Expression Change

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Travis Salway - One of the best experts on this subject based on the ideXlab platform.

Alex Abramovich - One of the best experts on this subject based on the ideXlab platform.

  • the scope and nature of sexual orientation and gender identity and Expression Change efforts a systematic review protocol
    Systematic Reviews, 2021
    Co-Authors: David J Kinitz, Trevor Goodyear, Elisabeth Dromer, Olivier Ferlatte, Travis Salway, Dean Giustini, Florence Ashley, Hannah Kia, Alex Abramovich
    Abstract:

    Sexual orientation and gender identity and Expression Change efforts (SOGIECE) are a set of scientifically discredited practices that aim to deny and suppress the sexual orientations, gender identities, and/or gender Expressions of sexual and gender minorities (SGM). SOGIECE are associated with significant adverse health and social outcomes. SOGIECE continue to be practiced around the world, despite denouncements from professional bodies and survivors, as well as calls for legislative advocacy to prohibit SOGIECE and protect SGM. There are substantial gaps in the availability of consolidated international research to support and refine legislative proposals related to SOGIECE, including those currently underway to enforce bans in Canada and elsewhere. We therefore propose the first systematic review of international data on SOGIECE that will outline the scope and nature of these practices worldwide. Specifically, we aim to estimate how many SGM have been exposed to SOGIECE, which sub-groups of SGM experience higher rates of SOGIECE, and how estimates of SOGIECE vary over time and place. In addition, we aim to describe when, where, how, and under what circumstances SGM are exposed to SOGIECE. To locate an interdisciplinary swath of papers, nine (9) bibliographic databases will be searched: Medline (OVID), Embase (OVID), PsycInfo and Social Work Abstracts via EBSCO, CINAHL, Web of Science Core Collection, LGBTQ+ Source, and Proquest Dissertations & Theses Global and Sociology Collection (ProQuest). A gold standard search will be developed for Medline and adapted to the other databases. Grey literature will be searched at relevant websites, and reference harvesting will be performed in relevant SOGIECE scientific consensus statements. Two authors will independently screen abstracts/titles, screen full texts, abstract data, and apply risk of bias assessments. A narrative synthesis will be implemented to summarize findings. This review will address the gap in synthesized data regarding the prevalence of SOGIECE, social correlates of SOGIECE, variations of SOGIECE over time and place, and the circumstances, settings, and time-points of SOGIECE exposure. Findings from this review will directly inform ongoing and new legislative efforts to ban SOGIECE and other interventions that aim to stem SOGIECE practices and support SOGIECE survivors. Registration with PROSPERO can be found under the registration number: CRD42020196393 .

David J Kinitz - One of the best experts on this subject based on the ideXlab platform.

Tatsuhiko Tsunoda - One of the best experts on this subject based on the ideXlab platform.

  • alterations of gene Expression during colorectal carcinogenesis revealed by cdna microarrays after laser capture microdissection of tumor tissues and normal epithelia
    Cancer Research, 2001
    Co-Authors: Osamu Kitahara, Yoichi Furukawa, Toshihiro Tanaka, Chikashi Kihara, Kenji Ono, Renpei Yanagawa, Marcelo E Nita, Toshihisa Takagi, Yusuke Nakamura, Tatsuhiko Tsunoda
    Abstract:

    To identify a set of genes involved in the development of colorectal carcinogenesis, we compared Expression profiles of colorectal cancer cells from eight tumors with corresponding noncancerous colonic epithelia using a DNA microarray consisting of 9216 human genes. These cell populations had been rendered homogeneous by laser-capture microdissection. Expression Change in more than half of the tumors was observed for 235 genes, i.e., 44 up-regulated and 191 down-regulated genes. The differentially expressed genes include those associated with signal transduction, metabolizing enzymes, production of reactive oxygen species, cell cycle, transcription, mitosis, and apoptosis. Subsequent examination of 10 genes (five up-regulated and five down-regulated) by semiquantitative reverse transcription-PCR using the eight tumors together with an additional 12 samples substantiated the reliability of our analysis. The extensive list of genes identified in these experiments provides a large body of potentially valuable information of colorectal carcinogenesis and represents a source of novel targets for cancer therapy.

  • alterations of gene Expression during colorectal carcinogenesis revealed by cdna microarrays after laser capture microdissection of tumor tissues and normal epithelia
    Cancer Research, 2001
    Co-Authors: Osamu Kitahara, Yoichi Furukawa, Toshihiro Tanaka, Chikashi Kihara, Renpei Yanagawa, Marcelo E Nita, Toshihisa Takagi, Yusuke Nakamura, Tatsuhiko Tsunoda
    Abstract:

    To identify a set of genes involved in the development of colorectal carcinogenesis, we compared Expression profiles of colorectal cancer cells from eight tumors with corresponding noncancerous colonic epithelia using a DNA microarray consisting of 9216 human genes. These cell populations had been rendered homogeneous by laser-capture microdissection. Expression Change in more than half of the tumors was observed for 235 genes, i.e., 44 up-regulated and 191 down-regulated genes. The differentially expressed genes include those associated with signal transduction, metabolizing enzymes, production of reactive oxygen species, cell cycle, transcription, mitosis, and apoptosis. Subsequent examination of 10 genes (five up-regulated and five down-regulated) by semiquantitative reverse transcription-PCR using the eight tumors together with an additional 12 samples substantiated the reliability of our analysis. The extensive list of genes identified in these experiments provides a large body of potentially valuable information of colorectal carcinogenesis and represents a source of novel targets for cancer therapy.

Trevor Goodyear - One of the best experts on this subject based on the ideXlab platform.