building in APP/PS1 mutant mice. Memantine (10 mg/kg, i.p.) was better than placebo during the reversal phase of left-right discrimination, though equivalent to saline for Morris water maze and passive avoidance learning. The drug had no effect on non-learned behaviors in elevated plus-maze exploration and nest-building. These results support a specific action of the NMDA receptor antagonist on behavioral flexibility in mutant mice with amyloid pathology.
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Subchronic memantine administration on spatial learning, Exploratory Activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease.
Neuropharmacology, 2011Co-Authors: Mohammed Filali, R. Lalonde, Serge RivestAbstract:Glutamate neurotoxicity has been proposed to be involved in Alzheimer pathogenesis, with clinical data supporting succesful treatment with the NMDA receptor antagonist memantine. In the present study, the effects of subchronic memantine administration were assessed on spatial and non-spatial learning as well as Exploratory Activity and nest-building in APP/PS1 mutant mice. Memantine (10 mg/kg, i.p.) was better than placebo during the reversal phase of left-right discrimination, though equivalent to saline for Morris water maze and passive avoidance learning. The drug had no effect on non-learned behaviors in elevated plus-maze exploration and nest-building. These results support a specific action of the NMDA receptor antagonist on behavioral flexibility in mutant mice with amyloid pathology.
David Eldridge - One of the best experts on this subject based on the ideXlab platform.
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Visual Exploratory Activity and resultant behavioural analysis of youth midfield soccer players
Journal of Human Sport and Exercise, 2013Co-Authors: David Eldridge, Craig Pulling, Matthew T. RobinsAbstract:Eldridge D, Pulling C, Robins M. Visual Exploratory Activity and resultant behavioural analysis of youth midfield soccer players. J. Hum. Sport Exerc. Vol. 8, No. Proc3, pp. S560-S577, 2013. The purpose of this study was to examine the effects of visual Exploratory Activity, prior to receiving the ball in the middle third of the pitch, on the actions of youth midfield soccer players. The visual Exploratory Activity of three youth central midfield players was examined using a player cam approach, which in turn, was related to each player’s actions, after receiving the ball, through the use of a wide angle perspective. SportsCode Elite software was used to analyse all player actions post-event. Players participated in five training games, each 20 minutes in duration. The player’s actions were divided into five themes: (1) maintaining possession, (2) loss of possession, (3) field location of maintained possessions (4) defensive pressure, and, (5) turning. Associations between visual Exploratory Activity and each of the resultant behavioural themes were examined using a chi-squared test (p
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Visual Exploratory Activity and resultant behavioural analysis of youth midfield soccer players
Journal of Human Sport and Exercise, 2013Co-Authors: David Eldridge, Craig Pulling, Matthew RobinsAbstract:The purpose of this study was to examine the effects of visual Exploratory Activity, prior to receiving the ball in the middle third of the pitch, on the actions of youth midfield soccer players. The visual Exploratory Activity of three youth central midfield players was examined using a player cam approach, which in turn, was related to each player’s actions, after receiving the ball, through the use of a wide angle perspective. SportsCode Elite software was used to analyse all player actions post-event. Players participated in five training games, each 20 minutes in duration. The player’s actions were divided into five themes: (1) maintaining possession, (2) loss of possession, (3) field location of maintained possessions (4) defensive pressure, and, (5) turning. Associations between visual Exploratory Activity and each of the resultant behavioural themes were examined using a chi-squared test (p
C. Strazielle - One of the best experts on this subject based on the ideXlab platform.
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Exploratory Activity and motor coordination in old versus middle-aged C57BL/6J mice.
Archives of gerontology and geriatrics, 2008Co-Authors: R. Lalonde, C. StrazielleAbstract:Aged mice were compared to middle-aged mice in two tests of Exploratory Activity and two tests of motor coordination. The 16-month-old mice had more ambulatory and rearing movements than 24-month-old mice, but fewer sterotyped movements. In contrast, no difference was found in the emergence test. The 16-month-old group outperformed the 24-month-old group on the stationary beam and coat-hanger tests. Regression analyses indicate that the number of falls from the stationary beam was positively correlated with movement times (MTs) before reaching the end of the horizontal bar. However, there was no significant correlation between open-field measures and emergence latencies, indicating that the two tests of Exploratory Activity estimate separate aspects of behavior.
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Exploratory Activity and motor coordination in wild-type SOD1/SOD1 transgenic mice.
Brain research bulletin, 2005Co-Authors: R. Lalonde, C. Strazielle, M. Le Pêcheur, Jacqueline LondonAbstract:SOD1 is one of several overexpressed genes in trisomy 21. In order to dissect possible genetic causes of the syndrome, wild-type SOD1/SOD1 transgenic mice were compared to FVB/N non-transgenic controls at 5 months of age in tests of Exploratory Activity and motor coordination. Wild-type SOD1/SOD1 transgenic mice had fewer stereotyped movements in an open-field and fell sooner from a rotorod than controls. In contrast, wild-type SOD1/SOD1 transgenic mice had fewer falls on a wire suspension test. There was no intergroup difference for ambulatory movements in the open-field, exploration of the elevated plus-maze, emergence from a small compartment, and motor coordination on a stationary beam. These results indicate that homozygous mice expressing human SOD1 are impaired in their ability to adjust their posture in response to a moving surface and make fewer small-amplitude movements without any change in general Exploratory Activity.
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PS1 knockin mice with the Japanese I213T mutation: effects on Exploratory Activity, motor coordination, and spatial learning.
Behavioural brain research, 2005Co-Authors: R. Lalonde, C. StrazielleAbstract:Knockin (KI) mice with a PS1/I213T mutation were compared to wild-type controls on the SHIRPA primary screening battery and for Exploratory Activity, motor coordination, and spatial learning. By comparison to non-transgenic controls, PS1/I213T KI mice had retarded acquisition of place learning in the Morris water maze without being impaired in the probe trial and in the visible platform subtest. PS1/I213T KI mice were more likely to display whole-body startle to an auditory stimulus and a tighter grip on a horizontal grid. PS1/I213T KI mice also had fewer enclosed arm entries in the elevated plus-maze, but did not differ from controls in open-field, photocell actimeter, and T-maze spontaneous alternation tests. No intergroup difference was seen in three motor coordination tests. The dissociation between hidden and visible platform versions in the water maze is consistent with the hypothesis that elevated Abeta42 concentrations cause cognitive disturbances.
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Transgenic mice expressing the βAPP695SWE mutation: effects on Exploratory Activity, anxiety, and motor coordination
Brain research, 2003Co-Authors: R. Lalonde, C. Strazielle, Hong Duck Kim, Terry L. Lewis, Ken Ichiro FukuchiAbstract:Abstract The functional consequences of the βAPP transgene with the Swedish mutation in mice were assessed in tests of Exploratory Activity and motor coordination. The βAPP695SWE (Tg2576) transgenic mice are characterized by Aβ plaque formation in the neocortex and hippocampus. By comparison to non-transgenic mice controlled for age and gender, 17-month-old βAPP695SWE transgenic mice displayed impaired spontaneous alternation, increased Activity levels in the peripheral part of the open-field, and reduced anxiety in the elevated plus-maze. These results are similar to the loss of inhibitory control observed in some patients with Alzheimer’s disease. These measures may be added to cognitive dysfunctions as testing ground for Aβ vaccination and other attempts at experimental therapies.
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Characterization of NFH-LacZ transgenic mice with the SHIRPA primary screening battery and tests of motor coordination, Exploratory Activity, and spatial learning
Behavioural processes, 2003Co-Authors: R. Lalonde, Joël Eyer, V. Wunderle, C. StrazielleAbstract:NFH-LacZ transgenic mice express a fusion protein between a truncated form of the endogenous neurofilament of heavy molecular weight and the complete E. coli β-galactosidase. NFH-LacZ transgenic mice could be distinguished from controls in the SHIRPA neurological battery by the appearance of action tremor and hindlimb clasping and a lower body weight. Despite normal Exploratory Activity and spatial learning, NFH-LacZ transgenic mice were deficient in stationary beam, coat-hanger, and rotorod tests of motor coordination. These results are concordant with neuropathological findings in spinal motoneurons and the cerebellum and indicate that despite the absence of paralysis, these transgenic mice may serve as an experimental model of the early stage of amyotrophic lateral sclerosis.
